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[Effects of normobaric hyperoxia intervention on renal ischemia-reperfusion injury in rats].

Zhonghua Yi Xue Za Zhi 2021 Apr;101(14):1036-1040

Department of Nephrology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.

To investigate the effects of normobaric hyperoxia intervention on renal ischemia-reperfusion injury in rats and its possible mechanism. Twenty-one adult male SD rats were enrolled and their right kidneys were excised. After two weeks, they were randomly assigned to 3 groups, with 7 rats in each group, namely sham-operated group (Group S), ischemia-reperfusion group (Group I/R), and normobaric hyperoxia+ischemia-reperfusion group (Group NBHO+I/R). Read More

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[Characteristics of esophageal motility and clinical presentation in gastroesophageal reflux disease patients of different age groups].

Zhonghua Yi Xue Za Zhi 2021 Apr;101(14):1015-1019

Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China;Academy of Chinese Medical Sciences, Beijing 100102, China.

To explore the characteristics of esophageal motility and clinical presentation in gastroesophageal reflux disease (GERD) patients of different age groups. This was a case-control study. Confirmed GERD patients in the Department of Gastroenterology of Peking Union Medical College Hospital from January 2015 to September 2018 were enrolled and divided into two groups: elderly group (≥60 years old) and young and middle-aged group (<60 years old). Read More

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[Effect of the pessary treatment on anxiety disorder in patients with symptomatic pelvic organ prolapse].

Zhonghua Yi Xue Za Zhi 2021 Apr;101(14):1009-1014

Department of Obstetrics & Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing 100730, China.

To evaluate the effect of the pessary treatment on general anxiety disorder in patients with symptomatic pelvic organ prolapse (POP). Between December 2018 and January 2020, 213 patients who received the pessary treatment for symptomatic POP in the Peking Union Medical College Hospital (PUMCH) were enrolled in this prospective observational study. Accepting the pessary successfully means that the patient keeping the pessary for 2 weeks were satisfied with it and willing to use it afterwards, or means that the patient having changed a new pessary and keeping it for 2 weeks were satisfied with it and willing to use it afterwards. Read More

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[Risk factors of massive introperative blood loss in posterior spinal fusion for adolescent idiopathic scoliosis].

Zhonghua Yi Xue Za Zhi 2021 Apr;101(14):1002-1008

Department of Anesthesiology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing 210008, China.

To investigate the risk factors and prognostic impact of massive introperative blood loss in posterior spinal fusion (PSF) surgery for adolescent idiopathic scoliosis (AIS). Clinical data were collected of 1 896 AIS patients who underwent PSF surgery under general anesthesia in Drum Tower Hospital Affiliated to Nanjing University Medical School from November 2010 to October 2019 and retrospectively analyzed. According to the volume of intraoperative blood loss, the patients were divided into the massive introperative blood loss group [estimated blood loss (EBL)/estimated blood volume (EBV)≥30%] and the non-massive introperative blood loss group (EBL/EBV<30%). Read More

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Prevalence of Sarcopenia Among the Elderly in Korea: A Meta-Analysis.

J Prev Med Public Health 2021 Mar 4;54(2):96-102. Epub 2021 Mar 4.

Department of Physical Medicine and Rehabilitation, Yeungnam University College of Medicine, Daegu, Korea.

Objectives: Sarcopenia is a common disease in the elderly population that causes disability, poor quality of life, and a high risk of death. In the current study, we conducted a meta-analysis to report basic knowledge about the prevalence of sarcopenia in the elderly in Korea.

Methods: We searched for articles in the MEDLINE, Cochrane Library, Embase, and Scopus databases published until December 28, 2020. Read More

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Effectiveness of antibiotic prophylaxis in patients with centipede stings: a randomized controlled trial.

Clin Exp Emerg Med 2021 Mar 31;8(1):43-47. Epub 2021 Mar 31.

