674,336 results match your criteria group animals

Relationship between Innate Immune Response Toll-Like Receptor 4 (TLR-4) and the Pathophysiological Process of Obesity Cardiomyopathy.

Arq Bras Cardiol 2021 Jul;117(1):91-99

Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de Botucatu Faculdade de Medicina , Botucatu , SP - Brasil.

Background: Obesity is a chronic low-grade inflammation condition related to cardiac disorders. However, the mechanism responsible for obesity-related cardiac inflammation is unclear. The toll-like receptor 4 (TLR-4) belongs to a receptor of the transmembrane family responsible for the immune response whose activation stimulates the production of proinflammatory cytokines. Read More

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Extract from Zanthoxylum piperitum Induces Apoptosis of AGS Gastric Cancer Cells Through Akt/MDM2/p53 Signaling Pathway.

Chin J Integr Med 2021 Jul 28. Epub 2021 Jul 28.

Department of Biological science and Biotechnology, College of Life science and Nano Technology, Hannam University, 1646 Yuseong-daero, Yuseong-gu, Daejeon, 34054, South Korea.

Objective: To determine the effect of Zanthoxylum piperitum extracet (ZPE) on apoptosis and analyze anticancer substances in ZPE, changes in proteins related to apoptosis, and pathological changes in tumors in mouse.

Methods: Fifteen 4-week-old female BALB/c nu/nu mice were divided into 3 groups depending on ZPE dose, with 5 in each group. AGS gastric carcinoma cells (1 × 10 cells/200 µL) were subcutaneously injected into the flank of each mouse. Read More

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The effects of long-term moderate exercise and Western-type diet on oxidative/nitrosative stress, serum lipids and cytokines in female Sprague Dawley rats.

Eur J Nutr 2021 Jul 28. Epub 2021 Jul 28.

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 15/1 Auenbruggerplatz, 8036, Graz, Austria.

Purpose: Regular exercise reduces obesity and the risk of cardiovascular disease. However, health-promoting benefits of physical activity are commonly associated with increased inflammation and oxidative stress. Here, we tested whether constant moderate exercise is able to prevent or attenuate the oxidative/nitrosative stress, inflammation, and serum lipids in lean and obese rats. Read More

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Effects of pomegranate peel and olive pomace supplementation on reproduction and oxidative status of rabbit doe.

J Anim Physiol Anim Nutr (Berl) 2021 Jul 27. Epub 2021 Jul 27.

Department of Veterinary Medicine, College of Applied and Health Sciences, A'Sharqiyah University, Ibra, Oman.

The current study aimed to investigate the effects of pomegranate peel and olive pomace supplementation on the reproductive hormones, antioxidative status, reproductive capacity and maternal behaviour of rabbit does. Forty does were used for the experiments. The animals were randomly assigned to four groups of ten does. Read More

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["They always think you're a killer"-slaughterhouse workers' reactions to moral stigma].

Marcel Sebastian

OZS Osterr Z Soziol 2021 22;46(2):207-227. Epub 2021 Jul 22.

Fachbereich Sozialwissenschaften, Universität Hamburg, Allende-Platz 1, 20146 Hamburg, Deutschland.

Slaughterhouse work has a bad reputation and many slaughterhouse workers experience moral stigmatization, although meat consumption is the dominant diet in Western societies. So far, moral stigmatization of slaughterhouse workers has not been analyzed systematically. The article answers the following research questions: Which coping strategies regarding moral stigmatization can be found among slaughterhouse workers and how do these strategies relate to hegemonic narratives about their job? The article answers the research questions using concepts from sociological theories of culture, stigma and and is based on a qualitative content analysis of 13 problem-centered interviews with workers from six German slaughterhouses. Read More

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ethanol extract prevents monosodium glutamate adverse effects on the serum levels of reproductive hormones, sperm quality, and testis histology in male rats.

Vet World 2021 Jun 15;14(6):1529-1536. Epub 2021 Jun 15.

Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang 65145, East Java, Indonesia.

Background And Aim: is an aquatic plant that contains high antioxidants level and could prevent cell damages caused by free radicals. The present study aimed to investigate the effect of . ethanol extract on luteinizing hormone (LH), testosterone levels, sperm quality, and testis histology of adult male rats induced by monosodium glutamate (MSG). Read More

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Allele and genotype frequencies of the gene polymorphism associated with canine degenerative myelopathy in Belgian Malinois dogs in Greece.

