12,962 results match your criteria growth gold

Unraveling the influence of substrate on the growth rate, morphology and covalent structure of surface adherent polydopamine films.

Colloids Surf B Biointerfaces 2021 Jun 2;205:111897. Epub 2021 Jun 2.

Department of Chemistry and Physics of Surfaces and Interfaces, Institute of Macromolecular Chemistry, Czech Academy of Sciences, 162 06, Prague 6, Czech Republic. Electronic address:

Polydopamine (PDA), also known as synthetic melanin, is widely used as a biomimetic anchoring layer for the modification of various solid substrates. PDA is utilized for a wide range of biomedical, sensing and tribological applications, even though the polymer's precise covalent structure has not been completely revealed yet. Even more, it is not evident to which extent the chemical nature of the substrate, on which the layer is formed, influences and predetermines the covalent structure of resulting PDA. Read More

View Article and Full-Text PDF

GMP compliant isolation of mucosal epithelial cells and fibroblasts from biopsy samples for clinical tissue engineering.

Sci Rep 2021 Jun 11;11(1):12392. Epub 2021 Jun 11.

Cancer Institute, Department of Haematology, University College London, London, UK.

Engineered epithelial cell sheets for clinical replacement of non-functional upper aerodigestive tract mucosa are regulated as medicinal products and should be manufactured to the standards of good manufacturing practice (GMP). The current gold standard for growth of epithelial cells for research utilises growth arrested murine 3T3 J2 feeder layers, which are not available for use as a GMP compliant raw material. Using porcine mucosal tissue, we demonstrate a new method for obtaining and growing non-keratinised squamous epithelial cells and fibroblast cells from a single biopsy, replacing the 3T3 J2 with a growth arrested primary fibroblast feeder layer and using pooled Human Platelet lysate (HPL) as the media serum supplement to replace foetal bovine serum (FBS). Read More

View Article and Full-Text PDF

Biodegradable Polymers and Gold Nanoparticle-Decorated Skin Substitutes: Synthesis, Characterization, and In Vitro Biological Activities.

Appl Biochem Biotechnol 2021 Jun 10. Epub 2021 Jun 10.

Department of Chemistry, Avinashilingam Institute for Home Science and Higher Education for Women, 641043, Coimbatore, India.

Skin substitutes are a restorative material used to treat many skin injuries by replacing or masking the wound. It is also capable of producing an original skin type. In this study, gold nanoparticle-aided skin substitutes were prepared using biodegradable materials (chitosan, sodium alginate, and gelatin) under the magnetic stirring method. Read More

View Article and Full-Text PDF

Design, physico-chemical characterization and biological activity of organogold(III) glycoconjugates.

Dalton Trans 2021 Jun 10. Epub 2021 Jun 10.

National University of Ireland Galway, School of Chemistry, University Road, H91 TK33 Galway, Co. Galway, Ireland.

To develop new metal-based glycoconjugates as potential anticancer agents, four organometallic gold(iii)-dithiocarbamato glycoconjugates of the type [AuIII(2-Bnpy)(SSC-Inp-GlcN)](PF6) (2-Bnpy: 2-benzylpyridine; Inp: isonipecotic moiety; GlcN: amino-glucose scaffold; Au3-Au6) and the corresponding model non-glycosylated counterparts [AuIII(2-Bnpy)(SSC-Inp-R)](PF6) (R: OEt (Au1), NH2 (Au2)) have been generated and characterized by means of several analytical techniques (elemental analysis, FT-IR, 1H-/13C-NMR, ESI-MS, UV-Vis, X-ray crystallography). Their stability under physiologically-relevant conditions (PBS solution) and n-octanol/PBS distribution coefficient (D7.4) have also been evaluated. Read More

View Article and Full-Text PDF

Novel method for quantifying cells on carriers and its demonstration during SARS-2 vaccine development.

Biotechnol Bioeng 2021 Jun 10. Epub 2021 Jun 10.

Department of Biotechnology.

The most effective way to prevent and control infectious disease outbreak is through vaccines. The increasing use of vaccines has elevated the need to establish new manufacturing strategies. One of the major approaches is cell-based production, which creates a need for high cell density to enable higher cell production levels. Read More

View Article and Full-Text PDF

Single-parameter-tuned synthesis for shape-controlled gold nanocrystals stimulated by iron carbonyl.

J Colloid Interface Sci 2021 May 29;601:773-781. Epub 2021 May 29.

