2,080,517 results match your criteria growth development


[Effect of miR-186 targeting E-cadherin on proliferation and metastasis of renal cell carcinoma].

Zhonghua Yi Xue Za Zhi 2021 Apr;101(14):1020-1025

Department of Nephrology, Shanxi Provincial People's Hospital, Taiyuan 030012, China.

To investigate the role of miR-186 in renal cell carcinoma (RCC) and its molecular mechanism of miR-186 targeting E-cadherin to inhibit cell proliferation and metastasis of RCC. A total of 40 RCC samples which were collected in Shanxi Provincial People's Hospital from January 2015 to January 2019 and four RCC cell lines were measured the expression of miR-186 by real-time quantitative polymerase chain reaction (qPCR). The effect of miR-186 overexpression on the proliferation, invasion, migration and apoptosis of 786-O cells were detected by cell counting kit-8(CCK-8), colony formation, wound healing and Transwell assay and flow cytometric analysis. Read More

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Antifungal activity and potential mechanism of Asiatic acid alone and in combination with fluconazole against Candida albicans.

Biomed Pharmacother 2021 Apr 9;139:111568. Epub 2021 Apr 9.

Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Engineering and Technology Research Center for Pediatric Drug Development, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Jinan, Shandong Province 250014, People's Republic of China. Electronic address:

Candida albicans (C. albicans) infection remains a challenge to clinicians due to the limited available antifungals. With the widespread use of antifungals in the clinic, the drug resistance has been emerging continuously, especially fluconazole. Read More

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Plants-nematodes-microbes crosstalk within soil: A trade-off among friends or foes.

Microbiol Res 2021 Apr 2;248:126755. Epub 2021 Apr 2.

Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, 143005, Punjab, India. Electronic address:

Plants interact with enormous biotic and abiotic components within ecosystem. For instance, microbes, insects, herbivores, animals, nematodes etc. In general, these interactions are studied independently with plants, that condenses only specific information about the interaction. Read More

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Mutual functional dependence of cyclase-associated protein 1 (CAP1) and cofilin1 in neuronal actin dynamics and growth cone function.

Prog Neurobiol 2021 Apr 10:102050. Epub 2021 Apr 10.

Molecular Neurobiology Group, Institute of Physiological Chemistry, University of Marburg, 35032, Marburg, Germany; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus-Liebig-University Giessen, 35032, Marburg, Germany; DFG Research Training Group, Membrane Plasticity in Tissue Development and Remodeling, GRK 2213, Philipps-University of Marburg, 35032, Marburg, Germany. Electronic address:

Neuron connectivity depends on growth cones that navigate axons through the developing brain. Growth cones protrude and retract actin-rich structures to sense guidance cues. These cues control local actin dynamics and steer growth cones towards attractants and away from repellents, thereby directing axon outgrowth. Read More

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Neonatal maternal separation increases the number of p27-positive Sertoli cells in prepuberty.

Reprod Toxicol 2021 Apr 9. Epub 2021 Apr 9.

Department of Anatomy, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan.

Neonatal maternal separation (NMS) is an experimental model for early life stress, which affects the growth and development of various organs, resulting in adverse health effects in humans and animals. In our previous study, we demonstrated that NMS [(0.5-, 1-, 2-h/day NMS, from postnatal day (PND) 1 to 10] induced morphological changes to the male reproductive system, including decreased Sertoli cell numbers in mouse testes at PND 70. Read More

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Do we really understand how drug eluted from stents modulates arterial healing?

Int J Pharm 2021 Apr 9:120575. Epub 2021 Apr 9.

Division of Biomedical Engineering, University of Glasgow, Glasgow, UK. Electronic address:

The advent of drug-eluting stents (DES) has revolutionised the treatment of coronary artery disease. These devices, coated with anti-proliferative drugs, are deployed into stenosed or occluded vessels, compressing the plaque to restore natural blood flow, whilst simultaneously combating the evolution of restenotic tissue. Since the development of the first stent, extensive research has investigated how further advancements in stent technology can improve patient outcome. Read More

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LncRNA MEG3 regulates breast cancer proliferation and apoptosis through miR-141-3p/RBMS3 axis.

Genomics 2021 Apr 9. Epub 2021 Apr 9.

Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. Electronic address:

Maternally expressed 3 (MEG3) and RNA binding motif single stranded interacting protein 3 (RBMS3) are abnormally expressed breast cancer susceptibility genes (BRCA), but the mechanism of the two in breast cancer (BC) is unclear. By performing in vivo and in vitro experiments, we found that MEG3 and RBMS3 were low-expressed, negatively correlated with high-expressed miR-141-3p, were positively correlated with each other in BC. MEG3 targeted miR-141-3p, and miR-141-3p targeted RBMS3. Read More

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Automated multi-scale cascade of parallel stirred-tank bioreactors for fast protein expression studies.

J Biotechnol 2021 Apr 9. Epub 2021 Apr 9.

Technical University of Munich, Institute of Biochemical Engineering, Boltzmannstr. 15, 85748, Garching, Germany. Electronic address:

Automation, parallelization and autonomous operation of standard lab equipment, usually applied for manual bioprocess development, is considered as the key for reduction of bioprocess development time and costs. An automated bioreactor system with 4 stirred-tank bioreactors on a L-scale was combined with a custom-made biomass transfer system to distribute the cell suspensions produced on the L-scale into 48 parallel stirred-tank bioreactors on a mL-scale. Afterwards parallel protein expression studies automated by a liquid handling system with integrated fluorescence reader were performed. Read More

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Fraxinellone alleviates kidney fibrosis by inhibiting CUG-binding protein 1-mediated fibroblast activation.

Toxicol Appl Pharmacol 2021 Apr 9:115530. Epub 2021 Apr 9.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China. Electronic address:

Chronic Kidney Disease (CKD) is a serious threat to human health. In addition, kidney fibrosis is a key pathogenic intermediate for the progression of CDK. Moreover, excessive activation of fibroblasts is key to the development of kidney fibrosis and this process is difficult to control. Read More

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Exosome-transmitted circ-CARD6 facilitates posterior capsule opacification development by miR-31/FGF7 axis.

Exp Eye Res 2021 Apr 9:108572. Epub 2021 Apr 9.

Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. Electronic address:

Background: Posterior capsular opacification (PCO) is the major vision-disrupting complication arising after cataract surgery. Circular RNAs (circRNAs) are biological active RNAs which were involved in various physiological functions. So far, the role of circRNA caspase recruitment domain family member 6 (circ-CARD6) in PCO is still unclear. Read More

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Comparison of Multiple Machine Learning-based Predictions of Growth in COVID-19 Confirmed Infection Cases in Countries using Non-Pharmaceutical Interventions and Cultural Dimensions Data: Development and Validation.

J Med Internet Res 2021 Mar 23. Epub 2021 Mar 23.

Department of Computer Science, University of Toronto, 27 King's College Cir, Toronto, CA.

Background: National governments have implemented non-pharmaceutical interventions to control and mitigate against the COVID-19 pandemic.

Objective: We investigate the prediction of future daily national Confirmed Infection Growths - the percentage change in total cumulative cases across 14 days for 114 countries using non-pharmaceutical intervention metrics and cultural dimension metrics, which are metrics indicative of specific national sociocultural norms.

Methods: We combine the OxCGRT dataset, Hofstede's cultural dimensions, and COVID-19 daily reported infection case numbers to train and evaluate five non-time series machine learning models in predicting Confirmed Infection Growth. Read More

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Trans-ovo permethrin exposure affects growth, brain morphology and cardiac development in quail.

Environ Toxicol 2021 Apr 12. Epub 2021 Apr 12.

School of Biological Sciences and Center for Reproductive Biology, Washington State University, Pullman, Washington, USA.

Permethrin is a commonly used, highly effective pesticide in poultry agriculture, and has recently been trialed in conservation efforts to protect Galápagos finch hatchlings from an invasive ectoparasite. Although permethrin is considered safe for adults, pesticides can have health consequences when animals are exposed during early life stages. The few studies that have examined permethrin's effects in embryonic chicks and rats have shown hydrocephaly, anencephaly, reduced cellular energy conversion, and disruption of developing heart muscle. Read More

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Development of an alternative test system for chronic testing of lotic macroinvertebrate species - a case study with the insecticide imidacloprid.

Environ Toxicol Chem 2021 Apr 12. Epub 2021 Apr 12.

Fraunhofer Institute for Molecular Biology and Applied Ecology, Auf den Aberg 1, 57392, Schmallenberg, Germany.

