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AGEs promote calcification of HASMCs by mediating Pi3k/AKT-GSK3β signaling.

Front Biosci (Landmark Ed) 2021 May;26(6):125-134

Department of General Surgery (Vascular Surgery), The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, China.

This study aimed to investigate the effects of advanced glycation end products (AGEs) on the calcification of human arterial smooth muscle cells (HASMCs) and to explore whether AGEs can promote the calcification of HASMCs by activating the phosphoinositide 3-kinase (PI3K)/AKT-glycogen synthase kinase 3 beta (GSK3-β) axis. Cultured HASMCs were divided into five groups: blank control group, dimethyl sulfoxide (vehicle) group, AGEs group, LY294002 (AKT inhibitor) group, and TWS119 (GSK3-β inhibitor) group. Cells were pretreated with either vehicle, LY294002, or TWS119 for 2 hours followed by incubation with AGEs (25 μg/mL) for 5 days, and the expression levels of proteins in each group were analyzed by western blotting. Read More

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Acetylsalicylic acid improves cognitive performance in sleep deprived adult Zebrafish () model.

Front Biosci (Landmark Ed) 2021 May;26(6):114-124

Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, 570015 Mysuru, India.

Sleep deprivation (SD) is commonly associated with decreased attention, reduced responsiveness to external stimuli, and impaired locomotor and cognitive performances. Strong evidence indicates that SD disrupts neuro-immuno-endocrine system which is also linked to cognitive function. Recently Zebrafish have emerged as a powerful model sharing organizational and functional characteristics with other vertebrates, providing great translational relevance with rapid and reliable screening results. Read More

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Evaluation of children with type 1 diabetes mellitus in terms of overweight/obesity in tertiary care hospital.

J Pediatr Endocrinol Metab 2021 Jun 23. Epub 2021 Jun 23.

Department of Pediatrics, Ondokuz Mayis University, Faculty of Medicine, Division of Pediatric Endocrinology, Samsun, Turkey.

Objectives: Obesity is a growing problem in type 1 diabetes mellitus (T1DM) today. The aim of our study is to determine the frequency of overweight/obesity at the time of diagnosis and during follow-up in children with T1DM as well as review the conditions that may accompany.

Methods: A total of 315 patients with T1DM were retrospectively analyzed. Read More

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Metabolic syndrome and cardiorespiratory fitness in children and adolescents: the role of obesity as a mediator.

J Pediatr Endocrinol Metab 2021 Jun 23. Epub 2021 Jun 23.

CIAFEL-Faculdade de Desporto, Universidade do Porto, Porto, Portugal.

Objectives: To analyse the prevalence and association between metabolic syndrome (MetS), clustered cardiometabolic risk (CCMR), obesity (body mass index [BMI], fat mass [FM] and waist circumference [WC]), and cardiorespiratory fitness (CRF); and to assess whether obesity (BMI, FM, and WC) acts as a mediator between CRF and MetS or CCMR.

Methods: This cross-sectional study included a subsample of the AFINA-te Study (n = 209; 11.51 ± 0. Read More

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MAN1B1-CDG: novel patients and novel variant.

J Pediatr Endocrinol Metab 2021 Jun 23. Epub 2021 Jun 23.

Department of Pediatrics, Center for Metabolic Diseases, KU Leuven, Leuven, Belgium.

Objectives: Congenital disorders of glycosylation (CDGs) are a group of genetic disorders due to hypoglycosylation of proteins and lipids. A type I pattern is associated with defects in glycan assembly and transfer (CDG-I; cytosol; and endoplasmic reticulum defects), a type II pattern is seen in processing defects of the Golgi apparatus. MAN1B1-CDG is an autosomal recessive CDG-II due to mutations in the 1,2-mannosidase gene (MAN1B1), mainly characterized by psychomotor disability, facial dysmorphism, truncal obesity, and hypotonia. Read More

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A non-inferiority randomized controlled clinical trial comparing Unani formulations & PUVAsol in non-segmental vitiligo.

J Complement Integr Med 2021 Jun 23. Epub 2021 Jun 23.

Department of Moalajat, Luqman Unani Medical College Hospital & Research Center, Bijapur, Karnataka, India.

