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Facial root entry/exit zone contact in microvascular decompression for hemifacial spasm: a historical control study.

Ann Transl Med 2021 May;9(10):834

Department of Neurosurgery, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Background: Microvascular decompression (MVD) surgery is recognized as an effective treatment for hemifacial spasm (HFS). In MVD surgery, biocompatible materials are usually implanted at the neurovascular conflict site in contact with the offending vessel and the facial root entry/exit zone (REZ). Another procedure of implanting the materials between the responsible vessel and the supraolivary fossa without REZ contact has also been applied. Read More

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A precision medicine classification for treatment of acute myeloid leukemia in older patients.

J Hematol Oncol 2021 Jun 23;14(1):96. Epub 2021 Jun 23.

The Ohio State University Comprehensive Cancer Center, 320 West 10th Avenue, Starling Loving Hall B302, Columbus, OH, 43210, USA.

Background: Older patients (≥ 60 years) with acute myeloid leukemia (AML) often have multiple, sequentially acquired, somatic mutations that drive leukemogenesis and are associated with poor outcome. Beat AML is a Leukemia and Lymphoma Society-sponsored, multicenter umbrella study that algorithmically segregates AML patients based upon cytogenetic and dominant molecular abnormalities (variant allele frequencies (VAF) ≥ 0.2) into different cohorts to select for targeted therapies. Read More

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Long-term growth in offspring of infertile parents: a 20-year follow-up study.

Acta Obstet Gynecol Scand 2021 Jun 22. Epub 2021 Jun 22.

Department of Obstetrics and Gynecology, Aalborg University Hospital, Aalborg, Denmark.

Introduction: Long-term growth has been poorly investigated in boys and girls born by parents receiving fertility treatment. This study aimed to investigate the growth of children born following fertility treatment up to adulthood hypothesizing comparable growth in children born by parents receiving fertility treatment or by subfertile parents conceiving spontaneously to that of children spontaneously conceived by fertile parents.

Material And Methods: In this historical long-term follow-up study the study population consisted of 4151 singletons born at term in the Aarhus Birth Cohort between 1990 and 1992. Read More

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Intravenous methylprednisolone with or without tocilizumab in patients with severe COVID-19 pneumonia requiring oxygen support: A prospective comparison.

J Infect Public Health 2021 Jun 10;14(8):985-989. Epub 2021 Jun 10.

Health Regulation Sector, Dubai Health Authority, United Arab Emirates. Electronic address:

Background: Cytokine storm is a marker of severity and severe mortality in patients with coronavirus disease 2019 (COVID-19) pneumonia. Immunomodulatory treatments may reduce morbidity and mortality.

Objectives: To determine whether a 7-day course of methylprednisolone (MP) administered with and without tocilizumab improves outcomes in patients with severe COVID-19 (SARS-CoV-2) pneumonia requiring oxygen therapy, relative to historical controls. Read More

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PROTACs, molecular glues and bifunctionals from bench to bedside: Unlocking the clinical potential of catalytic drugs.

Prog Med Chem 2021 27;60:67-190. Epub 2021 Mar 27.

Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, United Kingdom. Electronic address:

The vast majority of currently marketed drugs rely on small molecules with an 'occupancy-driven' mechanism of action (MOA). Therefore, the efficacy of these therapeutics depends on a high degree of target engagement, which often requires high dosages and enhanced drug exposure at the target site, thus increasing the risk of off-target toxicities (Churcher, 2018 [1]). Although small molecule drugs have been successfully used as treatments for decades, tackling a variety of disease-relevant targets with a defined binding site, many relevant therapeutic targets remain challenging to drug due, for example, to lack of well-defined binding pockets or large protein-protein interaction (PPI) interfaces which resist interference (Dang et al. Read More

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Phylogenomic framework of the IRLC legumes (Leguminosae subfamily Papilionoideae) and intercontinental biogeography of tribe Wisterieae.

Mol Phylogenet Evol 2021 Jun 16:107235. Epub 2021 Jun 16.

Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. Electronic address:

The inverted repeat-lacking clade (IRLC) is one of the most derived clades within the subfamily Papilionoideae of the legume family, and includes various economically important plants, e.g., chickpeas, peas, liquorice, and the largest genus of angiosperms, Astragalus. Read More

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Perceptions of pastoralist problems: A participatory study on animal management, disease spectrum and animal health priorities of small ruminant pastoralists in Georgia.

Prev Vet Med 2021 Jun 11;193:105412. Epub 2021 Jun 11.

State Laboratory of Agriculture, Tbilisi, Georgia. Electronic address:

Small ruminants support the livelihoods of millions of poor pastoralist and sedentary households around the world. While pastoralists are generally not amongst the poorest in terms of assets, they are frequently marginalised in terms of their access to political power, health and education. This study was undertaken among pastoralist households keeping small ruminants in four regions of the country of Georgia. Read More

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Mapping supply of and demand for ecosystem services to assess environmental justice in New York City.

Ecol Appl 2021 Jun 17:e2390. Epub 2021 Jun 17.

Urban Systems Lab, The New School, New York, NY, USA.

Livability, resilience, and justice in cities are challenged by climate change and the historical legacies that together create disproportionate impacts on human communities. Urban green infrastructure has emerged as an important tool for climate change adaptation and resilience given their capacity to provide ecosystem services such as local temperature regulation, stormwater mitigation, and air purification. However, realizing the benefits of ecosystem services for climate adaptation depend on where they are locally supplied. Read More

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The DNA history of a lonely oak: phylogeography in the Colombian Andes.

Ecol Evol 2021 Jun 7;11(11):6814-6828. Epub 2021 May 7.

Escuela Nacional de Estudios Superiores (ENES) Unidad Morelia Universidad Nacional Autónoma de México (UNAM) Morelia Mexico.

The climatic and geological changes that occurred during the Quaternary, particularly the fluctuations during the glacial and interglacial periods of the Pleistocene, shaped the population demography and geographic distribution of many species. These processes have been studied in several groups of organisms in the Northern Hemisphere, but their influence on the evolution of Neotropical montane species and ecosystems remains unclear. This study contributes to the understanding of the effect of climatic fluctuations during the late Pleistocene on the evolution of Andean mountain forests. Read More

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Moral distress and ethical climate in intensive care medicine during COVID-19: a nationwide study.

BMC Med Ethics 2021 06 17;22(1):73. Epub 2021 Jun 17.

Department of Intensive Care, Maastricht University Medical Center+, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.

Background: The COVID-19 pandemic has created ethical challenges for intensive care unit (ICU) professionals, potentially causing moral distress. This study explored the levels and causes of moral distress and the ethical climate in Dutch ICUs during COVID-19.

Methods: An extended version of the Measurement of Moral Distress for Healthcare Professionals (MMD-HP) and Ethical Decision Making Climate Questionnaire (EDMCQ) were online distributed among all 84 ICUs. Read More

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From uniprofessionality to interprofessionality: dual vs dueling identities in healthcare.

J Interprof Care 2021 Jun 18:1-6. Epub 2021 Jun 18.

Associate Professor, Dalhousie University; Affiliate Scientist, IWK Health Centre, Canada.

Healthcare systems are at times still viewed as siloed performances of single professions, wherein some groups hold hierarchical positions based on their expertise and prestige, rather than a collective functioning of interprofessional teams. Current policies, procedures, and regulations in healthcare education and practice seem to contribute to this context in which the various health and social care professions are set in opposition to one another. The historical, and still prominent, uniprofessional education and socialization practices position health and social care professions to view each as rivals and threats toward achieving their profession/al advancement and growth. Read More

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Epidemic spread simulation in an area with a high-density crowd using a SEIR-based model.

PLoS One 2021 17;16(6):e0253220. Epub 2021 Jun 17.

School of Civil Engineering and Transportation, Hohai University, Nanjing, China.

