Angew Chem Int Ed Engl 2021 Jun 9. Epub 2021 Jun 9.
The University of Tokyo, Graduate School of Engineering, 7-3-1 Hongo, Bunkyo-ku, Department of Applied Chemistry, 113-8656, Tokyo, JAPAN.
This review article discusses, along with historical background, the principle and the proof-of-concept studies of crystalline sponge (CS) method, a new single-crystal X-ray diffraction (SCD) for the analysis of the structures of small molecules without sample crystallization. The method uses single crystalline porous coordination networks, called crystalline sponges, that can absorb small guest molecules into the pores. The absorbed guest molecules are ordered via molecular recognition in the pores and become observable by conventional SCD analysis. Read More