Vet World 2021 Jun 9;14(6):1472-1479. Epub 2021 Jun 9.

School of Animal Biosciences, Department of Animal Science, Laboratory of Animal Breeding and Husbandry, Agricultural University of Athens, Athens, Greece.

Background And Aim: Canine degenerative myelopathy (CDM) is an adult-onset fatal disorder associated with a point mutation of the superoxide dismutase 1 () gene (). This study aimed to determine the allele and genotype frequencies of this mutation in a group of Belgian Malinois dogs in Greece.

Materials And Methods: Samples (n=72) of whole blood were collected from 72 purebred dogs of the Hellenic Armed Forces; these samples were processed for DNA isolation, polymerase chain reaction, and digestion with the restriction endonuclease . Read More

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Effectiveness of dry cow therapy and/or internal teat sealant on existing infections in smallholder dairy farms in Kenya.

Vet World 2021 Jun 4;14(6):1430-1436. Epub 2021 Jun 4.

Department of Health Management, University of Prince Edward Island, Canada.

Background And Aim: Dry cow therapy (DCT) can be an effective treatment of mastitis that has not responded to conventional treatment during lactation. The aim of this study was to establish the effectiveness of DCT options available in reducing intramammary infections in smallholder dairy farms in Kiambu County, Kenya.

Materials And Methods: The study targeted smallholder dairy farms which were registered at the local dairy cooperatives and which had cows that were at the point of dry-off. Read More

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Prospective clinical trial evaluating spironolactone in Doberman pinschers with congestive heart failure due to dilated cardiomyopathy.

J Vet Cardiol 2021 Jun 25. Epub 2021 Jun 25.

Department of Clinical Studies, Ontario Veterinary College, University of Guelph, 28 College Ave W, Guelph, Ontario, N1G 2W1, Canada. Electronic address:

Introduction/objectives: Whether the aldosterone antagonist spironolactone has beneficial survival effects in dogs with dilated cardiomyopathy (DCM) is not known. The primary objective of the study was to evaluate the effect of spironolactone, when added to conventional therapy, on survival time in Doberman pinschers with congestive heart failure (CHF) due to DCM.

Animals: Sixty-seven client-owned Doberman pinschers with CHF due to DCM. Read More

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Comparison between three dosages of intramuscular alfaxalone and a ketamine-dexmedetomidine-midazolam-tramadol combination in golden-headed lion tamarins (Leontopithecus chrysomelas).

Vet Anaesth Analg 2021 Jun 26. Epub 2021 Jun 26.

Veterinary Medical Center, Oregon Zoo, Portland, OR, USA.

Objectives: To characterize the cardiopulmonary and anesthetic effects of alfaxalone at three dose rates in comparison with a ketamine-dexmedetomidine-midazolam-tramadol combination (KDMT) for immobilization of golden-headed lion tamarins (GHLTs) (Leontopithecus chrysomelas) undergoing vasectomy.

Study Design: Prospective clinical trial.

Animals: A total of 19 healthy, male, wild-caught GHLTs. Read More

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Consumption of a high-fat-high-sucrose diet partly diminishes mechanical and structural adaptations of cardiac muscle following resistance training.

Phys Act Nutr 2021 Jun 30;25(2):8-14. Epub 2021 Jun 30.

Human Performance Laboratory, University of Calgary, Calgary, Canada.

Purpose: The purpose of this study was to investigate the effects of a high-fat high-sucrose (HFHS) diet on previously reported adaptations of cardiac morphological and contractile properties to resistance training.

Methods: Twelve-week-old rats participated in 12-weeks of resistance exercise training and consumed an HFHS diet. Echocardiography and skinned cardiac muscle fiber bundle testing were performed to determine the structural and mechanical adaptations. Read More

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α-Gal immunization positively impacts Trypanosoma cruzi colonization of heart tissue in a mouse model.

PLoS Negl Trop Dis 2021 Jul 27;15(7):e0009613. Epub 2021 Jul 27.

