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promoter DNA-methylation level and glucose metabolism in Ecuadorian women with Turner syndrome.

Horm Mol Biol Clin Investig 2020 Dec 22;42(2):159-165. Epub 2020 Dec 22.

Institute of Biomedicine Research, Central University of Ecuador, Quito, Ecuador.

Objectives: Reduced gene expression of in subjects with insulin resistance (IR) has been reported. Insulin resistance occurs early on the course of Turner syndrome (TS). The main objective of this study was to evaluate the relationship between promoter DNA methylation status in lymphocytes and insulin sensitivity and secretion in Ecuadorian females with TS. Read More

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December 2020

Outcomes of surgical and/or medical treatment in patients with prolactinomas during long-term follow-up: a retrospective single-centre study.

Horm Mol Biol Clin Investig 2020 Dec 17;42(2):153-157. Epub 2020 Dec 17.

Division of Endocrinology, Faculty of Medicine, Cukurova University, Adana, Turkey.

Objectives: Prolactinoma is the most common cause of pituitary tumours. Current medical guidelines recommend dopamine agonists (cabergoline or bromocriptine) as the initial therapy for prolactinoma. However, surgical removal can also be considered in selected cases, such as patients with macroadenomas with local complications (bleeding or optic chiasm pressure) or those not responding to medical treatment. Read More

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December 2020

JAK2/STAT3 in role of arsenic-induced cell proliferation: a systematic review and meta-analysis.

Rev Environ Health 2021 Jul 29. Epub 2021 Jul 29.

Department of Public Health, College of Medicine, Shihezi University, Shihezi, Xinjiang, China.

Objectives: Malignant cell proliferation is one of the important mechanisms of arsenic poisoning. A large number of studies have shown that STAT3 plays an important role in cell malignant proliferation, but there are still many contradictions in the effect of arsenic on JAK2/STAT3. This study aims to explore the role of JAK2/STAT3 in arsenic-induced cell proliferation. Read More

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The aflatoxin B1 content of peanut-based foods in Iran: a systematic review.

Rev Environ Health 2021 Jul 29. Epub 2021 Jul 29.

Tehran, Iran.

Backgrounds: One of the common consumed snacks among Iranian is nuts. The aim of this systematic review was to determine the rate of peanut contamination with aflatoxin B1 (AfB1) in different provinces of the Iran.

Materials And Methods: The research studies with keywords "aflatoxin B1", "peanut", "peanut butter", "peanut oil", "coated peanut", "roasted peanut", "snack peanut" were searched in PubMed, Scopus, Science Direct, Google Scholar and scientific information databases (SID), regardless of publication time. Read More

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Association of the apoptotic marker APO1/Fas with children's predisposing factors for metabolic syndrome and with mean platelet volume.

J Pediatr Endocrinol Metab 2021 Aug 2. Epub 2021 Aug 2.

Laboratory of Biology and Biochemistry, Faculty of Health Sciences, Department of Nursing, University of Peloponnese, Tripoli, Greece.

Background: Apoptosis antigen 1/FAS receptor (APO1/Fas) signaling in endothelial cells plays a significant role in angiogenesis while increased mean platelet volume (MPV) is an important marker for platelet activation. We investigated the possible correlation between APO1/Fas and both metabolic parameters and platelet activity (indicated by the MPV) in a healthy pediatric population.

Methods: One hundred and eighty-five children, aged 5-17 years old, were enrolled in the study. Read More

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Isolation, characterization, and antimicrobial activity of communic acid from .

J Complement Integr Med 2021 Jul 29. Epub 2021 Jul 29.

Laboratory of Organic Synthesis, Extraction and Valorisation, Faculty of Sciences Aïn Chock, Hassan II University of Casablanca, BP. 20000, Casablanca, Morocco.

Objectives: A mixture of Z and E communic acid is isolated for the first time from the cones of Its biological activity was studied.

Methods: The plant material was extracted in a Soxhlet apparatus with -hexane, the resulting extract was subjected to column chromatography (CC) on silica gel. The structure elucidation of the constituents of the isolated fraction was identified by comparison of its spectroscopic properties H and C NMR data with those reported in the literature. Read More

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Cytomorphological spectrum of cysticercosis: a study of 26 cases.

