331,013 results match your criteria growing

Restoration-oriented stressors of bereavement.

Anxiety Stress Coping 2021 Jul 31:1-15. Epub 2021 Jul 31.

Department of Clinical Psychology and Experimental Psychopathology, Faculty of Behavioral and Social Sciences, University of Groningen, Groningen, The Netherlands.

Background And Objectives: The Dual Process Model of Coping with Bereavement holds that bereaved people who respond flexibly to loss-oriented stressors (i.e., relating to the loss; to the deceased person) and restoration-oriented stressors (i. Read More

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Adopting medical technology: the case for a fast-tracked approach.

Barbara Harpham

Br J Hosp Med (Lond) 2021 Jul 20;82(7):1-4. Epub 2021 Jul 20.

Medical Technology Group, London, UK.

The NHS has always struggled to effectively adopt innovative medical technologies. A report by The Medical Technology Group argues that a new system for the widespread adoption of technology is needed. The report argues that, considering the growing backlog of procedures caused by the COVID-19 pandemic, medical technology can increase efficiency and deliver better outcomes for patients, while helping the NHS to recover. Read More

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North central London elective orthopaedic network and health service innovation to improve the quality of NHS patient care.

Br J Hosp Med (Lond) 2021 Jul 30;82(7):1-4. Epub 2021 Jul 30.

Department of Trauma and Orthopaedic Surgery, University College London Hospital Foundation NHS Trust, London, UK.

Health service innovation is required to meet the ever-growing demands of modern medicine. This editorial discusses the transformation of the north central London elective orthopaedic network and the essential principles which future integrated care systems could incorporate. Read More

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Teaching of professional skills in US colleges and schools of veterinary medicine in 2019 and comparisons with 1999 and 2009.

J Am Vet Med Assoc 2021 Aug;259(4):379-384

Objective: To quantify the extent that professional skills topics were presented to veterinary students at US colleges and schools of veterinary medicine (ie, veterinary schools) in 2019 and compare findings with similar data collected in 1999 and 2009.

Sample: All 30 US veterinary schools in 2019.

Procedures: An electronic questionnaire was sent to the associate deans for academic affairs of all 30 veterinary schools in the United States during fall of 2019. Read More

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PTCSC3-mediated glycolysis suppresses thyroid cancer progression via interfering with PGK1 degradation.

J Cell Mol Med 2021 Aug 1. Epub 2021 Aug 1.

Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China.

The Warburg effect (aerobic glycolysis), a hallmark of cancer, serves as a promising target for diagnosis and therapy. Growing evidence indicates that long non-coding RNAs (lncRNAs) play an important role in aerobic glycolysis of various tumours. However, the correlation between lncRNAs and glycolysis in thyroid cancer cells is still poorly understood. Read More

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Gastric accommodation: Physiology, diagnostic modalities, clinical relevance, and therapies.

Neurogastroenterol Motil 2021 Aug 1:e14213. Epub 2021 Aug 1.

Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Baylor College of Medicine, Houston, Texas, USA.

Background: Gastric accommodation is an essential gastric motor function which occurs following ingestion of a meal. Impaired gastric fundic accommodation (IFA) is associated with dyspeptic symptoms. Gastric accommodation is mediated by the vagal pathway with several important physiologic factors such as duodenal nutrient feedback playing a significant role. Read More

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Comparison of beta-ligands used in cattle production: structures, safety, and biological effects.

J Anim Sci 2021 Aug;99(8)

RLEConsult, Bolivia, NC, USA.

Technologies that increase the efficiency and sustainability of food animal production to provide meat for a growing population are necessary and must be used in a manner consistent with good veterinary practices, approved labeled use, and environmental stewardship. Compounds that bind to beta-adrenergic receptors (β-AR), termed beta-adrenergic receptor ligands (β-ligands), are one such technology and have been in use globally for many years. Though all β-ligands share some similarities in structure and function, the significance of their structural and pharmacological differences is sometimes overlooked. Read More

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Hypofractionated Postoperative Radiotherapy for Prostate Cancer: Is the Field Ready Yet?

