35,256 results match your criteria group searched


Effectiveness of equine-assisted therapies for improving health outcomes in people with multiple sclerosis: A systematic review and meta-analysis.

Mult Scler Relat Disord 2021 Jul 23;55:103161. Epub 2021 Jul 23.

Universidade de Vigo, Departamento de Didácticas Especiais, Facultade de Ciencias da Educación e do Deporte, Pontevedra 36005, Spain; WellMove Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Spain. Electronic address:

Background: Scientific evidence has shown that equine-assisted therapies (EAT) lead to improvements in the physical function and the quality of life (QoL) of people with disabilities through the practice of hippotherapy or therapeutic riding (TR). There is a need to confirm whether people with multiple sclerosis (PwMS) can also benefit from its practice. This review aimed to systematically evaluate and meta-analyze the available data on the potential health benefits of EAT in PwMS. Read More

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Neoadjuvant chemotherapy before surgery versus surgery followed by chemotherapy for initial treatment in advanced ovarian epithelial cancer.

Cochrane Database Syst Rev 2021 Jul 30;7:CD005343. Epub 2021 Jul 30.

Department of Gynaecological Oncology, Musgrove Park Hospital, Taunton, UK.

Background: Epithelial ovarian cancer presents at an advanced stage in the majority of women. These women require a combination of surgery and chemotherapy for optimal treatment. Conventional treatment has been to perform surgery first and then give chemotherapy. Read More

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The influence of biologics on the microbiome in immune-mediated inflammatory diseases: A systematic review.

Biomed Pharmacother 2021 Jul 14;141:111904. Epub 2021 Jul 14.

Department of Pathophysiology, Faculty of Medicine, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, Poland.

Background: Immune-mediated inflammatory diseases (IMIDs) are a group of several chronic disorders with elusive pathogenesis that results in dysregulation of the normal immune response and leads to organ-specific or systemic inflammation. There are many reports on gastrointestinal or skin dysbiosis in patients with IMIDs; however, it is not clear whether dysbiosis is a cause or a result of the observed inflammation. We aimed to determine whether treatment of IMIDs patients with biologics affects their microbiota in comparison with baseline or placebo. Read More

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Effect of periodontal-orthodontic treatment of teeth with pathological tooth flaring, drifting and elongation in patients with severe periodontitis: a systematic review with meta-analysis.

J Clin Periodontol 2021 Jul 29. Epub 2021 Jul 29.

Department of Periodontology, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.

Aim: To assess the beneficial and adverse effects of periodontal-orthodontic treatment of teeth with pathological tooth flaring, drifting and elongation in patients with severe periodontitis on the dental and periodontal tissues.

Materials And Methods: Nine databases were searched in April 2020 for randomized/non-randomized clinical studies. After duplicate study selection, data extraction, and risk-of-bias assessment, random effects meta-analyses of mean differences (MDs) and their 95% confidence intervals (CIs) were performed, followed by subgroup/meta-regression analyses. Read More

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Improving the quality of maternal and newborn care in the Pacific region: A scoping review.

Lancet Reg Health West Pac 2020 Oct 23;3:100028. Epub 2020 Sep 23.

Maternal, Child and Adolescent Health Program, Burnet Institute, Australia.

Background: Quality care is essential for improving maternal and newborn health. Low- and middle-income Pacific Island nations face challenges in delivering quality maternal and newborn care. The aim of this review was to identify all published studies of interventions which sought to improve the quality of maternal and newborn care in Pacific low-and middle-income countries. Read More

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October 2020

A Systematic Review of the Patterns of Associative Multimorbidity in Asia.

Biomed Res Int 2021 3;2021:6621785. Epub 2021 Jul 3.

Clinical Research Unit, National Healthcare Group Polyclinics, Singapore.

Patients with multimorbidity are commonly seen in primary care. An increasing number of multimorbidity patterns are being reported in the Western literature with a few from Asia. The main objective of this systematic review was to describe patterns of associative multimorbidity, defined as associations beyond chance or patterns of diseases, in the Asian population. Read More

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Impact of aspirin use on clinical outcomes in patients with vasospastic angina: a systematic review and meta-analysis.

