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The effect of platelet-rich fibrin (PRF) on wound healing, adhesion, and hemostasis after endoscopic sinus surgery in patients with nasal polyposis.

Am J Otolaryngol 2021 Mar 29;42(5):103010. Epub 2021 Mar 29.

Prof. Dr. Cemil Tascioglu City Hospital, Otorhinolaryngology Department, Turkey.

Purpose: Chronic rhinosinusitis (CRS) is one of the most common chronic diseases seen worldwide. Endoscopic sinus surgery (ESS) has become a widely accepted procedure for medically refractory chronic rhinosinusitis and nasal polyps. Prevention of revision surgery often depends on good wound healing and less adhesion formation. Read More

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Mobile Apps to Support Family Caregivers of People With Alzheimer Disease and Related Dementias in Managing Disruptive Behaviors: Qualitative Study With Users Embedded in a Scoping Review.

JMIR Aging 2021 Apr 16;4(2):e21808. Epub 2021 Apr 16.

School of Rehabilitation, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.

Background: People with Alzheimer disease and related dementias often display disruptive behaviors (eg, aggression, wandering, and restlessness), which increase family caregivers' burden of care. However, there are few tools currently available to help these caregivers manage disruptive behaviors. Mobile apps could meet this need, but to date little is known about them. Read More

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Prevalence of SARS-CoV-2 infection and risk factors in health care workers.

Przegl Epidemiol 2020 ;74(4):606-619

Medical University of Silesia in Katowice, Faculty of Medical Sciences, Department of Epidemiology.

The COVID-19 pandemic verifies the preparation of medical care in individual countries in terms of the fluent of guaranteed medical services provided to the people in need. Due to the easy spread of SARS-CoV-2 virus when in direct contact with the patients, health care workers are at an increased risk of infection. Nurses and auxiliary staff, as well as medical doctors, were most frequently infected. Read More

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January 2020

Parabens and bisphenol A and its structural analogues in over-the-counter medicines from China.

Environ Sci Pollut Res Int 2021 Apr 16. Epub 2021 Apr 16.

Guangdong Key Laboratory of Environmental Pollution and Health, and School of Environment, Jinan University, Guangzhou, 510632, China.

Pharmaceuticals, such as over-the-counter (OTC) medicines, may be an important source of human exposure to several endocrine disruptors, though unnoticed to date. In the present study, we investigated the presence of six parabens and nine bisphenol A (BPA) and its analogues in OTC medicines manufactured in China. Parabens and bisphenols were present in more than 90% of the samples. Read More

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Implementation of preventive measures to prevent COVID-19: a national study of English primary schools in summer 2020.

Health Educ Res 2021 Apr 16. Epub 2021 Apr 16.

Department of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London WC1H 9SH, UK.

We examined the feasibility of implementing preventive measures to prevent SARS-CoV-2 transmission across 105 English primary schools in summer 2020 via a survey and interviews with headteachers. High rates of implementation of most recommended measures were noted with the exception of requiring 2 m distance for students, fitting hand sanitizers in classrooms and introducing one-way systems in school corridors. Measures such as regular handwashing and stopping assemblies were considered easy to implement. Read More

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Endoscopic carpal tunnel release with or without suture: does it make a difference? A case-control study.

Hand Surg Rehabil 2021 Apr 12. Epub 2021 Apr 12.

Department of Orthopedics and Traumatology, AZ Maria Middelares, Buitenring-Sint-Denijs 30, Gent, Belgium; Department of Orthopedics and Traumatology, University Hospital Brussels (Vrije Universiteit Brussel), Laarbeeklaan 101, Brussels, Belgium. Electronic address:

A case-control study was conducted to compare wound healing with or without skin suture after endoscopic carpal tunnel release. The primary endpoint was esthetics on the Manchester Scar Scale (MSS). Patients were recruited between April 2016 and April 2017. Read More

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Management of incontinence-associated dermatitis with topical antibiotics and antifungal medication.