Eur Urol Open Sci 2020 Dec 23;22:9-16. Epub 2020 Oct 23.

Weill Cornell Medicine, New York, NY, USA.

Context: Radiotherapy (RT) is a valid adjuvant treatment for men with high-risk pathological features after radical prostatectomy and a salvage treatment for biochemical recurrence. A major inconvenience is that RT takes course over 7-8 wk in these settings, which has been shown to limit its use. Retrospective and pilot prospective investigations suggest that hypofractionation may provide noninferior outcomes but report variable results regarding toxicities. Read More

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December 2020

Priming mycobacterial ESX-secreted protein B to form a channel-like structure.

Curr Res Struct Biol 2021 30;3:153-164. Epub 2021 Jun 30.

Division of Nanoscopy, Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, the Netherlands.

ESX-1 is a major virulence factor of , a secretion machinery directly involved in the survival of the microorganism from the immune system defence. It disrupts the phagosome membrane of the host cell through a contact-dependent mechanism. Recently, the structure of the inner-membrane core complex of the homologous ESX-3 and ESX-5 was resolved; however, the elements involved in the secretion through the outer membrane or those acting on the host cell membrane are unknown. Read More

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Degree of resistance of cultivars to -virulent and avirulent isolates of , , and .

J Nematol 2021 30;53. Epub 2021 Jul 30.

Department of Plant Protection, Faculty of Agriculture, Akdeniz University, Antalya, Turkey.

Root-knot nematodes (RKN) cause yield losses in eggplant-growing areas. There are no known varieties of eggplant ( L.) that are resistant to RKNs. Read More

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Phase II trial of proton therapy versus photon IMRT for GBM: secondary analysis comparison of progression-free survival between RANO versus clinical assessment.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab073. Epub 2021 Jun 1.

Department of Radiation Oncology, MD Anderson Cancer Center, Houston, Texas, USA.

Background: This secondary image analysis of a randomized trial of proton radiotherapy (PT) versus photon intensity-modulated radiotherapy (IMRT) compares tumor progression based on clinical radiological assessment versus Response Assessment in Neuro-Oncology (RANO).

Methods: Eligible patients were enrolled in the randomized trial and had MR imaging at baseline and follow-up beyond 12 weeks from completion of radiotherapy. "Clinical progression" was based on a clinical radiology report of progression and/or change in treatment for progression. Read More

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Effect of the Concentration and the Type of Dispersant on the Synthesis of Copper Oxide Nanoparticles and Their Potential Antimicrobial Applications.

ACS Omega 2021 Jul 18;6(29):18576-18590. Epub 2021 Jul 18.

4MAT, Université Libre de Bruxelles, CP 194/03, 50 Avenue Roosevelt, B-1050 Brussels, Belgium.

The bactericidal properties of copper oxide nanoparticles have growing interest due to potential application in the medical area. The present research investigates the influence of sodium dodecyl sulfate (SDS) and poly(vinylpyrrolidone) (PVP) on the production of copper oxide nanoparticles prepared from copper sulfate (CuSO) and sodium borohydride (NaBH) solutions. Different analytical techniques were used to determine the crystal nature, mean size diameter, and surface morphology of the copper oxide nanoparticles. Read More

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Polystyrene and Polyethylene Microplastics Decrease Cell Viability and Dysregulate Inflammatory and Oxidative Stress Markers of MDCK and L929 Cells In Vitro.

Expo Health 2021 Jul 25:1-11. Epub 2021 Jul 25.

Department of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, ME 04005 USA.

