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Effects of long-term unilateral cochlear implant use on large-scale network synchronization in adolescents.

Hear Res 2021 Jul 8;409:108308. Epub 2021 Jul 8.

Archie's Cochlear Implant Laboratory, Department of Otolaryngology, The Hospital for Sick Children, ON, Canada; Program in Neuroscience and Mental Health, Hospital for Sick Children Research Institute, ON, Canada; Institute of Medical Sciences, Faculty of Medicine, University of Toronto, ON, Canada; Department of Otolaryngology - Head and Neck Surgery, Faculty of Medicine, University of Toronto, ON, Canada. Electronic address:

Unilateral cochlear implantation (CI) limits deafness-related changes in the auditory pathways but promotes abnormal cortical preference for the stimulated ear and leaves the opposite ear with little protection from auditory deprivation. In the present study, time-frequency analyses of event-related potentials elicited from stimuli presented to each ear were used to determine effects of unilateral CI use on cortical synchrony. CI-elicited activity in 34 adolescents (15. Read More

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Using thermal effect of 970 nm diode laser to reduce nasal swell body.

Am J Otolaryngol 2021 Jul 29;42(6):103165. Epub 2021 Jul 29.

Department of Automation and Control Processes, Saint Petersburg Electrotechnical University "LETI", Saint Petersburg, Russian Federation. Electronic address:

In recent decades, semiconductor lasers have been successfully used in rhinology. However, their usage in the reduction of the nasal swell body (NSB) is barely studied. Our research aimed to conduct an experimental selection of the laser exposure mode in the NSB zone using a 970 nm diode laser for safe and effective NSB reduction. Read More

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Insight of bacteria and archaea in Feammox community enriched from different soils.

Environ Res 2021 Jul 31:111802. Epub 2021 Jul 31.

MOE Key Laboratory of Pollution Processes and Environmental Criteria/Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, No. 38 Tongyan Road, Jinnan District, Tianjin, 300350, China. Electronic address:

Anaerobic ammonium oxidation coupled to Fe(III) reduction, known as Feammox, is a newly discovered nitrogen-cycling process, which serves an important role in the pathways of nitrogen loss in the environment. However, the specific types of microorganisms involved in Feammox currently remain unclear. In this study, we selected two groups of soil samples (paddy and mine), from considerably different habitats in South China, to acclimate Feammox colonies. Read More

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Factors of surface thermal variation in high-mountain lakes of the Pyrenees.

PLoS One 2021 3;16(8):e0254702. Epub 2021 Aug 3.

CSIC, Centre for Advanced Studies of Blanes CEAB, Integrative Freshwater Ecology Group, Blanes, Catalonia, Spain.

Thermal variables are crucial drivers of biological processes in lakes and ponds. In the current context of climate change, determining which factors better constrain their variation within lake districts become of paramount importance for understanding species distribution and their conservation. In this study, we describe the regional and short-term interannual variability in surface water temperature of high mountain lakes and ponds of the Pyrenees. Read More

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Congruence between ocean-dispersal modelling and phylogeography explains recent evolutionary history of Cycas species with buoyant seeds.

New Phytol 2021 Aug 3. Epub 2021 Aug 3.

CAS Key Laboratory for Plant Diversity and Biogeography of East Asia, Kunming Institute of Botany, Chinese Academy of Sciences, 650201, Yunnan, China.

Ocean currents play a significant role in driving long-distance dispersal (LDD), spatial distribution, and phylogeographic patterns of many organisms. Integrating phylogeographic analyses and mechanistic ocean current modelling can provide novel insights into the evolutionary history of terrestrial littoral species but has been rarely applied in this context. We focused on a group of Cycas that have buoyant seeds and occupy coastal habitats. Read More

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Within-host evolutionary dynamics of seasonal and pandemic human influenza A viruses in young children.

Elife 2021 Aug 3;10. Epub 2021 Aug 3.

Laboratory of Applied Evolutionary Biology, Department of Medical Microbiology & Infection Prevention, Amsterdam University Medical Center, Amsterdam, Netherlands.