Objectives: Greco-Arab medicine is an ancient system of medicine with greater treasure on therapeutics of vitiligo. The trial Unani formulations have not been scientifically explored for their safety and efficacy, but have been repeatedly prescribed by the great Unani physicians in the management of (vitiligo). Hence, these interventions were selected for the trial. Read More

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Dinoprostone vaginal insert (DVI) versus adjunctive sweeping of membranes and DVI for term induction of labor.

J Obstet Gynaecol Res 2021 Jun 23. Epub 2021 Jun 23.

Department of Obstetrics & Gynaecology, St George's University of London, London, UK.

Aim: To compare the efficacy and safety of dinoprostone vaginal insert (DVI) alone versus DVI with adjunctive sweeping of membranes (ASM) for induction of labor (IOL).

Methods: Single-center, prospective, randomized controlled trial; women with singleton term pregnancies, cervical dilation ≥1 and <3 cm, intact membranes allocated to either DVI or DVI with ASM. The primary outcome was vaginal delivery within 24 h of insertion. Read More

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Polycaprolactone Mesh for Asian Rhinoplasty: Outcomes and Complications of Composite Septal Extension Graft Compared to Mesh-Only Graft.

Facial Plast Surg 2021 Jun 23. Epub 2021 Jun 23.

Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Despite the great demand of aesthetic rhinoplasty in Asian population, it is difficult to obtain the lasting ideal tip projection along with lengthening of the nose due to the small and weak nasal septum. The shortage of available septal cartilage to work with is another major obstacle. A retrospective study was conducted between January 2017 and December 2019 in Seoul, Korea. Read More

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Structural Validity of the Hospital Anxiety and Depression Scale Among Family Members of Critically Ill Patients.

Am J Crit Care 2021 May;30(3):212-220

Ronald L. Hickman Jr is an associate professor of nursing and associate dean for research, Frances Payne Bolton School of Nursing, Case Western Reserve University.

Background: The Hospital Anxiety and Depression Scale (HADS) is commonly used clinically and scientifically among surrogate decision makers for critically ill patients. The validity of the HADS has been scrutinized, but its use among surrogate decision makers has not been examined.

Objective: To examine the structural validity of the HADS. Read More

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Implementing the Pediatric Family Satisfaction in the Intensive Care Unit (ICU) Survey in a Pediatric Cardiac ICU.

John Manna

Am J Crit Care 2021 May;30(3):230-236

John Manna is a family nurse practitioner, Lexington Medical Center, Lexington, South Carolina.

Background: Few responses to the Child Hospital Consumer Assessment of Healthcare Providers and Systems and no use of family satisfaction scores indicated the need to implement a program to collect and use family satisfaction data at a pediatric cardiac intensive care unit (ICU) at a southeastern academic medical center.

Objectives: To improve response rates for family satisfaction surveys, to identify future quality improvement initiatives, to receive qualitative feedback from key stakeholders, and to better understand nursing staff's satisfaction with the project implementation process.

Methods: A quality improvement program using the Pediatric Family Satisfaction in the Intensive Care Unit (pFS-ICU) survey was implemented to evaluate family satisfaction data from a pediatric cardiac ICU. Read More

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Impact of a Nurse-Driven Heparin Monitoring Protocol for Ventricular Assist Devices.

AACN Adv Crit Care 2021 Jun;32(2):146-151

Pamela B. Simone is Cardiology Clinical Pharmacist Specialist, Department of Pharmacy, UChicago Medicine, 5841 S Maryland Ave, Chicago, IL 60637

Background: Ventricular assist devices require anticoagulation to reduce thrombosis risk. Nurse-driven unfractionated heparin monitoring protocols have been validated for various indications, although data in patients with ventricular assist devices are lacking.

Objective: To evaluate a nurse-driven protocol for managing unfractionated heparin therapy in stable patients with ventricular assist devices. Read More

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Can Xenobiotics Alter the Sex Ratio of Crocodilians in the Wild?

Satomi Kohno

Sex Dev 2021 Jun 23:1-8. Epub 2021 Jun 23.

Aquatic Toxicology Laboratory, Department of Biological Sciences, Saint Cloud State University, St. Cloud, Minnesota, USA.

