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Hydro-alcoholic extract of reduces fasting blood glucose and HbA1c% in diabetic patients, probably via competitive and allosteric interaction with alpha-glucosidase enzyme; a clinical trial and analysis.

J Complement Integr Med 2021 May 5. Epub 2021 May 5.

Department of Nursing, Khomein University of Medical Sciences, Khomein, Iran.

Objectives: 1-Deoxynojirimycin (1-DNJ), the main active component found in () is reported to be effective in controlling diabetes. We have evaluated the effect of hydro-alcoholic extract of leaves on the fasting blood glucose (FBS) and hemoglobin A1c% (HbA1c%) in diabetic patients. Furthermore, we compared the interaction of 1-DNJ and glucose molecules with the alpha-glucosidase enzyme, which has a critical role in the lysis of glucose-based polymers in human cells. Read More

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Mobilization in the evening to prevent delirium: A pilot randomized trial.

Nurs Crit Care 2021 May 4. Epub 2021 May 4.

Department of Anaesthesiology, University Hospital Mannheim, Heidelberg, Germany.

Background: Delirium is a common complication in patients in Intensive Care Units (ICU). Interventions such as mobilization are effective in the prevention and treatment of delirium, although this is usually completed during the daytime.

Aim: The aim of this study was to assess the feasibility of mobilization in the evening to prevent and treat ICU patients from delirium by an additional mobility team over 2 weeks. Read More

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Single-Dose del Nido Cardioplegia Compared With Standard Cardioplegia During Coronary Artery Bypass Grafting at a Veterans Affairs Hospital.

Tex Heart Inst J 2021 Jan;48(1)

Division of Cardiothoracic Surgery, Baylor College of Medicine, Houston, Texas.

Del Nido cardioplegic solution (DNC), used chiefly in pediatric patients, rapidly induces prolonged cardiac arrest during cardiac surgery. To determine whether surgical outcomes after coronary artery bypass grafting in a United States military veteran population differed when DNC was used instead of our standard Plegisol cardioplegia, we retrospectively reviewed 155 consecutive operations performed from July 2016 through June 2017. Del Nido cardioplegia was used to induce cardiac arrest in 70 patients, and Plegisol in 85. Read More

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January 2021

Can text messages encourage flossing among orthodontic patients?

Angle Orthod 2021 May 4. Epub 2021 May 4.

Objectives: To assess the extent to which text messages on WhatsApp play a role in patient awareness of the importance of proper oral hygiene and flossing on a daily basis and to test the null hypothesis that daily text messages do not influence the flossing habits of orthodontics patients.

Materials And Methods: Forty-four patients wearing fixed orthodontic appliances with a mean age of 14.3 years participated in the study. Read More

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Assisted reproductive technology outcomes in women with a chronic viral disease.

AIDS 2021 Jun;35(7):1073-1081

Université de Paris, Faculté de Médecine.

Objective: The aim of this study was to evaluate the cumulative live birth rate in women undergoing in-vitro fertilization/intracytoplasmic-sperm-injection (IVF/ICSI) according to the type of chronic viral infection [HIV, hepatitis-B virus (HBV) and hepatitis-C virus (HCV)].

Design: A cohort study.

Setting: A tertiary-care university hospital. Read More

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The Poor Prognosis of Patients with Stage III Gastric Cancer after D2 Dissection Is Mainly due to Lymphatic Metastasis, Especially the Metastasis of No.12a LN: A Nested Case-Control Study.

Oncol Res Treat 2021 May 4:1-7. Epub 2021 May 4.

Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: The prognosis of stage III gastric cancer (GC) patients based on the 8th edition TNM staging system after D2 dissection was still heterogeneous. We aimed to explore clinicopathological reasons that led to the poor prognosis of these patients, especially from a surgical aspect.

Methods: We divided 320 stage III GC patients who underwent distal or total gastrectomy with D2 lymphadenectomy into group 1 and group 2, according to the disease-free survival (DFS), and compared the clinicopathological features between these 2 groups. Read More

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Think Twice before Interpreting the Skin Prick Test as Age, Body Mass Index, and Atopy Affect Reaction Time and Size.