The evolution of influenza viruses is fundamentally shaped by within-host processes. However, the within-host evolutionary dynamics of influenza viruses remain incompletely understood, in part because most studies have focused on infections in healthy adults based on single timepoint data. Here, we analysed the within-host evolution of 82 longitudinally-sampled individuals, mostly young children, infected with A/H1N1pdm09 or A/H3N2 viruses between 2007 and 2009. Read More

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A Multiphase Multiobjective Dynamic Genome-Scale Model Shows Different Redox Balancing among Yeast Species of the Genus in Fermentation.

mSystems 2021 Aug 3:e0026021. Epub 2021 Aug 3.

(Bio)process Engineering Group, IIM-CSIC, Vigo, Spain.

Yeasts constitute over 1,500 species with great potential for biotechnology. Still, the yeast Saccharomyces cerevisiae dominates industrial applications, and many alternative physiological capabilities of lesser-known yeasts are not being fully exploited. While comparative genomics receives substantial attention, little is known about yeasts' metabolic specificity in batch cultures. Read More

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Chemical Gradients of Plant Substrates in an Fungus Garden.

mSystems 2021 Aug 3:e0060121. Epub 2021 Aug 3.

Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.

Many ant species grow fungus gardens that predigest food as an essential step of the ants' nutrient uptake. These symbiotic fungus gardens have long been studied and feature a gradient of increasing substrate degradation from top to bottom. To further facilitate the study of fungus gardens and enable the understanding of the predigestion process in more detail than currently known, we applied recent mass spectrometry-based approaches and generated a three-dimensional (3D) molecular map of an fungus garden to reveal chemical modifications as plant substrates pass through it. Read More

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Studying Microtemporal, Within-Person Processes of Diet, Physical Activity, and Related Factors Using the APPetite-Mobile-App: Feasibility, Usability, and Validation Study.

J Med Internet Res 2021 Jul 5;23(7):e25850. Epub 2021 Jul 5.

Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt, Germany.

Background: Diet and physical activity (PA) have a major impact on physical and mental health. However, there is a lack of effective strategies for sustaining these health-protective behaviors. A shift to a microtemporal, within-person approach is needed to capture dynamic processes underlying eating behavior and PA, as they change rapidly across minutes or hours and differ among individuals. Read More

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Social decision-making in severe alcohol use disorder: Scoping review and experimental perspectives.

Alcohol Clin Exp Res 2021 Aug 2. Epub 2021 Aug 2.

Louvain Experimental Psychopathology research group (LEP), Psychological Science Research Institute, UCLouvain, Louvain-la-Neuve, Belgium.

Background: Patients with severe alcohol use disorder (SAUD) demonstrate multifaceted impairments in social cognition abilities like emotional decoding or Theory of Mind. Such impairments are related to real-life interpersonal difficulties, which in turn might be involved in the persistence of SAUD. However, far less is known regarding how patients with SAUD make decisions in social context, and this literature has not yet been gathered in a comprehensive review. Read More

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Differential impact of stay-at-home orders on mental health in adults who are homeschooling or "childless at home" in time of COVID-19.

Fam Process 2021 Aug 2. Epub 2021 Aug 2.

University of Salamanca, Salamanca, Spain.

The COVID-19 pandemic has forced the confinement of most populations worldwide, through stay-at-home orders. Children have continued their education process at home, supervised by parents, who, in most cases, have adopted the role of prime drivers of their learning processes. In this study, the psychological impact of confinement was explored, as well as the relationship of the forced homeschooling situation with psychological well-being. Read More

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Effects of metals on activity and community of sulfate-reducing bacterial enrichments and the discovery of a new heavy metal-resistant SRB from Santos Port sediment (São Paulo, Brazil).

Environ Sci Pollut Res Int 2021 Aug 3. Epub 2021 Aug 3.

School of Technological Sciences, Federal University of Alfenas (UNIFAL-MG), Minas Gerais, Rodovia Aurélio Vilela, n 11.999 Cidade Universitária, Poços de Caldas, Minas Gerais, 37715400, Brazil.