Universidade Federal de Minas Gerais, Departamento de Parasitologia, Belo Horizonte, Brazil.

Chagas disease, caused by the parasite Trypanosoma cruzi, is considered endemic in more than 20 countries but lacks both an approved vaccine and limited treatment for its chronic stage. Chronic infection is most harmful to human health because of long-term parasitic infection of the heart. Here we show that immunization with a virus-like particle vaccine displaying a high density of the immunogenic α-Gal trisaccharide (Qβ-αGal) induced several beneficial effects concerning acute and chronic T. Read More

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Strongyloides stercoralis and HTLV-1 coinfection in CD34+ cord blood stem cell humanized mice: Alteration of cytokine responses and enhancement of larval growth.

PLoS Negl Trop Dis 2021 Jul 27;15(7):e0009559. Epub 2021 Jul 27.

Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America.

Viral and parasitic coinfections are known to lead to both enhanced disease progression and altered disease states. HTLV-1 and Strongyloides stercoralis are co-endemic throughout much of their worldwide ranges resulting in a significant incidence of coinfection. Independently, HTLV-1 induces a Th1 response and S. Read More

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Landscape of tissue-specific RNA Editome provides insight into co-regulated and altered gene expression in pigs ().

RNA Biol 2021 Jul 27:1-12. Epub 2021 Jul 27.

Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.

RNA editing generates genetic diversity in mammals by altering amino acid sequences, miRNA targeting site sequences, influencing the stability of targeted RNAs, and causing changes in gene expression. However, the extent to which RNA editing affect gene expression via modifying miRNA binding site remains unexplored. Here, we first profiled the dynamic A-to-I RNA editome across tissues of Duroc and Luchuan pigs. Read More

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In vivo evaluation of a recombinant N-acylhomoserine lactonase formulated in a hydrogel using a murine model infected with MDR Pseudomonas aeruginosa clinical isolate, CCASUP2.

AMB Express 2021 Jul 27;11(1):109. Epub 2021 Jul 27.

Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, African Union Organization St. Abbassia, Cairo, 11566, Egypt.

Failure in the treatment of P. aeruginosa, due to its broad spectrum of resistance, has been associated with increased patient mortality. One alternative approach for infection control is quorum quenching which was found to decrease virulence of such pathogen. Read More

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Seroprevalence of Toxoplasma gondii and associated risk factors in domestic pigs raised from Cuba.

Parasitol Res 2021 Jul 27. Epub 2021 Jul 27.

Animal Health and Zoonosis Research Group (GISAZ), Department of Animal Health, University of Cordoba, 14014, Córdoba, Spain.

A cross-sectional study was carried out to determine the seroprevalence of Toxoplasma gondii and associated risk factors in pigs in the largest pork-producing region in Cuba. Serum samples from 420 pigs, including 210 sows and 210 post-weaning pigs, were tested for antibodies against T. gondii using a commercial indirect enzyme-linked immunosorbent assay. Read More

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The two-component system RstAB regulates production of a polysaccharide capsule with a role in virulence in the marine pathogen Photobacterium damselae subsp. damselae.

Environ Microbiol Rep 2021 Jul 26. Epub 2021 Jul 26.

Departamento de Microbioloxía e Parasitoloxía, Instituto de Acuicultura, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.

The marine bacterium Photobacterium damselae subsp. damselae (Pdd) causes disease in marine animals and in humans. Previous studies demonstrated that mutation of the two-component system RstAB strongly impacts virulence of this pathogen, but the RstAB regulon has not been thoroughly elucidated. Read More

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Impact of e-cigarettes on colonic mucosa and the role of recovery: involvement of oxidative and inflammatory pathway.

Environ Sci Pollut Res Int 2021 Jul 26. Epub 2021 Jul 26.

Department of Human Anatomy & Embryology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Electronic cigarettes (e-cigarettes) (EC) are often advertised as a safer alternative to conventional cigarettes. Its widespread use has led to increased interest in its adverse health effects, thanks to few restrictions and a lack of regulatory guidelines. The study aimed to evaluate the influence of exposure to e-cigarette aerosol inhalation in rat colon model and conduct a follow-up after cessation of exposure. Read More

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Effects of gender and slaughter age on meat quality of Anatolian water buffaloes.

