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Immune response of adult horses, pregnant mares and foals to an experimental vaccine with recombinant EMA-2 protein of Theileria equi.

Res Vet Sci 2021 Jul 20;139:186-192. Epub 2021 Jul 20.

Centro de Desenvolvimento Tecnológico, Biotecnologia, Pelotas, Rio Grande do Sul, Brazil. Electronic address:

Equine theileriosis, caused by the Theileria equi protozoan, is a disease of worldwide importance. T. equi expresses surface proteins, of which the EMA-2 protein is a promising antigen for vaccine use. Read More

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Exercise in Aging: Be Balanced.

Aging Dis 2021 Aug 1;12(5):1140-1149. Epub 2021 Aug 1.

7Department of Psychological Sciences, Texas Tech University, USA.

The beneficial effects of exercise are recognized for preventing physical and cognitive decline during the aging process. However, there is still a gap concerning recommended intensity, volume, frequency and mode of exercise especially for older people. The aim of this study was to investigate an appropriate type of physical activity (PA) model for healthy aging. Read More

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Kawasaki disease associated pulmonary involvement in infants.

Pediatr Pulmonol 2021 Aug 2. Epub 2021 Aug 2.

Department of Rheumatology and Immunology, Shenzhen Children's hospital, Shenzhen, China.

Objectives: Kawasaki disease (KD) is an acute, self-limited multisystemic vasculitis of unknown cause. Pulmonary involvement has been reported in case reports and limited small case series, which is not commonly recognized, especially in younger patients <1 year. Here, we describe clinical and radiological features of infants with KD-associated pulmonary involvement (KD-PI). Read More

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Cationic Photothermal Hydrogels with Bacteria-Inhibiting Capability for Freshwater Production via Solar-Driven Steam Generation.

ACS Appl Mater Interfaces 2021 Aug 2. Epub 2021 Aug 2.

State Key Laboratory of Material Processing and Die & Mould Technology, Key Laboratory of Material Chemistry for Energy Conversion and Storage (HUST) of Ministry of Education, and School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan 430074, China.

Solar-driven steam generation has been recognized as a sustainable and low-cost solution to freshwater scarcity using abundant solar energy. To harvest freshwater, various interfacial evaporators with rational designs of photothermal materials and structures have been developed concentrating on increasing the evaporation rate in the past few years. However, pathogenic microorganism accumulation on the evaporators by long-duration contact with natural water resources may lead to the deterioration of water transportation and the reduction of the evaporation rate. Read More

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National Health Systems and COVID-19 Death Toll Doubling Time.

Front Public Health 2021 15;9:669038. Epub 2021 Jul 15.

Facultad de Ingeniería y Tecnología, Universidad San Sebastián, Santiago, Chile.

Coronavirus disease 2019 (COVID-19) has placed stress on all National Health Systems (NHSs) worldwide. Recent studies on the disease have evaluated different variables, namely, quarantine models, mitigation efforts, damage to mental health, mortality of the population with chronic diseases, diagnosis, use of masks and social distancing, and mortality based on age. This study focused on the four NHSs recognized by the WHO. Read More

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Influence of SGLT2 Inhibitor Treatment on Urine Antioxidant Status in Type 2 Diabetic Patients: A Pilot Study.

Oxid Med Cell Longev 2021 14;2021:5593589. Epub 2021 Jul 14.

Department of Internal Medicine, Diabetology and Nephrology in Zabrze, Faculty of Medical Sciences in Zabrze (41-800), Medical University of Silesia, Katowice, Poland.

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been recognized as potent antioxidant agents. Since SGLT2i are nephroprotective drugs, we aimed to examine the urine antioxidant status in patients with type 2 diabetes mellitus (T2DM). One hundred and one subjects participated in this study, including 37 T2DM patients treated with SGLT2i, 31 T2DM patients not using SGLT2i, and 33 healthy individuals serving as a control group. Read More

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Characteristics of Deaths With Evidence of Pathological Hoarding in Cook County 2017 to 2018.

