162,360 results match your criteria group trials


Adjuvanting a subunit COVID-19 vaccine to induce protective immunity.

Nature 2021 Apr 19. Epub 2021 Apr 19.

Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.

The development of a portfolio of COVID-19 vaccines to vaccinate the global population remains an urgent public health imperative. Here we demonstrate the capacity of a subunit vaccine, comprising the SARS-CoV-2 spike receptor binding domain displayed on a protein nanoparticle (RBD-NP), to stimulate robust and durable neutralizing antibody (nAb) responses and protection against SARS-CoV-2 in non-human primates. We evaluated five adjuvants including Essai O/W 1849101, a squalene-in-water emulsion; AS03, an alpha-tocopherol-containing oil-in-water emulsion; AS37, a TLR-7 agonist adsorbed to Alum; CpG1018-Alum, a TLR-9 agonist formulated in Alum; and Alum. Read More

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Effects of a Mindfulness-Based Intervention versus Health Self-Management on Subclinical Anxiety in Older Adults with Subjective Cognitive Decline: The SCD-Well Randomized Superiority Trial.

Psychother Psychosom 2021 Apr 19:1-10. Epub 2021 Apr 19.

Swiss Center for Affective Sciences, Department of Medicine and Department of Psychology, Department of Political Science and International Relations, University of Geneva, Geneva, Switzerland.

Introduction: Older adults experiencing subjective cognitive decline (SCD) have a heightened risk of developing dementia and frequently experience subclinical anxiety, which is itself associated with dementia risk.

Objective: To understand whether subclinical anxiety symptoms in SCD can be reduced through behavioral interventions.

Methods: SCD-Well is a randomized controlled trial designed to determine whether an 8-week mindfulness-based intervention (caring mindfulness-based approach for seniors; CMBAS) is superior to a structurally matched health self-management program (HSMP) in reducing subclinical anxiety. Read More

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The Relationship Between Neuromuscular Function and the W' in Elite Cyclists.

Int J Sports Physiol Perform 2021 Apr 19:1-7. Epub 2021 Apr 19.

Purpose: To assess the association between the W' and measures of neuromuscular function relating to the capacity of skeletal muscle to produce force in a group of elite cyclists.

Methods: Twenty-two athletes specializing in a range of disciplines and competing internationally volunteered to participate. Athletes completed assessments of maximum voluntary torque (MVT), voluntary activation, and isometric maximum voluntary contraction to measure rate of torque development (RTD). Read More

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Effect of dexmedetomidine on hemodynamic responses to tracheal intubation: A meta-analysis with meta-regression and trial sequential analysis.

J Clin Anesth 2021 Apr 16;72:110287. Epub 2021 Apr 16.

UOC Anesthesia and Intensive Care Unit, University Hospital of Padua, Padua, Italy; UOC Anesthesia and Intensive Care Unit, Department of Medicine-DIMED, University of Padua, Padua, Italy.

Study Objective: An uncontrolled adrenergic response during tracheal intubation may lead to life-threatening complications. Dexmedetomidine binds to α2-receptors and may attenuate this response. The primary aim of our meta-analysis is to investigate dexmedetomidine efficacy in attenuating sympathetic response to tracheal intubation, compared with placebo or no dexmedetomidine, in terms of heart rate and blood pressure at intubation. Read More

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Ultra-high field (7T) functional magnetic resonance imaging in amyotrophic lateral sclerosis: a pilot study.

Neuroimage Clin 2021 Mar 30;30:102648. Epub 2021 Mar 30.

Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital, Department of Neurology, Neurological Clinical Research Institute, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA; Sanofi Genzyme, Cambridge, MA, USA.

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the central nervous system that results in a progressive loss of motor function and ultimately death. It is critical, yet also challenging, to develop non-invasive biomarkers to identify, localize, measure and/or track biological mechanisms implicated in ALS. Such biomarkers may also provide clues to identify potential molecular targets for future therapeutic trials. Read More

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Design and challenges of a large HIV prevention clinical study on mother-to-child transmission: ANRS 12397 PROMISE-EPI study in Zambia and Burkina Faso.

Contemp Clin Trials 2021 Apr 16:106402. Epub 2021 Apr 16.