Department of Emergency Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Objective: Centipede stings are a common problem in tropical countries. Current treatment guidelines do not include recommendations for antibiotic prophylaxis to prevent the associated bacterial infection since no previous study has assessed the effectiveness of antibiotic treatment in patients bitten by centipedes. Thus, this study aimed to compare the effectiveness of antibiotic prophylaxis over placebo for the skin infections that occur after a centipede sting. Read More

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HIV and Surgery for Degenerative Spine Disease: A Systematic Review.

J Neurol Surg A Cent Eur Neurosurg 2021 Apr 12. Epub 2021 Apr 12.

Health Sciences Postgraduate Program, University of Caxias do Sul, Caxias do Sul, RS, Brazil.

Background And Study Aims:  The objective of this review is to evaluate the incidence of operative treatment, outcomes, and complications of surgery for degenerative spine disease (DSD) on human immunodeficiency virus (HIV) positive patients. Combined antiretroviral treatment led HIV patients to live long enough to develop many chronic conditions common in the uninfected population. Surgery for DSD is one of the most commonly performed neurosurgical procedures. Read More

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Reconstruction of Craniectomy for Microvascular Decompression with Autologous Particulate Bone.

J Neurol Surg A Cent Eur Neurosurg 2021 Apr 12. Epub 2021 Apr 12.

Department of International Education, Tongji Medical College, Huazhong University of science and Technology, Wuhan, China.

Background And Study Objective:  Cranioplasty after microvascular decompression (MVD) is important for preventing postoperative complications such as headache. Autologous particulate bone is a common material for cranioplasty. The purpose of this study was to evaluate the effect of using autologous particulate bone to reconstruct the cranial defect produced by MVD. Read More

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Alloplastic or Autologous? Bone Chips versus PEEK Cage for Lumbar Interbody Fusion in Degenerative Spondylolisthesis.

J Neurol Surg A Cent Eur Neurosurg 2021 Apr 12. Epub 2021 Apr 12.

Department of Neurosurgery, University Hospital Würzburg, Würzburg, Germany.

Introduction:  This study was conducted to compare bone-filled intervertebral cages with autologous bone chips for instrumented lumbar interbody fusion in patients with spinal stenosis and degenerative spondylolisthesis.

Methods:  Surgery consisted of posterior instrumentation and decompression, diskectomy, and intervertebral fusion using a polyetheretherketone (PEEK) cage surrounded and filled with spongious bone chips (group 1,  = 57) or spongious bone chips alone (group 2,  = 37). The choice of method was left to the discretion of the surgeon. Read More

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The Influence of Music on Neurosurgical Cases: A Neglected Knowledge.

J Neurol Surg A Cent Eur Neurosurg 2021 Apr 12. Epub 2021 Apr 12.

Division of Neurosurgery, Department of Clinical Medicine, University Witten/Herdecke, Witten, Nordrhein-Westfalen, Germany.

Background:  The human brain can respond to and participate in music. Learning to play a musical instrument requires complex multimodal skills involving the simultaneous perception of several sensory modalities. In case of brain damage, the musician and nonmusician brains may have different capacities for reorganization and neural remapping. Read More

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Health Care Utilization and Associated Economic Burden of Postoperative Surgical Site Infection after Spinal Surgery with Follow-Up of 24 Months.

J Neurol Surg A Cent Eur Neurosurg 2021 Apr 12. Epub 2021 Apr 12.

Department of Neurosurgery, University of Louisville, Louisville, Kentucky, United States.

Background:  Surgical site infection (SSI) may lead to vertebral osteomyelitis, diskitis, paraspinal musculoskeletal infection, and abscess, and remains a significant concern in postoperative management of spinal surgery. SSI is associated with greater postoperative morbidity and increased health care payments.

Methods:  We conducted a retrospective analysis using MarketScan to identify health care utilization payments and risk factors associated with SSI that occurs postoperatively. Read More

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Physicians' perceptions of their knowledge and the preparedness of health facilities in Angola to diagnose and manage COVID-19.

Int Health 2021 Apr 12. Epub 2021 Apr 12.

CISA - Health Research Centre of Angola, Caxito, Bengo, Angola.