Am J Forensic Med Pathol 2021 Jul 29. Epub 2021 Jul 29.

From the Pathology Division, Cook County Medical Examiner's Office, Chicago, IL Pathology Division, Eason Forensic Pathology Services, LLC, Charleston, SC.

Abstract: Hoarding disorder was recently recognized as an independent diagnosis; it is characterized by the accumulation of objects causing a functional impairment and is commonly associated with increased risk of injury or death. Limited data exist about deaths of persons found in hoarding environments. This study investigated the characteristics and circumstances surrounding deaths found in "hoarding" environments. Read More

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Depolymerization of Hydroxylated Polymers via Light-Driven C-C Bond Cleavage.

J Am Chem Soc 2021 Jul 31. Epub 2021 Jul 31.

Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.

The accumulation of persistent plastic waste in the environment is widely recognized as an ecological crisis. New chemical technologies are necessary both to recycle existing plastic waste streams into high-value chemical feedstocks and to develop next-generation materials that are degradable by design. Here, we report a catalytic methodology for the depolymerization of a commercial phenoxy resin and high molecular weight hydroxylated polyolefin derivatives upon visible light irradiation near ambient temperature. Read More

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Dentist-patient communication on dental anxiety using the social media: A randomized controlled trial.

Scand J Psychol 2021 Jul 31. Epub 2021 Jul 31.

Department of Psychiatry, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.

The purpose of the present study was to assess the effects of dentist-patient communication via social media on dental anxiety and to determine the appropriate timing of such communications. In this randomized, double-blinded and controlled trial, we used Instagram's quick replies system to answer patients' questions to alleviate dental anxiety for patients undergoing impacted teeth extraction under local anesthesia. Patients were assigned randomly into four groups according to the timing of such communications: only after (group 1, n = 36), only before (group 2, n = 35), before and after the operation (group 3, n = 36), and a control group who received no communication on social media (group 4, n = 36). Read More

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Soil organic carbon (SOC) enrichment in aeolian sediments and SOC loss by dust emission in the desert steppe, China.

Sci Total Environ 2021 Jul 27;798:149189. Epub 2021 Jul 27.

Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou, Gansu 730000, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Dust emission is an important mechanism for carbon exchange between terrestrial and atmospheric carbon pools. However, undetermined soil organic carbon (SOC) enrichment in aeolian sediment limits the accurate estimation of SOC loss induced by wind erosion. Herein, we examined wind erosion and SOC loss measurements in the desert steppe of Inner Mongolia, China. Read More

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Neurochemical signs of astrocytic and neuronal injury in acute COVID-19 normalizes during long-term follow-up.

EBioMedicine 2021 Jul 29;70:103512. Epub 2021 Jul 29.

Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Infectious Diseases, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.

Background: Neurologic manifestations are well-recognized features of coronavirus disease 2019 (COVID-19). However, the longitudinal association of biomarkers reflecting CNS impact and neurological symptoms is not known. We sought to determine whether plasma biomarkers of CNS injury were associated with neurologic sequelae after COVID-19. Read More

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Neuroprotective effect of combined use of nicotine and celecoxib by inhibiting neuroinflammation in ischemic rats.

Brain Res Bull 2021 Jul 29. Epub 2021 Jul 29.

Department of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Introduction: The contribution of neuroinflammation in cognitive impairment is increasingly recognized. Non-steroidal anti-inflammatory drugs had been proven that it could improve cognitive impairment in large dose but with more side effect, which limited the application. The main objective of this study was to investigate whether the combined use of nicotine and celecoxib could obtain synergistic neuroprotective effect in ischemic rats. Read More

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Molecular mechanisms of plant peptide binding to receptors.

Authors:
Satohiro Okuda

Peptides 2021 Jul 29:170614. Epub 2021 Jul 29.

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-0033, Japan.

