463,330 results match your criteria group controlled

A non-inferiority randomized controlled clinical trial comparing Unani formulations & PUVAsol in non-segmental vitiligo.

J Complement Integr Med 2021 Jun 23. Epub 2021 Jun 23.

Department of Moalajat, Luqman Unani Medical College Hospital & Research Center, Bijapur, Karnataka, India.

Objectives: Greco-Arab medicine is an ancient system of medicine with greater treasure on therapeutics of vitiligo. The trial Unani formulations have not been scientifically explored for their safety and efficacy, but have been repeatedly prescribed by the great Unani physicians in the management of (vitiligo). Hence, these interventions were selected for the trial. Read More

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Dinoprostone vaginal insert (DVI) versus adjunctive sweeping of membranes and DVI for term induction of labor.

J Obstet Gynaecol Res 2021 Jun 23. Epub 2021 Jun 23.

Department of Obstetrics & Gynaecology, St George's University of London, London, UK.

Aim: To compare the efficacy and safety of dinoprostone vaginal insert (DVI) alone versus DVI with adjunctive sweeping of membranes (ASM) for induction of labor (IOL).

Methods: Single-center, prospective, randomized controlled trial; women with singleton term pregnancies, cervical dilation ≥1 and <3 cm, intact membranes allocated to either DVI or DVI with ASM. The primary outcome was vaginal delivery within 24 h of insertion. Read More

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Structural Validity of the Hospital Anxiety and Depression Scale Among Family Members of Critically Ill Patients.

Am J Crit Care 2021 May;30(3):212-220

Ronald L. Hickman Jr is an associate professor of nursing and associate dean for research, Frances Payne Bolton School of Nursing, Case Western Reserve University.

Background: The Hospital Anxiety and Depression Scale (HADS) is commonly used clinically and scientifically among surrogate decision makers for critically ill patients. The validity of the HADS has been scrutinized, but its use among surrogate decision makers has not been examined.

Objective: To examine the structural validity of the HADS. Read More

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Can Xenobiotics Alter the Sex Ratio of Crocodilians in the Wild?

Satomi Kohno

Sex Dev 2021 Jun 23:1-8. Epub 2021 Jun 23.

Aquatic Toxicology Laboratory, Department of Biological Sciences, Saint Cloud State University, St. Cloud, Minnesota, USA.

All crocodilians exhibit temperature-dependent sex determination without sex chromosomes. This temperature dependency can be overridden by exposure to estrogen via estrogen receptor 1. Thus, the sex ratio of crocodilian species is vulnerable to estrogenic xenobiotics. Read More

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Effectiveness of Acupuncture for Poststroke Aphasia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Complement Med Res 2021 Jun 23:1-11. Epub 2021 Jun 23.

South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China.

Background: Aphasia is one of the common complications of stroke, and it considerably influences the quality of life of patients. Acupuncture, a therapy used in traditional Chinese medicine for aphasia after stroke, has potential therapeutic effects. We aimed to investigate the therapeutic effect of acupuncture on individuals with poststroke aphasia. Read More

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Effects of a Video-Based mHealth Program for Homebound Older Adults: Study Protocol for a Pilot Randomized Controlled Trial.

Gerontology 2021 Jun 23:1-8. Epub 2021 Jun 23.

The Hong Kong Lutheran Social Service, Homantin, Hong Kong, China.

Background: Although homebound older adults are among the highest users of hospital services, the existing health and social services that are provided to them in the community are limited and fragmented. This study attempts to bring this group of older adults to providers' attention by designing a health-social-oriented self-care mobile Health (mHealth) program and subjecting it to empirical testing. The aim of this study is to shift the current reactive, cure-oriented approach to a preventive and health-promoting model, empowering homebound older adults to take an active role in their health, be responsive to their care needs, and subsequently improve their holistic health. Read More

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The effect of selected in ovo green light photostimulation periods on post-hatch broiler growth and somatotropic axis activity.

Poult Sci 2021 Apr 30;100(8):101229. Epub 2021 Apr 30.

Department of Animal Sciences, The Hebrew University of Jerusalem, Robert H. Smith Faculty of Agriculture, Food and Environment, Rehovot 76100, Israel.