There are currently few suitable test systems for the chronic toxicity testing of aquatic macroinvertebrates under stream conditions. Therefore, a new test system mimicking running water conditions was developed for testing with lotic insects. This system uses small test cages, with 10 of these suspended inside each 25L container and rotating at 0. Read More

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Transcriptional regulation of the basic helix-loop-helix factor AmeloD during tooth development.

J Cell Physiol 2021 Apr 12. Epub 2021 Apr 12.

Department of Oral Health and Development Sciences, Division of Pediatric Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan.

The epithelial-mesenchymal interactions are essential for the initiation and regulation of the development of teeth. Following the initiation of tooth development, numerous growth factors are secreted by the dental epithelium and mesenchyme that play critical roles in cellular differentiation. During tooth morphogenesis, the dental epithelial stem cells differentiate into several cell types, including inner enamel epithelial cells, which then differentiate into enamel matrix-secreting ameloblasts. Read More

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The association between imbalances in vaginal microflora and duration of pregnancy as well as selected maternal and neonatal parameters.

Ginekol Pol 2021 Apr 12. Epub 2021 Apr 12.

Department of Surgical and Oncologic Gynecology, 1st Department of Gynecology and Obstetrics, Medical University of Lodz, Poland.

Objectives: Abnormal vaginal flora (AVF) is a result of excessive growth of some aerobic bacteria and fungi in relation to the scarce presence of Lactobacillus spp. It has been suggested that AVF is responsible for preterm birth and such neonatal conditions as infections or sepsis. The aim of the study was to assess the influence of excessive vaginal colonization with aerobic bacteria and fungi on the selected postnatal parameters of newborns, duration of pregnancy and length of hospitalisation of neonates. Read More

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Short-term developmental outcomes in neonates born to mothers with COVID-19 from Wuhan, China.

World J Pediatr 2021 Apr 12. Epub 2021 Apr 12.

National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.

Background: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging disease. The consequences of SARS-CoV-2 exposure in infants remain unknown. Therefore, this study aims to investigate whether neonates born to mothers with COVID-19 have adverse brain development. Read More

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The effects of international tourism, electricity consumption, and economic growth on CO2 emissions in North Africa.

Environ Sci Pollut Res Int 2021 Apr 12. Epub 2021 Apr 12.

Department of Economics and Management, Research Laboratory in Management, Economics and Social Sciences (LARGESS), Faculty of Law, Economics and Social of El Jadida, Chouaib Doukkali University, El Jadida, Morocco.

This study examines the influence of tourism, economic growth, and electricity consumption on carbon dioxide (CO) emission in the presence of the Environmental Kuznets Curve (EKC) model for a panel of four countries of North Africa, namely, Morocco, Algeria, Tunisia, and Egypt, over the period 1980-2014. Since we find the existence of cross-sectional dependence, we apply the unit root tests of CIPS and CADF, the Westerlund cointegration test as well as the dynamic seemingly unrelated regression (DSUR), and the Dumitrescu-Hurlin Granger causality test. The empirical results show that electricity consumption has a positive effect on CO2 emissions. Read More

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Distribution and invasion risk assessments of Chrysodeixis includens (Walker, [1858]) (Lepidoptera: Noctuidae) using CLIMEX.

Int J Biometeorol 2021 Apr 12. Epub 2021 Apr 12.

Dept de Agronomia, Universidade Federal de Viçosa, Avenida P. H. Rolfs, s/n, Viçosa, MG, 36570-900, Brazil.

Chrysodeixis includens is a polyphagous pest restricted to the American continent. The occurrence of C. includens is allied, among other factors, by favorable conditions such as temperature, humidity, presence of hosts, and migratory behavior. Read More

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Pitx genes in development and disease.

Cell Mol Life Sci 2021 Apr 12. Epub 2021 Apr 12.

Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR, 97331, USA.

Homeobox genes encode sequence-specific transcription factors (SSTFs) that recognize specific DNA sequences and regulate organogenesis in all eukaryotes. They are essential in specifying spatial and temporal cell identity and as a result, their mutations often cause severe developmental defects. Pitx genes belong to the PRD class of the highly evolutionary conserved homeobox genes in all animals. Read More

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MELATONIN AND GRHELIN AS "EARLY" PROGNOSIS MARKERS OF PROGRESSION OF ARTERIAL HYPERTENSION AND OSTEOARTHRITIS IN THE CASE OF THEIR COMORBIDITY.