Int Arch Allergy Immunol 2021 May 4:1-9. Epub 2021 May 4.

Department of Pediatric Allergy and Immunology, Trakya University School of Medicine, Edirne, Turkey.

Introduction: The skin prick test (SPT) is a reliable method to confirm sensitization in IgE-mediated allergic diseases; however, it has been reported to be affected by several personal and environmental factors. Our objective was to determine the factors affecting the skin reactivity to histamine and allergens and investigate whether it differs according to age in terms of reading time.

Methods: A total of 500 patients, aged 4 months-18 years, were enrolled in the study. Read More

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Effectiveness of a Guided Web-Based Intervention to Reduce Depressive Symptoms before Outpatient Psychotherapy: A Pragmatic Randomized Controlled Trial.

Psychother Psychosom 2021 May 4:1-10. Epub 2021 May 4.

Department of Rehabilitation Psychology and Psychotherapy, University of Freiburg, Freiburg, Germany.

Introduction: Psychotherapy is a first-line treatment for depression. However, capacities are limited, leading to long waiting times for outpatient psychotherapy in health care systems. Web-based interventions (WBI) could help to bridge this treatment gap. Read More

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Efficacy and Safety of Lenvatinib-Transcatheter Arterial Chemoembolization Sequential Therapy for Patients with Intermediate-Stage Hepatocellular Carcinoma.

Oncology 2021 May 4:1-11. Epub 2021 May 4.

Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Introduction: We evaluated the efficacy and safety of lenvatinib-transcatheter arterial chemoembolization (LEN-TACE) sequential therapy for patients (n = 88) with intermediate-stage hepatocellular carcinoma (HCC).

Methods: Eighty-eight patients who obtained tumor control by LEN treatment were analyzed; 30 received LEN followed by TACE (LEN-TACE sequential therapy), and 58 received LEN monotherapy. Propensity score matching was performed, and the outcomes of 19 patients in the LEN-TACE group and 19 patients in the LEN-alone group were compared. Read More

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Aging-related genes are potential prognostic biomarkers for patients with gliomas.

Aging (Albany NY) 2021 May 4;13. Epub 2021 May 4.

Department of Neurosurgery, Xiangya Hospital, Central South University, Hunan, China.

Aging has a significant role in the proliferation and development of cancers. This study explored the expression profiles, prognostic value, and potential roles of aging-related genes in gliomas. We designed risk score and cluster models based on aging-related genes and glioma cases using LASSO Cox regression analysis, consensus clustering analysis and univariate cox regression analyses. Read More

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Evaluation of an antigen-based test for hospital point-of-care diagnosis of SARS-CoV-2 infection.

J Clin Virol 2021 Apr 21;139:104838. Epub 2021 Apr 21.

Microbiology and Virology Unit, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy.

Background: An accurate diagnosis is essential to identify and manage SARS-CoV-2 infected patients and implement infection control measures. Although real-time reverse transcription polymerase chain reaction (RT-PCR) is the current recommended laboratory method, several rapid antigen point-of-care tests (POCTs) were developed as frontline testing for SARS-CoV-2 infection diagnosis.

Objectives: The aim of this study was to assess a recently CE-approved POCT, SARS-CoV-2 Ag Test on the LumiraDx™ Platform (LumiraDx GmbH, Cologne, Germany) for the identification of SARS-COV-2 infected subjects at hospital setting. Read More

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Efficacy of lateral stair walking training in patients with chronic stroke: A pilot randomized controlled study.

Gait Posture 2021 Apr 20;88:10-15. Epub 2021 Apr 20.

Department of Physical Medicine and Rehabilitation, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan. Electronic address:

Background: Patients with chronic stroke have reduced capacity for performing activities of daily living (ADLs) and are at increased risk for falls during walking due to long-term changes to muscle tone and force, as well as movement control.

Research Question: To investigate the efficacy of lateral stair walking training on muscle strength of affected lower extremities, balance, ADLs, and gait ability in patients with chronic stroke.