Targeted in ovo green light (GL) photostimulation during the last days of broiler egg incubation increases embryonic expression of the somatotropic axis, similar to in ovo green light photostimulation from embryonic day (ED) 0 to the end of incubation. The aim of this study was to examine the effect of selected in ovo GL photostimulation periods on post-hatch broiler growth. Four hundred twenty fertile broiler eggs were divided into 7 treatment groups: the first incubated in the dark (standard conditions) as a negative control; the second incubated under monochromatic GL from ED0-ED20 (positive control); the third group incubated under monochromatic GL light from ED15-ED20; the fourth, fifth and sixth groups were incubated under monochromatic GL on ED16, ED17, and ED18, respectively; and the seventh group was incubated under monochromatic GL from ED18-ED20. Read More

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Correlation between ambulatory blood pressure monitoring and office blood pressure measurement in patients with hypertension: A Community Study.

Am J Med Sci 2021 Jun 20. Epub 2021 Jun 20.

Medical Affairs Department, Eris Life Sciences, Ahmedabad. Electronic address:

Background: The current gold standard for blood pressure (BP) measurements is based on office BP measurements (OBPMs) by a sphygmomanometer or a digital device. Ambulatory BP measurement (ABPM) is a noninvasive method for continuous monitoring of BP over a 24-hour period during routine activities of the patient. Thus, ABPM offers multiple BP readings during the patients' daily routine as compared to the single reading by OBPM at rest. Read More

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Neuropathic cancer pain in patients treated with an EGFR-inhibitor.

J Pain Symptom Manage 2021 Jun 20. Epub 2021 Jun 20.

Department of Research, Sørlandet Hospital Trust, Kristiansand, Norway.

Context: Novel treatments of neuropathic pain (NP) are urgently needed. Based on repeated observation of rapid relief of neuropathic cancer pain (NCP) after single doses of intravenous epidermal growth factor receptor inhibitor (EGFR-I), we have successfully treated patients with and without cancer who suffer from severe, treatment-refractory NP with EGFR-Is. Pain research is complicated by endpoint subjectivity. Read More

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Selfcare Management Intervention in Heart Failure (SMART-HF) -A multicentre randomized controlled trial.

J Card Fail 2021 Jun 20. Epub 2021 Jun 20.

Department of Clinical Sciences, Lund University, Malmö, Sweden. Electronic address:

Background: Self-care behaviour is important in avoiding hospitalization for patients with heart failure (HF) and refers to those activities performed with the intention of improving or restoring health and well-being, as well as treating or preventing disease. The purpose was to study the effects of a home-based mobile device on self-care behaviour and hospitalizations in a representative HF-population.

Methods And Results: SMART-HF is a randomized controlled multi-centre clinical trial, where patients were randomized 1:1 to receive standard care (control group, CG) or intervention with a home-based tool designed to enhance self-care behaviour (intervention group, IG) and followed for 240 days. Read More

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Azithromycin or Doxycycline for Asymptomatic Rectal .

N Engl J Med 2021 Jun;384(25):2418-2427

From the University of Melbourne (A.L., F.Y.S.K., S.P., E.P.F.C., N.C., J.S.H.), the Melbourne Sexual Health Centre (C.K.F., M.Y.C., C.S.B., E.P.F.C., J.S.H.), and Monash University (C.K.F., M.Y.C., C.S.B., E.P.F.C.), Melbourne, VIC, Macquarie University, Macquarie, NSW (J.A.), Central Clinical School, Faculty of Medicine and Health, University of Sydney (D.J.T.), Sydney Sexual Health Centre (A.M., B.D.), and the School of Population Health (A.M.) and the Kirby Institute (D.J.T., M.L., B.D., D.G.R., J.K., J.A.), University of New South Wales, Sydney, the Department of Sexual Health Medicine and Sexual Assault Medicine, Sydney Local Health District, Camperdown, NSW (D.J.T.), Western Sydney Sexual Health Centre, Parramatta, NSW, and Westmead Clinical School, University of Sydney, Westmead, NSW (D.A.L.), the Adelaide Sexual Health Centre (C.K., M.R.) and the University of Adelaide (M.A.B.), Adelaide, SA, and the University of the Sunshine Coast, Sippy Downs, QLD (P.T.) - all in Australia.

Background: Rectal chlamydia is a common bacterial sexually transmissible infection among men who have sex with men. Data from randomized, controlled trials are needed to guide treatment.