Wiad Lek 2021 ;74(3 cz 2):697-701

BUKOVINIAN STATE MEDICAL UNIVERSITY, CHERNIVTSI, UKRAINE.

Objective: The aim: Of the study was to investigate the effect of melatonin on the serum levels of ghrelin in patients with hypertension combined with osteoarthritis in order to identify them as informative and reliable markers of early diagnosis of progression of these comorbid diseases.

Patients And Methods: Material and methods: To achieve the goals and objectives of this study, 60 patients with hypertension combined with osteoarthritis were involved and examined, in particular, serum ghrelin and melatonin levels were determined twice and divided into two groups.

Results: Results: It was found that in patients of group I on the background of the four-week main course of treatment with the addition of melatonin (3 mg 1 time per day before bedtime), the average value of ghrelin increased by an average of ± 2. Read More

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January 2021

Prospective BMI changes in preschool children are not effected by changes in EBRBs but by parental characteristics and body weight perceptions: The ToyBox-study.

Public Health Nutr 2021 Apr 12:1-25. Epub 2021 Apr 12.

Department of Dietetics, Nutrition and Sport, School of Allied Health, Human Services and Sport, La Trobe University, Victoria, Australia.

Objective: To examine the effect of the intervention implemented in the ToyBox study on changes observed in age and sex specific BMI percentile and investigate the role of perinatal factors, parental perceptions and characteristics on this change.

Design: A multicomponent, kindergarten-based, family-involved intervention with a cluster-randomized design. A standardized protocol was used to measure children's body weight and height. Read More

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Latent class derived patterns of musculoskeletal disorders in sedentary workers and chair ergonomic design.

Int J Occup Saf Ergon 2021 Apr 12:1-20. Epub 2021 Apr 12.

Isfahan Health Center, Isfahan University of Medical Sciences, Isfahan, Iran, Email:

The present study aimed to define specific patterns of multisite MSDs of office employees and to examine how derived patterns are related to the ergonomic chair design. in this cross-sectional study of 254 office employees, major patterns of MSDs were extracted using latent class analysis and investigated its association with the ergonomic chair design. Four major patterns of MSDs were extracted using latent class analysis. Read More

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Tribolium castaneum defensin 1 kills Moraxella catarrhalisin an in vitro infection model but does not harm commensal bacteria.

Virulence 2021 Dec;12(1):1003-1010

Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, Marburg, Germany.

is a bacterial pathogen that causes respiratory tract infections in humans. The increasing prevalence of antibiotic-resistant strains has created a demand for alternative treatment options. We therefore tested 23 insect antimicrobial peptides (AMPs) for their activity against in a human infection model with primary macrophages, and against commensal bacteria. Read More

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December 2021

MicroRNA-1297 suppressed the Akt/GSK3 signaling pathway and stimulated neural apoptosis in an sevoflurane exposure model.

J Int Med Res 2021 Apr;49(4):300060520982104

Department of Hepatobiliary Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

Objective: Common inhalation anesthetics used for clinical anesthesia (such as sevoflurane) may induce nerve cell apoptosis during central nervous system development. Furthermore, anesthetics can produce cognitive impairments, such as learning and memory impairments, that continue into adulthood. However, the precise mechanism remains largely undefined. Read More

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A new approach to predicting shoulder dystocia: Fetal clavicle length.

Authors:
Elif Terzi

Turk J Med Sci 2021 Apr 12. Epub 2021 Apr 12.

Objective: This study aimed to evaluate the relationship between second- and third-trimester clavicle length and birth weight and shoulder dystocia.

Methods: This prospective observational study included 181 patients who presented to the Private Etlik Lokman Hekim Hospital for routine pregnancy visits between March 2019 and March 2020. In addition to routine pregnancy examinations, the patients also underwent ultrasonography twice at weeks 20-23 and 33-36 to determine the length of the fetal clavicle. Read More

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Fetal growth, fetal development, and placental features in women with polycystic ovary syndrome: analysis based on fetal and placental magnetic resonance imaging.

J Zhejiang Univ Sci B 2020 Dec.;21(12):977-989

Department of Chinese Integrative Medicine, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.