Pathogenesis and Control of Chronic and Emerging Infections, INSERM, University of Montpellier, Etablissement Français du Sang, Antilles University, CHU Montpellier, Montpellier, France.

Post-natal HIV infection through breastfeeding remains a challenge in many low and middle-income countries, particularly due to non-availability of alternative infant feeding options and the suboptimal Prevention of Mother to Child Transmission of HIV-1 (PMTCT) cascade implementation and monitoring. The PROMISE-EPI study aims to address the latter by identifying HIV infected mothers during an almost never-missed visit for their infant, the second extended program on immunization visit at 6-8 weeks of age (EPI-2). The study is divided into 3 components inclusive of an open-label randomized controlled trial aiming to assess the efficacy of a responsive preventive intervention compared to routine intervention based on the national PMTCT guidelines for HIV-1 uninfected exposed breastfeeding infants. Read More

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The combined recombinant cathepsin L1H and cathepsin B3 vaccine against Fasciola gigantica infection.

Parasitol Int 2021 Apr 16:102353. Epub 2021 Apr 16.

Department of Anatomy, Faculty of Science, Mahidol University, Rama VI Road, Ratchathewi, Bangkok 10400, Thailand. Electronic address:

Protections against Fasciola gigantica infection in mice immunized with the individual and combined cathepsin L1H and cathepsin B3 vaccines were assessed. The vaccines comprised recombinant (r) pro-proteins of cathepsin L1H and B3 (rproFgCatL1H and rproFgCatB3) and combined proteins which were expressed in Pichia pastoris. The experimental trials were performed in ICR mice (n = 10 per group) by subcutaneous injection with 50 μg of the recombinant proteins combined with Alum or Freund's adjuvants. Read More

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Vasculitis therapy refines vasculitis mechanistic classification.

Autoimmun Rev 2021 Apr 16:102829. Epub 2021 Apr 16.

Department of Biomedicine, Aarhus University, Aarhus, Denmark; Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark; Department of Rheumatology, Silkeborg Regional Hospital, Silkeborg, Denmark. Electronic address:

The primary vasculitides constitute a heterogeneous group of immune mediated diseases of incompletely understood pathogenesis currently classified by the size of blood vessels affected (Chapel Hill classification). In recent years, several drugs with well-characterized immunological targets have been tested in clinical trials in large vessel vasculitis and small vessel vasculitis. Such trials provide "reverse translational" or bedside to bench information about underlying pathogenic mechanisms. Read More

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Long-term recurrence rates of actinic keratosis: a systematic review and pooled analysis of randomized controlled trials.

J Am Acad Dermatol 2021 Apr 16. Epub 2021 Apr 16.

Department of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Ulmenweg 18, 91054 Erlangen, Germany; Comprehensive Cancer Center Erlangen - European Metropolitan Region of Nürnberg, 91054 Erlangen, Germany. Electronic address:

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PLGA based film forming systems for superficial fungal infections treatment.

Eur J Pharm Sci 2021 Apr 16:105855. Epub 2021 Apr 16.

Department of Biological and Medical Sciences, Charles University, Faculty of Pharmacy in Hradec Kralove, Akademika Heyrovskeho 1203, Hradec Kralove 500 05, Czech Republic.

As proven in clinical trials, superficial fungal infections can be effectively treated by single topical application of terbinafine hydrochloride (Ter-HCl) in a film forming system (FFS). Poly(lactic-co-glycolic acid) (PLGA) derivatives, originally synthesized with intention to get carriers with optimized properties for drug delivery, and multifunctional plasticizers - ethyl pyruvate, methyl salicylate, or triacetin - were used for formulation of Ter-HCl loaded FFSs. After spraying, a biodegradable, transparent, adhesive, and occlusive thin layer is formed on the skin, representing drug depot. Read More

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The clinical applications of five-alpha reductase inhibitors.

Authors:
Kevin R Loughlin

Can J Urol 2021 Apr;28(2):10584-10588

Harvard Medical School, Vascular Biology Laboratory, Boston Children's Hospital, Boston, Massachusetts, USA.