Methods: In this double-blind trial conducted at five sexual health clinics in Australia, we randomly assigned men who have sex with men and who had asymptomatic rectal chlamydia to receive doxycycline (100 mg twice daily for 7 days) or azithromycin (1-g single dose). Read More

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Changes in Biomarkers of Cigarette Smoke Exposure After 6 Days of Switching Exclusively or Partially to Use of the JUUL System with Two Nicotine Concentrations: A Randomized Controlled Confinement Study in Adult Smokers.

Nicotine Tob Res 2021 Jun 23. Epub 2021 Jun 23.

Pinney Associates, Inc., Bethesda MD.

Introduction: Evidence suggests that cigarette smokers who switch to electronic nicotine delivery systems (ENDS) reduce their exposure to harmful toxicants and carcinogens. It is unclear if dual use is associated with decreases in exposure to toxicants.

Methods: This parallel-group confinement study assessed changes in biomarkers of exposure (BOEs) over six days among healthy adult smokers who were randomized into 1 of 11 study groups: eight JUUL-brand System (JUUL) groups (4 JUUL flavors [Virginia Tobacco, Menthol, Mint, Mango] × 2 nicotine concentrations [5. Read More

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A Randomized Controlled Trial Evaluating a Pain Assessment and Management Program for Respite Workers Supporting Children With Disabilities Part One: Pain-Related Knowledge and Perceptions.

Am J Intellect Dev Disabil 2021 Jul;126(4):271-288

Lara M. Genik, Elisabeth L. Aerts, and Paula C. Barata, University of Guelph, Ontario, Canada.

This parallel group randomized controlled trial tested effectiveness of the Let's Talk About Pain training on respite workers' (RW) pain-related knowledge and feasibility-confidence-skill ratings using between-group and within-group analyses. Fourteen children's respite organizations were randomized to pain or control training. Participants (nintervention = 66; ncontrol = 92) underwent a 3-3. Read More

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A Randomized Controlled Trial Evaluating a Pain Training for Respite Workers Supporting Children With Disabilities Part Two: Training Evaluations and the Impact of Training on Knowledge Application.

Am J Intellect Dev Disabil 2021 Jul;126(4):289-306

Lara M. Genik, Elisabeth L. Aerts, and Hiba Nauman, University of Guelph, Ontario, Canada.

Within a parallel-group randomized control trial, pain training's impact on Respite Workers' (RW) care approaches and training evaluations was explored. RW (n = 158) from 14 organizations received pain or control training following randomization. Researchers were blind until randomization; allocations were not shared explicitly with organizations/participants. Read More

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Risk of Death in the Elderly with Excessive Daytime Sleepiness, Insomnia and Depression: Prospective Cohort Study in an Urban Population in Northeast Brazil.

Arq Bras Cardiol 2021 Jun 18. Epub 2021 Jun 18.

Universidade Federal do Rio Grande do Norte - Odontologia, Natal, RN - Brasil.

Background: The close relationship between sleep regulation and cardiovascular events is one of the main focuses of research in contemporary medicine. Sleep habits and characteristics interfere with the cardiac rhythm and also with life expectancy, especially in the elderly.

Objective: To estimate the risk of death and cardiovascular events in community-dwelling elderly individuals complaining of insomnia and excessive daytime sleepiness over eight years of follow-up. Read More

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Transcutaneous electrical nerve stimulation and solifenacin succinate versus solifenacin succinate alone for treatment of overactive bladder syndrome: A double-blind randomized controlled study.

PLoS One 2021 23;16(6):e0253040. Epub 2021 Jun 23.

Department of Urology, The Second Hospital of Shandong University, Jinan, China.

Objective: We evaluated a combination of transcutaneous electrical nerve stimulation (TENS) and solifenacin succinate versus solifenacin alone in the treatment of overactive bladder (OAB).

Methods: Ninety-seven female outpatients with OAB were screened for this double-blind randomized controlled study. Eighty-six patients who met our inclusion criteria were divided randomly into two groups. Read More

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Microfracture Augmentation With Trypsin Pretreatment and Growth Factor-Functionalized Self-assembling Peptide Hydrogel Scaffold in an Equine Model.

Am J Sports Med 2021 Jun 23:3635465211021798. Epub 2021 Jun 23.

Department of Clinical Sciences, Orthopaedic Research Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.