Methods: The experimental group received 15 min of lateral stair walking exercise along with 15 min of traditional physiotherapy, whereas the control group received only traditional physiotherapy for 30 min. Read More

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Machine learning in diagnosis and disability prediction of multiple sclerosis using optical coherence tomography.

Comput Biol Med 2021 Apr 26;133:104416. Epub 2021 Apr 26.

Group of Biomaterials, Aragon Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, Spain; Department of Mechanical Engineering, University of Zaragoza, Zaragoza, Spain. Electronic address:

Background: Multiple sclerosis (MS) is a neurodegenerative disease that affects the central nervous system, especially the brain, spinal cord, and optic nerve. Diagnosis of this disease is a very complex process and generally requires a lot of time. In addition, treatments are applied without any information on the disability course in each MS patient. Read More

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Epidemiology and prognostic factors of pediatric brain tumor survival in the US: Evidence from four decades of population data.

Cancer Epidemiol 2021 May 1;72:101942. Epub 2021 May 1.

Program of Epidemiology, College of Health Sciences, University of Delaware, 100 Discovery Blvd, Newark, DE, 19713, United States.

Brain tumors, a group of heterogeneous diseases, are the second most common cancer and the leading cause of cancer-related deaths in children. Insight into the prognosis of pediatric brain tumor survival has led to improved outcomes and could be further advanced through precision in prognosis. We analyzed the United States SEER population-based dataset of 15,723 pediatric brain tumor patients diagnosed and followed between 1975 and 2016 using a stratified Cox proportional hazards model. Read More

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Cost-effectiveness of feedback-informed psychological treatment: Evidence from the IAPT-FIT trial.

Behav Res Ther 2021 Apr 24;142:103873. Epub 2021 Apr 24.

Department of Health Sciences and Hull York Medical School, University of York, United Kingdom; Department of Epidemiology and Biostatistics, Western University, Canada.

Background: Feedback-informed treatment (FIT) involves using computerized routine outcome monitoring technology to alert therapists to cases that are not responding well to psychotherapy, prompting them to identify and resolve obstacles to improvement. In this study, we present the first health economic evaluation of FIT, compared to usual care, to enable decision makers to judge whether this approach represents a good investment for health systems.

Methods: This randomised controlled trial included 2233 patients clustered within 77 therapists who were randomly assigned to a FIT group (n = 1176) or a usual care control group (n = 1057). Read More

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A randomized double-blind placebo-controlled trial of intravenous thiamine for prevention of delirium following allogeneic hematopoietic stem cell transplantation.

J Psychosom Res 2021 Apr 27;146:110503. Epub 2021 Apr 27.

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Objective: To determine if high dose intravenous (IV) thiamine can prevent delirium during hospitalization following allogeneic HSCT. Secondarily, we evaluated the effects of high dose IV thiamine on thiamine levels and explored risk factors for delirium.

Methods: Randomized, double-blind, placebo-controlled trial in patients undergoing allogeneic HSCT at a U. Read More

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Evaluation of digital otoscopy in pediatric patients: A prospective randomized controlled clinical trial.

Am J Emerg Med 2021 Apr 27;46:150-155. Epub 2021 Apr 27.

Division of Pediatric Emergency Medicine, Department of Pediatrics, Johns Hopkins University, United States of America.

Background: Acute otitis media is often misdiagnosed. Pediatric trainees learn otoscopy from supervisors who cannot concurrently view the eardrum. Digital, smartphone otoscopes show promise to improve the visibility and learning due to a concurrent view by trainees and supervisors. Read More

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Effects of bi-axial ankle strengthening on muscle co-contraction during gait in chronic stroke patients: A randomized controlled pilot study.

Gait Posture 2021 Apr 15;87:177-183. Epub 2021 Apr 15.