Understanding the spread of infectious diseases is an extremely essential step to preventing them. Thus, correct modeling and simulation approaches are critical for elucidating the transmission of infectious diseases and improving the control of epidemics. The primary objective of this study is to simulate the spread of communicable diseases in an urban rail transit station. Read More

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Hyper-CVAD plus ofatumumab versus hyper-CVAD plus rituximab as frontline therapy in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia: A propensity score analysis.

Cancer 2021 Jun 17. Epub 2021 Jun 17.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: The outcome of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone plus ofatumumab hyper-CVAD + ofatumumab (hyper-CVAD + ofatumumab) has not been compared with the outcome of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone plus ofatumumab hyper-CVAD plus rituximab (hyper-CVAD + Rituximab) in Philadelphia chromosome-negative acute lymphoblastic leukemia (ALL) in a randomized clinical trial.

Methods: The authors compared the outcomes of 69 patients treated with hyper-CVAD + ofatumumab and 95 historical-control patients treated with hyper-CVAD + Rituximab. Historical-control patients were treated with hyper-CVAD + Rituximab if they had CD20 expression ≥ 20%. Read More

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Cue-Based Feeding as Intervention to Achieve Full Oral Feeding in Preterm Infants Primarily Managed with Bubble CPAP.

Am J Perinatol 2021 Jun 15. Epub 2021 Jun 15.

Department of Rehabilitation, the George Washington University Hospital, Washington, District of Columbia.

Objective:  Cue-based feeding aims at matching introduction of per oral (PO) feeding with physiological readiness of preterm infants to facilitate PO intake and avoid oral aversion. It was claimed that cue-based feeding may lead to delay in the initiation or achieving full PO feeding in clinical setting primarily using bubble nasal continuous positive airway pressure (CPAP). The study aimed to examine the association of cue-based feeding with time of introduction and completing oral feeding in infants primarily managed with bubble CPAP. Read More

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Inferring Population Histories for Ancient Genomes Using Genome-Wide Genealogies.

Mol Biol Evol 2021 Jun 15. Epub 2021 Jun 15.

Department of Statistics, University of Oxford, Oxford, UK.

Ancient genomes anchor genealogies in directly observed historical genetic variation and contextualise ancestral lineages with archaeological insights into their geography and cultural associations. However, the majority of ancient genomes are of lower coverage and cannot be directly built into genealogies. Here, we present a fast and scalable method, Colate, the first approach for inferring ancestral relationships through time between low-coverage genomes without requiring phasing or imputation. Read More

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Overcoming Historical Barriers: Enhancing Positive Perceptions of Medical Research Among African Americans Through a Conference-Based Workshop.

J Gen Intern Med 2021 Jun 14. Epub 2021 Jun 14.

Department of Family Medicine, Mayo Clinic Arizona, Scottsdale, AZ, USA.

Background: African Americans (AAs) and other racial/ethnic minority groups continue to be underrepresented in medical research and clinical trials. Failure to create more racially diverse research cohorts can exacerbate existing health disparities among these groups.

Objective: To investigate best practices and strategies for enhancing participation of AAs in medical research among attendees of a preconference Institute at a faith-based public health conference. Read More

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The geographic distribution of bioavailable strontium isotopes in Greece - A base for provenance studies in archaeology.

Sci Total Environ 2021 Jun 4;791:148156. Epub 2021 Jun 4.

Department of Research, Collections and Conservation, Environmental Archaeology and Materials Science, National Museum of Denmark, Kongens Lyngby DK 2800, Denmark. Electronic address:

Sr isotopes are a powerful tool used to reconstruct human mobility in archaeology. This requires extensive bioavailable Sr/Sr baselines used as reference for deciphering potential areas of origin. We define the first extensive bioavailable Sr isotope baselines for the different geographical regions and surface lithologies of Greece by combining new Sr data with previously published bioavailable Sr/Sr data. Read More

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Psychosocial aspects of Historical and Cultural Learning: Historical Trauma and Resilience among Indigenous Young Adults.

J Health Care Poor Underserved 2021 ;32(2):987-1018

Purpose: The purpose of this manuscript is to evaluate the impact of the Remember the Removal (RTR) program, with specific emphasis on participants' experiences learning about and reacting to Cherokee history, including historical trauma.