Sulfate-reducing bacteria (SRB) can be used to remove metals from wastewater, sewage, and contaminated areas. However, metals can be toxic to this group of bacteria. Sediments from port areas present abundance of SRB and also metal contamination. Read More

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Longitudinal changes of spinal cord grey and white matter following spinal cord injury.

J Neurol Neurosurg Psychiatry 2021 Aug 2. Epub 2021 Aug 2.

Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland

Objectives: Traumatic and non-traumatic spinal cord injury produce neurodegeneration across the entire neuraxis. However, the spatiotemporal dynamics of spinal cord grey and white matter neurodegeneration above and below the injury is understudied.

Methods: We acquired longitudinal data from 13 traumatic and 3 non-traumatic spinal cord injury patients (8-8 cervical and thoracic cord injuries) within 1. Read More

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SUpporting wellbeing through PEeR-Befriending (SUPERB) feasibility trial: fidelity of peer-befriending for people with aphasia.

BMJ Open 2021 08 2;11(8):e047994. Epub 2021 Aug 2.

Centre for Language and Communication Science Research, City University of London, London, UK

Objective: To evaluate systematically the fidelity of a peer-befriending intervention for people with aphasia.

Design: SUpporting wellbeing through Peer-befriending (SUPERB) was a feasibility randomised controlled trial comparing usual care to usual care +peer-befriending. This paper reports on the fidelity of all intervention aspects (training and supervision of providers/befrienders; intervention visits) which was evaluated across all areas of the Behaviour Change Consortium framework. Read More

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Three-dimensional numerical analysis as a tool for optimization of acoustophoretic separation in polymeric chips.

J Acoust Soc Am 2021 Jul;150(1):646

Group of Ultrasonic Resonators RESULT, Department of Sensors and Ultrasonic Systems, Institute of Physical Technologies and Information (ITEFI), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, 28006, Spain.

Polymeric separators have been developed since 2010 to produce acoustophoretic separation of particles or cells in suspension with high efficiency. They rely on three-dimensional (3D) resonances of their whole structure actuated by ultrasounds. In this paper, a numerical 3D analysis is presented and validated as the only tool for optimization of these polymeric chips to perform efficient separation applications. Read More

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Guiding propagation to localized target nodes in complex networks.

Chaos 2021 Jul;31(7):073104

School of Systems Science, Beijing Normal University, Beijing 100875, People's Republic of China.

Spreading is an important type of dynamics in complex networks that can be used to model numerous real processes such as epidemic contagion and information propagation. In the literature, there are many methods in vital node identification and node immunization proposed for controlling the spreading processes. As a novel research problem, target spreading aims to minimize or maximize propagation toward a group of target nodes. Read More

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Design and engineering of artificial microbial consortia for biohydrogen production.

Curr Opin Biotechnol 2021 Jul 30;73:74-80. Epub 2021 Jul 30.

Archaea Physiology & Biotechnology Group, Department of Functional and Evolutionary Ecology, Universität Wien, Wien, Austria. Electronic address:

In natural microbial ecosystems the metabolic diversity of the organisms enables interaction among the community members and allows them to engage in syntrophic interactions. With regard to biotechnology, artificial microbial consortium engineering is used to improve productivities and yields of bioprocesses. However, to achieve supreme productivity or efficiency at industrial scale, defined ecosystems must be physiologically well-selected to meet eco-biotechnological demands. Read More

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BDNF genotype Val66Met interacts with acute plasma BDNF levels to predict fear extinction and recall.

Behav Res Ther 2021 Jul 30;145:103942. Epub 2021 Jul 30.

School of Psychological Sciences, University of Melbourne, Australia.

Brain-derived neurotropic factor (BDNF) is a potent regulator of memory processes and is believed to influence the consolidation of fear extinction memories. No previous human study has tested the effect of unstimulated BDNF on fear extinction recall, and no study has tested the association between plasma BDNF levels and psychophysiological responding during an extinction paradigm. We tested the association between fear responses during a 2-day differential conditioning, extinction and extinction recall paradigm and Val66Met genotype in a group of healthy participants (N = 191). Read More

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The neurocognitive and functional profile of schizophrenia in a genetically homogenous European sample.

Psychiatry Res 2021 Jul 26;304:114140. Epub 2021 Jul 26.