Department of Chemistry, Laboratory of Advanced Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, PR China. Electronic address:

Shape-controlled synthesis is essential for functional nanomaterials, allowing deeper insights intothe relationship between the structures and the catalytic properties. Synthesis of nanocrystals with particular morphologies are usually studied independently among various synthetic methods, those underline that different surface capping ligands or shape-directing agents bring about disparate shapes. However, a single quantitative parameter method is still lacking to realize precise control of well-defined morphology nanocrystals, especially anisotropic structures, which is essential to understanding the growth process of nanocrystals. Read More

View Article and Full-Text PDF

Dmp1Cre-directed knockdown of PTHrP in murine decidua is associated with a life-long increase in bone mass, width, and strength in male progeny.

J Bone Miner Res 2021 Jun 8. Epub 2021 Jun 8.

St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.

Parathyroid hormone related-protein (PTHrP) is a pleiotropic regulator of tissue homeostasis. In bone, Dmp1Cre-targeted PTHrP deletion in osteocytes causes osteopenia and impaired cortical strength. We report here that this outcome depends on parental genotype. Read More

View Article and Full-Text PDF

Agreement between body composition techniques in children and adolescents: narrative review of the literature.

Rev Med Inst Mex Seguro Soc 2020 04 13;58(2):181-196. Epub 2020 Apr 13.

Secretaría de Salud, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Centro de Investigación en Enfermedades Infecciosas, Ciudad de México. México.

Body composition monitoring is important to understand the effect of diet, physical activity, illness and growth on body stores. Body composition determination by accuracy and reproducibility techniques is essential. The objective of this study was to analyze the agreement between body composition techniques in children and adolescents. Read More

View Article and Full-Text PDF

Insulin-like Growth Factor 1, but Not Insulin-Like Growth Factor-Binding Protein 3, Predicts Central Precocious Puberty in Girls 6-8 Years Old: A Retrospective Study.

Horm Res Paediatr 2021 Jun 7:1-8. Epub 2021 Jun 7.

Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.

Background: Central precocious puberty (CPP) in females is characterized by thelarche before 8 years of age. Evidence of reproductive axis activation confirms the diagnosis (basal serum luteinizing hormone (LH) ≥0.3 IU/L or LH-releasing hormone (LHRH)-stimulated LH ≥5 IU/L). Read More

View Article and Full-Text PDF

Evaluation of an online education module designed to reduce stillbirth.

Aust N Z J Obstet Gynaecol 2021 Jun 7. Epub 2021 Jun 7.

Centre of Research Excellence in Stillbirth, Mater Research Institute, The University of Queensland, Brisbane, Queensland, Australia.

Background: The Safer Baby Bundle (SBB) eLearning is an online education module that addresses practice gaps in stillbirth prevention in Australia. It provides healthcare professionals with evidence-based resources for: smoking cessation; fetal growth restriction; decreased fetal movements; maternal safe going-to-sleep position; and timing of birth for women with risk factors for stillbirth.

Aims: To determine whether participants' reported knowledge and confidence in providing care designed to reduce stillbirth changed following completion of the module. Read More

View Article and Full-Text PDF

Sorafenib derivatives-functionalized gold nanoparticles confer protection against tumor angiogenesis and proliferation via suppression of EGFR and VEGFR-2.

Exp Cell Res 2021 Jun 2:112633. Epub 2021 Jun 2.

Department of Urology Surgery, Chinese Medical Hospital of Hainan Province, Haikou 570203, P.R. China. Electronic address:

Increasing evidence has reported the great promise of multicomponent and multifunctional nanoparticles as advanced therapies of human diseases, especially tumors. In the current study, we investigated the functionality of new sorafenib derivatives-capped gold nanoparticles (AuNPs-New Sor) in tumor growth as well as their anti-tumor mechanisms. Initially, new sorafenib derivatives were constructed and combined with AuNPs to form AuNPs-New Sor. Read More

View Article and Full-Text PDF

Stepwise immobilization of keratin-dopamine conjugates and gold nanoparticles on PET sheets for potential vascular graft with the catalytic generation of nitric oxide.

Colloids Surf B Biointerfaces 2021 May 17;205:111855. Epub 2021 May 17.

Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, PR China. Electronic address:

Gold nanoparticles(AuNPs) are capable to catalyze the nitric oxide (NO) generation from endogenous and exogenous donors, thereby promoting re-endothelialization and inhibiting intimal hyperplasia and thrombosis. Herein, keratin-dopamine conjugates were synthesized and then immobilized on the surface of the pre-aminolyzed poly(ethylene terephthalate) (PET) via self-polymerization of dopamine residue, following by the formation of AuNPs in situ without extra reductant. The modified PET sheets(PET-AuNPs) could promote the growth of HUVECs while inhibit the proliferation of HUASMCs due to their catalytic generation of NO from GSNO. Read More

View Article and Full-Text PDF

Voltammetric detection of vitamin D employing Au-MoS hybrid as immunosensing platform.