All crocodilians exhibit temperature-dependent sex determination without sex chromosomes. This temperature dependency can be overridden by exposure to estrogen via estrogen receptor 1. Thus, the sex ratio of crocodilian species is vulnerable to estrogenic xenobiotics. Read More

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Effectiveness of Acupuncture for Poststroke Aphasia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Complement Med Res 2021 Jun 23:1-11. Epub 2021 Jun 23.

South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China.

Background: Aphasia is one of the common complications of stroke, and it considerably influences the quality of life of patients. Acupuncture, a therapy used in traditional Chinese medicine for aphasia after stroke, has potential therapeutic effects. We aimed to investigate the therapeutic effect of acupuncture on individuals with poststroke aphasia. Read More

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Downregulation of ITM2A Gene Expression in Macrophages of Patients with Ankylosing Spondylitis.

Int Arch Allergy Immunol 2021 Jun 23:1-9. Epub 2021 Jun 23.

Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Objectives: Ankylosing spondylitis (AS) is a rheumatic disorder that is mostly determined by genetic and environmental factors. Given the known importance of macrophage in AS pathogenesis, we investigated the transcriptional profile of macrophage cells in the disease.

Methods And Results: Two approaches of differential expression and subsequently, weighted gene co-expression network analysis was utilized to analyze a publicly available microarray dataset of macrophages. Read More

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Association of Serum Sclerostin Level, Coronary Artery Calcification, and Patient Outcomes in Maintenance Dialysis Patients.

Blood Purif 2021 Jun 23:1-10. Epub 2021 Jun 23.

Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Objective: The objective of this study is to investigate the association between the serum sclerostin, the coronary artery calcification (CAC), and patient outcomes in maintenance dialysis patients.

Methods: We performed a prospective cohort study of 65 maintenance dialysis patients in 2014, including 39 patients on peritoneal dialysis and 26 on hemodialysis, and followed up for 5 years. Parameters of mineral metabolism including bone-specific alkaline phosphatase, fibroblast growth factor 23, sclerostin, and other biochemical factors were determined at the baseline. Read More

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Aging and Mesenchymal Stem Cells: Therapeutic Opportunities and Challenges in the Older Group.

Gerontology 2021 Jun 23:1-14. Epub 2021 Jun 23.

Hunan Key Laboratory of Oral Health Research, Hunan 3D Printing Engineering Research Center of Oral Care, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, and Xiangya School of Stomatology, Central South University, Changsha, China.

With aging, a portion of cells, including mesenchymal stem cells (MSCs), become senescent, and these senescent cells accumulate and promote various age-related diseases. Therefore, the older age group has become a major population for MSC therapy, which is aimed at improving tissue regeneration and function of the aged body. However, the application of MSC therapy is often unsatisfying in the aged group. Read More

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Effects of a Video-Based mHealth Program for Homebound Older Adults: Study Protocol for a Pilot Randomized Controlled Trial.

Gerontology 2021 Jun 23:1-8. Epub 2021 Jun 23.

The Hong Kong Lutheran Social Service, Homantin, Hong Kong, China.

Background: Although homebound older adults are among the highest users of hospital services, the existing health and social services that are provided to them in the community are limited and fragmented. This study attempts to bring this group of older adults to providers' attention by designing a health-social-oriented self-care mobile Health (mHealth) program and subjecting it to empirical testing. The aim of this study is to shift the current reactive, cure-oriented approach to a preventive and health-promoting model, empowering homebound older adults to take an active role in their health, be responsive to their care needs, and subsequently improve their holistic health. Read More

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Multiferroic order parameters in rhombic antiferromagnets RCrO3.

J Phys Condens Matter 2021 Jun 23. Epub 2021 Jun 23.

School of Materials Science and Engineering, Zhejiang University, 38 Zheda Road, Hangzhou, 310027, CHINA.

Currently, active research is focused on multiferroic rare-earth orthochromites (RCrO3), due to various structural instabilities and couplings in these materials understanding the underlying magnetoelectric mechanisms is a challenge. In this paper, we explore magnetoelectric properties of RCrO3 in the framework of symmetry analysis. We demonstrate the presence of electric dipole moments localized in the vicinity of Cr3+ ions in RCrO3. Read More

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ESB Clinical Biomechanics Award 2020: Pelvis and hip movement strategies discriminate typical and pathological femoral growth - Insights gained from a multi-scale mechanobiological modelling framework.