Microplastics are ubiquitous environmental pollutants that are a growing concern to many ecosystems, as well as human health. Many of the effects of microplastics on mammalian cells and tissues remain unknown. To address this, we treated L929 murine fibroblasts and Madin-Darby canine kidney (MDCK) epithelial cell lines with 1 μg/mL, 10 μg/mL, or 20 μg/mL of polyethylene (PE) or polystyrene (PS) microspheres in vitro for 6 and 24 h and measured the resulting changes in cell viability, metabolism, and transcriptional expression of inflammatory cytokines and antioxidant enzymes. Read More

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Breast Cancer Segmentation Methods: Current Status and Future Potentials.

Biomed Res Int 2021 20;2021:9962109. Epub 2021 Jul 20.

Radiology Department, Affiliated Hospital of Guizhou, Medical Hospital, China.

Early breast cancer detection is one of the most important issues that need to be addressed worldwide as it can help increase the survival rate of patients. Mammograms have been used to detect breast cancer in the early stages; if detected in the early stages, it can drastically reduce treatment costs. The detection of tumours in the breast depends on segmentation techniques. Read More

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Effect of Serum Albumin Changes on Mortality in Patients with Peritoneal Dialysis: A Joint Modeling Approach and Personalized Dynamic Risk Predictions.

Biomed Res Int 2021 21;2021:6612464. Epub 2021 Jul 21.

Department of Biostatistics, Hacettepe University, Ankara 06100, Turkey.

Peritoneal dialysis (PD) is a frequently used and growing therapy for end-stage renal diseases (ESRD). Survival analysis of PD patients is an ongoing research topic in the field of nephrology. Several biochemical parameters (e. Read More

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Low Carbohydrate Dietary Approaches for People With Type 2 Diabetes-A Narrative Review.

Front Nutr 2021 15;8:687658. Epub 2021 Jul 15.

X-PERT Health, Hebden Bridge, United Kingdom.

Although carbohydrate restriction is not a new approach for the management of Type 2 diabetes, interest in its safety and efficacy has increased significantly in recent years. The purpose of the current narrative review is to summarise the key relevant research and practical considerations in this area, as well as to explore some of the common concerns expressed in relation to the use of such approaches. There is a strong physiological rationale supporting the role of carbohydrate restriction for the management of Type 2 diabetes, and available evidence suggests that low carbohydrate dietary approaches (LCDs) are as effective as, or superior to, other dietary approaches for its management. Read More

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Thiopurines in Inflammatory Bowel Disease. How to Optimize Thiopurines in the Biologic Era?

Front Med (Lausanne) 2021 16;8:681907. Epub 2021 Jul 16.

Department of Gastroenterology, University Clinic Hospital Lozano Blesa, Zaragoza, Spain.

Thiopurines have been a cornerstone in the treatment of inflammatory bowel disease (IBD). Although they have been used for more than 50 years, there are still some unsolved issues about their efficacy and, also, some safety concerns, mainly the risk of myelosuppression and life-threatening lymphoproliferative disorders. Furthermore, the development of biological therapy raises the question whether there is still a role for thiopurines in the IBD treatment algorithm. Read More

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CBFB-MYH11 Fusion Sequesters RUNX1 in Cytoplasm to Prevent DNMT3A Recruitment to Target Genes in AML.

Front Cell Dev Biol 2021 15;9:675424. Epub 2021 Jul 15.

The Fifth People's Hospital of Shanghai and the Molecular and Cell Biology Research Lab of the Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

A growing number of human diseases have been found to be associated with aberrant DNA methylation, including cancer. Mutations targeting genes encoding DNA methyltransferase (DNMT), TET family of DNA demethylases, and isocitrate dehydrogenase (IDH1, IDH2) that produce TET inhibitory metabolite, 2-hyoxyglutarate (2-HG), are found in more than half of acute myeloid leukemia (AML). To gain new insights into the regulation of DNA de/methylation and consequence of its alteration in cancer development, we searched for genes which are mutated in a manner that is linked with gene mutations involved in DNA de/methylation in multiple cancer types. Read More

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One-Time Optimization of Advanced T Cell Culture Media Using a Machine Learning Pipeline.

