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Binding Analysis of Functionalized Multimode Optical-Fiber Sandwich-like Structure with Organic Polymer and Its Sensing Application for Humidity and Breath Monitoring.

Biosensors (Basel) 2021 Sep 8;11(9). Epub 2021 Sep 8.

Departamento de Alimentos, Centro Interdisciplinario del Noreste (CINUG), Universidad de Guanajuato, Tierra Blanca, Guanajuato 37975, Mexico.

In recent years, the chemical modification of optical fibers (OFs) has facilitated the manufacture of sensors because OFs can identify several analytes present in aqueous solutions or gas phases. Nevertheless, it is imperative better to understand the chemical interactions in this molecular system to generate low-cost and efficient sensors. This work presents a theoretical and experimental study of organic polymeric functionalized OF structures and proposes a cost-effective alternative to monitor breathing and humidity. Read More

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September 2021

A 2021 consensus statement on osteotomies around the knee by the UK Knee Osteotomy consensus Group (KOG).

Knee 2021 Sep 22;33:73-83. Epub 2021 Sep 22.

North Cumbria University Hospital NHS Trust, UK. Electronic address:

Background: There are significant deficiencies in the evidence base of modern-day osteotomy which result in significant variation in practice between surgeons. The purpose of this statement was to develop a consensus statement on the practice of osteotomy so that a more standardized approach to the indications, surgical technique, and postoperative care could be outlined. The article is also intended to educate and inform the practice of individuals who are early in their experience and/or clinical practice. Read More

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September 2021

Effects as a function of implementation fidelity of a transdiagnostic prevention program in young school-aged children.

Eval Program Plann 2021 Sep 16;89:102011. Epub 2021 Sep 16.

Miguel Hernández University, Department of Health Psychology, Avda. de la Universidad s/n, Elche, 03202, Alicante, Spain.

Super Skills for Life (SSL) is a transdiagnostic prevention program for school-aged children with internalizing problems. The current study aimed to examine the short- and long-term (12-month follow-up) effectiveness of SSL, depending on implementation fidelity. Participants were 123 Spanish-speaking children aged 6-8 years with internalizing symptoms and their parents. Read More

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September 2021

Adjunctive interleukin-2 for the treatment of drug-susceptible tuberculosis: a randomized control trial in China.

Infection 2021 Sep 25. Epub 2021 Sep 25.

Fuyang No.2 Hospital, Fuyang, China.

Purpose: Evaluation of the efficacy and safety of IL-2 in the treatment of drug-susceptible tuberculosis.

Methods: First, the cases of diagnosed drug-susceptible tuberculosis were randomized into two groups-the control group that received the background regimen of isoniazid, rifampin, pyrazinamide, and ethambutol, and the experimental group that received the background regimen plus IL-2. The efficacy and safety evaluations were performed throughout the therapy process as well as 12 months after the treatment completion. Read More

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September 2021

Effect of oral health literacy on self-reported tooth loss: A multiple mediation analysis.

Community Dent Oral Epidemiol 2021 Sep 24. Epub 2021 Sep 24.

School of Public Health, The University of Adelaide, Adelaide, Australia.

Background: This study aims to investigate the mediating pathways of oral health literacy (OHL) and oral health-related behaviours on the relationship between education and self-reported tooth loss among Australian adults.

Methods: Data used for studying the effects of mediating pathways are from the National Dental Telephone Interview Survey 2013, a random sample survey of Australian adults aged 18+ years. To study the mediating effects, we use counterfactual-based analysis. Read More

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September 2021

Remediation of Pb-Contaminated Soil Using a Novel Magnetic Nanomaterial Immobilization Agent.

Bull Environ Contam Toxicol 2021 Sep 24. Epub 2021 Sep 24.

Henan Collaborative Innovation Center of Environmental Pollution Control and Ecological Restoration, Zhengzhou University of Light Industry, Zhengzhou, 45000, People's Republic of China.

The management of heavy metal contaminated soil has received extensive research attention. In this study, a novel immobilization agent ([email protected]@C-COOH) was combined with traditional immobilization agents (TIAs), i.e. Read More

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September 2021

Palladium-catalyzed regio- and enantioselective migratory allylic C(sp)-H functionalization.

