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Exploring the effect of two different teaching strategies on first-year nursing students' understanding of nutritional concepts: A mixed-method approach.

Nurse Educ Pract 2021 Sep 4;56:103193. Epub 2021 Sep 4.

Basque Nurse Education Research Group, Department of Nursing I, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Bº Sarriena s/n, 48940 Leioa, Spain; Biocruces Bizkaia Health Research Institute, Cruces Plaza, 48903 Barakaldo, Spain. Electronic address:

Aim: The aim of the study was twofold. First, to explore understanding difficulties in nutritional concepts among nursing students and second, to analyse the effect of two teaching strategies on the level of understanding.

Background: Previous studies have pointed out the need to improve the nutritional care education offered to undergraduates in health sciences. Read More

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September 2021

Effect of ultrasound-guided selective sensory nerve blockade of the knee on pain management compared with periarticular injection for patients undergoing total knee arthroplasty: A prospective randomized controlled trial.

Knee 2021 Sep 15;33:1-10. Epub 2021 Sep 15.

Department of Anesthesiology, King Chulalongkorn Memorial Hospital, The Thai Red Cross Society and Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Ultrasound-guided selective sensory nerve blockade (SSNB) of the knee, including an adductor canal block (ACB), anterior femoral cutaneous nerve block, and infiltration between the popliteal artery and posterior capsule of the knee may provide effective motor-sparing knee analgesia for total knee arthroplasty (TKA). We hypothesized that the SSNB would manage pain better on ambulation 24 hours postoperatively compared to periarticular infiltration (PAI), when combined with postoperative continuous ACB.

Methods: Seventy-two patients undergoing elective TKA under spinal anesthesia were randomly assigned to either SSNB (SSNB group) or intraoperative PAI (PAI group). Read More

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September 2021

Disulfiram and metformin combination anticancer effect reversible partly by antioxidant nitroglycerin and completely by NF-κB activator mebendazole in hamster fibrosarcoma.

Biomed Pharmacother 2021 Sep 15;143:112168. Epub 2021 Sep 15.

Department of Histology and Embryology, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.

We investigated the anticancer effect of disulfiram and metformin combination on fibrosarcoma in hamsters. Hamsters of both sexes (~ 70 g) were randomly allocated to control and experimental groups (8 animals per group). In all 10 groups, 2 × 10 BHK-21/C13 cells in 1 ml were injected subcutaneously into the animals' backs. Read More

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September 2021

Effect of a novel laser-initiated photoacoustic activation of a solvent or sodium hypochlorite in the removal of filling remnants after retreatment of curved root canals.

Photodiagnosis Photodyn Ther 2021 Sep 15:102535. Epub 2021 Sep 15.

Department of Endodontics and Restorative Dentistry, School of Dental Medicine, University of Zagreb, Croatia.

Background: This study aimed to evaluate the effect of Er:YAG laser-initiated shockwave-enhanced emission of photoacoustic streaming (SWEEPS®) and passive ultrasonic irrigation (PUI) combining thymol-based solvent or sodium hypochlorite (NaOCl) in the removal of filling remnants from curved canals.

Methods: Forty-eight curved root canals were instrumented and filled with an epoxy-resin-based sealer and gutta-percha. The canals were retreated with a Wave One Gold primary file (tip size 25; variable taper) and sodium hypochlorite (NaOCl). Read More

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September 2021

Sensitivity, specificity and limitation of in vitro hippocampal slice and neuron-based assays for assessment of drug-induced seizure liability.

Toxicol Appl Pharmacol 2021 Sep 15:115725. Epub 2021 Sep 15.

Department of Gene Tox and In Vitro Cellular Toxicology, Safety Assessment & Laboratory Animal Resources (SALAR), Merck & Co., Inc., West Point, PA 19486, USA.

An effective in vitro screening assay to detect seizure liability in preclinical development can contribute to better lead molecule optimization prior to candidate selection, providing higher throughput and overcoming potential brain exposure limitations in animal studies. This study explored effects of 26 positive and 14 negative reference pharmacological agents acting through different mechanisms, including 18 reference agents acting on glutamate signaling pathways, in a brain slice assay (BSA) of adult rat to define the assay's sensitivity, specificity, and limitations. Evoked population spikes (PS) were recorded from CA1 pyramidal neurons of hippocampus (HPC) in the BSA. Read More

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September 2021

Natalizumab Versus Fingolimod in Patients with Relapsing-Remitting Multiple Sclerosis: A Subgroup Analysis From Three International Cohorts.