Cytopathology 2021 Jul 31. Epub 2021 Jul 31.

Department Of Pathology, Atal Bihari Vajpayi Institute Of Medical Sciences & Dr. Ram Manohar Lohia Hospital, New Delhi, India.

Background: Cysticercosis is a systemic parasitic disease caused by the larval stage of Taenia solium. It is the most common parasitic disease worldwide. Fine needle aspiration cytology plays an important role in prompt recognition of this disease. Read More

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Intraoperative Cochlear Nerve Monitoring for Vestibular Schwannoma Resection and Simultaneous Cochlear Implantation in Neurofibromatosis Type 2: A Case Series.

Oper Neurosurg (Hagerstown) 2021 Jul 31. Epub 2021 Jul 31.

Department of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.

Background: Neurofibromatosis type 2 (NF2) often results in profound hearing loss and cochlear implantation is an emerging hearing rehabilitation option. However, cochlear implant (CI) outcomes in this population vary, and intraoperative monitoring to predict cochlear nerve viability and subsequent outcomes is not well-established.

Objective: To review the use of intraoperative electrically evoked cochlear nerve monitoring in patients with NF2 simultaneous translabyrinthine (TL) vestibular schwannoma (VS) resection and cochlear implantation. Read More

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The "Three on a Stick" Incision-A Curvilinear Solution for the Occipital and Suboccipital Region.

Oper Neurosurg (Hagerstown) 2021 Jul 31. Epub 2021 Jul 31.

Division of Neurosurgery, Schneider Children's Medical Center of Israel, Clalit Health System, Petah Tikva, Israel.

Background: Different conditions of the posterior fossa such as Chiari malformations, tumors, and arachnoid cysts require surgery through a suboccipital approach, for which a typical midline vertical linear incision is used. Curvilinear incisions have been carried in all other scalp regions other than the sub region for better cosmetic outcomes; a vertical curvilinear incision in the occipital and suboccipital region has not been reported.

Objective: To evaluate the cosmetic value and safety of the "3 on a stick" vertical suboccipital curvilinear incision. Read More

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Development of an inherent system safety index (ISSI) for ranking of chemical processes at the concept development stage.

J Hazard Mater 2021 Jul 10;421:126590. Epub 2021 Jul 10.

Department of Marine Technology, Norwegian University of Science & Technology, NTNU, Norway.

Inherently safer design is the most proactive approach to manage risk, as referred by scientists and experts. Researchers have adopted various methods in evaluating inherent safety indices like parameter-based indexing, risk-based indexing, consequence-based indexing, etc. However, the existing approaches have their limitations. Read More

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Translation and cross-cultural adaptation of the Clinical Care Classification system.

Int J Med Inform 2021 Jul 16;153:104534. Epub 2021 Jul 16.

Saint Camillus International University of Health Sciences, Via di Sant'Alessandro 8, Rome 00131, Italy.

Introduction: The Clinical Care Classification (CCC) system is one of the standard nursing terminologies recognized by the American Nurses Association, developed to describe nursing care through electronic documentation in different healthcare settings. The translation of the CCC system into languages other than English is useful to promote its widespread use in different countries and to provide the standard nursing data necessary for interoperable health information exchange. The aim of this study was to translate the CCC system from English to Italian and to test its clinical validity. Read More

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Challenges in replicating secondary analysis of electronic health records data with multiple computable phenotypes: A case study on methicillin-resistant Staphylococcus aureus bacteremia infections.

Int J Med Inform 2021 Jul 16;153:104531. Epub 2021 Jul 16.

Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, USA. Electronic address:

Background: Replication of prediction modeling using electronic health records (EHR) is challenging because of the necessity to compute phenotypes including study cohort, outcomes, and covariates. However, some phenotypes may not be easily replicated across EHR data sources due to a variety of reasons such as the lack of gold standard definitions and documentation variations across systems, which may lead to measurement error and potential bias. Methicillin-resistant Staphylococcus aureus (MRSA) infections are responsible for high mortality worldwide. Read More

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Telehealth in US hospitals: State-level reimbursement policies no longer influence adoption rates.