National Rehabilitation Research Institute, National Rehabilitation Center, Seoul, South Korea. Electronic address:

Introduction: Ankle dysfunction in patients with stroke is a common but serious cause of balance and gait impairments. However, comprehensive paretic ankle training seldom exists. Thus, we investigated the effects of a bi-axial ankle muscle training program using visual feedback as a means to improve ankle strength and performance of functional activities in patients with stroke. Read More

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Can we determine recurrent epistaxis by hemogram parameters in children?

Int J Pediatr Otorhinolaryngol 2021 Apr 27;146:110747. Epub 2021 Apr 27.

Nizip State Hospital, Otorhinolaryngology Department, Gaziantep, Turkey.

Objective: Epistaxis in children is a common reason for admission at otolaryngology outpatient clinics. Patients are diagnosed by clinical examination and laboratory tests. We aimed to evaluate epistaxis using simple blood parameters useful for diagnosis. Read More

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A study of tryptophan, kynurenine and serotonin transporter in first-episode drug-naïve major depressive disorder.

Psychiatry Res Neuroimaging 2021 Apr 24;312:111296. Epub 2021 Apr 24.

Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Center for Quality Management, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address:

Major depressive disorder (MDD) is associated with the disharmonic functioning of the serotonin system. The serotonin system is mainly modulated by the serotonin transporter (SERT) which regulates serotonin uptake and the metabolism of its precursor, tryptophan and following kynurenine pathway. Currently, there is a lack of research examining both markers concurrently in MDD. Read More

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Impact of a pharmacist-led education and counseling interventions on quality of life in epilepsy: A randomized controlled trial.

Epilepsy Res 2021 Apr 27;174:106648. Epub 2021 Apr 27.

Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka, Nigeria. Electronic address:

Background: The impact of epilepsy on the quality of life of the patient can be considerably high with far-reaching and life-long consequences. The goal of patient counseling and education is to achieve positive clinical outcomes and optimize the patient's health-related quality of life.

Objective: To evaluate the impact of a pharmacist-led education and counselling interventions on the health-related quality of life of patients living with epilepsy. Read More

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The association of childhood trauma, lifetime stressful events and general psychopathological symptoms in euthymic bipolar patients and healthy subjects.

J Affect Disord 2021 Apr 16;289:66-73. Epub 2021 Apr 16.

Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, via Francesco Sforza 28, Milano, Italy; Department of Pathophysiology and Transplantation, University of Milan, Via Francesco Sforza 35, 20122 Milano, Italy.

Background: Psychopathological symptoms during euthymia in Bipolar Disorder (BD) affect quality of life and predispose to the occurrence of new acute episodes, however only few studies investigated potential risk-factors. This study aims to explore the association between childhood trauma (CT), lifetime stressful events (SLEs) and psychopathological symptoms in BD patients during euthymia and controls (HC).

Methods: A total of 261 participants (93 euthymic patients with BD, 168 HC) were enrolled. Read More

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Efficacy of home-based physical activity interventions in patients with autoimmune rheumatic diseases: A systematic review and meta-analysis.

Semin Arthritis Rheum 2021 Apr 16;51(3):576-587. Epub 2021 Apr 16.

Applied Physiology & Nutrition Research Group, School of Physical Education and Sport, Rheumatology Division, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, SP, Brazil. Laboratory of Assessment and Conditioning in Rhematology, Faculdade de Medicina FMUSP, Disciplina de Reumatologia, Universidade de Sao Paulo, Sao Paulo, SP, Brazil Av. Dr. Arnaldo, 455, ZIP code: 01246-903, Sao Paulo-SP, Brazil; Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. Electronic address:

Introduction: Physical activity (PA) has been receiving increasing interest in recent years as an adjuvant therapy for autoimmune rheumatic disease (ARDs), but there is scarce information about the efficacy of home-based PA for patients with ARDs.

Objective: To perform a systematic review and meta-analysis on the efficacy of home-based physical activity (PA) interventions in improving health-related quality of life, functional capacity, pain, and disease activity in patients with ARDs.

Methods: Searches were performed in PubMed, Web of Science, Scopus, Cochrane, CINAHL database and Sport Discus. Read More

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Investigation of two cases of Mycobacterium chelonae infection in haemato-oncology patients using whole genome sequencing and a potential link to the hospital water supply.