Background: Healthcare professionals represent a vulnerable group in terms of responding to COVID-19. Knowledge can influence healthcare professionals through adoption of the correct attitudes and practices. The aim of this study was to evaluate, by a questionnaire, the perceptions of physicians about their level of knowledge as well as conditions in their workplaces for dealing with COVID-19. Read More

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Central Nervous System International Prognostic Index Impacts Overall Survival in Diffuse Large B-cell Lymphoma Treated with R-Chop in a third Level Cancer Center from Mexico: A Survey of 642 Patients.

Rev Invest Clin 2021 Apr 12. Epub 2021 Apr 12.

Department of Division of Clinical Research, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.

Background: Central nervous system international prognosis index (CNS-IPI) is validated in European and the USA cancer databases. However, no validation has been done in Mexican population.

Objective: The objective of the study was to assess the impact of the CNS-IPI on central nervous system (CNS) relapse and survival in Mexican patients with diffuse large B-cell lymphoma (DLBCL). Read More

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Efficacy and Safety of Cone-Beam Computed Tomography-Derived Augmented Fluoroscopy Combined with Endobronchial Ultrasound in Peripheral Pulmonary Lesions.

Respiration 2021 Apr 12:1-9. Epub 2021 Apr 12.

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.

Background: The diagnostic yield of peripheral pulmonary lesions (PPLs) using radial endobronchial ultrasound (EBUS) remains challenging without navigation systems. Cone-beam computed tomography-derived augmented fluoroscopy (CBCT-AF) represents a recently developed technique, and its clinical utility remains to be investigated.

Objectives: The aim of this study was to investigate the diagnostic yield of transbronchial biopsy (TBB) using a combination of CBCT-AF and radial EBUS. Read More

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Neuroprotective Effects of Long-Term Metformin Preconditioning on Rats with Ischemic Brain Injuries.

Eur Neurol 2021 Apr 12:1-7. Epub 2021 Apr 12.

Department of Medicine, Xi'an Jiao Tong University, Xi'an, China.

Introduction: This study is to analyze the neuroprotective effects of long-term metformin (Met) preconditioning on rats with ischemic brain injuries and the related mechanisms.

Methods: Twenty-five Sprague-Dawley rats were randomly divided into 5 groups: sham group, middle cerebral artery occlusion (MCAO) group, normal saline + MCAO group, pre- Met + MCAO group, and 3-MA + Met + MCAO group. Pathological changes of brain were observed by hematoxylin-eosin staining. Read More

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Early PARacetamol (EPAR) Trial: A Randomized Controlled Trial of Early Paracetamol to Promote Closure of the Ductus Arteriosus in Preterm Infants.

Neonatology 2021 Apr 12:1-8. Epub 2021 Apr 12.

Department of Newborn Care, Royal Hospital for Women, Sydney, New South Wales, Australia.

Introduction: This study aimed to investigate whether early treatment with paracetamol reduces the number of infants requiring intervention for patent ductus arteriosus (PDA) and assess the safety profile of paracetamol during the early postnatal period.

Methods: This was a double-blind, parallel, randomized, placebo-controlled trial. Preterm infants born at <29-week gestation with a ductus arteriosus >0. Read More

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Functionalization of Electronic, Spin and Optical Properties of GeSe Monolayer by Substitutional Doping: A First-Principles Study.

Nanotechnology 2021 Apr 12. Epub 2021 Apr 12.

Electrical and Electronic Engineering, Bangladesh University of Engineering and Technology, Dhaka, Dhaka District, BANGLADESH.

Substitutional doping has traditionally been used to modulate the existing properties of semiconductors and introduce new exciting properties, especially in two-dimensional materials. In this work, we have investigated the impact of substitutional doping (using group III, IV, V, and VI dopants) on the structural, electronic, spin, and optical properties of GeSe monolayer by using first-principles calculations based on density functional theory. Our calculated binding energies, formation energies and phonon dispersion curves of the doped systems support their stability and hence the feasibility of physical realization. Read More

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Accelerating Advances in Cancer Care Research: A Lookback at the 21st Century Cures Act in 2020.