Clin Biomech (Bristol, Avon) 2021 Jun 5;87:105405. Epub 2021 Jun 5.

Human Movement Biomechanics Research Group, KU Leuven, Belgium.

Background: Many children with cerebral palsy (CP) develop skeletal deformities during childhood. So far, it is unknown why some children with CP develop bony deformities whereas others do not. The aims of this study were to (i) investigate what loading characteristics lead to typical and pathological femoral growth, and (ii) evaluate why some children with CP develop femoral deformities whereas other do not. Read More

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Polystyrene microplastics induce microbial dysbiosis and dysfunction in surrounding seawater.

Environ Int 2021 Jun 20;156:106724. Epub 2021 Jun 20.

Center for Excellence in Regional Atmospheric Environment, Institute of Urban Environment, Chinese Academy of Sciences, 1799 Jimei Road, Xiamen 361021, China; Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, 1799 Jimei Road, Xiamen 361021, China. Electronic address:

Microplastics are ubiquitously present in the environment, accumulate in aquaculture water, and cause toxicological effects on aquatic organisms. Besides, microplastics provide ecological niches for microorganisms in aquatic environments. However, the effects of microplastics on microbial balance and function in surrounding water are still unclear, especially for aquaculture water. Read More

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Firefighters' occupational exposure: Contribution from biomarkers of effect to assess health risks.

Environ Int 2021 Jun 20;156:106704. Epub 2021 Jun 20.

REQUIMTE-LAQV, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto. Electronic address:

Firefighting is physically and physiologically exhausting besides encompassing exposure to toxic fire emissions. Biomonitoring studies from the past five years have been significantly contributing to characterize the occupational-related health effects in this group of professionals and to improve risk assessment. Therefore, this study gathers and critically discusses the most characterized biomarkers of effect (oxidative stress, DNA and protein damage, stress hormones, inflammation, and vascular, lung, and liver injury), including those potentially more promising to be explored in future studies, and their relation with health outcomes. Read More

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Prevalence, healthcare resource utilization and mortality of Lennox-Gastaut syndrome: retrospective linkage cohort study.

Seizure 2021 Jun 9;91:159-166. Epub 2021 Jun 9.

Evidence Synthesis, Modeling, Communications, Evidera, The Ark, 201 Talgarth Road, London W6 8BJ, UK. Electronic address:

Purpose: To retrospectively investigate the prevalence, demography, antiseizure medication (ASM) usage, healthcare resource utilization (HCRU), and mortality of patients with Lennox-Gastaut syndrome (LGS) in primary and secondary care in the UK.

Methods: Patients with confirmed LGS were anonymously identified from the UK Clinical Practice Research Datalink (CPRD) GOLD database (01/01/1987-31/10/2018) using the LGS Read Code (F250500). Probable LGS was identified using the International Classification of Diseases-10/Read Code for epilepsy (Hospital Episode Statistics [HES]/CPRD) plus rufinamide prescription. Read More

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When particulate matter strikes cities: Social disparities and health costs of air pollution.

J Health Econ 2021 Jun 5;78:102478. Epub 2021 Jun 5.

CEIS, University of Rome "Tor Vergata", Via Columbia 2, 00133 Rome, Italy; Gran Sasso Science Institute (GSSI), Viale Francesco Crispi 7, 67100, L'Aquila, Italy. Electronic address:

We investigate the heterogeneous effects of particle pollution on Italian daily hospitalizations and their costs by exploiting public transportation strikes as plausibly-exogenous shocks in pollution exposure. We find that a one standard deviation increase in PM causes additional 0.79 hospitalizations per 100,000 residents, and the effect is stronger for the elderly, low educated individuals and migrants. Read More

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Outcomes on Social and Classic Cognition in adults with Pediatric-onset Multiple Sclerosis.

Mult Scler Relat Disord 2021 Jun 8;53:103071. Epub 2021 Jun 8.

Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Department of Neurology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal. Electronic address:

Background: Cognitive impairment affecting classic and social domains has been consistently reported in patients with Multiple Sclerosis (MS). However, little is known about the cognitive outcomes, particularly on social cognition, in adults with pediatric-onset multiple sclerosis (POMS).