Int J Med Inform 2021 Jul 22;153:104540. Epub 2021 Jul 22.

Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

Objectives: Prior to COVID-19, levels of adoption of telehealth were low in the U.S., though they exploded during the pandemic. Read More

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Differences in information accessed in a pharmacologic knowledge base using a conversational agent vs traditional search methods.

Int J Med Inform 2021 Jul 16;153:104530. Epub 2021 Jul 16.

IBM Watson Health, Cambridge, MA, USA; Vanderbilt University Medical Center, Nashville, TN, USA.

Introduction: Clinicians rely on pharmacologic knowledge bases to answer medication questions and avoid potential adverse drug events. In late 2018, an artificial intelligence-based conversational agent, Watson Assistant (WA), was made available to online subscribers to the pharmacologic knowledge base, Micromedex®. WA allows users to ask medication-related questions in natural language. Read More

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Post-embolization outcomes of splenic artery pseudoaneurysms: A single-center experience.

Clin Imaging 2021 Jul 26;80:160-166. Epub 2021 Jul 26.

Department of Radiology, Section of Interventional Radiology, Northwestern University, Chicago, IL, USA. Electronic address:

Purpose: Splenic artery pseudoaneurysms (PSA) are relatively rare but associated with high mortality/morbidity when presenting acutely. Embolization has emerged as the treatment of choice. We aim to evaluate the outcomes of embolization for the treatment of splenic artery PSAs. Read More

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MRI study of changes in knee bone marrow edema-like signal in asymptomatic amateur marathon runners before and after half-marathon running.

Clin Imaging 2021 May 18;80:150-157. Epub 2021 May 18.

Department of Radiology, The Affiliated Hospital of Hangzhou Normal University, No. 126, Wenzhou Road, Gongshu District, Hangzhou 310000, Zhejiang, China.

Objective: To evaluate the incidence of knee bone marrow edema-like signal and its changes before and after running a half marathon running in asymptomatic amateur marathon runners to explore the impact of the half marathon on knee bone marrow edema-like signal.

Methods: 50 asymptomatic amateur marathon runners (30 males, 20 females) were recruited. T1-weighted imaging (T1WI), fat-suppressed protein density weighted imaging (fs-PDWI) and three-dimensional double-echo steady-state (3D-DESS) sequence on the right knee were performed before and within 3 h after a half-marathon running. Read More

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High-dose biotin for multiple sclerosis: A systematic review and meta-analyses of randomized controlled trials.

Mult Scler Relat Disord 2021 Jul 21;55:103159. Epub 2021 Jul 21.

Division of Neurology, Department of Medicine, St. Michael\220s Hospital, University of Toronto, ON M5B 1W8, Canada. Electronic address:

Background: Biotin may activate the acetyl-CoA-, 3-methylcrotonyl-CoA-, propionyl-CoA-, and pyruvate carboxylases to increase myelin repair and/or synthesis, and may enhance the production of adenosine triphosphate (ATP), which may be essential to prevent neurodegeneration. The purpose of this review was to determine the effectiveness and safety of high-dose biotin (HDB) in multiple sclerosis via a systematic review of randomized controlled trials.

Methods: We searched the following electronic databases for relevant articles: MEDLINE, CENTRAL, EMBASE, Scopus, and ClinicalTrials. Read More

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Therapeutic plasma exchange in MS refractory relapses: Long-term outcome.

Mult Scler Relat Disord 2021 Jul 25;55:103168. Epub 2021 Jul 25.

Department of Neurology. Fleni. Buenos Aires, Argentina. Electronic address:

Introduction: Therapeutic plasma exchange (TPE) is considered a treatment option for steroid-refractory multiple sclerosis (MS) relapses. Our objective was to assess long-term clinical response to TPE in MS steroid-refractory exacerbations.

Methods: Retrospective study of relapsing remitting MS (RRMS) patients presenting intravenous methylprednisolone (IVMPS)-refractory relapses, who underwent TPE. Read More

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Theory of mind and its neuroanatomical correlates in people with multiple sclerosis.

Mult Scler Relat Disord 2021 Jul 20;55:103156. Epub 2021 Jul 20.