J Wound Care 2021 Apr;30(Sup4):S24-S27

Division of Plastic Surgery, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Taiwan.

Objective: The primary goals of managing incontinence-associated dermatitis (IAD) are to control the incontinence and to stop the progress of dermatitis. This study evaluated the effectiveness of using a combination of topical antibiotic and topical antifungal medication to manage IAD.

Method: Patients with grade 2 IAD treated with a combination of topical antibiotic Biomycin (CBC Biotechnological and Pharmaceutical, Taiwan) and antifungal clotrimazole (Sinphar Group, Taiwan) between January 2017 and January 2019 were included in this retrospective study. Read More

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A novel method for measuring tooth angulation in permanent mandibular second molars with delayed tooth eruption.

J Orthod 2021 Apr 15:14653125211003911. Epub 2021 Apr 15.

Private Practice, Bursa, Turkey.

Objective: To investigate the effect of angulation of permanent mandibular second molars (MM2) on eruption problems and investigate a new method of measuring MM2 angulation for the diagnosis and evaluation of delayed tooth eruption (DTE) for easy use in dental practice.

Design: Retrospective study.

Setting: Department of Orthodontics, Necmettin Erbakan University. Read More

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Improvement of short straws for sperm cryopreservation: installing an air-permeable filter facilitates handling.

J Reprod Dev 2021 Apr 14. Epub 2021 Apr 14.

Bioresource Center, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.

Saving space for sperm cryopreservation would aid mouse genetics research. We previously developed the ST (sperm freezing in ShorT STraw to reduce STorage space) method for cryopreserving mouse sperm in a smaller storage space than conventional methods. However, our ST method has two drawbacks: difficulties during freeze-thaw procedures and the potential risk of sperm loss during storage. Read More

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Cluster randomised controlled trial of a menu box delivery service for Australian long day care services to improve menu guideline compliance: a study protocol.

BMJ Open 2021 Apr 14;11(4):e045136. Epub 2021 Apr 14.

College of Nursing and Health Sciences, Flinders University Caring Futures Institute, Adelaide, South Australia, Australia.

Introduction: Globally, children are not meeting the recommended serves of the five food group foods, particularly vegetables. Childcare is an opportune setting to improve children's diet quality. This study aims to assess the effectiveness of a menu box delivery service tailored to the long day care setting to improve menu compliance with recommendations and improve children's food intake while in care. Read More

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Comparison of Ligand Architecture on Vapor Deposition Precursors: Synthesis, Characterization, and Reactivity of Volatile Cadmium Bis-Amidinate Complexes.

Inorg Chem 2021 Apr 14. Epub 2021 Apr 14.

Department of Chemistry, Illinois Institute of Technology, 3101 South Dearborn Street, Chicago, Illinois 60616, United States.

The lack of low-temperature (<200 °C) and easy-to-handle vapor deposition precursors for cadmium has been a limitation for cadmium chalcogenide ALD. Here, the cadmium amidinate system is presented as a scaffold for vapor deposition precursor design because the alkyl groups can be altered to change the properties of the precursor. Thus, the molecular structure affects the precursor stability at elevated temperature, onset of volatility, and reactivity. Read More

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The use of new oral anticoagulants in geriatric patients: A survey study for physicians.

Tuberk Toraks 2021 Mar;69(1):65-73

Department of Chest Diseases, Ahi Evran University, Kırşehir, Turkey.

Introduction: The use of new oral anticoagulants (NOACs) for the treatment of thromboembolic diseases is becoming more widespread. The present study brings together the opinions and daily routine clinical practices of physicians regarding the use of NOACs in the geriatric age group for the treatment of venous thromboembolic diseases.

Materials And Methods: The study accessed 274 physicians (197 attending, 70 resident and seven primary care physicians) with various specialties and academic positions through face-to-face interviews or e-mails, and asked them to complete a questionnaire form prepared for NOAC use on a voluntary basis between 1 May and 31 December 2019. Read More

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Topical Imiquimod Does not Provide an Adjuvant Effect when Administered with Inactivated Influenza A/H5N1 Vaccine in Healthy Young Adults.