INTRODUCTION Five-alpha reductase (5-AR) deficiency was first identified by Imperato-McGinley and Walsh as the cause of pseudohermaphroditism in two separate studies. The discoveries led to the development of finasteride (inhibitor of type 2 isoenzyme of 5-AR) and dutasteride (inhibitor of type 1 and type 2 isoenzymes of 5-AR. Both drugs have been proven effective for the treatment of benign prostatic hyperplasia and improve voiding symptoms, reduce the risk of urinary retention and the need for prostate surgery. Read More

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Effectiveness of a family nurse-led programme on accuracy of blood pressure self-measurement: A randomised controlled trial.

J Clin Nurs 2021 Apr 19. Epub 2021 Apr 19.

Department of Biomedical Science and Human Oncology, University of Bari "Aldo Moro", Bari, Italy.

Aims And Objectives: To evaluate the effectiveness of a Family Nurse Practitioner (FNP)-led programme on the degree of adherence of current recommendations on home blood pressure self-measurement (HBPM) as compared to routine care and management.

Background: HBPM plays an important role for monitoring hypertensive patients; however, patients' adherence to current guidelines is unsatisfactory. A nurse-led training programme in the community setting could be an effective strategy to achieve high level of patients' adherence to recommendations. Read More

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Progestogens for preventing miscarriage: a network meta-analysis.

Cochrane Database Syst Rev 2021 Apr 19;4:CD013792. Epub 2021 Apr 19.

Tommy's National Centre for Miscarriage Research, Institute of Metabolism and Systems Research (IMSR), WHO Collaborating Centre for Global Women's Health Research, University of Birmingham, Birmingham, UK.

Background: Miscarriage, defined as the spontaneous loss of a pregnancy before 24 weeks' gestation, is common with approximately 25% of women experiencing a miscarriage in their lifetime, and 15% to 20% of pregnancies ending in a miscarriage. Progesterone has an important role in maintaining a pregnancy, and supplementation with different progestogens in early pregnancy has been attempted to rescue a pregnancy in women with early pregnancy bleeding (threatened miscarriage), and to prevent miscarriages in asymptomatic women who have a history of three or more previous miscarriages (recurrent miscarriage).

Objectives: To estimate the relative effectiveness and safety profiles for the different progestogen treatments for threatened and recurrent miscarriage, and provide rankings of the available treatments according to their effectiveness, safety, and side-effect profile. Read More

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Chlamydia pneumoniae and chronic asthma: Updated systematic review and meta-analysis of population attributable risk.

Authors:
David L Hahn

PLoS One 2021 19;16(4):e0250034. Epub 2021 Apr 19.

St Marys Hospital, Madison, Wisconsin, United States of America.

Background: Chlamydia pneumoniae (Cp) is an obligate intracellular human respiratory pathogen producing persisting lung infection with a plausible link to asthma pathogenesis. The population attributable risk of potentially treatable Cp infection in asthma has not been reported.

Methods: The author searched from 2000 to 2020 inclusive for previously un-reviewed and new cross sectional and prospective controlled studies of Cp biomarkers and chronic asthma in both children and adults. Read More

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Diagnostic performance of anti-Zika virus IgM, IgAM and IgG ELISAs during co-circulation of Zika, dengue, and chikungunya viruses in Brazil and Venezuela.

PLoS Negl Trop Dis 2021 Apr 19;15(4):e0009336. Epub 2021 Apr 19.

Section Clinical Tropical Medicine, Department for Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany.

Background: Serological diagnosis of Zika virus (ZIKV) infection is challenging because of the antibody cross-reactivity among flaviviruses. At the same time, the role of Nucleic Acid Testing (NAT) is limited by the low proportion of symptomatic infections and the low average viral load. Here, we compared the diagnostic performance of commercially available IgM, IgAM, and IgG ELISAs in sequential samples during the ZIKV and chikungunya (CHIKV) epidemics and co-circulation of dengue virus (DENV) in Brazil and Venezuela. Read More

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Perfusion Assessment in Left-Sided/Low Anterior Resection (PILLAR III): A Randomized, Controlled, Parallel, Multicenter Study Assessing Perfusion Outcomes with PINPOINT Near-Infrared Fluorescence Imaging in Low Anterior Resection.