J Hosp Infect 2021 May 1. Epub 2021 May 1.

Scottish Mycobacteria Reference Laboratory, Royal Infirmary of Edinburgh.

Background: Haemato-oncology patients are at increased risk of infection from atypical mycobacteria such as Mycobacterium chelonae which are commonly found in both domestic and hospital water systems.

Aims: To describe the investigation and control measures following two patient cases of M. chelonae and positive water samples in our hospital. Read More

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The Association between QuantiFERON-TB Gold Test and Clinical Manifestations of Uveitis in the United States.

Am J Ophthalmol 2021 May 1. Epub 2021 May 1.

National Eye Institute, National Institutes of Health, Bethesda, MD. Electronic address:

Purpose: To report the prevalence of QuantiFERON-TB Gold (QFT-G) positivity among uveitis patients compared to general population and to evaluate the differences in clinical features of uveitis.

Design: Retrospective cohort study.

Methods: SETTING: Institutional. Read More

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Clinically Relevant Activity of the Novel RASP Inhibitor Reproxalap in Allergic Conjunctivitis: The Phase 3 ALLEVIATE Trial.

Am J Ophthalmol 2021 May 1. Epub 2021 May 1.

Aldeyra Therapeutics, Lexington, MA. Electronic address:

Purpose: To assess the post-acute activity and clinical utility of reproxalap, a novel reactive aldehyde species (RASP) inhibitor, versus vehicle in patients with seasonal allergic conjunctivitis.

Design: Parallel-group, double-masked, randomized Phase 3 trial.

Methods: Two topical ocular reproxalap concentrations (0. Read More

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Fanaticism: Reflections based on phenomena in the analytic field.

Int J Psychoanal 2019 Dec;100(6):1338-1357

Brazilian Psychoanalytic Society of São Paulo and Campinas Psychoanalytic Study Group, Campinas, Brazil.

The paper presents and discusses hypotheses related to the manifestation of fanatical aspects in the analytical field. Initially, fanaticism is discussed as a social phenomenon. In sequence, clinical facts are presented. Read More

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December 2019

Mini-Patient-derived Xenograft Assay Based on Microfluidic Technology Promises to be an Effective Tool for Screening Individualized Chemotherapy Regimens for Advanced Non-Small Cell Lung Cancer.

Cell Biol Int 2021 May 4. Epub 2021 May 4.

Department of Shanghai Lung Cancer center, Shanghai Chest Hospital, Shanghai Jiao Tong University, 200030, Shanghai, China.

Background: Patient-derived xenograft (PDX) assay has been widely used in preclinical researches in patients with multidrug-resistant lung cancer.

Methods: 100 patients with non-small cell lung cancer (NSCLC) were divided into MiniPDX group and conventional group, with 50 cases in each group. The MiniPDX assay was established by enriching high-purity tumor cells using microfluidic technology to detect the drug sensitivity of NSCLC cells. Read More

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Shape of the anterior surface of the cornea after extended wear of silicone hydrogel soft contact lenses.

Ophthalmic Physiol Opt 2021 May 4. Epub 2021 May 4.

Division of Ophthalmology and Optometry, Department of Ophthalmology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.

Purpose: To measure geometrical changes in the anterior surface of the cornea after wearing silicon hydrogel (SiH) soft contact lenses continuously for 1 week.

Methods: Forty-three eyes with 3.0D of myopia and 22 eyes with 3. Read More

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Established soft contact lens wearers' awareness of and initial experiences with orthokeratology.

Ophthalmic Physiol Opt 2021 May 4. Epub 2021 May 4.

University of Alabama at Birmingham, Birmingham, Alabama, USA.

Objectives: To understand the initial awareness of and experience with orthokeratology in a group of adult, symptomatic, soft contact lens (CL) wearers.

Methods: This was a prospective, 3-month, open-label study of symptomatic soft CL wearers who were between the ages of 18 and 45 years. Baseline measurements were taken and then all subjects were treated with orthokeratology. Read More

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