BMJ Open 2021 Jul 29;11(7):e048719. Epub 2021 Jul 29.

Department of Pharmacy, Shenzhen People's Hospital, Second Clinical Medical College of Jinan University, First affiliated Hospital of South University of Science and Technology, Shenzhen, China

Objectives: The use of aspirin to prevent cardiovascular disease in vasospastic angina (VSA) patients without significant stenosis has yet to be investigated. This study aimed to investigate the efficacy of aspirin use among VSA patients.

Design: Systematic review and meta-analysis. Read More

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The efficacy and safety of MR-HIFU and US-HIFU in treating uterine fibroids with the volume <300 cm: a meta-analysis.

Int J Hyperthermia 2021 ;38(1):1126-1132

Department of Gynecology, Jiangsu Province Hospital, Nanjing, China.

Background: High-intensity focused ultrasound (HIFU) is a promising and non-invasive therapy for symptomatic uterine fibroids. Currently, the main image-guided methods for HIFU include magnetic resonance-guided (MR-HIFU) and ultrasound-guided (US-HIFU). However, there are few comparative studies on the therapeutic efficacy and safety of MR-HIFU and US-HIFU in treating symptomatic uterine fibroids with a volume <300 cm. Read More

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January 2021

Instrumentation Techniques to Prevent Proximal Junctional Kyphosis and Proximal Junctional Failure in Adult Spinal Deformity Correction: A Systematic Review of Clinical Studies.

Global Spine J 2021 Jul 30:21925682211034500. Epub 2021 Jul 30.

Department of Orthopaedic Surgery, Research School CAPHRI, Maastricht University Medical Center, Maastricht, The Netherlands.

Study Design: Systematic review.

Objectives: To summarize the results of clinical studies investigating spinal instrumentation techniques aiming to reduce the postoperative incidence of proximal junctional kyphosis (PJK) and/or failure (PJF) in adult spinal deformity (ASD) patients.

Methods: EMBASE and Medline® were searched for articles dating from January 2000 onward. Read More

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Lactate based Scoring System in the diagnosis of necrotizing fasciitis.

J Burn Care Res 2021 Jul 29. Epub 2021 Jul 29.

Department of Plastic, Reconstructive, Hand and Burn Surgery, Cologne Merheim Medical Center, University of Witten-Herdecke, Cologne, Germany.

Introduction: Necrotizing fasciitis (NF) is a rare and quickly progressing infection and leads to 100% mortality if untreated. Quick diagnosis and an early and radical surgical treatment are essential for stopping bacterial progression. Unfortunately, the absence of clear clinical signs makes the diagnosis often challenging. Read More

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Reducing mosquito-borne disease transmission to humans: A systematic review of cluster randomised controlled studies that assess interventions other than non-targeted insecticide.

PLoS Negl Trop Dis 2021 Jul 29;15(7):e0009601. Epub 2021 Jul 29.

The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.

Background: Mosquito control interventions are widely used to reduce mosquito-borne diseases. It is unclear what combination of interventions are most effective in reducing human disease. A novel intervention study for Buruli ulcer targeting mosquito vectors was proposed for a Buruli ulcer-endemic area of Victoria, Australia. Read More

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Differences in survival and mortality in minority ethnic groups with dementia: A systematic review and meta-analysis.

Int J Geriatr Psychiatry 2021 Jun 18. Epub 2021 Jun 18.

Department of Health Service and Population Research, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Objectives: Although there are disparities in both risk of developing dementia and accessibility of dementia services for certain minority ethnic groups in the United States and United Kingdom, disparities in survival after a dementia diagnosis are less well-studied. Our objective was to systematically review the literature to investigate racial/ethnic differences in survival and mortality in dementia.

Methods: We searched Embase, Ovid MEDLINE, Global Health and PsycINFO from inception to November 2018 for studies comparing survival or mortality over time in at least two race/ethnicity groups. Read More

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Nutrition/Dietary Supplements and Chronic Pain in Patients with Cancer and Survivors of Cancer: A Systematic Review and Research Agenda.