Dis Colon Rectum 2021 Apr 13. Epub 2021 Apr 13.

University of California, Irvine, Orange, CA Kaiser Permanente LAMC, Los Angeles, CA Washington University School of Medicine, St Louis, MO Houston Methodist Hospital, Houston, TX University of South Florida, Tampa, FL Suburban Surgical Associates, St Louis, MO University of Cincinnati Physicians, Cincinnati, OH University of Nevada School of Medicine Johns Hopkins University, Baltimore, MD MD Anderson Cancer Center - Baptist Medical Center, Jacksonville, FL University of California, San Francisco, San Francisco, CA Ochsner Clinic Foundation, New Orleans, LA NSLIJ/Hofstra North Shore School of Medicine At Lenox Hill Hospital, New York, NY Mount Sinai, New York, NY Medical College of South Carolina, Charleston, SC Baylor University Medical Center, Dallas, TX Cleveland Clinic Foundation, Cleveland, OH.

Background: Indocyanine green fluoroscopy has been shown to improve anastomotic leak rates in early phase trials.

Objective: We hypothesized that the use of fluoroscopy to ensure anastomotic perfusion may decrease anastomotic leak following low anterior resection.

Design: We performed a 1:1 randomized, controlled, parallel study. Read More

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Spinal cord stimulation for the management of painful diabetic neuropathy: a systematic review and meta-analysis of individual patient and aggregate data.

Pain 2021 Mar 9. Epub 2021 Mar 9.

Liverpool Reviews and Implementation Group, Department of Health Data Science, University of Liverpool, Liverpool, United Kingdom Departments of Neurosurgery and Anesthesiology, Aarhus University Hospital, Aarhus, Denmark Institute of Health and Well Being, University of Glasgow, Glasgow, United Kingdom College of Medicine and Health, University of Exeter, Exeter, United Kingdom Department of Pain Medicine, The James Cook University Hospital, Middlesbrough, United Kingdom Department of Neurology and Neurosurgery, Medisch Spectrum Twente, Enschede, the Netherlands Centre for Pain Medicine, Department of Anesthesiology, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands.

Abstract: Spinal cord stimulation (SCS) has been suggested as a treatment option for patients with painful diabetic neuropathy (PDN). We conducted a systematic review and undertook a meta-analysis on individual patient data from randomised controlled trials (RCTs) to assess the effectiveness of SCS for the management of PDN. Electronic databases were searched from inception to May 2020 for RCTs of SCS for PDN. Read More

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Five-Year Outcomes With Pembrolizumab Versus Chemotherapy for Metastatic Non-Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score ≥ 50.

J Clin Oncol 2021 Apr 19:JCO2100174. Epub 2021 Apr 19.

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD.

Purpose: We report the first 5-year follow-up of any first-line phase III immunotherapy trial for non-small-cell lung cancer (NSCLC). KEYNOTE-024 (ClinicalTrials.gov identifier: NCT02142738) is an open-label, randomized controlled trial of pembrolizumab compared with platinum-based chemotherapy in patients with previously untreated NSCLC with a programmed death ligand-1 (PD-L1) tumor proportion score of at least 50% and no sensitizing or alterations. Read More

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Randomized Controlled Trials 7: On Contamination and Estimating the Actual Treatment Effect.

Methods Mol Biol 2021 ;2249:307-318

Department of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.

The intention-to-treat analysis is the gold standard for evaluating the efficacy in a randomized controlled trial. However, when non-adherence to randomized treatments is high the actual treatment effect may be underestimated. The impact of drop-out from the intervention group or drop-in to the control group may be controlled by trial design, increasing the sample size, effective study execution, and a pre-specified analytical plan to take contamination into account. Read More

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January 2021

Randomized Controlled Trials 6: Determining the Sample Size and Power for Clinical Trials and Cohort Studies.

Authors:
Tom Greene

Methods Mol Biol 2021 ;2249:281-305

Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.