Department of Neurology, Nitobe Memorial Nakano General Hospital, 4-59-16, Chuo, Nakano-ku, Tokyo, 164-8607, Japan.

Background Theory of mind (ToM) is one of the several different concepts in social cognition and is defined as the ability to access the mental states of others or to adopt the point of view of others. Although studies have shown that ToM is impaired in people with multiple sclerosis (MS), the results based on individual ToM tasks are conflicting; some studies have shown deficits only in the 'Reading the Mind in the Eyes' Test (RMET), while others have reported poor performance in the Faux Pas Test (FPT) as well as RMET. Furthermore, little is known about the relationship between ToM performance and neuroanatomical characteristics in MS. Read More

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Multiple sclerosis incidence and prevalence in Poland: Data from administrative health claims.

Mult Scler Relat Disord 2021 Jul 22;55:103162. Epub 2021 Jul 22.

Department of Neurology, Jagiellonian University Medical College, Krakow, Poland; Department of Neurology, University Hospital in Krakow, Krakow, Poland.

Background: The detailed data concerning multiple sclerosis (MS) epidemiology in Poland are based on studies from few and less populated provinces. Therefore, we evaluated MS incidence and prevalence in Poland using electronic administrative health claims (AHCs) from the National Health Fund.

Methods: We retrospectively analyzed the AHC financial database collected from 2009 to 2019, encompassing all patients using public health resources. Read More

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A cross-sectional survey of cannabis use by people with MS in Oregon and Southwest Washington.

Mult Scler Relat Disord 2021 Jul 25;55:103172. Epub 2021 Jul 25.

Department of Neurology Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239 USA; Department of Neurology, Portland VA Health Care System, 3710 SW US Veterans Hospital Rd, Portland, OR, 97239, USA.

Background: Evidence supports that cannabinoids reduce self-reported spasticity and neuropathic pain in people with MS (PwMS), and legal access to cannabis for medical and recreational use continues to rise. However, there are limited data regarding patterns of cannabis use and perceived benefits of cannabis among PwMS in the US. This study describes the prevalence of cannabis use, routes of administration, perceived benefit of cannabis for MS, and characteristics associated with cannabis use and perception of benefit among a population of PwMS living in two states where cannabis is legal for both medical and recreational use. Read More

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Multiple sclerosis in Peru: National prevalence study using capture-recapture analysis.

Mult Scler Relat Disord 2021 Jul 12;55:103147. Epub 2021 Jul 12.

Asociación de pacientes con Esclerosis Múltiple en el Perú, Lima, Peru.

Background: There is scarce epidemiological data on Multiple Sclerosis (MS) in Latin America. National epidemiological studies are needed to guide the health policy related to MS.

Objective: To determine MS national prevalence in Peru and describe clinical and epidemiological characteristics of the disease. Read More

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Degree of interruptions experienced by emergency department nurses and interruption related factors.

Int Emerg Nurs 2021 Jul 28;58:101036. Epub 2021 Jul 28.

College of Nursing, Woosuk University, Jeonju, Republic of Korea. Electronic address:

Aims: This study examined the degree of interruptions experienced by emergency department nurses and related factors.

Methods: This study is a descriptive survey using standardized observation tools. A total of 23 nurses working in an emergency department participated in this study. Read More

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Elderly patients presenting to a rural hospital emergency department in inland Croatia - A retrospective study.

Int Emerg Nurs 2021 Jul 28;58:101035. Epub 2021 Jul 28.

Zagreb University of Applied Sciences, Mlinarska cesta 38, HR-10000 Zagreb, Croatia. Electronic address:

Background: Emergency departments are faced with a high influx of patients presenting for various complaints. The aim of the present study was to assess the basic characteristics of elderly patients presenting to a rural hospital emergency department in inland Croatia in 2017.

Methods: Retrospective data collected from the Hospital Information System and by analysis of medical records on patients presenting to emergency department in 2017 were used in the study. Read More

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Enhanced biogas production from Lantana camara via bioaugmentation of cellulolytic bacteria.

Bioresour Technol 2021 Jul 24;340:125652. Epub 2021 Jul 24.

