1,408,370 results match your criteria growth factors


Georgian Med News 2021 Mar(312):82-87

Tbilisi State Medical University, Department of Peadiatric Neurology; Iashvili Children's Central Hospital, Tbilisi, Georgia.

The purpose of this review is study of literature for the development of biological effect of Kalcipherol (D vitamin group) on children population. Different factors seem, that D- vitamin deficiency disbalance elevated, children specifically negative effect, which have a major impact on health, growth and development of infants, children and adolescents. Vitamin D and calcium deficiencies are preventable global public health problems in pediatric medicine. Read More

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Anammox bacteria in treating ammonium rich wastewater: Recent perspective and appraisal.

Bioresour Technol 2021 Apr 28;334:125240. Epub 2021 Apr 28.

Ecosphere Resilience Research Centre, Faculty of Applied Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka. Electronic address:

The discovery of anammox process has provided eco-friendly and low-cost means of treating ammonia rich wastewater with remarkable efficiency. Furthermore, recent studies have shown that the possibility of operating the anammox process under low temperatures and high organic matter contents broadening the application of the anammox process. However, short doubling time and extensive levels of sensitivity towards nutrients and environmental alterations such as salinity and temperature are the limitations in practical applications of the anammox process. Read More

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Discovery of thieno[2,3-d]pyrimidine-based derivatives as potent VEGFR-2 kinase inhibitors and anti-cancer agents.

Bioorg Chem 2021 Apr 27;112:104947. Epub 2021 Apr 27.

Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Ad Diriyah 13713, Riyadh, Saudi Arabia; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address:

Vascular endothelial growth factor-2 (VEGFR-2) is considered one of the most important factors in tumor angiogenesis, and consequently a number of anticancer therapeutics have been developed to inhibit VEGFR-2 signaling. Accordingly, eighteen derivatives of thieno[2,3-d]pyrimidines having structural characteristics similar to VEGFR-2 inhibitors were designed and synthesized. Anticancer activities of the new derivatives were assessed against three human cancer cell lines (HCT-116, HepG2, and MCF-7) using MTT. Read More

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A basic helix-loop-helix transcription factor CabHLH113 positively regulate pepper immunity against Ralstonia solanacearum.

Microb Pathog 2021 May 5:104909. Epub 2021 May 5.

Innovative Institute for Plant Health, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, People's Republic of China; College of Agriculture and Biology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, People's Republic of China. Electronic address:

Pepper's (Capsicum annum) response to bacterial pathogen Ralstonia solanacearm inoculation (RSI) and abiotic stresses is known to be synchronized by transcriptional network; however, related molecular mechanisms need extensive experimentation. We identified and characterized functions of CabHLH113 -a basic helix-loop-helix transcription factor-in pepper immunity to R. solanacearum infection. Read More

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Injectable Hydrogel for Co-Delivery of 5-Azacytidine in Zein Protein Nanoparticles with Stem Cells for Cardiac Function Restoration.

Int J Pharm 2021 May 5:120673. Epub 2021 May 5.

Stem cell and Molecular Biology Laboratory, Bhupat and Jyoti Mehta School of Biosciences, Department of Biotechnology, Indian Institute of Technology Madras, Chennai-600036, TN, India. Electronic address:

Heart failure is major cause of mortality associated with mostly Myocardial infarction (MI). Transplanting mesenchymal stem cells (MSC) have exhibited potential role in myocardial regeneration. Secretion of immune-modulatory cytokines and various growth factors after transplantation plays significant role in remodelling process of MI region. Read More

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Dual-specificity phosphatase 6 (DUSP6) mRNA and protein abundance is regulated by fibroblast growth factor 2 in sheep granulosa cells and inhibits c-Jun N-terminal kinase (MAPK8) phosphorylation.

Mol Cell Endocrinol 2021 May 5:111297. Epub 2021 May 5.

Centre de recherche en reproduction animale, Faculté de médecine vétérinaire, Université de Montréal, St-Hyacinthe, J2S 7C6, QC, Canada. Electronic address:

Growth factors regulate ovarian follicle development and they signal through intracellular pathways including mitogen-activated protein kinase (MAPK) phosphorylation, which is negatively regulated by a subfamily of 23 dual-specificity phosphatases (DUSP). Using sheep granulosa cells as a model, we detected mRNA encoding 16 DUSPs in vivo and in vitro. Stimulation of cells in vitro with FGF2 increased (p < 0. Read More

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The evolution characteristics and influence factors of carbon productivity in China's industrial sector: from the perspective of embodied carbon emissions.