Background: Microfracture augmentation can be a cost-effective single-step alternative to current cartilage repair techniques. Trypsin pretreatment combined with a growth factor-functionalized self-assembling KLD hydrogel ("functionalized hydrogel") has been shown to improve overall cartilage repair and integration to surrounding tissue in small animal models of osteochondral defects.

Hypothesis: Microfracture combined with trypsin treatment and a functionalized hydrogel will improve reparative tissue quality and integration as compared with microfracture alone in an equine model. Read More

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Manual Acupuncture Plus Usual Care Versus Usual Care Alone in the Treatment of Endometriosis-Related Chronic Pelvic Pain: A Randomized Controlled Feasibility Study.

J Altern Complement Med 2021 Jun 23. Epub 2021 Jun 23.

NICM Health Research Institute, Western Sydney University, Penrith, Australia.

To determine the acceptability and feasibility of acupuncture for the treatment of endometriosis-related chronic pelvic pain. A prospective, randomized controlled feasibility study. Outpatient setting in Sydney, Australia. Read More

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Glutathione Reductase-Sensitive Polymeric Micelles for Controlled Drug Delivery on Arthritic Diseases.

ACS Biomater Sci Eng 2021 Jun 23. Epub 2021 Jun 23.

3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco 4805-017, Guimarães, Portugal.

Inflammation plays an essential role in arthritis development and progression. Despite the advances in the pharmaceutical field, current treatments still present low efficacy and severe side effects. Considering the high activity of the glutathione reductase (GR) enzyme in inflamed joints, a distinctive drug delivery system sensitive to the GR enzyme was designed for efficient drug delivery on arthritic diseases. Read More

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Long-term response to cabergoline and multi-modal treatment in men with macroprolactinoma: does size really matter?

Clin Endocrinol (Oxf) 2021 Jun 23. Epub 2021 Jun 23.

Institute of Endocrinology, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel.

Objective: To study the outcome of men with macroprolactinoma following cabergoline treatment based on tumour size.

Design: Retrospective cohort study.

Methods: The study included 94 men, divided into 3 groups according to adenoma diameter: 10-19 mm (group A, n = 36); 20-39 mm (group B, n = 41); or ≥40 mm (group C, giant prolactinomas, n = 17). Read More

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A programme for early diagnosis of atrial fibrillation: a multi-centre study in primary care.

Fam Pract 2021 Jun 23. Epub 2021 Jun 23.

Atrial Fibrillation Unit, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.

Background: Atrial fibrillation (AF) is a morbid disease whose complications can be prevented if prompt and correctly treated.

Objective: To assess the usefulness of an early AF diagnosis programme in at-risk individuals in primary care centres.

Methods: In an open-label, multi-centre, controlled interventional study, individuals with one or more risk factors for AF but without known AF were enrolled. Read More

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Efficacy of Yukmijihwang-tang on symptoms of Alzheimer disease: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(25):e26363

Research Group of Neuroscience, East-West Medical Research Institute, WHO Collaborating Center.

Background: Alzheimer disease (AD) is the most common cause of dementia, which may lead to severe memory loss and other cognitive disorders. Yukmijihwang-tang (YMJ), a type of Korean traditional herbal medicine, has been shown to be effective against neurodegenerative diseases. Although a meta-analysis on the efficacy of YMJ on AD exists, the study had some limitations, and there have been several newly published studies assessing the effect of YMJ. Read More

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Self-administered acupressure for chronic severe functional constipation: A study protocol for a randomized controlled trial.

Medicine (Baltimore) 2021 Jun;100(25):e26349

Department of Intervertebral Discs, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, China.

Background: Functional constipation is a disease with a high incidence, which has a bad effect on general health, mental health, and social functioning. However, current treatment is sometimes unsatisfactory. Acupuncture has been proven effective in some randomized controlled trials. Read More

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The effect of face-to-face and virtual prenatal care training of spouses on the pregnancy experience and fear of childbirth of primiparous women: A controlled quasi-experimental study.

J Telemed Telecare 2021 Jun 23:1357633X211024101. Epub 2021 Jun 23.

Department of Biostatistics, Nursing Care Research Center, 440827Iran University of Medical Sciences, Tehran, Iran.