Front Bioeng Biotechnol 2021 15;9:614324. Epub 2021 Jul 15.

R&D Cell Culture Systems, CellGenix GmbH, Freiburg, Germany.

The growing application of cell and gene therapies in humans leads to a need for cell type-optimized culture media. Design of Experiments (DoE) is a successful and well known tool for the development and optimization of cell culture media for bioprocessing. When optimizing culture media for primary cells used in cell and gene therapy, traditional DoE approaches that depend on interpretable models will not always provide reliable predictions due to high donor variability. Read More

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Factors Associated With Uptake of Iron Supplement During Pregnancy Among Women of Reproductive Age in Tanzania: an Analysis of Data From the 2015 to 2016 Tanzania Demographic and Health Survey and Malaria Indicators Survey.

Front Public Health 2021 14;9:604058. Epub 2021 Jul 14.

Department of Obstetric and Gynecology, School of Medicine and Dentistry, University of Dodoma, Dodoma, Tanzania.

Pregnant women are vulnerable to iron deficiency due to the fact that more iron is needed primarily to supply the growing fetus and placenta and to increase the maternal red cell mass. Little is known on the factors associated with uptake of iron supplement during pregnancy. The study used data from the 2015 to 2016 Tanzania Demographic and Health Survey and Malaria Indicators Survey. Read More

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Desensitization of Capsaicin-Sensitive Afferents Accelerates Early Tumor Growth Increased Vascular Leakage in a Murine Model of Triple Negative Breast Cancer.

Front Oncol 2021 14;11:685297. Epub 2021 Jul 14.

János Szentágothai Research Centre, Molecular Pharmacology Research Team and Centre for Neuroscience, University of Pécs, Pécs, Hungary.

There is growing interest in the role of nerve-driven mechanisms in tumorigenesis and tumor growth. Capsaicin-sensitive afferents have been previously shown to possess antitumoral and immune-regulatory properties, the mechanism of which is currently poorly understood. In this study, we have assessed the role of these terminals in the triple negative 4T1 orthotopic mouse model of breast cancer. Read More

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Perception of Non-Alcoholic Fatty Liver Disease: Real-Life Experience From Pakistan.

Cureus 2021 Jun 29;13(6):e16029. Epub 2021 Jun 29.

Internal Medicine, Dow University of Health Sciences, Karachi, PAK.

Introduction Non-alcoholic fatty liver disease (NALFD) has become one of the most pervasive causes of hepatic pathology. Because of its marked association with metabolic syndrome, type II diabetes and cardiovascular disease, NAFLD has gained substantial focus recently. Its prevalence and incidence are on the rise in Pakistan. Read More

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Coaxial Double-Pigtail Stent Placement: A Simple Solution to Decrease Bleeding Risk Associated With Lumen-Apposing Metal Stent?

Cureus 2021 Jun 28;13(6):e15981. Epub 2021 Jun 28.

Gastroenterology, Valleywise Health Medical Center, Phoenix, USA.

Endoscopic cystogastrostomy using lumen-apposing metal stent (LAMS) is considered the first-line therapy for symptomatic pancreatic fluid collections (PFCs). Routine coaxial placement of a double-pigtail stent (DPS) through LAMS is debated. We report the case of a patient with delayed massive gastrointestinal bleed eight weeks after LAMS placement due to splenic artery pseudoaneurysm leading to a complicated hospitalization. Read More

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HRV-Spark: Computing Heart Rate Variability Measures Using Apache Spark.

Proceedings (IEEE Int Conf Bioinformatics Biomed) 2020 13;2020. Epub 2020 Jan 13.

School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, Texas, USA.

Heart rate variability (HRV) analysis has been serving as a significant promising marker in clinical research over the last few decades. The rapidly growing heart rate data generated from various devices, particularly the electrocardiograph (ECG), need to be stored properly and processed timely. There is a pressing need to develop efficient approaches for performing HRV analyses based on ECG signals. Read More

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January 2020

: An Uncommon Human Pathogen Causing Infective Endocarditis in a Valve-in-Valve Transcatheter Aortic Valve Replacement.