J Infect Dis 2021 Apr 14. Epub 2021 Apr 14.

Departments of Molecular Virology and Microbiology and Medicine, Baylor College of Medicine, Houston, Texas, United States of America.

Background: Safe, effective and easy to deploy adjuvants are needed for influenza pre-pandemic preparedness. Based on recent reports we hypothesized that pre-application of topical imiquimod followed by intradermal (ID) vaccination with monovalent inactivated influenza A/H5N1 vaccine (MIV A/H5N1) results in improved serologic responses.

Methods: We randomized 50 healthy adults in a 1:1 ratio to receive topical imiquimod (Group 1) or control cream (Group 2) followed by ID injection of 9µg of the hemagglutinin (HA) MIV A/H5N1 in two doses, 21 days apart. Read More

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Evaluation of Minimal Change Lesions Using Linked Color Imaging in Patients With Nonerosive Reflux Esophagitis.

J Clin Gastroenterol 2021 Apr 13. Epub 2021 Apr 13.

Department of Gastroenterology, The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, People's Republic of China.

Background And Aims: High prevalence of minimal change lesion (MCL) in nonerosive reflux esophagitis (NERD) patients is commonly recognized by many endoscopists. However, it is difficult to detect MCL with conventional white-light imaging (WLI) endoscopy. Linked color imaging (LCI), a novel image-enhanced endoscopy technology with strong, unique color enhancement, is used for easy recognition of early gastric cancer and detection of Helicobacter pylori infection. Read More

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Impact of Individual, Organizational, and Technological Factors on the Implementation of an Online Portal to Support a Clinical Pathway Addressing Psycho-Oncology Care: Mixed Methods Study.

JMIR Hum Factors 2021 04 14;8(2):e26390. Epub 2021 Apr 14.

Psycho-Oncology Co-operative Research Group, School of Psychology, The University of Sydney, Sydney, Australia.

Background: Clinical pathways (CPs) can improve patient outcomes but can be complex to implement. Technologies, such as clinical decision support (CDS) tools, can facilitate their use, but require end-user testing in clinical settings.

Objective: This study applied the Technology Acceptance Model to evaluate the individual, organizational, and technological contexts impacting application of a portal to facilitate a CP for anxiety and depression (the ADAPT Portal) in a metropolitan cancer service. Read More

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A Dance Program to Manage A Fatigue-Sleep Disturbance-Depression Symptom Cluster among Breast Cancer Patients Receiving Adjuvant Chemotherapy: A Feasibility Study.

Asia Pac J Oncol Nurs 2021 May-Jun;8(3):337-339. Epub 2021 Feb 4.

The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

Objective: Fatigue, sleep disturbance, and depression (FSD) are highly prevalent among breast cancer (BC) patients undergoing adjuvant chemotherapy, constituting a common symptom cluster (i.e., FSD cluster). Read More

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February 2021

Effect of Electrical Stimulation on Gastrointestinal Symptoms in Lung Cancer Patients during Chemotherapy: A Randomized Controlled Trial.

Asia Pac J Oncol Nurs 2021 May-Jun;8(3):246-254. Epub 2021 Feb 4.

Department of Hospital Office, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.

Objective: The objective was to evaluate the effects of transcutaneous acupoint electric stimulation (TAES) and gastric electrical stimulation (GES) on cancer patients with chemotherapy-induced gastrointestinal (GI) symptoms.

Methods: A total of 122 lung cancer patients receiving chemotherapy were assigned randomly to the following two groups: control group (usual care group, = 61) and intervention group (TAES plus GES, = 61). TAES involved two acupoints such as Neiguan (PC6) and Zusanli (ST36). Read More

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February 2021

Factors influencing student choice of a degree in physiotherapy: a population-based study in Catalonia (Spain).

PeerJ 2021 1;9:e10991. Epub 2021 Apr 1.