Department of Environmental Studies, Siksha -Bhavana, Visva-Bharati, Santiniketan, West Bengal, 731235, India. Electronic address:

A study was designed to isolate cellulolytic bacteria from termite-gut and soil, optimizing their cellulase production to enhance biogas generation, using Lantana camara as a substrate. Out of 57 bacteria screened, two isolates DSB1 and DSB12, showed significant cellulolytic activity. 16S rRNA based methods identified these isolates as Microbacterium sp. Read More

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Cutaneous involvement in anti-HMGCR positive necrotizing myopathy.

J Autoimmun 2021 Jul 28;123:102691. Epub 2021 Jul 28.

Department of Rheumatology and Immunology, University Hospital and, University of Bern, CH-3010, Bern, Switzerland; Medical Center Monbijou (MZM), CH-3011, Bern, Switzerland. Electronic address:

Objective: Anti-3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) positive immune-mediated necrotizing myopathy (IMNM) is a rare disease. It is induced by exogenous substances, most often by statins. Little is known about cutaneous manifestations of HMGCR positive IMNM and about HMGCR antibody positivity in other diseases. Read More

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Fifteen years of the proficiency testing program for HIV-1 viral load testing laboratories in China, 2005-2019.

J Clin Virol 2021 Jul 14;142:104911. Epub 2021 Jul 14.

National AIDS Reference Laboratory, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

Background: HIV-1 viral load (VL) testing is essential for monitoring the effects of antiretroviral therapy in HIV-infected patients. In order to identify factors that impact testing performance of HIV-1 VL testing laboratories, this study performed a retrospective analysis on data from the domestic HIV-1 VL proficiency testing (PT) program in China during 2005 to 2019.

Methods: Analysis was conducted on testing results of 155 PT panel specimens that were distributed to HIV-1 VL testing laboratories nationwide during 2005 to 2019. Read More

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Chronotype in individuals with schizophrenia: A meta-analysis.

Schizophr Res 2021 Jul 28;235:74-79. Epub 2021 Jul 28.

Faculty of Psychology University of Warsaw, Warsaw, Poland.

Objective: Emerging evidence shows that evening chronotype is associated with mental health problems, especially mood disorders, but few studies have investigated its association with schizophrenia. Based on meta-analytic methods, we aimed to test whether eveningness is greater in individuals with schizophrenia compared with healthy controls and patients with bipolar I disorder.

Method: Medline/Pubmed, Google Scholar, and EBSCO databases were searched up to April 2021 for articles investigating chronotype in individuals with schizophrenia. Read More

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Exploring miniaturized sample preparation approaches combined with LC-QToF-MS for the analysis of sulfonamide antibiotic residues in meat- and/or egg-based baby foods.

Food Chem 2021 Jul 14;366:130587. Epub 2021 Jul 14.

Department of Food Science, School of Food Engineering, University of Campinas (UNICAMP), Rua Monteiro Lobato, 80, CEP 13083-862, Campinas, SP, Brazil.

Miniaturized and simplified sample preparation methods with reduced consumption of chemicals and non-halogenated solvents are presented for the determination of 12 sulfonamides in baby foods. Hydrophilic interaction liquid chromatography coupled to quadrupole time-of-flight mass spectrometry was used for the identification and quantification of the compounds based on the acquisition of full spectrum at high resolution with accurate mass for precursor and its fragment ions. Three miniaturized protocols based on QuEChERS, salting-out assisted liquid-liquid extraction or low-temperature cleanup were evaluated regarding the extraction efficiency and removal capability of matrix co-extractives. Read More

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The use of analytical techniques coupled with chemometrics for tracing the geographical origin of oils: A systematic review (2013-2020).

Food Chem 2021 Jul 20;366:130633. Epub 2021 Jul 20.

Biomedical Research Institute, Darfur College, Nyala, Sudan.

The global market for imported, high-quality priced foods has grown dramatically in the last decade, as consumers become more conscious of food originating from around the world. Many countries require the origin label of food to protect consumers need about true characteristics and origin. Regulatory authorities are looking for an extended and updated list of the analytical techniques for verification of authentic oils and to support law implementation. Read More

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