Nat Commun 2021 Sep 24;12(1):5626. Epub 2021 Sep 24.

CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Shanghai, China.

Transition metal-catalyzed asymmetric allylic substitution with a suitably pre-stored leaving group in the substrate is widely used in organic synthesis. In contrast, the enantioselective allylic C(sp)-H functionalization is more straightforward but far less explored. Here we report a catalytic protocol for the long-standing challenging enantioselective allylic C(sp)-H functionalization. Read More

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September 2021

Effects of vitamin D supplementation on the functional outcome in patients with osteoporotic vertebral compression fracture and vitamin D deficiency.

J Orthop Surg Res 2021 Sep 24;16(1):571. Epub 2021 Sep 24.

Department of Orthopaedic Surgery, School of Medicine, Daegu Catholic University, Daegu Catholic University Hospital, 33, Duryugongwon-ro 17-gil, Nam-gu, Daegu, 42472, Korea.

Background: In osteoporotic vertebral compression fractures, supplementation using vitamin D preparations and maintenance of blood vitamin D level within the normal range are necessary for proper fracture union, enhancement of muscle strength, and maintenance of body balance. The purpose of this study is to investigate the effects of vitamin D supplementation on blood vitamin D level, pain relief, union time, and functional outcome in patients with osteoporotic vertebral compression fracture and vitamin D deficiency.

Methods: One hundred thirty patients who were deficient in blood vitamin D level and had osteoporotic vertebral compression fracture were divided into supplementation group and non-supplementation group. Read More

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September 2021

[Dissemination of National Physical Activity Recommendations: Participatory Development of Dissemination Strategies in Germany].

Gesundheitswesen 2021 Sep 24. Epub 2021 Sep 24.

Department für Sportwissenschaft und Sport Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Deutschland.

Background: In 2016, the first evidence-based National Recommendations for Physical Activity and Physical Activity Promotion were published in Germany. These recommendations are primarily intended for experts, decision makers and stakeholders.

Objectives: This study aims to describe the development of dissemination strategies for these recommendations. Read More

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September 2021

STEPS to Enhance Physical Activity After Hematopoietic Cell Transplantation for Multiple Myeloma.

Cancer Nurs 2021 Sep 23. Epub 2021 Sep 23.

Author Affiliations: Schools of Nursing (Drs Hacker and Chung and Ms Richards) and Medicine (Drs Abu Zaid, Farag, and Perkins), Indiana University, Indianapolis.

Background: Finding effective ways to increase physical activity immediately following high-dose chemotherapy and autologous hematopoietic cell transplantation (HCT) for treatment of multiple myeloma (MM) is challenging.

Objective: This pilot randomized clinical trial tested the acceptability, feasibility, and preliminary effects of a free-living physical activity intervention (STEPS) compared with usual care (UC) on physical activity, fatigue, muscle strength, functional ability, sleep, and quality of life following treatment for MM with HCT.

Methods: Using a 2-group pretest/posttest design (N = 32), this study compared the 6-week STEPS intervention to UC. Read More

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September 2021

Feasibility assessment of infectious keratitis depicted on slit-lamp and smartphone photographs using deep learning.

Int J Med Inform 2021 Sep 17;155:104583. Epub 2021 Sep 17.

School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China. Electronic address:

Background: This study aims to investigate how infectious keratitis depicted on slit-lamp and smartphone photographs can be reliably assessed using deep learning.

Materials And Methods: We retrospectively collected a dataset consisting of 5,673 slit-lamp photographs and 400 smartphone photographs acquired on different subjects. Based on multiple clinical tests (e. Read More

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September 2021

Circumferential fusion with open versus percutaneous posterior fusion for lumbar isthmic spondylolisthesis.

Clin Neurol Neurosurg 2021 Sep 3;209:106935. Epub 2021 Sep 3.

Department of Orthopaedic Surgery, Rothman Institute, Thomas Jefferson University, Philadelphia, PA 19107, United States.

Study Design: Retrospective cohort study.