Objective: Polycystic ovary syndrome (PCOS), a common endocrine-metabolic dysfunction in reproductive-aged women, may be involved in compromised pregnancy and offspring outcomes. This study aimed to investigate whether maternal PCOS affects fetal growth, fetal development, and placental features.

Methods: This retrospective case-control study included 60 pregnant women with PCOS (PCOS group) and 120 healthy pregnant women without PCOS (control group). Read More

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Functional analysis of XRCC4 mutations in reported microcephaly and growth defect patients in terms of radiosensitivity.

J Radiat Res 2021 Apr 12. Epub 2021 Apr 12.

Laboratory for Advanced Nuclear Energy, Institute of Innovative Research, Tokyo Institute of Technology, Tokyo 152-8550, Japan.

Non-homologous end joining is one of the main pathways for DNA double-strand break (DSB) repair and is also implicated in V(D)J recombination in immune system. Therefore, mutations in non-homologous end-joining (NHEJ) proteins were found to be associated with immunodeficiency in human as well as in model animals. Several human patients with mutations in XRCC4 were reported to exhibit microcephaly and growth defects, but unexpectedly showed normal immune function. Read More

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Neointimal Hyperplasia after Carotid Transection and Anastomosis Surgery is Associated with Degradation of Decorin and Platelet Derived Growth Factor Signaling.

JVS Vasc Sci 2021 21;2:2-12. Epub 2020 Oct 21.

Nemours - Alfred I. duPont Hospital for Children, Wilmington, DE 19803.

Objective: Intimal hyperplasia (IH) is the expansion of the vascular intimal region after intervention, which can lead to stenosis and eventual failure of vascular grafts or interventional procedures such as angioplasty or stent placement. Our goals were to investigate the development of IH in a rabbit open surgical model and to evaluate the associated pathophysiological processes involving decorin and the platelet derived growth factor-BB / platelet derived growth factor receptor-β / mitogen activated protein kinase (PDGF/PDGFR-β/MAPK) pathway.

Methods: We conducted carotid transection and primary anastomosis on five New Zealand White rabbits to induce IH and examined the associated pathophysiological changes. Read More

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October 2020

Antivirulence DsbA inhibitors attenuate serovar Typhimurium fitness without detectable resistance.

FASEB Bioadv 2021 Apr 10;3(4):231-242. Epub 2021 Feb 10.

Institute of Health and Biomedical Innovation School of Biomedical Sciences Queensland University of Technology Herston QLD Australia.

Inhibition of the DiSulfide Bond (DSB) oxidative protein folding machinery, a major facilitator of virulence in Gram-negative bacteria, represents a promising antivirulence strategy. We previously developed small molecule inhibitors of DsbA from K-12 (EcDsbA) and showed that they attenuate virulence of Gram-negative pathogens by directly inhibiting multiple diverse DsbA homologues. Here we tested the evolutionary robustness of DsbA inhibitors as antivirulence antimicrobials against serovar Typhimurium under pathophysiological conditions in vitro. Read More

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Identification of methylation changes associated with positive and negative growth deviance in Gambian infants using a targeted methyl sequencing approach of genomic DNA.

FASEB Bioadv 2021 Apr 5;3(4):205-230. Epub 2021 Feb 5.

Department of Pathology University of Cambridge Cambridge UK.

Low birthweight and reduced height gain during infancy (stunting) may arise at least in part from adverse early life environments that trigger epigenetic reprogramming that may favor survival. We examined differential DNA methylation patterns using targeted methyl sequencing of regions regulating gene activity in groups of rural Gambian infants: (a) low and high birthweight (DNA from cord blood ( = 16 and  = 20, respectively), from placental trophoblast tissue ( = 21 and  = 20, respectively), and DNA from peripheral blood collected from infants at 12 months of age ( = 23 and  = 17, respectively)), and, (b) the top 10% showing rapid postnatal length gain (high,  = 20) and the bottom 10% showing slow postnatal length gain (low,  = 20) based on z score change between birth and 12 months of age (LAZ) (DNA from peripheral blood collected from infants at 12 months of age). Using BiSeq analysis to identify significant methylation marks, for birthweight, four differentially methylated regions (DMRs) were identified in trophoblast DNA, compared to 68 DMRs in cord blood DNA, and 54 DMRs in 12-month peripheral blood DNA. Read More

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