Pain Physician 2021 Aug;24(5):335-344

Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium; Department of Physiotherapy, Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium; "Pain in Motion" international research group, www.paininmotion.be.

Background: Chronic pain is one of the most often seen, but often undertreated, sequelae in survivors of cancer. Also, this population often shows significant nutritional deficiencies, which can affect quality of life, general health status, and even risk of relapse. Given the influence of nutrition on brain plasticity and function, which in turn is associated with chronic pain in the population with cancer, it becomes relevant to focus on the association between pain and nutritional aspects in this population. Read More

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Systematic review with meta-analysis: dietary intake in adults with inflammatory bowel disease.

Aliment Pharmacol Ther 2021 Jul 29. Epub 2021 Jul 29.

University of New South Wales, Sydney, New South Wales, Australia.

Background: Poor dietary intake is associated with the development of malnutrition, micronutrient deficiencies, anaemia and osteoporosis in individuals with inflammatory bowel disease. While trials are underway to manipulate the diet of people with IBD, there has been no comprehensive systematic review of the dietary intake of adults with IBD.

Aims: To conduct a systematic evaluation and meta-analysis of the dietary intake of adults with IBD, including macronutrients, micronutrients and food group data. Read More

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Statins and risk of amyotrophic lateral sclerosis: a systematic review and meta-analysis.

Acta Neurol Belg 2021 Jul 28. Epub 2021 Jul 28.

Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.

Amyotrophic lateral sclerosis (ALS) is a paralytic, heterogeneous and progressive disease characterized by the degeneration of both upper and lower motor neurons. Several studies about the effects of statins drug on the risk of ALS showed contradictory results and evidence for this is inconclusive. So we aimed to perform a meta-analysis on previous studies to clarify the association between statin use and risk of ALS. Read More

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Interventions to improve the well-being of family caregivers of patients on hemodialysis and peritoneal dialysis: a systematic review.

PeerJ 2021 20;9:e11713. Epub 2021 Jul 20.

Escola de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Background: The family caregivers of patients on hemodialysis (HD) and peritoneal dialysis (PD) typically experience higher burden than the general population because of the nature of tasks these caregivers need to carry out as a part of homecare. This fact influences both the caregivers' quality of life and the quality of their care toward the patient. Thus, this study aimed to review the effectiveness and limitations of interventions in improving the well-being of family caregivers of patients on HD and PD. Read More

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Admission hyperglycemia is associated with reperfusion failure in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: a systematic review and meta-analysis.

Am J Cardiovasc Dis 2021 15;11(3):348-359. Epub 2021 Jun 15.

Division of Cardiovascular Medicine, Keck School of Medicine of University of Southern California Los Angeles, CA, USA.

Background: Admission hyperglycemia (AH) is a common finding in patients with acute coronary syndrome and has been reported to be associated with increased morbidity and mortality. Prior studies suggest that AH could be associated with reperfusion failure. We conducted a systematic review and meta-analysis to explore an association between AH and risk of reperfusion failure in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). Read More

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Laboratory microwave spectroscopy of the doubly deuterated cyanomethyl radical, DCCN.

J Mol Spectrosc 2021 Mar 12;377. Epub 2021 Mar 12.

Instituto de Física Fundamental (IFF-CSIC), Group of Molecular Astrophysics, C/ Serrano 121, 28006 Madrid, Spain.

The microwave spectrum of the doubly deuterated cyanomethyl radical (D2CCN) in its ground electronic state ( ) has been observed for the lowest four rotational transitions ( = 1-0, 2-1, 2-1 and 2-1) using a Fourier transform microwave spectrometer in combination with a pulsed discharge nozzle. A total of 394 hyperfine components were measured and subjected to a least squares analysis which allowed determining twelve hyperfine constants for nitrogen and deuterium nuclei. With this new set of molecular constants we obtained accurate predictions for low rotational transitions with hyperfine structure, and searched for this species in TMC-1. Read More

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Role of occupational therapy in reducing and managing violence among mental health inpatients: a scoping review protocol.