Objective: To investigate the clinical and radiographic differences between patients who underwent anterior lumber interbody fusion (ALIF) with either open or percutaneous posterior fusion for lumbar isthmic spondylolisthesis.

Summary Of Background Data: Circumferential fusion for isthmic spondylolisthesis is commonly performed with superior clinical outcomes, fusion rates, and restoration of sagittal balance when compared to posterior fusion alone. Read More

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September 2021

Transependymal edema as a predictor of endoscopic third ventriculostomy success in pediatric hydrocephalus.

World Neurosurg 2021 Sep 21. Epub 2021 Sep 21.

Department of Neurosurgery, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, Fuchu 183-8561, Tokyo, Japan.

Introduction: The endoscopic third ventriculostomy success score (ETVSS) is based on the clinical features of hydrocephalus except radiological findings. A previous study suggested that transependymal edema (TEE) as a radiological finding may be a reliable predictor of ETV success in patients of all ages. We aimed to investigate whether TEE on preoperative MRI can predict ETV success in pediatric patients. Read More

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September 2021

Coronary stent infection: Are patients amenable to surgical treatment? A systematic review and narrative synthesis.

Int J Cardiol 2021 Sep 21. Epub 2021 Sep 21.

Sapienza University, Rome, Italy.

Objective: Coronary stent infection is a fearsome complication with high mortality rate. Since antibiotics may have only partial efficacy, invasive surgery may be needed. We present a systematic review about outcomes achieved by surgical versus medical treatment in this scenario. Read More

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September 2021

Comparison of Mid- to Long-term follow-up of Patient-Reported Outcomes Measures after Single-level Lumbar Total Disc Arthroplasty, Multi-level Lumbar Total Disc Arthroplasty, and the Lumbar Hybrid Procedure for the Treatment of Degenerative Disc Disease.

Spine (Phila Pa 1976) 2021 Sep 22. Epub 2021 Sep 22.

Gold Coast Spine, Gold Coast, QLD AUSTRALIA 4229 Faculty of Health Science & Medicine, Bond University, Gold Coast, QLD AUSTRALIA 4229 Department of Orthopaedic Surgery, Cairns Hospital, Cairns North, QLD AUSTRALIA 4870.

Study Design: Prospective Cohort Study.

Objective: The aim of this paper is to compare the mid- to long-term patient-reported outcome measures (PROMs) between single-level total disc arthroplasty (TDA), multi-level TDA, and hybrid constructs (combination of TDA and anterior lumbar interbody fusion (ALIF) across multiple levels) for symptomatic degenerative disc disease (DDD).

Summary Of Background Data: The treatment of single-level DDD is well documented using TDA. Read More

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September 2021

Enhanced biological S accumulation by using signal molecules during simultaneous desulfurization and denitrification.

Environ Technol 2021 Sep 24:1-44. Epub 2021 Sep 24.

School of Environmental and Municipal Engineering, Xi'an University of Architecture and Technology, 710055 Shaanxi, Xi'an, China.

A high rate of elemental sulfur (S) accumulation from sulfide-containing wastewater has great significance in terms of resource recovery and pollution control. This experimental study used and denitrifying bacteria incorporated with signal molecules (C6 and OHHL) for simultaneous sulfide (S) and nitrate (NO) removal in synthetic wastewater. Also, the effects on S accumulation due to changes in organic matter composition and bacteria proportion through signal molecules were analyzed. Read More

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September 2021

Echocardiographic assessment of left atrial function for prediction of efficacy of catheter ablation for atrial fibrillation.

Medicine (Baltimore) 2021 Sep;100(38):e27278

Department of Cardiology, Centre of Postgraduate Medical Education, Grochowski Hospital, Warsaw, Poland.

Abstract: Proper selection for catheter ablation (CA) for atrial fibrillation (AF) is still an issue. Echocardiographic assessment of left atrium (LA) is complex and challenging. Speckle tracking echocardiography (STE) with recent standardized LA deformation analysis allows for the quantitative assessment of various LA function parameters. Read More

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September 2021

Transcatheter Aortic Valve Replacement versus Sutureless Aortic Valve Replacement: A Single Center Retrospective Cohort Study.