Plants have evolved diverse peptide hormones and cognate receptors to orchestrate plant growth and development. Secreted peptide ligands are mainly sensed by membrane receptor kinases that mediate cell-cell communication. The secreted peptides are categorized into two groups: small linear post-translationally modified peptides and cysteine-rich peptides. Read More

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Children's long-term retention is directly constrained by their working memory capacity limitations.

Dev Sci 2021 Jul 30. Epub 2021 Jul 30.

University of Missouri.

We explored the causal role of individual and age-related differences in working memory (WM) capacity in long-term memory (LTM) retrieval. Our sample of 160 participants included 120 children (6 - 13-years old) and 40 young adults (18 - 24 years). Participants performed a WM task with images of unique everyday items, presented at varying set sizes. Read More

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Scientific publication trends of emergency department of International Federation for Emergency Medicine members, 2009 to 2018.

Am J Emerg Med 2021 Jul 21;50:85-92. Epub 2021 Jul 21.

Department of Emergency Medicine, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Keelung, Taiwan. Electronic address:

Background: Emergency medicine (EM) is a rapidly developing specialty worldwide. The scientific publications trend is one of the parameters to evaluate national EM developmental milestones. This study was performed to analyze the publication trends from emergency departments (EDs) of International Federation for Emergency Medicine (IFEM) full member countries from 2009 to 2018. Read More

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Reliability, Validity, Clinical Utility, and Responsiveness of Measures for Assessing Mobility and Physical Function in Patients with Traumatic Injury in the Acute Care Hospital Setting: A Prospective Study.

Phys Ther 2021 Jul 29. Epub 2021 Jul 29.

Department of Physiotherapy, The Alfred Hospital, Prahran, Melbourne, VIC 3181.

Objective: The longer-term impact of injury is increasingly recognized, but the early phases of recovery are less well understood. The best tools to measure early recovery of mobility and physical function following traumatic injury are unclear. The purpose of this study was to assess the clinical utility, validity, reliability, and responsiveness of 4 mobility and physical function measures in patients following traumatic injury. Read More

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Growth dynamics among adolescent girls in Bangladesh: Evidence from nationally representative data spanning 2011-2014.

PLoS One 2021 29;16(7):e0255273. Epub 2021 Jul 29.

The World Bank Group Cambodia, Phnom Penh, Cambodia.

Background: Adolescence is the last opportunity to reverse any growth faltering accumulated from fetal life through childhood and it is considered a crucial period to optimize human development. In Bangladesh, a growing double burden of underweight and obesity in adolescents is recognized, yet limited data exists on how, when, and where to intervene. This study assesses the dynamics of growth among adolescent girls in Bangladesh, providing insight about critical junctures where faltering occurs and where immediate interventions are warranted. Read More

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Cardiac remodeling in fetuses conceived by ARTs: fresh versus frozen embryo transfer.

Hum Reprod 2021 Jul 27. Epub 2021 Jul 27.

BCNatal | Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), Universitat de Barcelona, Barcelona, Spain.

Study Question: Do fetuses from frozen embryo transfer (FET) present signs of cardiac remodeling and suboptimal function similar to those observed in fetuses from fresh embryo transfer (ET)?

Summary Answer: Fetuses from both fresh ET and FET present signs of fetal cardiac remodeling and suboptimal function, with more pronounced changes after fresh ET as compared to FET.

What Is Known Already: Our group and others have previously demonstrated that fetuses and children conceived by ARTs present cardiac remodeling and suboptimal function. These fetuses show dilated atria, more globular and thicker ventricles, reduced longitudinal motion, and impaired relaxation. Read More

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Resistance mechanisms and genetic relatedness among carbapenem-resistant isolates from three major hospitals in Hanoi, Vietnam (2011-15).

JAC Antimicrob Resist 2021 Sep 27;3(3):dlab103. Epub 2021 Jul 27.

Oxford University Clinical Research Unit, Hanoi, Vietnam.

Background: MDR bacteria including carbapenem-resistant are recognized as an important cause of hospital-acquired infections worldwide. This investigation seeks to determine the molecular characterization and antibiotic resistance genes associated with carbapenem-resistant .