CNS Drugs 2021 Sep 18. Epub 2021 Sep 18.

Neurology Unit, Garibaldi Hospital, Catania, Italy.

Introduction: Natalizumab has proved to be more effective than fingolimod in reducing disease activity in relapsing-remitting multiple sclerosis (RRMS). Whether this association is universal for all patient groups remains to be determined.

Objective: The aim of this study was to compare the relative effectiveness of natalizumab and fingolimod in RRMS subgroups defined by the baseline demographic and clinical characteristics of interest. Read More

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September 2021

Vascularization of Microvascular Fragment Isolates from Visceral and Subcutaneous Adipose Tissue of Mice.

Tissue Eng Regen Med 2021 Sep 18. Epub 2021 Sep 18.

Institute for Clinical and Experimental Surgery, Saarland University, 66421, Homburg, Germany.

Background: Adipose tissue-derived microvascular fragments (MVF) represent effective vascularization units for tissue engineering. Most experimental studies in rodents exclusively use epididymal adipose tissue as a visceral fat source for MVF isolation. However, in future clinical practice, MVF may be rather isolated from liposuctioned subcutaneous fat tissue of patients. Read More

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September 2021

Which factors increase informal care hours and societal costs among caregivers of people with dementia? A systematic review of Resource Utilization in Dementia (RUD).

Health Econ Rev 2021 Sep 18;11(1):37. Epub 2021 Sep 18.

Centre for Elderly and Nursing Home Medicine, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.

Background: Nearly 19 million people across OECD countries are living with dementia, and millions of family caregivers are affected by the disease. The costs of informal care are estimated to represent 40-75% of the total dementia cost exceeding formal care time and medical costs.

Objective: To conduct a systematic review to evaluate the methodological quality and factors associated with high informal care hours per month that increase societal costs, and to identify what type of interventions may alleviate the entire burden of informal and formal caregiving. Read More

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September 2021

Biochemical characteristics and calcium and PTH levels of patients with high normal and elevated serum 25(OH)D levels in Turkey: DeVIT-TOX survey.

Arch Osteoporos 2021 Sep 18;16(1):138. Epub 2021 Sep 18.

Department of Endocrinology, School of Medicine, Dicle University, Diyarbakır, Turkey.

Vitamin D intake over the recommended dose is usually associated with high serum 25(OH)D levels and generally not associated with symptoms of hypercalcemia. High doses of cholecalciferol need to be avoided to protect against vitamin D toxicity and related complications. Strict adherence to the clinical guidelines for treating vitamin D deficiency can ensure safe and effective treatment. Read More

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September 2021

Further evidence that antipsychotic medication does not prevent long-term psychosis in higher-risk individuals.

Eur Arch Psychiatry Clin Neurosci 2021 Sep 18. Epub 2021 Sep 18.

Shanghai Key Laboratory of Psychotic Disorders (No.13dz2260500), Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, 200030, PR China.

Objective: Although existing guidelines have discouraged use of antipsychotics for general clinical high-risk (CHR) individuals, it is unclear if antipsychotics can prevent psychosis in higher-risk population. We aimed to study the comparative real-world effectiveness of antipsychotic treatments for preventing psychosis in higher-risk CHR individuals.

Methods: A total of 300 CHR individuals were identified using the structured interview for prodromal syndromes (SIPS) and followed the participants for 3 years. Read More

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September 2021

New polyoxazoline loaded patches for hemostasis in experimental liver resection.

J Biomed Mater Res B Appl Biomater 2021 Sep 18. Epub 2021 Sep 18.

Department of Surgery, RadboudUMC, Nijmegen, The Netherlands.

A new cost-effective NHS functionalized polyoxazoline (POx) loaded polymer with strong hemostatic properties has been developed. In this study, we investigate POx loaded hemostatic patches regarding hemostatic efficacy, local inflammatory reaction and wound-healing, as compared to the non-POx treated blanks and commercially available hemostatic products. Hundred and ten rats divided into 11 groups of 10 animals underwent partial liver lobe resection. Read More

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September 2021

Blocking receptor for advanced glycation end products (RAGE) or toll-like receptor 4 (TLR4) prevents posttraumatic epileptogenesis in mice.

Epilepsia 2021 Sep 18. Epub 2021 Sep 18.

Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Objective: Effective treatment for the prevention of posttraumatic epilepsy is still not available. Here, we sought to determine whether blocking receptor for advanced glycation end products (RAGE) or toll-like receptor 4 (TLR4) signaling pathways would prevent posttraumatic epileptogenesis.