Environ Sci Pollut Res Int 2021 May 8. Epub 2021 May 8.

School of Economics and Management, China University of Petroleum, Beijing, 102249, China.

In the context of low-carbon economic development, carbon productivity has effectively integrated the two major objectives of carbon reduction and economic growth, and increasing carbon productivity has become the main approach to address global climate change. Using data from China's input-output table for 2002-2017, this study measures the evolutionary characteristics and influencing factors of carbon productivity from the perspective of embodied carbon emission in China's industrial sector. The results indicate that, first, China's industrial sectors' carbon productivity shows an increasing trend from 25. Read More

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Expression of CD44 variant 9 induces chemoresistance of gastric cancer by controlling intracellular reactive oxygen spices accumulation.

Gastric Cancer 2021 May 8. Epub 2021 May 8.

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: CD44 variant 9 (CD44v9) has been reported to suppress reactive oxygen spices (ROS) in association with antioxidant factors such as glutathione (GSH) and glutathione peroxidase 2 (GPx2), resulting in promoted tumor growth.

Methods: CD44v9 and GPx2 expression were investigated by immunohistochemistry in resected specimens from 193 gastric cancer (GC) patients without preoperative chemotherapy and in pretreatment biopsy specimens from 29 GC patients with preoperative chemotherapy. We analyzed the relationship between CD44v9 expression and clinicopathological factors, prognosis, and pathological response to chemotherapy. Read More

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Characterization of a transcription factor SlNAC7 gene from Suaeda liaotungensis and its role in stress tolerance.

J Plant Res 2021 May 8. Epub 2021 May 8.

School of Life Sciences, Liaoning Normal University, Dalian, 116081, China.

NAC (NAM, ATAF1/2, CUC2) transcription factors play important roles in plant growth, development, and responses to abiotic stress. In this study, we cloned an NAC2 subfamily transcription factor gene (SlNAC7) from the halophyte Suaeda liaotungensis K., and conducted a series of studies to determine the characteristics and functions of this gene. Read More

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Comprehensive characterization of stress tolerant bacteria with plant growth-promoting potential isolated from glyphosate-treated environment.

World J Microbiol Biotechnol 2021 May 8;37(6):94. Epub 2021 May 8.

Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, 6726, Hungary.

The application of plant growth-promoting bacteria in agricultural systems is an efficient and environment-friendly strategy to improve crop yields and maintain soil quality. However, as different soils have diverse and specific ecological characteristics and may represent adverse abiotic conditions, in vivo application requires the careful selection of the desired beneficial microorganisms. In this study we report Ensifer adhaerens SZMC 25856 and Pseudomonas resinovorans SZMC 25875 isolates recovered from glyphosate-treated soil to possess yet undiscovered plant growth-enhancing potential. Read More

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Intraovarian injection of platelet-rich plasma in assisted reproduction: too much too soon?

Hum Reprod 2021 May 8. Epub 2021 May 8.

Centre for Atherothrombosis and Metabolic Disease, Hull York Medical School, University of Hull, Hull, UK.

The prospect of ovarian rejuvenation offers the tantalising prospect of treating age-related declines in fertility or in pathological conditions such as premature ovarian failure. The concept of ovarian rejuvenation was invigorated by the indication of the existence of oogonial stem cells (OSCs), which have been shown experimentally to have the ability to differentiate into functional follicles and generate oocytes; however, their clinical potential remains unknown.  Furthermore, there is now growing interest in performing ovarian rejuvenation in situ. Read More

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Actions and interactions of IGF-I and MMPs during muscle regeneration.

Semin Cell Dev Biol 2021 May 4. Epub 2021 May 4.

Applied Physiology & Kinesiology, College of Health and Human Performance, University of Florida, 1864 Stadium Road, Gainesville, FL 32611, USA. Electronic address:

Muscle regeneration requires the coordination of several factors to mobilize satellite cells and macrophages, remodel the extracellular matrix surrounding muscle fibers, and repair existing and/or form new muscle fibers. In this review, we focus on insulin-like growth factor I and the matrix metalloproteinases, which are secreted proteins that act on cells and the matrix to resolve damage. While their actions appear independent, their interactions occur at the transcriptional and post-translational levels to promote feed-forward activation of each other. Read More

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Utilization and uptake of clinical genetics services in high-income countries: A scoping review.