Yonsei Med J 2021 Oct;62(10):885-894

Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.

Purpose: This study sought to compare clinical outcomes between transcatheter aortic valve replacement (TAVR) and sutureless aortic valve replacement (SU-AVR).

Materials And Methods: In total, 320 patients with symptomatic severe aortic stenosis who underwent TAVR (n=254) or SU-AVR (n=66) at Severance Cardiovascular Hospital between July 2011 and September 2019 were included for analysis. Propensity score matching and inverse probability weighted adjustment were performed to adjust for confounding baseline characteristics. Read More

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October 2021

Repairing whole facial nerve defects with xenogeneic acellular nerve grafts in rhesus monkeys.

Neural Regen Res 2022 May;17(5):1131-1137

Department of Pathology, Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University, Wuxi, Jiangsu Province, China.

Acellular nerve allografts conducted via chemical extraction have achieved satisfactory results in bridging whole facial nerve defects clinically, both in terms of branching a single trunk and in connecting multiple branches of an extratemporal segment. However, in the clinical treatment of facial nerve defects, allogeneic donors are limited. In this experiment, we exposed the left trunk and multiple branches of the extratemporal segment in six rhesus monkeys and dissected a gap of 25 mm to construct a monkey model of a whole left nerve defect. Read More

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Long-term and short-term outcomes after laparoscopic versus open surgery for advanced gastric cancer: An updated meta-analysis.

J Minim Access Surg 2021 Oct-Dec;17(4):423-434

Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chaoyang District, Beijing; Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.

Background: The efficacy of laparoscopy for advanced gastric cancer (AGC) remains controversial.

Materials And Methods: We conducted a literature search on the EMBASE, PubMed and Cochrane Library databases to identify relevant available articles published between the time of the databases' inception and July 2020.

Results: A total of 14,689 patients were included in the 41 studies identified. Read More

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September 2021

Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control.

G3 (Bethesda) 2021 Sep 2. Epub 2021 Sep 2.

Laboratory of Virology, Wageningen University & Research, 6708 PB Wageningen, The Netherlands.

The genus Spodoptera (Lepidoptera: Noctuidae) includes some of the most infamous insect pests of cultivated plants including Spodoptera frugiperda, Spodoptera litura, and Spodoptera exigua. To effectively develop targeted pest control strategies for diverse Spodoptera species, genomic resources are highly desired. To this aim, we provide the genome assembly and developmental transcriptome comprising all major life stages of S. Read More

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September 2021

Controllable Generation of Reactive Oxygen Species on Cyano-Group-Modified Carbon Nitride for Selective Epoxidation of Styrene.

Innovation (N Y) 2021 Feb 6;2(1):100089. Epub 2021 Feb 6.

State Key Laboratory of Coal Conversion, Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan 030001, China.

The controlled generation of reactive oxygen species (ROS) to selectively epoxidize styrene is a grand challenge. Herein, cyano-group-modified carbon nitrides (CNCY and CN-T ) are prepared, and the catalysts show better performance in regulating ROS and producing styrene oxide than the cyano-free sample. The diffuse reflectance infrared and density functional theory calculation results reveal that the cyano group acts as the adsorption and activation site of oxygen. Read More

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February 2021

Literature Mining and Mechanistic Graphical Modelling to Improve mRNA Vaccine Platforms.

Front Immunol 2021 7;12:738388. Epub 2021 Sep 7.

Data Science and Computational Vaccinology, GSK, Siena, Italy.

RNA vaccines represent a milestone in the history of vaccinology. They provide several advantages over more traditional approaches to vaccine development, showing strong immunogenicity and an overall favorable safety profile. While preclinical testing has provided some key insights on how RNA vaccines interact with the innate immune system, their mechanism of action appears to be fragmented amid the literature, making it difficult to formulate new hypotheses to be tested in clinical settings and ultimately improve this technology platform. Read More

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September 2021

Translation, Adaption, and Psychometric Testing of the Myanmar Version of the Medical Outcomes Study Social Support Survey for People Living With HIV/AIDS.

Front Psychol 2021 7;12:707142. Epub 2021 Sep 7.