Methods: In a mouse undercut model of posttraumatic epilepsy, daily injections of saline, RAGE monoclonal antibody (mAb), or TAK242, a TLR4 inhibitor, were made for 1 week. Read More

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September 2021

Can we learn lessons from the FDA's approval of aducanumab?

Nat Rev Neurol 2021 Sep 17. Epub 2021 Sep 17.

Division of Psychiatry, University College London, London, UK.

On 7 June 2021, aducanumab was granted accelerated approval for the treatment of Alzheimer disease (AD) by the FDA on the basis of amyloid-lowering effects considered reasonably likely to confer clinical benefit. This decision makes aducanumab the first new drug to be approved for the treatment of AD since 2003 and the first drug to ever be approved for modification of the course of AD. Many have questioned how scientific evidence, expert advice and the best interests of patients and families were considered in the approval decision. Read More

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September 2021

The Effectiveness of Stroke Riskometer™ in Improving Stroke Risk Awareness in Malaysia: A Study Protocol of a Cluster-Randomized Controlled Trial.

Neuroepidemiology 2021 Sep 15:1-11. Epub 2021 Sep 15.

National Institute for Stroke and Applied Neurosciences, Auckland University of Technology (AUT), Auckland City, New Zealand.

Background: Stroke is considered the second leading cause of mortality and disability worldwide. The increasing burden of stroke is strong evidence that currently used primary prevention strategies are not sufficiently effective. The Stroke Riskometer™ application (app) represents a new stroke prevention strategy distinctly different from the conventional high-cardiovascular disease risk approach. Read More

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September 2021

DNA Methylation Profile of the SREBF2 Gene in Human Fetal Aortas.

J Vasc Res 2021 Sep 14:1-8. Epub 2021 Sep 14.

Department of Advanced Medical and Surgical Sciences (DAMSS), University of Campania "Luigi Vanvitelli,", Naples, Italy.

Increasing evidence suggests that maternal cholesterol represents an important risk factor for atherosclerotic disease in offspring already during pregnancy, although the underlying mechanisms have not yet been elucidated. Eighteen human fetal aorta samples were collected from the spontaneously aborted fetuses of normal cholesterolemic and hypercholesterolemic mothers. Maternal total cholesterol levels were assessed during hospitalization. Read More

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September 2021

Benefit of an Internet-Based Management System among Hemodialysis Patients at the Risk of Intradialytic Hypotension and Muscle Cramps: A Controlled before and after Study.

Blood Purif 2021 Sep 15:1-8. Epub 2021 Sep 15.

Department of Nephrology, Hebei Key Laboratory of Vascular Calcification in Kidney Disease, Hebei Clinical Research Center for Chronic Kidney Disease, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

Background: The purpose of this study was to observe the impact of an internet-based management system on the incidence of intradialytic hypotension (IDH) and muscle cramps in hemodialysis patients.

Methods: The patients, who underwent maintenance hemodialysis in the center from January 2018 to June 2020, were recruited and divided into the pre-intervention group (before operation of the internet-based hemodialysis management system, from January 2018 to December 2018) and intervention group (after operation of the system, from June 2019 to June 2020). The clinical outcomes were compared between groups. Read More

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September 2021

'Learn from the lessons and don't forget them': identifying transferable lessons for COVID-19 from meningitis A, yellow fever and Ebola virus disease vaccination campaigns.

BMJ Glob Health 2021 Sep;6(9)

UK Public Health Rapid Support Team, London School of Hygiene & Tropical Medicine/Public Health England, London, UK.

Introduction: COVID-19 vaccines are now being distributed to low- and middle-income countries (LMICs), with global urgency surrounding national vaccination plans. LMICs have significant experience implementing vaccination campaigns to respond to epidemic threats but are often hindered by chronic health system challenges. We sought to identify transferable lessons for COVID-19 vaccination from the rollout of three vaccines that targeted adult groups in Africa and South America: MenAfriVac (meningitis A); 17D (yellow fever) and rVSV-ZEBOV (Ebola virus disease). Read More

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September 2021

Comparison of three different exercise training modalities (aerobic, strength and mixed) in patients with schizophrenia: study protocol for a multicentre randomised wait-list controlled trial.

BMJ Open 2021 Sep 17;11(9):e046216. Epub 2021 Sep 17.

Department of Nursing and Physiotherapy, Faculty of Health Sciences, Universidad Cardenal Herrera-CEU,CEU Universities, Moncada, Valencia, Spain.