Mikrochim Acta 2021 Jun 4;188(7):222. Epub 2021 Jun 4.

Department of Biochemistry, Panjab University, Chandigarh, 160014, India.

A voltammetric immunosensor based on molybdenum sulphide (MoS) and gold nanoparticles (Au NPs) for the determination of 25-hydroxy vitamin D (25(OH)D) is reported. Anti-vit D (Ab-25(OH)D) was immobilized onto the cysteamine-modified MoS and Au NPs which were deposited onto a fluoride tin oxide (FTO) electrode (Ab/Cys/Au/MoS/FTO). The MoS sheets were prepared by hydrothermal method followed by an in situ growth of Au film onto the MoS/FTO surface. Read More

View Article and Full-Text PDF

Recent advances in gold nanoparticle-based lateral flow immunoassay for the detection of bacterial infection.

Arch Microbiol 2021 Jun 4. Epub 2021 Jun 4.

Applied Science Department, The NorthCap University, Gurugram, India.

Diagnosis of bacterial infections (BI) is becoming an increasingly difficult task in clinical practice due to their high prevalence and frequency, as well as the growth of antibiotic resistance worldwide. World Health Organization (WHO) reported antibiotic resistance is a major public health problem. BI becomes difficult or impossible to treat when the bacteria acquire immunity against antibiotics. Read More

View Article and Full-Text PDF

Complex Metal Nanostructures with Programmable Shapes from Simple DNA Building Blocks.

Adv Mater 2021 Jun 4:e2100381. Epub 2021 Jun 4.

Molecular Biophysics Group, Peter Debye Institute for Soft Matter Physics, Universität Leipzig, 04103, Leipzig, Germany.

Advances in DNA nanotechnology allow the design and fabrication of highly complex DNA structures, uisng specific programmable interactions between smaller nucleic acid building blocks. To convey this concept to the fabrication of metallic nanoparticles, an assembly platform is developed based on a few basic DNA structures that can serve as molds. Programming specific interactions between these elements allows the assembly of mold superstructures with a range of different geometries. Read More

View Article and Full-Text PDF

Delivery of antisense oligonucleotides using multi-layer coated gold nanoparticles to methicillin-resistant S. aureus for combinatorial treatment.

Mater Sci Eng C Mater Biol Appl 2021 Jul 5;126:112167. Epub 2021 May 5.

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea; Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. Electronic address:

The spread of multidrug-resistant (MDR) bacterial infections has become a serious global threat. We introduce multi-layer coated gold nanoparticles (MLGNPs) delivering antisense oligonucleotides (ASOs) targeting the resistance gene of methicillin-resistant Staphylococcus aureus (MRSA), as a selective antimicrobial by restoring susceptibility. MLGNPs were prepared by multi-step surface immobilization of gold nanoparticles (GNPs) with polyethylenimine (PEI) and loaded with ASO targeting the mecA gene. Read More

View Article and Full-Text PDF

Gold Nanomaterials as a Promising Integrated Tool for Diagnosis and Treatment of Pathogenic Infections-A Review.

J Biomed Nanotechnol 2021 May;17(5):744-770

Department of Microbiology, College of Life Science, Hunan Normal University, Changsha 410081, Hunan, China.

This review summarizes research on functionalized gold nanomaterials as pathogen detection sensors and pathogen elimination integrated tools. After presenting the challenge of current severe threat from pathogenic bacteria and the increasingly serious growth rate of drug resistance, the first section mainly introduces the conspectus of gold nanostructures from synthesis, characterization, physicochemical properties and applications of gold nanomaterials. The next section deals with gold nanomaterials-based pathogen detection sensors such as colorimetric sensors, fluorescence sensors and Surface-Enhanced Raman Scattering sensors. Read More

View Article and Full-Text PDF

Lessons Learned from PACORES in Proliferative Diabetic Retinopathy Management, Data from Latin America and Spain: The Asbury Lecture 2020.

Retina 2021 May 31. Epub 2021 May 31.

Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD.

Purpose: To review the current literature on the management of proliferative diabetic retinopathy (PDR) and the challenges in the real-world setting.

Methods: A review of the literature was performed on the therapeutic options for PDR, with a focus on the real-world data presented by the Pan-American Collaborative Retina Study Group (PACORES).