Methods: Two cohorts of intervention participants (1984 and 2015) participated in focus groups. An exploratory analysis was performed to categorize themes around the effects of historical training. Read More

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January 2021

Phase II study of stereotactic body radiotherapy with hydrogel spacer for prostate cancer: acute toxicity and propensity score-matched comparison.

Radiat Oncol 2021 Jun 12;16(1):107. Epub 2021 Jun 12.

Department of Radiology, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyoku, Tokyo, 113-8655, Japan.

Background: The efficacy of a hydrogel spacer in stereotactic body radiotherapy (SBRT) has not been clarified. We evaluated the safety and efficacy of SBRT in combination with a hydrogel spacer for prostate cancer.

Methods: This is a prospective single-center, single-arm phase II study. Read More

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Outcomes of a Modified Treatment Ladder Algorithm using Retrobulbar Amphotericin B for Invasive Fungal Rhino-Orbital Sinusitis.

Am J Ophthalmol 2021 Jun 8. Epub 2021 Jun 8.

Department of Ophthalmology, University of California San Francisco, California, United States of America. Electronic address:

Purpose: To assess whether a modified treatment ladder algorithm incorporating transcutaneous retrobulbar amphotericin B (TRAMB) for invasive fungal rhino-orbital sinusitis (IFROS) can reduce the risk of exenteration without compromising survival.

Design: Retrospective, comparative clinical study with historical controls.

Methods: Fifty consecutive patients with biopsy-proven invasive fungal sinusitis and radiographic evidence of orbital involvement were evaluated at a single tertiary institution from 1999-2020. Read More

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Molecular Hallmarks, Agronomic Performances and Seed Nutraceutical Properties to Exploit Neglected Genetic Resources of Common Beans Grown by Organic Farming in Two Contrasting Environments.

Front Plant Sci 2021 25;12:674985. Epub 2021 May 25.

Department of Crop and Soil Sciences, University of Georgia, Athens, GA, United States.

Common bean ( L.) is an essential source of food proteins and an important component of sustainable agriculture systems around the world. Thus, conserving and exploiting the genetic materials of this crop species play an important role in achieving global food safety and security through the preservation of functional and serependic opportunities afforded by plant species diversity. Read More

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[Application of optimized catheter management strategy in interhospital patients transition with extracorporeal membrane oxygenation].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):600-604

Department of Emergency, Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China. Corresponding author: Wu Jiehua, Email:

Objective: To discuss the effect of optimized catheter management strategy on reducing the incidence of catheter-related adverse events in interhospital patients transition with extracorporeal membrane oxygenation (ECMO).

Methods: A historical control trial was conducted. The patients transferred with ECMO to the Second Affiliated Hospital of Nanchang University from January 2018 to December 2020 were enrolled. Read More

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Excess Mortality During the COVID-19 Pandemic in Philadelphia.

Am J Public Health 2021 Jun 10:e1-e6. Epub 2021 Jun 10.

All authors are with the Philadelphia Department of Public Health, Philadelphia, PA.

To estimate excess all-cause mortality in Philadelphia, Pennsylvania, during the COVID-19 pandemic and understand the distribution of excess mortality in the population. With a Poisson model trained on recent historical data from the Pennsylvania vital registration system, we estimated expected weekly mortality in 2020. We compared these estimates with observed mortality to estimate excess mortality. Read More

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Crystalline Sponge Method: X-ray Structure Analysis of Small Molecules via Post-Orientation within Porous Crystals. Principle and Proof-of-Concept Studies.

Makoto Fujita

Angew Chem Int Ed Engl 2021 Jun 9. Epub 2021 Jun 9.

The University of Tokyo, Graduate School of Engineering, 7-3-1 Hongo, Bunkyo-ku, Department of Applied Chemistry, 113-8656, Tokyo, JAPAN.