Center for Research in Neuropsychology and Cognitive Behavioral Intervention (CINEICC), University of Coimbra, Portugal.

Schizophrenia is a complex heritable brain disorder that entails significant social, neurocognitive, and functional deficits, and significant psychosocial challenges to affected and unaffected family members. In this cross-sectional study, we explore impairments in specific neurocognitive and social cognition processes in patients affected with schizophrenia, unaffected relatives, and in controls to provide a characterization of a genetically homogenous European sample from an endophenotypic and functional standpoint. A sample of 38 affected patients, 28 first-degree relatives, and 97 controls performed a series of computerized and skills-based assessments. Read More

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Identifying molecular insight of synergistic complexities for SARS-CoV-2 infection with pre-existing type 2 diabetes.

Comput Biol Med 2021 Jul 23;136:104668. Epub 2021 Jul 23.

Healthy Ageing Theme, Garvan Institute of Medical Research, Darlinghurst, NSW, 2010, Australia; WHO Collaborating Centre on eHealth, UNSW Digital Health, School of Public Health and Community Medicine, Faculty of Medicine, UNSW Sydney, NSW, 2052, Australia. Electronic address:

The ongoing COVID-19 outbreak, caused by SARS-CoV-2, has posed a massive threat to global public health, especially to people with underlying health conditions. Type 2 diabetes (T2D) is lethal comorbidity of COVID-19. However, its pathogenetic link remains unclear. Read More

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Data fusion and smoothing for probabilistic tracking of viral structures in fluorescence microscopy images.

Med Image Anal 2021 Jul 16;73:102168. Epub 2021 Jul 16.

Biomedical Computer Vision Group, BioQuant, IPMB, Heidelberg University, Im Neuenheimer Feld 267, Heidelberg, Germany. Electronic address:

Automatic tracking of viral structures displayed as small spots in fluorescence microscopy images is an important task to determine quantitative information about cellular processes. We introduce a novel probabilistic approach for tracking multiple particles based on multi-sensor data fusion and Bayesian smoothing methods. The approach exploits multiple measurements as in a particle filter, both detection-based measurements and prediction-based measurements from a Kalman filter using probabilistic data association with elliptical sampling. Read More

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Promoting inter-organisational knowledge sharing: A qualitative evaluation of England's Global Digital Exemplar and Fast Follower Programme.

PLoS One 2021 2;16(8):e0255220. Epub 2021 Aug 2.

Institute for the Study of Science, Technology and Innovation, School of Social and Political Science, The University of Edinburgh, Edinburgh, United Kingdom.

Background: The Global Digital Exemplar (GDE) Programme was designed to promote the digitisation of hospital services in England. Selected provider organisations that were reasonably digitally-mature were funded with the expectation that they would achieve internationally recognised levels of excellence and act as exemplars ('GDE sites') and share their learning with somewhat less digitally-mature Fast Follower (FF) sites.

Aims: This paper explores how partnerships between GDE and FF sites have promoted knowledge sharing and learning between organisations. Read More

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Profiling Analysis of Circular RNA and mRNA in Human Temporal Lobe Epilepsy with Hippocampal Sclerosis ILAE Type 1.

Cell Mol Neurobiol 2021 Aug 2. Epub 2021 Aug 2.

Department of Neurosurgery, The First Affiliated Hospital, Harbin Medical University, Harbin, 150001, Heilongjiang, China.

Hippocampal sclerosis (HS) is the most common surgical pathology associated with temporal lobe epilepsy (TLE). However, the cause of TLE with or without HS remains unknown. Our current study aimed to illustrate the essential molecular mechanism that is potentially involved in the pathogenesis of TLE-HS and to shed light on the transcriptional changes associated with hippocampal sclerosis. Read More

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Asymmetric desorption of lipid oxidation products induces membrane bending.

Soft Matter 2021 Aug 2. Epub 2021 Aug 2.

Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Lipid oxidation, detected in metabolic processes, is induced in excess when the cellular membrane suffers extra oxidative stress. Lipid oxidation can compromise biomembrane function in part through perturbations of lipid packing, membrane permeability, and morphology. Two major types of oxidation products, one with a partially truncated lipid tail with a hydrophilic group at the tail-end, and secondly, a lysolipid (with one of the chains completely truncated) can disturb the membrane bilayer packing significantly. Read More

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Hydrogen Peroxide: Its Use in an Extensive Acute Wound to Promote Wound Granulation and Infection Control - Is it Better Than Normal Saline?

Int J Low Extrem Wounds 2021 Aug 2:15347346211032555. Epub 2021 Aug 2.

Base Hospital Guwahati, Basistha Guwahati, India.

: Hydrogen peroxide (HO) is used as a topical antiseptic in contaminated wounds caused by road traffic accidents. It kills bacteria by producing oxidation through local, nascent, free oxygen radicals. It also removes dirt from the wound due to its frothing action. Read More

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Microbial Roles in Dissolved Organic Matter Transformation in Full-Scale Wastewater Treatment Processes Revealed by Reactomics and Comparative Genomics.

Environ Sci Technol 2021 Aug 2. Epub 2021 Aug 2.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, No. 163, Xianlin Avenue, Nanjing 210023, Jiangsu, P. R. China.

Understanding the degradation of dissolved organic matter (DOM) is vital for optimizing DOM control. However, the microbe-mediated DOM transformation during wastewater treatment remains poorly characterized. Here, microbes and DOM along full-scale biotreatment processes were simultaneously characterized using comparative genomics and high-resolution mass spectrometry-based reactomics. Read More

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Effecting change in academic dentistry through small groups.

J Dent Educ 2021 Aug 2. Epub 2021 Aug 2.

Department of Periodontics, University of Maryland School of Dentistry, Baltimore, Maryland, USA.

Purpose/objective: The work of faculty, staff, and students is driven by their alignment with an institution's vision and purpose, as set forth in its strategic plan. Any plan that calls for innovative growth must address certain aspects of organizational culture as roadblocks to success and should foster relationship building to achieve long-standing progress. This demonstration project investigates a method for effecting change through a Small Group Initiative (SGI). Read More

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Shedding light on developmental ERK signaling with genetically encoded biosensors.

Development 2021 Sep 2;148(18). Epub 2021 Aug 2.

Division of Quantitative Biology, National Institute for Basic Biology, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi 444-8787, Japan.

The extracellular signal-regulated kinase (ERK) pathway governs cell proliferation, differentiation and migration, and therefore plays key roles in various developmental and regenerative processes. Recent advances in genetically encoded fluorescent biosensors have unveiled hitherto unrecognized ERK activation dynamics in space and time and their functional importance mainly in cultured cells. However, ERK dynamics during embryonic development have still only been visualized in limited numbers of model organisms, and we are far from a sufficient understanding of the roles played by developmental ERK dynamics. Read More

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September 2021

An oscillating computational model can track pseudo-rhythmic speech by using linguistic predictions.

Elife 2021 Aug 2;10. Epub 2021 Aug 2.

Language and Computation in Neural Systems group, Max Planck Institute for Psycholinguistics, Nijmegen, Netherlands.

Neuronal oscillations putatively track speech in order to optimize sensory processing. However, it is unclear how isochronous brain oscillations can track pseudo-rhythmic speech input. Here we propose that oscillations can track pseudo-rhythmic speech when considering that speech time is dependent on content-based predictions flowing from internal language models. Read More

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Overcoming barriers to biosimilar adoption: real-world perspectives from a national payer and provider initiative.

J Manag Care Spec Pharm 2021 Aug;27(8):1129-1135

PRIME Education, LLC, Fort Lauderdale, FL.

In response to a published national payer survey indicating striking needs for multistakeholder initiatives to increase biosimilar adoption, a focus workgroup meeting joining payers and providers was conducted in December 2019 in Boston, MA. Before the focus group meeting, a survey was sent to health care providers to collect perceptions about barriers to biosimilar adoption and gather input on best potential strategies for addressing these barriers. The focus group panel consisted of 5 managed care pharmacists and 3 physician experts in rheumatology, dermatology, and gastroenterology, representing large managed care organizations and health care systems in the Boston area. Read More

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