BMJ Open 2021 Jul 28;11(7):e046260. Epub 2021 Jul 28.

School of Nursing, University of Birmingham, Birmingham, UK.

Introduction: Violence is pervasive among psychiatric inpatients and has profound consequences for its victims, its perpetrators and mental health services. Currently, the unique contribution of occupational therapists to reducing and managing violence among this patient group has not been systematically explored. However, an a priori model which provides an initial understanding of its role in this respect can be identified from the wider scholarly literature. Read More

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Behavioural interventions for CVD risk reduction for blue-collar workers: a systematic review.

J Epidemiol Community Health 2021 Jul 28. Epub 2021 Jul 28.

Department of Preventive Medicine, Rush University Medical Center, Chicago, Illinois, USA.

Objectives: Individuals working in blue-collar occupations experience high rates of cardiovascular disease (CVD). The purpose of this systematic review is to describe the characteristics and efficacy of behavioural interventions that have targeted CVD risk factors in this high-risk group.

Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we searched seven databases to find interventions focused on changing the following: blood pressure, cholesterol, diet, physical activity, smoking or weight. Read More

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Assessment of the reporting quality of randomised controlled trials of massage.

Chin Med 2021 Jul 28;16(1):64. Epub 2021 Jul 28.

Chinese Clinical Trial Registry (Hong Kong), Hong Kong Chinese Medicine Clinical Study Centre, School of Chinese Medicine, Hong Kong Baptist University, 307 Room, Jockey Club School of Chinese Medicine Building, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong, HKSAR, China.

Objective: To assess the reporting quality of randomised controlled trials (RCTs) of massage, particularly whether necessary elements related to massage interventions were adequately reported.

Methods: A total of 8 electronic databases were systematically searched for massage RCTs published in English and Chinese from the date of their inception to June 22, 2020. Quality assessment was performed using three instruments, namely the CONSORT (Consolidated Standards of Reporting Trials) 2010 Checklist (37 items), the CONSORT Extension for NPT (Nonpharmacologic Treatments) 2017 checklist (18 items), and a self-designed massage-specific checklist (16 items) which included massage rationale, intervention and control group details. Read More

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Transparent reporting of recruitment and informed consent approaches in clinical trials recruiting children with minor parents in sub-Saharan Africa: a secondary analysis based on a systematic review.

BMC Public Health 2021 Jul 28;21(1):1473. Epub 2021 Jul 28.

Swiss Tropical and Public Health Institute, Basel, Switzerland.

Background: Standardised checklists of items to be addressed in clinical study protocols and publications are promoting transparency in research. However, particular specifications for exceptional cases, such as children with minor parents are missing. This study aimed to examine the level of transparency regarding recruitment and informed consent approaches in publications of clinical trials recruiting children with minor parents in sub-Saharan Africa. Read More

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A Systematic Review and Meta-analysis of Randomized Controlled Trials Comparing Intraoperative Red Blood Cell Transfusion Strategies.

Ann Surg 2021 May 12. Epub 2021 May 12.

Department of Surgery, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.

Objective: The objective of this work was to carry out a meta-analysis of RCTs comparing intraoperative RBC transfusion strategies to determine their impact on postoperative morbidity, mortality, and blood product use.

Summary Of Background Data: RBC transfusions are common in surgery and associated with widespread variability despite adjustment for casemix. Evidence-based recommendations guiding RBC transfusion in the operative setting are limited. Read More

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Doxycycline and minocycline in Helicobacter pylori treatment: A systematic review and meta-analysis.

Helicobacter 2021 Jul 28:e12839. Epub 2021 Jul 28.

Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang, China.

Background And Aims: The decreasing Helicobacter pylori eradication rate and the increasing antibiotic resistance trend are of great concern. Therefore, new and effective therapies are needed for H. pylori infection. Read More

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Ivermectin for preventing and treating COVID-19.

Cochrane Database Syst Rev 2021 Jul 28;7:CD015017. Epub 2021 Jul 28.

Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Wuerzburg, Wuerzburg, Germany.