Introduction: Numerous studies support the practice of different physical exercise modalities as an effective treatment to address the problems associated with schizophrenia, reporting that they result in improvements in patient symptoms and quality of life. Given the lack of studies comparing different types of training in controlled environments, the aim of this proposed study will be to compare the effects of three physical exercise programmes (strength, aerobic and mixed) on the symptoms, body composition, level of physical activity and health-related quality of life of patients with schizophrenia.

Methods And Analysis: A multicentre, single-blinded (evaluator), randomised, wait-list controlled (ratio 2:2:2:1) trial will be conducted with 105 patients recruited from different psychosocial care centres. Read More

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September 2021

Identifying undercompensated groups defined by multiple attributes in risk adjustment.

BMJ Health Care Inform 2021 Sep;28(1)

Center for Health Policy and Center for Primary Care & Outcomes Research, Stanford University, Stanford, California, USA.

Objective: To identify undercompensated groups in plan payment risk adjustment that are defined by multiple attributes with a systematic new approach, improving on the arbitrary and inconsistent nature of existing evaluations.

Methods: Extending the concept of variable importance for single attributes, we construct a measure of 'group importance' in the random forests algorithm to identify groups with multiple attributes that are undercompensated by current risk adjustment formulas. Using 2016-2018 IBM MarketScan and 2015-2018 Medicare claims and enrolment data, we evaluate two risk adjustment scenarios: the risk adjustment formula used in the individual health insurance Marketplaces and the risk adjustment formula used in Medicare. Read More

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September 2021

Comparative efficacy of non-invasive neurostimulation therapies for poststroke dysphagia: A systematic review and meta-analysis.

Neurophysiol Clin 2021 Sep 15. Epub 2021 Sep 15.

Department of Physical Medicine and Rehabilitation, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, 266000, PR China. Electronic address:

Objective: To explore the effect of non-invasive neurostimulation therapies on dysphagia patients after stroke.

Methods: We searched MEDLINE (Ovid), PubMed, Embase, Web of Science, ScienceDirect, and Cochrane library databases until April 22, 2020. All published and unpublished randomized controlled trials (RCT) were included. Read More

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September 2021

The impact of COVID-19 on diet quality, food security and nutrition in low and middle income countries: A systematic review of the evidence.

Clin Nutr 2021 Aug 27. Epub 2021 Aug 27.

Ghent University, Faculty of Bioscience Engineering, Department of Food Technology, Safety and Health, Belgium; University of Namur, Faculty of Medicine, Department of Medicine, Belgium.

Background & Aims: The current global pandemic of Coronavirus (COVID-19), and measures adopted to reduce its spread, threaten the nutritional status of populations in Low- and middle-income countries (LMICs). Documenting how the COVID-19 affects diets, nutrition and food security can help generating evidence-informed recommendations for mitigating interventions and policies.

Methods: We carried out a systematic literature review. Read More

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Impact of Helicopter Transport on Reperfusion Times and Long-Term Outcomes in Acute Myocardial Infarction Patients in Rural Areas: A Report From the Mie Acute Coronary Syndrome Registry.

Air Med J 2021 Sep-Oct;40(5):337-343. Epub 2021 May 30.

Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.

Objective: Helicopter emergency medical services (HEMS) are effective for time-sensitive conditions, such as stroke and trauma. However, prognostic data on helicopter transport for acute myocardial infarction (AMI) patients are insufficient.

Methods: We registered 2,681 AMI patients in the Mie Acute Coronary Syndrome Registry and enrolled 163 patients from rural areas to HEMS base hospitals with HEMS or ground emergency medical services (GEMS). Read More

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Topical versus interlesional mitomycin C in auricular keloids.

Acta Otorrinolaringol Esp (Engl Ed) 2021 Sep-Oct;72(5):280-287

Faculty of Medicine, Benha University, Benha, Egypt.

Background: The Keloid is an elevated fibrous scar that may extend beyond the borders of the original wound.

Object: To compare between topical and intralesional mitomycin C in the treatment of auricular keloids.

Patients And Methods: Prospective randomized study in which 40 patients with auricular keloids were included. Read More

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Effectivity of a mHealth intervention for individuals with obesity: a study protocol for a controlled intervention study.

BMC Sports Sci Med Rehabil 2021 Sep 17;13(1):112. Epub 2021 Sep 17.

Institute for Sport and Sport Science, Karlsruhe Institute of Technology, Engler-Bunte-Ring 15, 76131, Karlsruhe, Germany.