This review article discusses, along with historical background, the principle and the proof-of-concept studies of crystalline sponge (CS) method, a new single-crystal X-ray diffraction (SCD) for the analysis of the structures of small molecules without sample crystallization. The method uses single crystalline porous coordination networks, called crystalline sponges, that can absorb small guest molecules into the pores. The absorbed guest molecules are ordered via molecular recognition in the pores and become observable by conventional SCD analysis. Read More

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Effect of Matching Therapists to Patients vs Assignment as Usual on Adult Psychotherapy Outcomes: A Randomized Clinical Trial.

JAMA Psychiatry 2021 Jun 9. Epub 2021 Jun 9.

Outcome Referrals Inc, Framingham, Massachusetts.

Importance: Psychotherapists possess strengths and weaknesses in treating different mental health problems, yet performance information is rarely harnessed in mental health care (MHC). To our knowledge, no prior studies have tested the causal efficacy of prospectively matching patients to therapists with empirically derived strengths in treating patients' specific concerns.

Objective: To test the effect of measurement-based matching vs case assignment as usual (CAU) on psychotherapy outcomes. Read More

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Interfaces between permanent education and interprofessional education in health.

Rev Esc Enferm USP 2021 4;55:e03733. Epub 2021 Jun 4.

Universidade Federal de São Carlos, Departamento de Enfermagem, São Carlos, SP, Brasil.

This was a reflective theoretical essay that was based on the national and international literature. The goal was to analyze the interfaces and historical-conceptual distinctions between permanent education in health and interprofessional education in health. In the international context, there have been educational movements aimed at health workers with an emphasis on the incentives of the Pan-American Health Organization. Read More

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[Feminist precursors of mutual support groups in the mad movement: a historical-critical analysis].

Salud Colect 2021 Apr 28;17:e3274. Epub 2021 Apr 28.

Doctor en Psicología Social. Profesor titular, Universidad Rey Juan Carlos de Madrid. Madrid, España.

Mutual support groups are one of the most important collective actions in the psychiatric survivors movement or mad movement. Among its precursors, different proposals from social movements and community perspectives on collective health have been mainly well-known. In this article we carry out a historical overview of their antecedents, pointing out different actions from the Women's Liberation Movement and the Women's Health Movement. Read More

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The early surgical period in robotic radical hysterectomy is related to the recurrence after surgery in stage IB cervical cancer.

Int J Med Sci 2021 13;18(12):2697-2704. Epub 2021 May 13.

Department of Gynecology Oncology and Robotic Surgery, Center of Hope, University of Nevada, Reno School of Medicine, Reno, NV, USA.

To identify the pattern of recurrence and assess the clinicopathologic prognostic factors for survival after robotic radical hysterectomy (RRH) in the treatment of stage IB cervical cancer. From December 2008 to March 2018, 64 cervical cancer patients who underwent RRH with pelvic lymph node dissection by a single surgeon were enrolled in this retrospective historical cohort timeline study. The patient's status was estimated in terms of operative outcomes, pathologic results, and survival outcomes. Read More

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Shifting the paradigms for tumor suppression: lessons from the p53 field.

Oncogene 2021 Jun 8. Epub 2021 Jun 8.

Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA, USA.

The TP53 gene continues to hold distinction as the most frequently mutated gene in cancer. Since its discovery in 1979, hundreds of research groups have devoted their efforts toward understanding why this gene is so frequently selected against by tumors, with the hopes of harnessing this information toward the improved therapy of cancer. The result is that this protein has been meticulously analyzed in tumor and normal cells, resulting in over 100,000 publications, with an average of 5000 papers published on p53 every year for the past decade. Read More

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A multimodal prehabilitation program in high-risk patients undergoing elective resection for colorectal cancer: A retrospective cohort study.

Eur J Surg Oncol 2021 May 29. Epub 2021 May 29.

Department of Surgery, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands. Electronic address:

Aim: Up to 50% of the patients experience complications after colorectal cancer (CRC) surgery. Improved preoperative physical and nutritional status can enhance clinical outcomes and reduce postoperative complications. This retrospective, single-center, observational cohort study assessed the impact of a four-week multimodal prehabilitation program on postoperative complications, unplanned readmissions, length of stay, and mortality in elective high-risk CRC patients. Read More

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