J Natl Compr Canc Netw 2021 Apr 1;19(4):378-384. Epub 2021 Apr 1.

1National Comprehensive Cancer Network, Plymouth Meeting, Pennsylvania.

The 21st Century Cures Act (Cures Act), signed into law in 2016, was designed to advance new therapies by modernizing clinical trials, funding research initiatives, and accelerating the development and use of health information technology. To analyze the current issues in cancer care related to the implementation and impact of the Cures Act, NCCN convened a multistakeholder working group. Participants discussed the legislation's impact on the oncology community since enactment and identified the remaining gaps and challenges as experienced by stakeholders. Read More

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Stimulated biodegradation of all alkanes in soil.

Chemosphere 2021 Apr 5;278:130444. Epub 2021 Apr 5.

School of Environmental and Municipal Engineering, Xi'an University of Architecture and Technology, 710055, Shaanxi, Xi'an, China; Key Laboratory of Northwest Water Resources, Environment and Ecology, MOE, China; Key Laboratory of Environmental Engineering, Shaanxi Province, China.

This study aim to investigate the biodegradation of all alkanes in soil by adding stimulater and indigenous bacteria. The experiments were carried out by adding native bacteria and the stimulater to the soil S1 (total petroleum hydrocarbon (TPH) = 22,745 mg/kg) and soil S2 (TPH = 13,833 mg/kg) to explored the effect and mechanism of the stimulated biodegradation of all alkanes in soil. The results showed that most alkanes were used as the main carbon source of TPH in the late stimulation stage, so that all alkanes could be biodegraded by stimulating. Read More

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A simple, rapid and sensitive method for the simultaneous determination of eighteen environmental phenols in human urine.

Chemosphere 2021 Apr 5;278:130494. Epub 2021 Apr 5.

Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. Electronic address:

Environmental phenols are a typical group of endocrine disrupting compounds (EDCs) and have caused growing concerns upon the potential adverse effects on humans. Urinary concentrations of phenols can be used as valid biomarkers for the assessment of human exposure. A method was developed for the simultaneous determination of eighteen environmental phenols (six parabens, seven bisphenols, four benzophenones and triclosan) in human urine using liquid-liquid extraction (LLE) coupled to high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Read More

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Emotional processing in panic disorder and its subtypes: An fMRI study using emotional faces.

J Affect Disord 2021 Mar 31;287:427-432. Epub 2021 Mar 31.

Department of Psychiatry and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.

Background: Inconsistent findings regarding the pathophysiology of panic disorder (PD) could result from clinical heterogeneity. Identifying subtypes could enhance insights into the neurobiological substrates of PD.

Methods: An emotional faces fMRI paradigm was used in a group of PD patients (n = 73) and healthy controls (n = 58). Read More

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Detection of Myocardial Infarction by Cardiac Magnetic Resonance in Embolic Stroke Related to First Diagnosed Atrial Fibrillation.

J Stroke Cerebrovasc Dis 2021 Apr 9;30(6):105753. Epub 2021 Apr 9.

Department of Cardiology, Dijon University Hospital, 21000 Dijon, France. Electronic address:

Introduction: Elevated troponin levels are found in a significant number of patients who are diagnosed with acute embolic stroke (AES) after first diagnosed atrial fibrillation (AF). These myocardial injuries, which are known as cardiocerebral infarction (CCI), are potentially caused by coronary embolism and correspond to simultaneous cardiac and cerebral embolisms. However, this severe condition remains poorly understood. Read More

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Seed tannin composition of tropical plants.

Phytochemistry 2021 Apr 9;187:112750. Epub 2021 Apr 9.

Natural Chemistry Research Group, Department of Chemistry, University of Turku, FI-20014, Turku, Finland. Electronic address:

Seeds collected from trees, shrubs and lianas growing on Barro Colorado Island, Panama, were analyzed for their content of phenolic compounds, oxidative activities and protein precipitation capacities. Proanthocyanidins and hydrolysable tannins were detected in one-third of 189 studied species. The most oxidatively active group of species were the ones containing prodelphinidins and ellagitannins whereas the species that had the highest protein precipitation capacity in relation to their total phenolics were the ones containing punicalagin. Read More

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Duration of overlap during lumbar fusion does not predict outcomes.