Results: Data from clinical trials and previous literature has reported that intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy is non-inferior to the gold standard panretinal photocoagulation (PRP) for treating PDR. Read More

View Article and Full-Text PDF

Investigation of Nano-Bio Interactions within a Pancreatic Tumor Microenvironment for the Advancement of Nanomedicine in Cancer Treatment.

Curr Oncol 2021 May 24;28(3):1962-1979. Epub 2021 May 24.

Physics and Astronomy, University of Victoria, Victoria, BC V8P 5C2, Canada.

Pancreatic cancer is one of the deadliest types of cancer, with a five-year survival rate of only 10%. Nanotechnology offers a novel perspective to treat such deadly cancers through their incorporation into radiotherapy and chemotherapy. However, the interaction of nanoparticles (NPs) with cancer cells and with other major cell types within the pancreatic tumor microenvironment (TME) is yet to be understood. Read More

View Article and Full-Text PDF

Bee Pollen: Current Status and Therapeutic Potential.

Nutrients 2021 May 31;13(6). Epub 2021 May 31.

Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt.

Bee pollen is a combination of plant pollen and honeybee secretions and nectar. The Bible and ancient Egyptian texts are documented proof of its use in public health. It is considered a gold mine of nutrition due to its active components that have significant health and medicinal properties. Read More

View Article and Full-Text PDF

Effects of Different Surfactant Charges on the Formation of Gold Nanoparticles by the LASiS Method.

Materials (Basel) 2021 May 29;14(11). Epub 2021 May 29.

Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.

The laser ablation synthesis in solution (LASiS) method has been widely utilized due to its significant prospects in laser microprocessing of nanomaterials. In this study, the LASiS method with the addition of different surfactant charges (cationic CTAB, nonionic TX-100, and anionic SDS) was used to produce Au NPs. An Nd:YAG laser system at 532 nm excitation with some synthetic parameters, including different laser fluences, ablation times, and surfactant concentrations was performed. Read More

View Article and Full-Text PDF

Emerging Molecular Receptors for the Specific-Target Delivery of Ruthenium and Gold Complexes into Cancer Cells.

Molecules 2021 May 25;26(11). Epub 2021 May 25.

Centro de Química Estrutural and Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisbon, Portugal.

Cisplatin and derivatives are highly effective in the treatment of a wide range of cancer types; however, these metallodrugs display low selectivity, leading to severe side effects. Additionally, their administration often results in the development of chemoresistance, which ultimately results in therapeutic failure. This scenario triggered the study of other transition metals with innovative pharmacological profiles as alternatives to platinum, ruthenium- (e. Read More

View Article and Full-Text PDF

Gold Nanoparticles Affect Pericyte Biology and Capillary Tube Formation.

Pharmaceutics 2021 May 17;13(5). Epub 2021 May 17.

Department of Anatomy, Faculty of Medicine, Chulalongkorn University, 1873 Rama 4 Rd., Wangmai, Pathumwan, Bangkok 10330, Thailand.

Gold nanoparticles (AuNPs) are used for diagnostic and therapeutic purposes, especially antiangiogenesis, which are accomplished via inhibition of endothelial cell proliferation, migration, and tube formation. However, no research has been performed on the effects of AuNPs in pericytes, which play vital roles in endothelial cell functions and capillary tube formation during physiological and pathological processes. Therefore, the effects of AuNPs on the morphology and functions of pericytes need to be elucidated. Read More

View Article and Full-Text PDF

Modified Gold Nanoparticles for Efficient Delivery of Betulinic Acid to Cancer Cell Mitochondria.

Int J Mol Sci 2021 May 11;22(10). Epub 2021 May 11.

Nano-Gene and Drug Delivery Group, Discipline of Biochemistry, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa.

Advances in nanomedicine have seen the adaptation of nanoparticles (NPs) for subcellular delivery for enhanced therapeutic impact and reduced side effects. The pivotal role of the mitochondria in apoptosis and their potential as a target in cancers enables selective induction of cancer cell death. In this study, we examined the mitochondrial targeted delivery of betulinic acid (BA) by the mitochondriotropic TPP-functionalized epigallocatechin gallate (EGCG)-capped gold NPs (AuNPs), comparing the impact of polyethylene glycol (PEG) and poly-L-lysine-graft-polyethylene glycol (PLL-g-PEG) copolymer on delivery efficacy. Read More

View Article and Full-Text PDF

Validation of a Novel Diagnostic Approach Combining the VersaTREK™ System for Recovery and Real-Time PCR for the Identification of in Water Samples.