Trop Anim Health Prod 2021 Jul 27;53(4):415. Epub 2021 Jul 27.

Department of Animal Breeding and Husbandry, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.

The study aimed to investigate the effects of slaughter age and gender on specific carcass and technological meat quality characteristics in Anatolian water buffaloes. The study was conducted on 55 water buffaloes using a 2 × 2 factorial design with two independent variables at two levels. Gender subgroups of male (n = 29) and female (n = 26) and slaughter age subgroups of younger than 2 years of age (n = 29) and older than 2 years of age (n = 26) were evaluated. Read More

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Hybrid Parallel Compliance Allows Robots to Operate With Sensorimotor Delays and Low Control Frequencies.

Front Robot AI 2021 16;8:645748. Epub 2021 Jun 16.

Dynamic Locomotion Group, Max Planck Institute for Intelligent Systems, Stuttgart, Germany.

Animals locomote robustly and agile, albeit significant sensorimotor delays of their nervous system and the harsh loading conditions resulting from repeated, high-frequent impacts. The engineered sensorimotor control in legged robots is implemented with high control frequencies, often in the kilohertz range. Consequently, robot sensors and actuators can be polled within a few milliseconds. Read More

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Spatial models of giant pandas under current and future conditions reveal extinction risks.

Nat Ecol Evol 2021 Jul 26. Epub 2021 Jul 26.

State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.

In addition to habitat loss and fragmentation, demographic processes-the vagaries of births, deaths and sex ratio fluctuations-pose substantial threats to wild giant panda populations. Additionally, climate change and plans for the Giant Panda National Park may influence (in opposing directions) the extinction risk for wild giant pandas. The Fourth National Giant Panda Census showed pandas living in 33 isolated populations. Read More

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Efficacy of an injectable toltrazuril - gleptoferron (Forceris®) to control coccidiosis (Cystoisospora suis) in comparison with iron supplemented piglets without anticoccidial treatment.

Vet Parasitol 2019 29;276S:100002. Epub 2019 Jan 29.

Albrecht - Daniel - Thaer - Institute for Agricultural Sciences e.V. at University of Leipzig, An den Tierkliniken 29, 04103 Leipzig, Germany; Institute of Parasitology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 35, 04103 Leipzig, Germany.

The efficacy and safety of an injectable combination product containing toltrazuril and gleptoferron (Forceris® - CEVA) for the control of coccidiosis due to Cystoisospora suis was investigated in neonatal piglets. The study was carried out on five European commercial pig farms in France, Germany and Spain and 122 litters consisting of 1508 piglets were selected and randomly allocated to one of two treatment groups. The first group received a single intramuscular injection per piglet of the test product, containing 45 mg toltrazuril and 200 mg iron and this was compared with a control group, which was administered a single intramuscular treatment of iron at 200 mg per piglet only. Read More

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January 2019

Effects of nematode parasitism on activity patterns in first-season grazing cattle.

Vet Parasitol 2019 8;276S:100011. Epub 2019 May 8.

Swedish University of Agricultural Sciences, Department of Biomedical Sciences and Veterinary Public Health, Parasitology Unit, Sweden.

We investigated the effects of gastrointestinal nematode (GIN) challenge on activity patterns in first season grazing (FSG) steers exposed to two different levels of Ostertagia ostertagi and Cooperia oncophora. At turn-out, experimental animals were allocated to one of two treatment groups grazing in different enclosures each with 32 animals. The first group (High) received 5000 third stage (L3) O. Read More

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[Rutin activates AMPKα to ameliorate liver damage caused by perfluorooctanoic acid in mice].

Wei Sheng Yan Jiu 2021 Jul;50(4):609-614

School of Public Health, Bengbu Medical College, Anhui Province Key Laboratory of Immunology in Chronic Diseases, Bengbu 233030, China.

Objective: To study the protective effect and mechanism of rutin on perfluorooctanoic acid(PFOA)-induced liver damage in mice.