Research group on Methodology, Methods, Models and Outcomes of Health and Social Sciences (M3O), Faculty of Health Sciences and Welfare, Centre for Health and Social Care Research (CESS), University of Vic-Central University of Catalonia (UVic-UCC), Vic, Barcelona, Spain.

Background: In other healthcare professions, there has been extensive research into students' motivation, but studies aiming to determine what leads individuals to choose a degree in physiotherapy are scarce. This research study had three main objectives: to obtain a sociodemographic profile of first-year physiotherapy students in Catalonia; to determine the factors that lead individuals to choose a degree in physiotherapy; and to determine potential differences, according to gender and country of origin.

Methods: This is an observational, cross-sectional, multicentre study. Read More

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Endoscopic full-thickness plication for the treatment of PPI-dependent GERD: results from a randomised, sham controlled trial.

Gut 2021 Apr 13. Epub 2021 Apr 13.

Asian Healthcare Foundation, Asian Institute of Gastroenterology, Hyderabad, Andhra Pradesh, India.

Background: The majority of endoscopic antireflux procedures for GERD are cumbersome to use and randomised long-term data are sparse. We conducted such a trial to determine the efficacy and safety of a novel, easy to use endoscopic full-thickness fundoplication (EFTP) device in patients with GERD.

Design: Patients with proton pump inhibitor (PPI)-dependent GERD were randomised to either EFTP or a sham procedure in 1:1 ratio. Read More

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Applying visual mapping techniques to promote learning in community-based medical education activities.

BMC Med Educ 2021 Apr 13;21(1):210. Epub 2021 Apr 13.

Department of Community Medicine, Jawaharlal Nehru Medical College, Wardha, Maharashtra, India.

Background: Teaching and learning Community-Based Medical Education (CBME) requires the active engagement of students in various activities to cover planned curricular content. CBME being multifaceted involves careful application and formation of links when attending to community health problems and public health issues. Students often depend on factual recall rather than 'engaging in', to counteract the broad and comprehensive nature of CBME. Read More

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Expasy, the Swiss Bioinformatics Resource Portal, as designed by its users.

Nucleic Acids Res 2021 Apr 13. Epub 2021 Apr 13.

SIB Swiss Institute of Bioinformatics, Quartier Sorge - Bâtiment Amphipôle, CH-1015 Lausanne, Switzerland.

The SIB Swiss Institute of Bioinformatics (https://www.sib.swiss) creates, maintains and disseminates a portfolio of reliable and state-of-the-art bioinformatics services and resources for the storage, analysis and interpretation of biological data. Read More

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Pure erythroid leukemia subsequent to acute myelomonocytic leukemia: A case report.

Medicine (Baltimore) 2021 Apr;100(15):e25528

Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Hematology of Nanjing Medical University.

Rationale: Pure erythroid leukemia is a rare subcategory of acute myeloid leukemia characterized by predominant immature erythroid population. Its occurrence subsequent to acute myelomonocytic leukemia has not been reported before. We reported this rare case to call attention because it may pose a diagnostic challenge. Read More

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Shorter anogenital distance is observed in patients with testicular microlithiasis using magnetic resonance imaging.

Insights Imaging 2021 Apr 12;12(1):46. Epub 2021 Apr 12.

Department of Radiology, Vejle Hospital, University of Southern Denmark, Beriderbakken 4, Vejle, Denmark.

Objective: To investigate the anogenital distance in patients with and without testicular microlithiasis (TML).

Methods: A total of 101 patients underwent a conventional standard clinical B-mode scrotal ultrasonography and scrotal MRI. The patients were divided into two groups: patients with TML and non-TML. Read More

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Drassanes Exprés: a public and confidential testing service for asymptomatic STIs with same-day result notification.

Sex Transm Infect 2021 Apr 12. Epub 2021 Apr 12.

Department of Microbiology, Vall d'Hebron University Hospital, Barcelona, Spain.

Background: STIs are a major public health concern. Screening programmes for asymptomatic users are key components of STI control. Traditional limitations of screening programmes include low population coverage and delays in treatments, thus reducing the expected impact on STI control. Read More

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Assessing the quality of cancer screening leaflets using the International Patient Decision Aids Standards instrument: A cross-sectional content analysis.