National AIDS Program, Department of Public Health, Ministry of Health and Sports, Nay Pyi Taw, Myanmar.

Valid and reliable instruments are crucial for measuring perceived social support among people living with HIV (PLHIV). We aimed to investigate the psychometric properties of the English version of the 19-item Medical Outcomes Study Social Support Survey (MOS-SSS) adapted for PLHIV in Myanmar. Based on a standard cross-cultural procedure, we adapted the MOS-SSS and formed a Myanmar version of the scale (MOS-SSS-M), and then tested its validity and reliability. Read More

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September 2021

Effect of Restricted Feeding on Metabolic Health and Sleep-Wake Rhythms in Aging Mice.

Front Neurosci 2021 7;15:745227. Epub 2021 Sep 7.

Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.

Aging, an irreversible and unavoidable physiological process in all organisms, is often accompanied by obesity, diabetes, cardiovascular diseases, sleep disorders, and fatigue. Thus, older adults are more likely to experience metabolic symptoms and sleep disturbances than are younger adults. Restricted feeding (RF) is a dietary regimen aimed at improving metabolic health and extending longevity, as well as reorganizing sleep-wake cycles. Read More

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September 2021

Deep Learning-Based Assessment of Brain Connectivity Related to Obstructive Sleep Apnea and Daytime Sleepiness.

Nat Sci Sleep 2021 17;13:1561-1572. Epub 2021 Sep 17.

Institute of Human Genomic Study, College of Medicine, Korea University Ansan Hospital, Ansan, Republic of Korea.

Purpose: Obstructive sleep apnea (OSA) is associated with altered pairwise connections between brain regions, which might explain cognitive impairment and daytime sleepiness. By adopting a deep learning method, we investigated brain connectivity related to the severity of OSA and daytime sleepiness.

Patients And Methods: A cross-sectional design applied a deep learning model on structural brain networks obtained from 553 subjects (age, 59. Read More

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September 2021

Self-management intervention to reduce pulmonary exacerbations by supporting treatment adherence in adults with cystic fibrosis: a randomised controlled trial.

Thorax 2021 Sep 23. Epub 2021 Sep 23.

Clinical Trials Research Unit, University of Sheffield, Sheffield, UK.

Introduction: Recurrent pulmonary exacerbations lead to progressive lung damage in cystic fibrosis (CF). Inhaled medications (mucoactive agents and antibiotics) help prevent exacerbations, but objectively measured adherence is low. We investigated whether a multi-component (complex) self-management intervention to support adherence would reduce exacerbation rates over 12 months. Read More

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September 2021

Evaluation of a Pharmacists' Patient Care Process Approach for Hypertension.

Am J Prev Med 2021 Sep 20. Epub 2021 Sep 20.

RTI International, Translational Health Sciences Division, Research Triangle Park, North Carolina.

Introduction: An estimated 116 million American adults (47.3%) have hypertension. Most adults with hypertension do not have it controlled-3 in 4 (92. Read More

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September 2021

Characteristics of patients with chronic hypoparathyroidism not adequately controlled with conventional treatment and management patterns in Spain.

Endocrinol Diabetes Nutr (Engl Ed) 2021 May 6;68(5):304-311. Epub 2021 Sep 6.

Shire Pharmaceuticals Ibérica SL, miembro del grupo empresarial Takeda, Madrid, Spain. Electronic address:

Background And Objective: The current guidelines on hypoparathyroidism offer a model for treating patients but do not cover real-world situations or patient diversity. Given the lack of data regarding hypoparathyroidism, a Delphi panel was convened in Spain to establish consensus in defining the characteristics of patients with chronic hypoparathyroidism not adequately controlled with conventional treatment, as well as to investigate patterns of management.

Material And Methods: A presentation matrix provided a framework for characterizing inadequately controlled chronic hypoparathyroidism, based on four predefined patient groups: group 1 (normal biochemical levels and the patient feeling well); group 2 (abnormal biochemical levels and the patient feeling well); group 3 (normal biochemical levels and the patient feeling unwell); and group 4 (abnormal biochemical levels and the patient feeling unwell). Read More

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