Health Policy 2021 Apr 18. Epub 2021 Apr 18.

Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada; Centre for Health Evaluation and Outcomes Sciences, Providence Health Research Institute, 588-1081 Burrard Street, St. Paul's Hospital, Vancouver, BC, V6Z 1Y6. Electronic address:

Ongoing rapid growth in the need for genetic services has the potential to severely strain the capacity of the clinical genetics workforce to deliver this care. Unfortunately, assessments of the scale of this health policy challenge and potential solutions are hampered by the lack of a consolidated evidence base on the growth in genetic service utilization. To enable health policy research and strategic planning by health systems in this area, we conducted a scoping review of the literature on the utilization and uptake of clinical genetics services in high-income countries published between 2010 and 2018. Read More

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Force balancing ACT-IN the tumor microenvironment: Cytoskeletal modifications in cancer and stromal cells to promote malignancy.

Int Rev Cell Mol Biol 2021 27;360:1-31. Epub 2020 Oct 27.

Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, United States.

The tumor microenvironment is a complex milieu that dictates the growth, invasion, and metastasis of cancer cells. Both cancer and stromal cells in the tumor tissue encounter and adapt to a variety of extracellular factors, and subsequently contribute and drive the progression of the disease to more advanced stages. As the disease progresses, a small population of cancer cells becomes more invasive through a complex process known as epithelial-mesenchymal transition, and nearby stromal cells assume a carcinoma associated fibroblast phenotype characterized by enhanced migration, cell contractility, and matrix secretion with the ability to reorganize extracellular matrices. Read More

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October 2020

3D bioprinted human iPSC-derived somatosensory constructs with functional and highly purified sensory neuron networks.

Biofabrication 2021 May 7. Epub 2021 May 7.

Medicine, Harvard Medical School, 65 Landsdowne Street, Rm. 252, PRB-252, Cambridge, Massachusetts, 02139, UNITED STATES.

Engineering three-dimensional (3D) sensible tissue constructs, along with the complex microarchitecture wiring of the sensory nervous system, has been an ongoing challenge in the tissue engineering field. By combining 3D bioprinting and human pluripotent stem cell (hPSC) technologies, sensible tissue constructs could be engineered in a rapid, precise, and controllable manner to replicate 3D microarchitectures and mechanosensory functionalities of the native sensory tissue (e.g. Read More

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Pulse wave velocity is decreased in acromegaly compared to non-acromegaly study participants with similar cardiovascular risk profile.

Growth Horm IGF Res 2021 Apr 29;57-58:101395. Epub 2021 Apr 29.

Almazov National Medical Research Centre, Ulica Akkuratova 2, St. Petersburg 197341, Russia.

Objective: Acromegaly patients were reported to have an increased arterial stiffness that could contribute to the frequent cardiovascular complications in this population. The chronic excess of GH and IGF-1 may lead to arterial stiffening via different mechanisms, including hypertension, impaired glucose tolerance and dyslipidemia, however, it is not known whether the activation of GH/IGF-1 axis might influence arterial stiffening independently of cardiovascular risk factors. The objective of this prospective case-control study was to compare arterial stiffness assessed with pulse-wave velocity (PWV) in acromegaly versus non-acromegaly group with similar cardiovascular risk profile. Read More

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Litter decomposition can be reduced by pesticide effects on detritivores and decomposers: Implications for tropical stream functioning.

Environ Pollut 2021 Apr 28;285:117243. Epub 2021 Apr 28.

Department of Plant Biology and Ecology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Spain; IKERBASQUE, Bilbao, Spain.

Understanding which factors affect the process of leaf litter decomposition is crucial if we are to predict changes in the functioning of stream ecosystems as a result of human activities. One major activity with known consequences on streams is agriculture, which is of particular concern in tropical regions, where forests are being rapidly replaced by crops. While pesticides are potential drivers of reduced decomposition rates observed in agricultural tropical streams, their specific effects on the performance of decomposers and detritivores are mostly unknown. Read More

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Caregiver burden and related factors during active cancer treatment: A latent growth curve analysis.

Eur J Oncol Nurs 2021 Apr 17;52:101962. Epub 2021 Apr 17.

National Institutes of Health, Clinical Center, Bethesda, MD, USA.