Patient Educ Couns 2021 Apr 2. Epub 2021 Apr 2.

Association of Medical Journalism, Japan.

Objective: To assess the quality of national cancer screening program leaflets in Japan from the informed-decision perspective.

Methods: Cross-sectional content analysis of invitation leaflets issued by centralized organizations and used nationwide in Japan was conducted. Three members independently evaluated the materials using International Patient Decision Aids Standards six-item minimum criteria for qualifying patient decision aids. Read More

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Application of Bacterial Nanocellulose in the Cancer Drug Delivery: A Review.

Curr Pharm Des 2021 Apr 12. Epub 2021 Apr 12.

Cellular and Molecular Endocrine Research Center, Research Institute of Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran. Iran.

Bacterial nanocellulose (BNC) is one of the natural biopolymers with unique features, the most important of which are nontoxicity, biocompatibility, high tensile profile, nanofiber structure, and purity. The current review aimed to summarize the latest development in BNC-based biomaterials in cancer drug delivery. The original articles were found by searching key databases including PubMed, Scopus, and Web of Scientific and using key terms such as "bacterial nanocellulose OR bacterial cellulose OR BNC" AND "cancer OR carcinoma OR tumor". Read More

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Healthcare professionals' views of the use of oral morphine and transmucosal diamorphine in the management of paediatric breakthrough pain and the feasibility of a randomised controlled trial: A focus group study (DIPPER).

Palliat Med 2021 Apr 13:2692163211008737. Epub 2021 Apr 13.

Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

Background: Oral morphine is frequently used for breakthrough pain but the oral route is not always available and absorption is slow. Transmucosal diamorphine is administered by buccal, sublingual or intranasal routes, and rapidly absorbed.

Aim: To explore the perspectives of healthcare professionals in the UK caring for children with life-limiting conditions concerning the assessment and management of breakthrough pain; prescribing and administration of transmucosal diamorphine compared with oral morphine; and the feasibility of a comparative clinical trial. Read More

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A generic emergency protocol for patients with inborn errors of metabolism causing fasting intolerance: a retrospective, single-center study and the generation of www.emergencyprotocol.net.

J Inherit Metab Dis 2021 Apr 12. Epub 2021 Apr 12.

Section of Metabolic Diseases, Beatrix Children's Hospital, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.

Introduction: Patients with inborn errors of metabolism causing fasting intolerance can experience acute metabolic decompensations. Long-term data on outcomes using emergency letters are lacking.

Methods: This is a retrospective, observational, single-center study of the use of emergency letters based on a generic emergency protocol in patients with hepatic glycogen storage diseases (GSD) or fatty acid oxidation disorders (FAOD). Read More

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The analysis of vaginal hysterectomy results depending on the uterine size.

Ginekol Pol 2021 Apr 12. Epub 2021 Apr 12.

Institute of Information Technology, Lodz University of Technology, Poland.

Objectives: Vaginal hysterectomy is one of the oldest but still rarely used minimally invasive techniques. Although new surgical methods making use of robots in laparoscopy have been introduced recently, when compared with vaginal hysterectomy, these approaches do not offer significant benefits for the patients and the doctors operating on them. The purpose of this study was a thorough analysis of vaginal removal of non-prolapsed uterus with benign pathology. Read More

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Effect of Meditation on Psychological and Functional Outcomes in Spinal Cord Injury Patients.

Int J Yoga 2021 Jan-Apr;14(1):36-42. Epub 2021 Feb 5.

Indian Spinal Injuries Centre, New Delhi, India.

Background: Spinal cord injury (SCI) is a debilitating disorder with dysfunction in daily activities and psychological consequences like anxiety as well as depression impacting the quality of life substantially. Existing treatments focus mainly on rehabilitation, symptom reduction, and secondary complications. However, psychological, social, and existential issues are least addressed in the prevailing models. Read More

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February 2021