Methods: We conducted WGS and phylogenetic analysis of 72 carbapenem-resistant isolated from hospital-acquired infection patients from August 2011 to March 2015 in three major hospitals in Hanoi, Vietnam. Read More

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September 2021

How do young men want to receive information about fertility? Young men's attitudes towards a fertility campaign targeting men in Copenhagen, Denmark.

Hum Reprod Open 2021 27;2021(3):hoab027. Epub 2021 Jul 27.

Department of Public Health, Section of Social Medicine, University of Copenhagen, Copenhagen K, Denmark.

Study Question: What are young men's attitudes towards the Danish fertility campaign 'How's your sperm?' and how do they want to receive fertility information in the future?

Summary Answer: The young men found that the campaign had limited impact because it was not relevant to their current life situation and they believed general fertility awareness should be a mandatory part of education, while more targeted information would be helpful through web-based venues when it was more relevant to their lives (e.g. when ready to have children). Read More

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A Case-Control Study on Behavioral Addictions and Neurocognition: Description of the BANCO and BANCO2 Protocols.

Neuropsychiatr Dis Treat 2021 20;17:2369-2386. Epub 2021 Jul 20.

CHU Nantes, Addictology and Psychiatry Department, Nantes, France.

Introduction: Only two behavioral addictions (BAs) are currently recognized in international classifications (gambling disorder: GbD; gaming disorder: GmD), while some of them await further investigation (food addiction: FA; sexual addiction: SA). Neurocognitive functioning is considered a risk factor for BAs. Research is quite abundant for GbD and highlights specific deficits in several cognitive functions. Read More

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Synthetic Peptides with Inadvertent Chemical Modifications Can Activate Potentially Autoreactive T Cells.

J Immunol 2021 Jul 28. Epub 2021 Jul 28.

Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.

The human CD8 T cell clone 6C5 has previously been shown to recognize the -butyl-modified Bax peptide LLSY(3-Bu)FGTPT presented by HLA-A*02:01. This nonnatural epitope was likely created as a by-product of fluorenylmethoxycarbonyl protecting group peptide synthesis and bound poorly to HLA-A*02:01. In this study, we used a systematic approach to identify and characterize natural ligands for the 6C5 TCR. Read More

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Preoperative walking recommendation for non-cardiac surgery patients to reduce the length of hospital stay: a randomized control trial.

BMC Sports Sci Med Rehabil 2021 Jul 28;13(1):80. Epub 2021 Jul 28.

Nursing Department, Fundación Oftalmológica de Santander-Clínica Carlos Ardila Lulle, FOSCAL, Calle 155A No23-60, Floridablanca, Colombia.

Background: Even though the importance of preparing patients for a surgical event is recognized, there are still gaps about the benefit of improving functional capacity by walking during the waiting time among patients scheduled for non-cardiac surgery. The aim of this study was to evaluate the impact of pre-surgical walking in-hospital length of stay, early ambulation, and the appearance of complications after surgery among patients scheduled for non-cardiac surgery.

Methods: A two-arm, single- blinded randomized controlled trial was developed from May 2016 to August 2017. Read More

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Morphological Lesion Types Are Associated with Primary and Secondary Patency Rates after High-Pressure Balloon Angioplasty for Dysfunctional Arteriovenous Fistulas.

Blood Purif 2021 Jul 28:1-10. Epub 2021 Jul 28.

Department of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.

Background: Neointimal hyperplasia (NIH) is believed to be the main reason for arteriovenous fistula (AVF) dysfunction, but other mechanisms are also recognized to be involved in the pathophysiological process. This study investigated whether different morphological types of AVF lesions are associated with the patency rate after percutaneous transluminal angioplasty (PTA).

Methods: This retrospective study included 120 patients who underwent PTA for autogenous AVF dysfunction. Read More

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Affective states in digital game-based learning: Thematic evolution and social network analysis.