Microorganisms 2021 May 11;9(5). Epub 2021 May 11.

Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, 10154 Torino, Italy.

is an emerging pathogen associated with endocarditis and vasculitis following cardiac surgery. Although it can take up to 6-8 weeks to culture on selective solid media, culture-based detection remains the gold standard for diagnosis, so more rapid methods are urgently needed. For the present study, we processed environmental infected simulates at volumes defined in international guidelines. Read More

View Article and Full-Text PDF

Unraveling the Central Role of Sulfur-Oxidizing LMS in Industrial Bioprocessing of Gold-Bearing Sulfide Concentrates.

Microorganisms 2021 May 1;9(5). Epub 2021 May 1.

JSC "Polyus Krasnoyarsk", Research Center, Poligonnaya Str., 15, 660118 Krasnoyarsk, Russia.

LMS is an acidophile isolated from industrial bioreactors during the processing of the gold-bearing pyrite-arsenopyrite concentrate at 38-42 °C. Most strains of this species are obligate organoheterotrophs that do not use ferrous iron or reduced sulfur compounds as energy sources. However, the LMS strain was identified as one of the predominant sulfur oxidizers in acidophilic microbial consortia. Read More

View Article and Full-Text PDF

Synthesizing Photoluminescent Au28(SCH2Ph-tBu)22 Nanoclusters with Feature Structures by Using A Joint Method.

Angew Chem Int Ed Engl 2021 Jun 1. Epub 2021 Jun 1.

Institute of Solid State Physics Chinese Academy of Sciences, Nanomaterials and nanotechnologies, CHINA.

Metal nanoclusters are currently widely researched; however, some fundamental studies, such as studies to improve the understanding of the kernel evolution pattern and structural photoluminescence, are far from complete due to the limitations of the synthesis method. Herein, we introduced a novel strategy-the joint of the current synthesis methods for atomically precise nanocluster synthesis. As an illustration, we introduced the reducing-ligand induction joint method and synthesized a novel nanocluster, which was determined to be Au 28 (SCH 2 Ph- t Bu) 22 with the same number of gold atoms as existing Au 28 (SR) 20 nanoclusters but different ligands (hetero-staple-homo-size). Read More

View Article and Full-Text PDF

Polypoidal Choroidal Vasculopathy after Stereotactic Radiotherapy for Neovascular Age-Related Macular Degeneration: A Case Report with Long-Term Follow-Up.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):299-305. Epub 2021 Apr 30.

Medical Retina Department, Vista Klinik Binningen, Binningen, Switzerland.

Several adjunct therapies to the gold standard anti-vascular endothelial growth factor (anti-VEGF) intravitreal injections have been discussed for the treatment of neovascular age-related macular degeneration (nAMD). Low-dose stereotactic radiotherapy (SRT) showed the potential to lower the treatment burden by reducing the anti-VEGF treatment frequency at least over 2-3 years but was associated with retinal microvascular abnormalities in a few cases. We report a 6-year follow-up of a case with bilateral nAMD under anti-VEGF treatment which developed multiple polypoid choroidal vasculopathy (PCV) lesions in the eye adjunct treated with low-dose SRT. Read More

View Article and Full-Text PDF

Gold nanoparticles show potential in vitro antiviral and anticancer activity.

Life Sci 2021 May 26:119652. Epub 2021 May 26.

Department of Bacteriology and Virology, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Aims: Gold nanoparticles (AuNPs) have been attracted interests in the various areas of clinical therapeutics. In this study, we investigated the anticancer and antiviral potential activity of AuNPs against influenza A virus and human glioblastoma (GMB) U-87 and U-251 cell lines.

Main Methods: Gold nanoparticles (AuNPs) were synthesized by citrate reduction method. Read More

View Article and Full-Text PDF

Revealing the etching process of water-soluble Au nanoclusters at the molecular level.

Nat Commun 2021 05 28;12(1):3212. Epub 2021 May 28.

Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, 117585, Singapore.

Etching (often considered as decomposition) is one of the key considerations in the synthesis, storage, and application of metal nanoparticles. However, the underlying chemistry of their etching process still remains elusive. Here, we use real-time electrospray ionization mass spectrometry to study the reaction dynamics and size/structure evolution of all the stable intermediates during the etching of water-soluble thiolate-protected gold nanoclusters (Au NCs), which reveal an unusual "recombination" process in the oxidative reaction environment after the initial decomposition process. Read More

View Article and Full-Text PDF