Background: Obesity is considered an epidemic problem with an increasing number of individuals affected. The physical and psychological complaints associated with obesity point to the importance of implementing effective interventions. Innovative mHealth applications appear to be promising in helping provide a continuous and flexible support during the intervention. Read More

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September 2021

DISCO App: study protocol for a randomized controlled trial to test the effectiveness of a patient intervention to reduce the financial burden of cancer in a diverse patient population.

Trials 2021 Sep 17;22(1):636. Epub 2021 Sep 17.

Wayne State University School of Medicine/Karmanos Cancer Institute, 4100 John R St., Detroit, MI, 48201, USA.

Background: Financial toxicity, the material and psychological burden of the cost of treatment, affects 30-50% of people with cancer, even those with health insurance. The burden of treatment cost can affect treatment adherence and, ultimately, mortality. Financial toxicity is a health equity issue, disproportionately affecting patients who are racial/ethnic minorities, have lower incomes, and are < 65 years old. Read More

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September 2021

Exploring women's experiences of participation in shared decision-making during childbirth: a qualitative study at a reference hospital in Spain.

BMC Pregnancy Childbirth 2021 Sep 17;21(1):631. Epub 2021 Sep 17.

Preventive Medicine and Epidemiology Department, Hospital Clínic, Barcelona, Spain.

Background: Women's engagement in healthcare decision-making during childbirth has been increasingly emphasised as a priority in maternity care, since it increases satisfaction with the childbirth experience and provides health benefits for women and newborns. The birth plan was developed as a tool to facilitate communication between health professionals and women in Spain, but their value in routine practice has been questioned. Besides, little is known about women's experiences of participation in decision-making in the Spanish context. Read More

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September 2021

The role of postoperative antibiotic duration on surgical site infection after lumbar surgery.

J Neurosurg Spine 2021 Sep 17:1-7. Epub 2021 Sep 17.

Departments of1Neurosurgery.

Objective: Despite a general consensus regarding the administration of preoperative antibiotics, poorly defined comparison groups and underpowered studies prevent clear guidelines for postoperative antibiotics. Utilizing a data set tailored specifically to spine surgery outcomes, in this clinical study the authors aimed to determine whether there is a role for postoperative antibiotics in the prevention of surgical site infection (SSI).

Methods: The Michigan Spine Surgery Improvement Collaborative registry was queried for all lumbar operations performed for degenerative spinal pathologies over a 5-year period from 2014 to 2019. Read More

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September 2021

Comparison of chidamide-contained treatment modalities versus chemotherapy in the second-line treatment for relapsed or refractory peripheral T-cell lymphoma.

Leuk Res 2021 Sep 14;111:106705. Epub 2021 Sep 14.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, PR China; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, PR China. Electronic address:

Peripheral T-cell lymphoma (PTCL) is characterized by an aggressive clinical behavior. Chidamide has been approved for the treatment of relapsed/refractory (R/R) PTCL in China. We compared the efficacy of chidamide-contained regimens with chemotherapy (ChT) in R/R PTCL. Read More

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September 2021

The association of social rank with paternity efficiency in competitive mating flocks of Zi goose ganders (Anser cygnoides L.).

Poult Sci 2021 Aug 2;100(11):101415. Epub 2021 Aug 2.

College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, P. R. China. Electronic address:

The purpose of this study was to investigate the influence of social rank (SR) on paternity efficiency (PE) in competitive mating flocks of geese. Thirty ganders and 150 geese (Zi geese, Anser cygnoides L.) aged approximately one, were divided into 3 groups. Read More

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Facile fabrication of N-doped hierarchical porous carbons derived from soft-templated ZIF-8 for enhanced adsorptive removal of tetracycline hydrochloride from water.

J Hazard Mater 2021 Sep 2;423(Pt B):127103. Epub 2021 Sep 2.

State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, Chengdu 610065, China; College of Water Resource and Hydropower, Sichuan University, Chengdu 610065, China.

N-doped hierarchical porous carbons (NHPCs) were successfully prepared from soft-templated zeolitic imidazolate framework-8 (ZIF-8) precursors using sodium dodecylbenzene sulfonate (SDBS) as a template through facile one-step carbonization and applied in tetracycline hydrochloride (TCH) adsorption. The NHPC synthesized at 1000 °C with an SDBS/Zn molar ratio of 0.075 exhibited the highest TCH adsorption (q = 80. Read More

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September 2021