Methods: A total of 24 male ICR mice were randomly divided into 3 groups, 8 in each group: control group(ctrl group: ddH_2O), perfluorooctanoic acid group(PFOA group: PFOA 20 mg/(kg·d)), rutin intervention group(rutin+PFOA group: PFOA 20 mg/(kg·d)+rutin 20 mg/(kg·d)), normal diet, oral gavage, daily observation, weighting, and recording. After 14 days of treatment, the liver was quickly stripped and weighted after blood sampling and execution. Read More

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[Effects of brown rice on metabolomics related to glucose and lipid in normal rats].

Wei Sheng Yan Jiu 2021 Jul;50(4):600-608

National Health and Family Planning Commission, National Institute for Nutrition and Health, China CDC, Beijing 100050, China.

Objective: To investigate the effects of whole grain rice on blood sugar, blood lipid and metabonomics compared with ordinary feed and refined rice.

Methods: According to the initial body weight and fasting blood glucose, 36 male SD rats were randomly divided into 3 groups: control group, RG-rice group and WG-rice group, fed with AIN-93 G feed, feeds prepared with refined rice flour or brown rice flour, respectively, for 18 weeks. Food intake and body weight were monitored weekly. Read More

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The effect induced by alternated mechanical loading on Notch-1 in mandibular condylar cartilage of growing rabbits.

Bone Joint Res 2021 Jul;10(7):437-444

School of Stomatology, Zhejiang Chinese Medical University, Hangzhou, China.

Aims: The aim of our study is to investigate the effect induced by alternated mechanical loading on Notch-1 in mandibular condylar cartilage (MCC) of growing rabbits.

Methods: A total of 64 ten-day-old rabbits were randomly divided into two groups according to dietary hardness: normal diet group (pellet) and soft diet group (powder). In each group, the rabbits were further divided into four subgroups by feeding time: two weeks, four weeks, six weeks, and eight weeks. Read More

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Clinical outcomes and prognostic factors associated with nonsteroidal anti-inflammatory drug overdose in dogs presented to an emergency room.

J Vet Emerg Crit Care (San Antonio) 2021 Jul 23. Epub 2021 Jul 23.

Department of Clinical Sciences and Advanced Medicine, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, USA.

Objective: To describe case presentations, clinical signs, and outcomes following nonsteroidal anti-inflammatory drug (NSAID) overdose in a clinical population of dogs and to identify factors associated with various outcomes including death or euthanasia, acute kidney injury, and suspected gastrointestinal ulceration (GIU).

Design: Retrospective study.

Setting: University teaching hospital. Read More

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Evaluation of lipolysis and toxicological parameters of low-level laser therapy at different wavelengths and doses in the abdominal subcutaneous tissue.

Lasers Med Sci 2021 Jul 23. Epub 2021 Jul 23.

Department of Cosmetics and Aesthetic, Lutheran University of Brazil, Canoas, RS, 92425-900, Brazil.

Investigate the effects of low-level lasers therapy (LLLT) aiming abdominal lipolysis. Female Wistar rats received applications of LLLT directly in the abdominal skin twice a week (5 weeks). Except the control group (n = 5), animals received treatments with red wavelength 660 nm being (I) R3. Read More

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Carotenoids obtained from an ionic liquid-mediated process display anti-inflammatory response in the adipose tissue-liver axis.

Food Funct 2021 Jul 23. Epub 2021 Jul 23.

Department of Biosciences, Federal University of São Paulo (UNIFESP), Silva Jardim Street, 136, Vila Mathias, 11015-020, Santos, SP, Brazil.

Ionic liquids (ILs) have been proposed as more efficient and sustainable solvents to replace volatile organic solvents (VOSs). However, the drawbacks associated with their use are still limiting the regular application of bioactive compounds obtained from the processes they mediate as food ingredients. It is true that the number of ILs approved by the Food and Drug Administration for food applications is still low and mainly focused on the ones from the quaternary ammonium family. Read More

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Depression of Pyroptosis by Inhibiting Caspase-1 Activation Improves Neurological Outcomes of Kernicterus Model Rats.

ACS Chem Neurosci 2021 Jul 23. Epub 2021 Jul 23.

Department of Neonatology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, China.

Kernicterus is a severe complication of extreme neonatal hyperbilirubinemia. Prolonged exposure to high-level unconjugated bilirubin (UCB) directly damages brain tissue. Neuroinflammation is believed to contribute to UCB-induced neurotoxicity. Read More

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