Performing well-powered, randomized, controlled trials is of fundamental importance in clinical research. The goal of sample size calculations is to assure that statistical power is sufficiently high when the probability of falsely rejecting a true null hypothesis (type I error) is kept acceptably small. This chapter overviews the fundamental of sample size calculation for standard types of outcomes for 2-group studies. Read More

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January 2021

Vitamin K and vascular calcification.

Curr Opin Nephrol Hypertens 2021 Apr 16. Epub 2021 Apr 16.

Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow AGE Research Group, NIHR Newcastle Biomedical Research Centre, Newcastle University and Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

Purpose Of Review: Vascular calcification is a common and important cardiovascular risk factor in patients with chronic kidney disease (CKD). Recent advances in the understanding of the biology of vascular calcification implicate vitamin K-dependent proteins as important regulators in this process. This review highlights recent key advances in vascular biology, epidemiology, and clinical trials in this rapidly evolving field. Read More

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Comparison of major bleeding events of uninterrupted non-vitamin K antagonist oral anticoagulants versus uninterrupted vitamin K antagonist during catheter ablation of atrial fibrillation: a meta-analysis of randomised controlled trials.

Acta Cardiol 2021 Apr 19:1-7. Epub 2021 Apr 19.

Department of Cardiology, Hebei General Hospital, Shijiazhuang, People's Republic of China.

Background: Previous meta-analyses comparing major bleeding of uninterrupted non-vitamin K antagonist oral anticoagulants (NOACs) versus uninterrupted vitamin K antagonist (VKA) during catheter ablation (CA) of atrial fibrillation (AF) had no consensus. This meta-analysis was performed to comprehensively evaluate the risk of major bleeding events of these two anticoagulant strategies.

Methods: We searched online databases for randomised controlled trials that compared major bleeding events of uninterrupted NOACs and VKA during CA of AF. Read More

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Ginseng for erectile dysfunction.

Cochrane Database Syst Rev 2021 Apr 19;4:CD012654. Epub 2021 Apr 19.

Department of Urology, Korea University Guro Hospital, Seoul, Korea, South.

Background: Dietary supplements with ginseng, or ginseng alone, are widely used for a broad range of conditions, including erectile dysfunction. Ginseng is particularly popular in Asian countries. Individual studies assessing its effects are mostly small, of uneven methodological quality and have unclear results. Read More

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Impact of changing gloves during caesarean section on postoperative infective complications: a systematic review and meta-analysis.

Acta Obstet Gynecol Scand 2021 Apr 19. Epub 2021 Apr 19.

Department of Obstetrics and Gynecology, Jessop Wing, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK.

Introduction: The caesarean section rate around the world, currently estimated at 21.1%, continues to increase. Women who undergo a cesarean section sustain a seven to ten-fold greater risk of infective morbidity compared to those who deliver vaginally. Read More

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Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.

Cochrane Database Syst Rev 2021 Apr 19;4:CD011535. Epub 2021 Apr 19.

Department of Dermatology, Hôpital Henri Mondor, Créteil, France.

Background: Psoriasis is an immune-mediated disease for which some people have a genetic predisposition. The condition manifests in inflammatory effects on either the skin or joints, or both, and it has a major impact on quality of life. Although there is currently no cure for psoriasis, various treatment strategies allow sustained control of disease signs and symptoms. Read More

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The effects of showering in 48-72 h after coronary artery bypass graft surgery through median sternotomy on wound infection, pain, comfort, and satisfaction: randomized controlled trial.

Eur J Cardiovasc Nurs 2021 Apr 19. Epub 2021 Apr 19.

Faculty of Medicine, Department of Cardiac Surgery, Pamukkale University, 20020 Denizli, Turkey.

Aims : Time of showering after surgery is still a controversial issue for surgical patients and health professionals. We evaluated the effects of showering in 48-72 h after median sternotomy on sternal wound infections, pain due to sternotomy, patient comfort, and satisfaction levels.

Methods And Results : The study was a randomized controlled clinical trial. Read More

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Severe Acute Respiratory Syndrome Coronavirus 2 Convalescent Plasma Versus Standard Plasma in Coronavirus Disease 2019 Infected Hospitalized Patients in New York: A Double-Blind Randomized Trial.

Crit Care Med 2021 Apr 16. Epub 2021 Apr 16.