Introduction: The spouse has a special role in promoting the health of mothers and infants during pregnancy, childbirth, and postpartum. Women's health during pregnancy requires the participation and cooperation of their spouses. Therefore, this study was conducted to determine the effect of face-to-face and virtual prenatal care training of spouses on the pregnancy experience and fear of childbirth of primiparous women. Read More

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The optimal choice for pancreatic anastomosis after pancreaticoduodenectomy: a network meta-analysis.

Yujie Li Rong Hua

Minerva Surg 2021 Jun 23. Epub 2021 Jun 23.

Department of Pancreaticobiliary Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China -

Introduction: Postoperative pancreatic fistula (POPF) remains a major cause of morbidity following pancreaticoduodenectomy (PD). This network meta-analysis (NMA) compared techniques of pancreatic anastomosis following PD to determine the technique with the best outcome profile.

Evidence Acquisition: A systematic literature search was performed on the Scopus, EMBASE, Medline and Cochrane databases to identify RCTs employing the international study group of pancreatic fistula(ISGPF) definition of POPF. Read More

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Comparison of flow characteristics in a bench-scale system with commercial-scale pipelines: Use of computational fluid dynamics (CFD).

J Food Sci 2021 Jun 23. Epub 2021 Jun 23.

Dale A. Seiberling Food Engineering Laboratory, Department of Food Science and Technology, The Ohio State University, Columbus, Ohio.

The challenges for scale-up are often encountered in cleaning operations during the interpretation of data from clean-in-place (CIP) research. The objective of this investigation was to design and characterize flow characteristics in a bench-scale system in a manner that evaluates scale-up to a commercial-scale CIP operation. A bench-scale temperature-controlled vessel was designed for evaluation of in-place cleaning, and for development of scale-up parameters. Read More

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Effectiveness of Exergame Intervention on Walking in Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Phys Ther 2021 Jun 21. Epub 2021 Jun 21.

Faculty of Sport and Health Sciences, University of Jyväskylä, FI-40014 Jyväskylä, Finland.

Objective: The objective of this review was to systematically evaluate the effectiveness of exergaming on walking in older adults. In addition, the aim was to investigate the relationship between the exergaming effect and age, baseline walking performance, exercise traits, technology used and the risk of bias.

Methods: A literature search was carried out in the databases MEDLINE, CINAHL, CENTRAL, EMBASE, WoS, PsycInfo and PEDro up to January 10, 2020. Read More

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Wiad Lek 2021 ;74(6):1439-1444


Objective: The aim: Of this publication is to evaluate the results of EPEA in functionally healthy respondents and patients with NCDs to deepen fundamental knowledge of Systemic Medicine, increase the effectiveness of measures to prevent and treat NCDs by improving their diagnosis and prevention through the introduction of modern science-intensive technologies.

Patients And Methods: Materials and methods: 114 respondents were included in an open non-randomized controlled study. 66 сcomorbid patients (71% - men; median age - 61(43; 80) years) with verified Ischemic Heart Disease: functional class II-III angina pectoris were included in the Main Group. Read More

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Postoperative analgesic effect of ultrasound-guided rectus sheath block and local anesthetic infiltration after laparoscopic cholecystectomy: Results of a prospective randomized controlled trial.

Asian J Endosc Surg 2021 Jun 22. Epub 2021 Jun 22.

Department of Surgery, Shiga University of Medical Science, Otsu, Japan.

Introduction: Even if laparoscopic cholecystectomy (LC) has lower invasiveness through small incisions compared with laparotomy, postoperative pain control is important.

Methods: This prospective, randomized, single-blinded, interventional, single-center study was conducted from December 2016 to March 2018 at the Shiga University of Medical Science Hospital in Japan. Enrolled patients were assigned to either a rectus sheath block (RSB) group or an infiltrative local anesthesia (LA) group. Read More

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The impact of autologous concentrated growth factors on the alveolar ridge preservation after posterior tooth extraction: A prospective, randomized controlled clinical trial.

Clin Implant Dent Relat Res 2021 Jun 23. Epub 2021 Jun 23.

First Clinical Division, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China.

Background: Alveolar ridge preservation can effectively decrease alveolar ridge resorption following tooth extraction, but it can be limited by reducing new bone formation and residual bone graft material. Efforts to develop more efficacious approaches are thus an area of active research.

Purpose: To assess the impact of autologous concentrated growth factors (CGF) on alveolar ridge absorption and osteogenesis following posterior tooth extraction. Read More

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