Objectives: To compare the performance in classic and social cognitive domains between adults with POMS and adult-onset MS (AOMS). Read More

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How to switch disease-modifying treatments in multiple sclerosis: Guidelines from the French Multiple Sclerosis Society (SFSEP).

Mult Scler Relat Disord 2021 Jun 10;53:103076. Epub 2021 Jun 10.

Service de Neurologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

Background: Today, there are no recommendations on switching disease-modifying treatments (DMTs) in multiple sclerosis (MS).

Objectives: To establish guidelines on switching DMTs MS.

Methods: A Steering Committee composed of seven MS experts from the French Group for Recommendations in Multiple Sclerosis (France4MS) defined 15 proposals. Read More

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Intrinsic functional connectivity in families genetically enriched for social anxiety disorder - an endophenotype study.

EBioMedicine 2021 Jun 19;69:103445. Epub 2021 Jun 19.

Department of Psychiatry, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands. Electronic address:

Background: Social anxiety disorder (SAD) is a serious psychiatric condition with a high prevalence, and a typical onset during childhood/adolescence. The condition runs in families, but it is largely unknown which neurobiological characteristics transfer this genetic vulnerability ('endophenotypes'). Using data from the Leiden Family Lab study on SAD, including two generations of families genetically enriched for SAD, we investigated whether social anxiety (SA) co-segregated with changes in intrinsic functional connectivity (iFC), and examined heritability. Read More

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Oestrogen receptor activity in hormone-dependent breast cancer during chemotherapy: ER activity in pre-menopausal HR+ breast cancer during CT.

EBioMedicine 2021 Jun 20;69:103451. Epub 2021 Jun 20.

Translational Genomics and Targeted Therapies in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain; Department of Medical Oncology, Hospital Clinic of Barcelona, Spain; SOLTI cooperative group, Barcelona, Spain; Institute of Oncology (IOB)-Hospital Quirónsalud, Barcelona, Spain; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA; Department of Medicine, University of Barcelona, Barcelona, Spain. Electronic address:

Background: Chemotherapy efficacy in early-stage hormone receptor-positive (HR+) breast cancer (BC) according to menopausal status needs a biological explanation.

Methods: We compared early-stage HR+ BC biological features before and after (neo)adjuvant chemotherapy or endocrine therapy (ET), and assessed oestrogen receptor (ER) pathway activity in both pre- and post-menopausal patients. The nCounter platform was used to detect gene expression levels. Read More

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Are other tick-borne infections overlooked in patients investigated for Lyme neuroborreliosis? A large retrospective study from South-eastern Sweden.

Ticks Tick Borne Dis 2021 Jun 4;12(5):101759. Epub 2021 Jun 4.

Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linköping University, Linköping, Sweden; Department of Infectious Diseases, Region Östergötland County, Linköping/Norrköping, Sweden.

In Europe, the hard tick Ixodes ricinus is considered the most important vector of human zoonotic diseases. Human pathogenic agents spread by I. ricinus in Sweden include Borrelia burgdorferi sensu lato (s. Read More

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Racial/ethnic differences in health-related quality of life among female breast cancer survivors: cross-sectional findings from the Medical Expenditure Panel Survey.

Public Health 2021 Jun 20;196:74-81. Epub 2021 Jun 20.

University of Texas School of Public Health, Center for Health Promotion and Prevention Research, Division of Health Promotion and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Objectives: Breast cancer survivors have reported worse health-related quality of life (HRQoL) outcomes on some subscales when compared with members of the general population. However, the increased attention to breast cancer survivorship should have improved the HRQoL of these survivors. Our aim was to examine whether physical and mental component scores (PCS-12 and MCS-12) using the Short Form (SF-12) questionnaire were different for racial/ethnic minorities, specifically for Black and Hispanic women relative to White women. Read More

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Urinary cytokines correlate with acute kidney injury in critically ill COVID-19 patients.

Cytokine 2021 May 24;146:155589. Epub 2021 May 24.

Department of Surgical Sciences, Anesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden; Department of Medical Cell Biology, Integrative Physiology, Uppsala University, Uppsala, Sweden.

Background: Acute kidney injury is common in COVID-19 patients admitted to the ICU. Urinary biomarkers are a non-invasive way of assaying renal damage, and so far, urinary cytokines are not fully investigated. The current study aimed to assess urinary cytokine levels in COVID-19 patients. Read More

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