PLoS One 2021 28;16(7):e0255184. Epub 2021 Jul 28.

Department of Mathematics and Information Technology, The Education University of Hong Kong, Hong Kong, Hong Kong SAR.

Research has indicated strong relationships between learners' affect and their learning. Emotions relate closely to students' well-being, learning quality, productivity, and interaction. Digital game-based learning (DGBL) has been widely recognized to be effective in enhancing learning experiences and increasing student motivation. Read More

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The role of twisting in driving excited-state symmetry breaking and enhanced two-photon absorption in quadrupolar cationic pyridinium derivatives.

Phys Chem Chem Phys 2021 Jul 28. Epub 2021 Jul 28.

Department of Chemistry, Biology and Biotechnology and Centro di Eccellenza sui Materiali Innovativi Nanostrutturati (CEMIN) University of Perugia, via Elce di Sotto 8, 06123 Perugia, Italy.

Two symmetric quadrupolar cationic push-pull compounds with a central electron-acceptor (N+-methylpyrydinium, A+) and different lateral electron-donors, (N,N-dimethylamino and N,N-diphenylamino, D) in a D-π-A+-π-D arrangement, were investigated together with their dipolar counterparts (D-π-A+) for their excited-state dynamics and NLO properties. As for the quadrupolar compounds, attention was focused on excited-state symmetry breaking (ESSB), which leads to a relaxed dipolar excited state. Both electron charge displacements and structural rearrangements were recognized in the excited-state dynamics of these molecules by resorting to femtosecond-resolved broadband fluorescence up-conversion experiments and advanced data analysis, used as a valuable alternative approach for fluorescent molecules compared to time-resolved IR spectroscopy, only suitable for compounds bearing IR markers. Read More

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One-step hydrothermal synthesis of nitrogen-doped carbon dots for high-sensitivity visual detection of nitrite and ascorbic acid.

Anal Methods 2021 Jul 28. Epub 2021 Jul 28.

School of Printing and Packaging, Wuhan University, Wuhan 430079, Hubei, China.

Ascorbic acid (AA) is an indispensable vitamin for the human body and is associated with critical processes of human metabolism. However, excessive intake of AA can also have a negative impact on human health. Nitrite is a commonly used food additive, and its overdose can increase the risk of cancer. Read More

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Activation of the Protein Kinase R-Like Endoplasmic Reticulum Kinase (PERK) Pathway of the Unfolded Protein Response after Experimental Traumatic Brain Injury and Treatment with a PERK Inhibitor.

Neurotrauma Rep 2021 6;2(1):330-342. Epub 2021 Jul 6.

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.

Neurodegeneration after traumatic brain injury (TBI) is increasingly recognized as a key factor contributing to poor chronic outcomes. Activation (i.e. Read More

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What we learned in the past year in managing our COVID-19 patients in intensive care units?

World J Crit Care Med 2021 Jul 9;10(4):81-101. Epub 2021 Jul 9.

Department of Medicine, Texas A&M University, Corpus Christi, TX 78404, United States.

Coronavirus disease 2019 is a pandemic, was first recognized at Wuhan province, China in December 2019. The disease spread quickly across the globe, spreading stealthily from human to human through both symptomatic and asymptomatic individuals. A multisystem disease which appears to primarily spread bio aerosols, it has exhibited a wide clinical spectrum involving multiple organ systems with the respiratory system pathology being the prime cause of morbidity and mortality. Read More

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Multi-tiered external facilitation: the role of feedback loops and tailored interventions in supporting change in a stepped-wedge implementation trial.

Implement Sci Commun 2021 Jul 27;2(1):82. Epub 2021 Jul 27.

VA HSR&D Center for Health Information and Communication (CHIC), Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA.

Background: Facilitation is a complex, relational implementation strategy that guides change processes. Facilitators engage in multiple activities and tailor efforts to local contexts. How this work is coordinated and shared among multiple, external actors and the contextual factors that prompt and moderate facilitators to tailor activities have not been well-described. Read More

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