Department of Anesthesiology, Stony Brook University, Stony Brook, NY. MSTP, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY. Department of Pathology/Blood Bank, Stony Brook Medicine, Stony Brook, NY. Enhanced Recovery Coordinator, Stony Brook Medicine, Stony Brook, NY. Department of Microbiology and Immunology, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY. Department of Medicine/Hematology, Stony Brook Medicine, Stony Brook, NY. Renaissance School of Medicine at Stony Brook University, Stony Brook, NY. Cancer Center Clinical Trials, Stony Brook Medicine, Stony Brook, NY. Department of Pediatrics, Stony Brook Medicine, Stony Brook, NY. Division of Infectious Diseases, Attending at U.S. Department of Veterans Affairs-Northport VA Medical Center, Northport, NY.

Objectives: Four peer-reviewed publications have reported results from randomized controlled trials of convalescent plasma for coronavirus disease 2019 infection; none were conducted in the United States nor used standard plasma as a comparator. To determine if administration of convalescent plasma to patients with coronavirus disease 2019 increases antibodies to severe acute respiratory syndrome coronavirus 2 and improves outcome.

Design: Double-blind randomized controlled trial. Read More

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A Core Outcome Set for Research Evaluating Interventions to Prevent and/or Treat Delirium in Critically Ill Adults: An International Consensus Study (Del-COrS).

Crit Care Med 2021 Apr 19. Epub 2021 Apr 19.

Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, London, United Kingdom. Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada. Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada. Faculty of Health, University of Technology Sydney, Sydney, NSW, Australia. College of Pharmacy, Purdue University, West Lafayette, IN. School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland Inaugural Research Chair in Geriatric Emergency Medicine, Schwartz/Reisman Emergency Medicine Institute, Sinai Health System, Toronto, ON, Canada. St Michael's Hospital and Li Ka Shing Research Institute, Toronto, ON, Canada. School of Pharmacy, Northeastern University, Boston, MA. Wellcome-Wolfson Institute of Experimental Medicine, Queen's University Belfast, Belfast, Northern Ireland. School of Medicine, Johns Hopkins University, Baltimore, MD. Hull York Medical School, University of York, York, United Kingdom. Watford General Hospital, Watford, United Kingdom.

Objectives: Delirium in critically ill adults is highly prevalent and has multiple negative consequences. To-date, trials of interventions to prevent or treat delirium report heterogenous outcomes. To develop international consensus among key stakeholders for a core outcome set for future trials of interventions to prevent and/or treat delirium in critically ill adults. Read More

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A systematic review and meta-analysis comparing the efficacy of cyanoacrylate ablation over endovenous thermal ablation for treating incompetent saphenous veins.

Phlebology 2021 Apr 17:2683555211008762. Epub 2021 Apr 17.

Department of Vascular Surgery, 71044Xuanwu Hospital, Capital Medical University, Beijing, China.

Objectives: The aim of this study was to systemically review and analyze the efficacy of cyanoacrylate ablation (CA) in comparison with endovenous thermal ablation (ETA) for the treatment of incompetent saphenous veins.

Methods: A systematic literature search was conducted using databases of Pubmed, Embase, and Cochrane Library from the times of their inception to April 2020. Studies were selected based on inclusion and exclusion criteria after assessing the risk of bias in comparative studies with Cochrane and rating quality of evidence with the GRADE methodology. Read More

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Duration of Antiplatelet Therapy Following Transcatheter Aortic Valve Replacement: Systematic Review and Network Meta-Analysis.

J Am Heart Assoc 2021 Apr 17:e019490. Epub 2021 Apr 17.

Division of Cardiovascular Medicine New York University School of Medicine New York NY.

Background Although current guidelines recommend dual antiplatelet therapy (DAPT) for 3 to 6 months following transcatheter aortic valve replacement (TAVR), there are no studies directly comparing outcomes of different durations of DAPT following TAVR. Methods and Results PubMed, EMBASE, and Cochrane Database were searched through November 2020 to identify clinical studies that investigated single antiplatelet therapy versus DAPT use following TAVR. Studies using oral anticoagulants and antiplatelet therapy concomitantly were excluded. Read More

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