Clin Neurol Neurosurg 2021 Mar 25;205:106610. Epub 2021 Mar 25.

Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

Introduction: The relationship between degree of surgical overlap and adverse postoperative outcomes remains poorly defined. This study aims to evaluate the impact of increasing duration of overlap on lumbar fusion outcomes.

Patients And Methods: 1302 adult patients undergoing overlapping surgery during single-level, posterior-only lumbar fusion at a multi-hospital, university health system were retrospectively assessed. Read More

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Effect of oxidized β-carotene on the growth and feed efficiency of broilers.

Poult Sci 2021 Mar 4;100(6):101088. Epub 2021 Mar 4.

Avivagen, Inc., Ottawa, Ontario, Canada. Electronic address:

Fully oxidized β-carotene (OxBC) containing β-carotene-oxygen copolymers is proposed as an alternative to antimicrobial growth promoters. Two trials were conducted to determine the efficacy of OxBC in enhancing growth and feed intake (FI) in male and female Ross × Ross 308 broilers in Ontario, Canada, and in Ross 308 male broilers in the United Kingdom. In the first trial, 0, 1, 2, or 5 ppm OxBC were added to diets in a 20% cornstarch premix, whereas in the second trial, 0, 2, or 5 ppm OxBC were added in a 1% cornstarch or 1% corncob grits premix. Read More

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Risk factors for pregnancy morbidity in women with antiphospholipid syndrome.

J Reprod Immunol 2021 Mar 29;145:103315. Epub 2021 Mar 29.

Obstetrics and Gynecology Department, Peking University People's Hospital, Beijing, China. Electronic address:

Antiphospholipid syndrome (APS) increases the risk of obstetric complications, but risk factors for pregnancy morbidity in women with APS remain incompletely characterized. This retrospective study included pregnant women with APS and a control group without APS admitted to Peking University People's Hospital between January 2013 and September 2019. Clinical data were extracted from medical records. Read More

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Surface-Enhanced Raman scattering of methylene blue on titanium nitride nanoparticles synthesized by laser ablation in organic solvents.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Mar 19;257:119721. Epub 2021 Mar 19.

Atomic and Molecular Physics Group, Department of Physics, Faculty of Basic Sciences, Tarbiat Modares University, Tehran, P.O. Box 14115-175, Islamic Republic of Iran. Electronic address:

Suspensions of titanium nitride (TiN) nanoparticles (NPs) were prepared using nanosecond Ce:Nd:YAG pulsed laser ablation (λ = 1064 nm) of a TiN target immersed in various solvents such as Toluene (CHCH), Acetonitrile (CHCN), and N, N-dimethylformamide (CHNO). The synthesized NPs were characterized by applying a range of spectroscopic, structural, and compositional analysis techniques. The obtained TiN NPs in N, N-dimethylformamide (DMF-TiN NPs) solvent showed strong optical absorption in the near-infrared (NIR) range; Whereas, the obtained TiN NPs in toluene (T-TiN NPs) and acetonitrile (AN-TiN NPs) solvents were covered with a carbon matrix layer that quenched their surface plasmon resonance (SPR). Read More

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Barriers to a healthy postpartum lifestyle and the possibilities of an information technology-based intervention: A qualitative study.

Midwifery 2021 Apr 3;98:102994. Epub 2021 Apr 3.

Centre for Innovative Medical Technology, Odense University Hospital, Odense, Denmark; Department of Endocrinology, Odense University Hospital, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark. Electronic address:

Background: Being overweight or obese is associated with higher risk of adverse maternal and fetal outcomes, including gestational diabetes and childhood obesity. Many women exceed the gestational weight gain recommendations. Thus, it is important to focus on the women's lifestyle between their pregnancies to lower the risk of weight retention before the next pregnancy as well as in a life course perspective. Read More

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