Case Rep Cardiol 2021 11;2021:5569533. Epub 2021 Jul 11.

Cardiovascular Division, Department of Medicine, VA Caribbean Healthcare System, San Juan, Puerto Rico.

is a fish pathogen and an uncommon cause of human infections. There is a growing body of evidence showing its potential for causing endocarditis especially in those with prior valve surgery. In this case report, we present what we believe is the first case of endocarditis by affecting a valve-in-valve transcatheter aortic valve replacement that was successfully treated. Read More

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Rapid growing mediastinal ectopic pancreas within ruptured thymic cyst treated using video-assisted thoracic surgery.

Respirol Case Rep 2021 Sep 29;9(9):e0815. Epub 2021 Jul 29.

Department of Thoracic Center Urasoe General Hospital Okinawa Japan.

Ectopic pancreas (EP) is typically found within other gastrointestinal organs. Its discovery in other parts of the body, especially in the mediastinum, is exceedingly rare. This paper presents a case of a 17-year-old female patient with EP in a large, rapidly growing thymic cyst. Read More

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September 2021

An unusual case of invasive pleuritis and miliary Mycoplasma pneumonia during check-point inhibitor therapy.

Respirol Case Rep 2021 Sep 29;9(9):e0813. Epub 2021 Jul 29.

Respiratory and Sleep Medicine Gold Coast University Hospital Gold Coast Queensland Australia.

A growing body of evidence suggests that check-point inhibitors not only increase the overall risk of infections, but, due to an altered immune response, may also result in atypical manifestations. We report a case of a 38-year-old man with pleuritic chest pain, dyspnoea, fevers and a dry cough receiving combination ipilimumab and nivolumab immunotherapy for metastatic melanoma. Radiological findings demonstrated a diffuse increased fluorodeoxyglucose avidity of the thoracic pleura in addition to a disseminated miliary pattern of pulmonary nodularities. Read More

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September 2021

Spatio-temporal differences in leaf physiology are associated with fire, not drought, in a clonally integrated shrub.

AoB Plants 2021 Aug 9;13(4):plab037. Epub 2021 Jun 9.

USDA-Agricultural Research Service, Eastern Oregon Agricultural Research Center, 67826-A Hwy 205, Burns, OR 97720, USA.

In highly disturbed environments, clonality facilitates plant survival via resprouting after disturbance, resource sharing among interconnected stems and vegetative reproduction. These traits likely contribute to the encroachment of deep-rooted clonal shrubs in tallgrass prairie. Clonal shrubs have access to deep soil water and are typically thought of as relatively insensitive to environmental variability. Read More

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Photobiomodulation Regulation as One Promising Therapeutic Approach for Myocardial Infarction.

Oxid Med Cell Longev 2021 17;2021:9962922. Epub 2021 Jul 17.

Department of Pharmacy at the Second Affiliated Hospital, Harbin Medical University, China.

Myocardial infarction refers to myocardial necrosis caused by acute or persistent coronary ischemia and hypoxia. It is considered to be one of the significant crises threatening human health in the world. Following myocardial infarction, collagen gradually replaces the original tissue due to the loss of many cardiomyocytes, myocardial contractile function decreases, and myocardial fibrosis eventually leads to heart failure. Read More

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The role of vitamin D in perinatology. An up-to-date review.

Arch Med Sci 2021 30;17(4):992-1005. Epub 2019 Jan 30.

First Department of Obstetrics and Gynecology, Center of Postgraduate Medical Education, Warsaw, Poland.

The role of vitamin D in perinatology is a subject of major interest in current medicine. There is growing evidence about the role of maternal vitamin D levels in pregnancy outcomes. The aim of this review is to summarize the current literature about the role of vitamin D in perinatology. Read More

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January 2019