Background: Ivermectin, an antiparasitic agent used to treat parasitic infestations, inhibits the replication of viruses in vitro. The molecular hypothesis of ivermectin's antiviral mode of action suggests an inhibitory effect on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in the early stages of infection. Currently, evidence on efficacy and safety of ivermectin for prevention of SARS-CoV-2 infection and COVID-19 treatment is conflicting. Read More

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Combat and Operational Stress Control Interventions and PTSD: A Systematic Review and Meta-Analysis.

Mil Med 2021 Jul 28. Epub 2021 Jul 28.

The Gehr Family Center for Health Systems Science and Innovation, Keck School of Medicine, RAND Corporation, Santa Monica, CA 90407, USA.

Introduction: Military personnel must prepare for and respond to life-threatening crises on a daily basis. This lifestyle places stress on personnel, and particularly so on deployed service members who are isolated from support systems and other resources. As part of a larger systematic review on the acceptability, efficacy, and comparative effectiveness of interventions designed to prevent, identify, and manage stress reactions, we assessed posttraumatic stress disorder (PTSD) outcomes. Read More

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Effectiveness of Companion Robot Care for Dementia: A Systematic Review and Meta-Analysis.

Innov Aging 2021 24;5(2):igab013. Epub 2021 Apr 24.

Department of Information Management, National Yunlin University of Science and Technology, Douliou, Taiwan.

Background And Objectives: Dementia and central nervous system degeneration are common problems in aging societies with regard to the number of people affected and total medical expenses. Socially assistive robotic technology has gradually matured; currently, most scholars believe it can be used as companions in long-term care facilities and to work as caregivers alongside staff to improve the social interaction and mental state of older adults and patients with dementia. Therefore, this study measured the effect of the duration of exposure to socially assistive robots in older adults with dementia. Read More

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Role of Invasive Mechanical Ventilation and ECMO in the Management of COVID-19: A Systematic Review.

Indian J Crit Care Med 2021 Jun;25(6):691-698

Centre for Trials Research, College of Biomedical and Life Sciences, Cardiff University, Cardiff, Wales, United Kingdom.

Objectives: This systematic review aims to provide insight into the outcome of extracorporeal membrane oxygenation (ECMO) and invasive mechanical ventilation use in critically ill COVID-19 patients.

Data Sources: Electronic databases PubMed Central and PubMed were searched from January 2020 to June 2020 for published studies about ECMO and/or invasive mechanical ventilation use in COVID-19 patients. Data Extraction and Study Selection: The search strategy retrieved 766 articles, of which 19 studies consisting of 204 patients fulfilled the inclusion criteria and were included in the analysis. Read More

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Tranexamic acid in non-traumatic intracranial bleeding: a systematic review and meta-analysis.

Sci Rep 2021 Jul 27;11(1):15275. Epub 2021 Jul 27.

CNRS, LaPSCo, Physiological and Psychosocial Stress, CHU Clermont-Ferrand, Occupational and Environmental Medicine, Université Clermont Auvergne, WittyFit, 63000, Clermont-Ferrand, France.

Non-traumatic intracranial bleeding (NTIB), comprising subarachnoid hemorrhage (SAH) and intra-cranial bleeding (ICH) is a significant public health concern. Tranexamic acid (TXA) is a promising treatment with benefits yet to be fully demonstrated. We conducted a systematic review and meta-analysis on the impact of TXA on mortality in NTIB. Read More

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Evaluation of the safety profile of COVID-19 vaccines: a rapid review.

BMC Med 2021 Jul 28;19(1):173. Epub 2021 Jul 28.

School of Public Health, Key Laboratory of Public Health Safety, Fudan University, Ministry of Education, Shanghai, China.

Background: The rapid process of research and development and lack of follow-up time post-vaccination aroused great public concern about the safety profile of COVID-19 vaccine candidates. To provide comprehensive overview of the safety profile of COVID-19 vaccines by using meta-analysis technique.

Methods: English-language articles and results posted on PubMed, Embase, Web of Science, PMC, official regulatory websites, and post-authorization safety surveillance data were searched through June 12, 2021. Read More

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