Purpose: Caregiver burden is frequently studied cross-sectionally, but longitudinal studies on family caregiver burden during active cancer treatment are lacking. The goals of this study were to characterize trajectories of caregivers' burden during a 6-month active treatment period, and to examine which predictors are associated with their burden.

Method: This study was a secondary analysis of data from a prospective study. Read More

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The insulin-like growth factors: ligands, binding proteins and receptors.

Mol Metab 2021 May 4:101245. Epub 2021 May 4.

The insulin-like growth factor family of ligands (IGF-I, IGF-II and insulin), receptors (IGF-IR, M6P/IGF-IIR and the insulin receptor, IR) as well as the IGF binding proteins (IGFBP-1-6) play critical roles in normal human physiology and disease states. Insulin and the insulin receptors are the focus of other chapters in this series and will therefore not be discussed further. IGF-I has effects via the circulation and locally within tissues to regulate cellular growth, differentiation and survival thereby controlling overall body growth. Read More

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Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2.

EMBO Mol Med 2021 May 7:e14045. Epub 2021 May 7.

A*STAR Infectious Disease Labs (A*STAR ID Labs), Agency for Science, Technology and Research, 8A Biomedical Grove, Immunos, Singapore, 138648.

The immune responses and mechanisms limiting symptom progression in asymptomatic cases of SARS-CoV-2 infection remain unclear. We comprehensively characterized transcriptomic profiles, cytokine responses, neutralization capacity of antibodies and cellular immune phenotypes of asymptomatic patients with acute SARS-CoV-2 infection to identify potential protective mechanisms. Compared to symptomatic patients, asymptomatic patients had higher counts of mature neutrophils and lower proportion of CD169+ expressing monocytes in the peripheral blood. Read More

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Environmental impacts on single-cell variation within a ubiquitous diatom: The role of growth rate.

PLoS One 2021 7;16(5):e0251213. Epub 2021 May 7.

Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung, Biologische Anstalt Helgoland, Helgoland, Germany.

Morphological and physiological characteristics of phytoplankton cells are highly sensitive to changes in environmental conditions and, in turn, influence the dynamics of phytoplankton populations and communities. To cope with environmental change, trait variability and phenotypic plasticity may play an important role. Since global change comprises simultaneous changes in abiotic parameters, we assessed the impact of multiple drivers on functional traits of the diatom Thalassiosira (Conticribra) weissflogii by manipulating concurrently temperature, pCO2, and dissolved nitrogen:phosphorus (N:P) ratio. Read More

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Studying factors influencing facial developmental instability.

Ann Hum Biol 2021 May 7:1-25. Epub 2021 May 7.

Department of Anthropology, Faculty of Science, Masaryk University, Kotlářská 2, 611 37 Brno, Czech Republic.

Background: Developmental instability is a component of non-genetic variation that results from random variation in developmental processes. It is considered a sensitive indicator of the physiological state of individuals. It is reflected in various ways, but in this study we focused on its reflection in fluctuating asymmetry (FA) and morphological integration. Read More

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Coronary Microvascular Adaptations Distal to Epicardial Artery Stenosis.

Am J Physiol Heart Circ Physiol 2021 May 7. Epub 2021 May 7.

Department of Physiology and Pharmacology and Michael E. DeBakey Institute for Comparative Cardiovascular Science and Biomedical Devices, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, United Statesgrid.264756.4.

Until recently, epicardial coronary stenosis has been considered the primary outcome of coronary heart disease and clinical interventions have been dedicated primarily to identification and removal of flow-limiting stenoses. However, a growing body of literature indicates that both epicardial stenosis and microvascular dysfunction contribute to damaging myocardial ischemia. In this review, we discuss the co-existence of macro- and microvascular disease, and how the structure and function of the distal microcirculation is impacted by the hemodynamic consequences of an epicardial, flow-limiting stenosis. Read More

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Astrocyte-Endotheliocyte Axis in the Regulation of the Blood-Brain Barrier.

Neurochem Res 2021 May 7. Epub 2021 May 7.

Department of Stem Cell Biology, State Research Institute Centre for Innovative Medicine, 01102, Vilnius, Lithuania.

The evolution of blood-brain barrier paralleled centralisation of the nervous system: emergence of neuronal masses required control over composition of the interstitial fluids. The barriers were initially created by glial cells, which employed septate junctions to restrict paracellular diffusion in the invertebrates and tight junctions in some early vertebrates. The endothelial barrier, secured by tight and adherent junctions emerged in vertebrates and is common in mammals. Read More

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Malignant pertussis in infants: factors associated with mortality in a multicenter cohort study.

Ann Intensive Care 2021 May 7;11(1):70. Epub 2021 May 7.

Service de Réanimation et Urgences Pédiatriques, Hospices Civils de Lyon, Hôpital Femme Mère Enfant, 59 Boulevard Pinel, 69677, Bron cedex, France.

Background: Malignant pertussis (MP) affects young infants and is characterized by respiratory distress, perpetual tachycardia and hyperleukocytosis up to 50 G/l, leading to multiple organ failure and death in 75% of cases. Leukodepletion may improve prognosis. A therapeutic strategy based on leukodepletion and extracorporeal life support (ECLS) according to different thresholds of leucocytes has been proposed by Rowlands and colleagues. Read More

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Metabolic syndrome and Growth Differentiation Factor 15 in older adults.

Geroscience 2021 May 7. Epub 2021 May 7.

Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid/Idipaz, Calle del Arzobispo Morcillo 4, 28029, Madrid, Spain.

Growth Differentiation Factor 15 (GDF-15) is a cytokine produced in response to tissue injury and inflammatory states that may capture distinct pathways between the risk factors aggregated within metabolic syndrome (MS) and the development of diabetes and cardiovascular disease. This work aims to study the association of MS and its components with GDF-15 among older adults, examining the roles of body fat distribution, glucose metabolism, and inflammation. Data were taken from the Seniors-ENRICA-2 study in Spain, which included 1938 non-institutionalized individuals aged ≥65 years free of diabetes and cardiovascular disease. Read More

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Harmine targets inhibitor of DNA binding-2 and activator protein-1 to promote preosteoclast PDGF-BB production.

J Cell Mol Med 2021 May 7. Epub 2021 May 7.

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.

Osteoporosis is one of the most common metabolic bone diseases affecting millions of people. We previously found that harmine prevents bone loss in ovariectomized mice via increasing preosteoclast platelet-derived growth factor-BB (PDGF-BB) production and type H vessel formation. However, the molecular mechanisms by which harmine promotes preosteoclast PDGF-BB generation are still unclear. Read More

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Salmonella in eggs: From shopping to consumption-A review providing an evidence-based analysis of risk factors.

Compr Rev Food Sci Food Saf 2021 May 7. Epub 2021 May 7.

Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Porto, Portugal.

Nontyphoidal salmonellae are among the most prevalent foodborne pathogens causing gastrointestinal infections worldwide. A high number of cases and outbreaks of salmonellosis are associated with the consumption of eggs and egg products, and several of these occur at the household level. The aim of the current study is to critically evaluate the current status of knowledge on Salmonella in eggs from a consumer's perspective, analyzing the hazard occurrence and the good practices that should be applied to reduce salmonellosis risk. Read More

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Antenatal low-intensity pulsed ultrasound reduces neurobehavioral deficits and brain injury following dexamethasone-induced intrauterine growth restriction.

Brain Pathol 2021 May 7:e12968. Epub 2021 May 7.

Department of Physical Medicine and Rehabilitation, Cheng Hsin General Hospital, Taipei, Taiwan.

Intrauterine growth restriction (IUGR) is a leading cause of perinatal mortality and morbidity, and IUGR survivors are at increased risk of neurodevelopmental deficits. No effective interventions are currently available to improve the structure and function of the IUGR brain before birth. This study investigated the protective effects of low-intensity pulsed ultrasound (LIPUS) on postnatal neurodevelopmental outcomes and brain injury using a rat model of IUGR induced by maternal exposure to dexamethasone (DEX). Read More

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Effects of advanced maternal age and acute prenatal alcohol exposure on mouse offspring growth and craniofacial phenotype.

Alcohol Clin Exp Res 2021 May 7. Epub 2021 May 7.

Department of Anatomy & Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario.

Background: Prenatal alcohol exposure (PAE) can result in developmental defects including growth restriction, craniofacial anomalies and cognitive-behavioral deficits, though the presence and severity of these adverse outcomes varies dramatically. Preclinical animal models have demonstrated that dose and timing of PAE account for much but not all, of this phenotypic variation, suggesting that additional factors mitigate effects of PAE. Here we used a mouse model to investigate whether maternal age modulates the effects of PAE on the severity and variation of offspring growth and craniofacial outcomes. Read More

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