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Intradialytic periodized exercise improves cardiopulmonary fitness and respiratory function: A randomized controlled trial.

Semin Dial 2021 Sep 18. Epub 2021 Sep 18.

Ciências Pneumológicas Post-Graduation Program, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Background: Chronic kidney disease (CKD) is a factor that predisposes to gradual physical deconditioning from its early stages leading to cardiorespiratory fitness and musculoskeletal system impairment. We evaluated the effects of combined and periodized intradialytic exercise training on cardiopulmonary fitness and respiratory function in HD subjects.

Methods: A randomized controlled trial with HD subjects was allocated into two groups: exercise group (EXG) and usual care group (UCG). Read More

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September 2021

Prospective analysis of myocardial strain through the evolution of Chagas disease in the hamster animal model.

Int J Cardiovasc Imaging 2021 Sep 18. Epub 2021 Sep 18.

Cardiology Division, Internal Medicine Department, Cardiology Center of the Medical School of Ribeirão Preto, University of São Paulo Ribeirão Preto, Bandeirantes Avenue, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.

Speckle tracking echocardiography (STE) enables early diagnosis of myocardial damage by evaluating myocardial strain. We aimed to study sequential changes in structural and ventricular functional parameters during Chagas disease (CD) natural history in an animal model. 37 Syrian hamsters were inoculated intraperitoneally with Trypanosoma cruzi (Chagas) and 20 with saline (Control). Read More

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September 2021

Variations of tongue coating microbiota in children with Henoch-Schönlein purpura nephritis.

Microb Pathog 2021 Sep 14:105192. Epub 2021 Sep 14.

Department of Nephrology, Zhongshan Hospital, Fudan University; Shanghai Institute of Kidney and Dialysis; Shanghai Key Laboratory of Kidney and Blood Purification; Shanghai Medical Center of Kidney Disease, Shanghai, 200433, China. Electronic address:

Background: Variations in the oral microbiota have been significantly correlated with the progress of autoimmune diseases, such as immunoglobulin A nephropathy and Henoch-Schönlein purpura (HSP). However, there is no report outlining the character of tongue coating microbiota variations in children with Henoch-Schönlein purpura nephritis (HSPN).

Method: A total of 20 children with HSPN and 14 healthy controls were recruited for this research. Read More

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September 2021

Active Bacteria in Carious Dentin of Mandibular Molars with Different Pulp Conditions: An in-vivo Study.

J Endod 2021 Sep 14. Epub 2021 Sep 14.

Department of Conservative Dentistry and Endodontics, Thai Moogambigai Dental College and Hospital, Dr. MGR Educational and Research Institute (Deemed to be University), Chennai 600 107, Tamilnadu, India. Electronic address:

Introduction: This study evaluated the relative abundance and ribosomal activity of selected bacteria in carious dentin of teeth with different pulp conditions.

Methods: Thirty healthy patients with Class I occlusal caries in molars were categorized into three groups based on the pulp diagnosis: Normal pulp (NP, n = 10) with caries extending less than half the thickness of dentin (as assessed radiographically); Reversible pulpitis (RP, n = 10) and Symptomatic irreversible pulpitis (SIP, n = 10) with caries extending more than two thirds of the thickness of dentin. Carious dentin samples were collected from the deepest part of the cavity and stored in RNAlater solution. Read More

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September 2021

Post-operative Renal Failure, Shunt Type and Mortality after Norwood Palliation.

Ann Thorac Surg 2021 Sep 14. Epub 2021 Sep 14.

Department of Pediatrics, Duke University Medical Center, 2301 Erwin Road, Durham, North Carolina 27710; Duke Clinical Research Institute, Duke University Medical Center, 2301 Erwin Road, Durham, North Carolina 27710.

Background: The Single Ventricle Reconstruction (SVR) trial demonstrated increased risk of death or heart transplant one year post-Norwood in subjects randomized to Blalock-Taussig shunts (mBTS) compared to right ventricle-to-pulmonary artery (RV-PA) shunts. We used the SVR public use database to evaluate incidence and risk factors for post-operative renal failure and relationships between renal failure, shunt type and outcomes post-Norwood.

Methods: Post-operative renal failure was defined a-priori as a 3-fold rise in creatinine from baseline, or dialysis use, within 7 days of Norwood. Read More

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September 2021

Effects of a low-carbohydrate ketogenic diet on reported pain, blood biomarkers and quality of life in patients with chronic pain: A pilot randomised clinical trial.

Pain Med 2021 Sep 17. Epub 2021 Sep 17.

The University of Sydney, Faculty of Medicine and Health, NSW Australia.

Background: A low-carbohydrate ketogenic diet has been reported to improve chronic pain by reducing inflammation, oxidative stress, and sensitivity within the nervous system. The main aim of this trial is to evaluate the effects of a ketogenic diet on reported pain, blood biomarkers and quality of life in patients with chronic pain.

Methods: Participants with chronic musculoskeletal pain were recruited for a 12-week diet intervention that commenced with a 3-week run-in diet removing ultra-processed foods, followed by randomisation to either a whole-food/well-formulated ketogenic diet (WFKD) or to continue with the minimally processed whole-food diet (WFD). Read More

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September 2021

Opiate prescribing patterns in the adolescent population following anterior cruciate ligament reconstruction.

J Opioid Manag 2021 Jul-Aug;17(4):321-325

Department of Pediatric Orthopaedics, Stanford University, Stanford, California.

Objective: We sought to determine prescribing patterns for opioid analgesia following anterior cruciate ligament (ACL) reconstruction among age- and gender-stratified adolescents in a nationally representative database.

Design: A retrospective study.

Setting: PearlDiver Patient Records. Read More

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September 2021

Clinical withdrawal symptom profile of synthetic cannabinoid receptor agonists and comparison of effects with high potency cannabis.

Psychopharmacology (Berl) 2021 Sep 17. Epub 2021 Sep 17.

Addiction and Mental Health Group (AIM), Department of Psychology, University of Bath, Bath, UK.

Synthetic cannabinoid receptor agonists (SCRAs) may be used as an alternative to natural cannabis; however, they may carry a greater risk of problematic use and withdrawal. This study aimed to characterise the withdrawal symptom profile of SCRAs and compare their profile of effect with high-potency herbal cannabis. Global Drug Survey data (2015 and 2016) were used to access a clinically relevant sample of people reporting use of SCRAs >10 times in the past 12-months, a previous SCRA quit attempt, and lifetime use of high-potency herbal cannabis. Read More

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September 2021

Glutathione Infusion Before and 3 Days After Primary Angioplasty Blunts Ongoing NOX2-Mediated Inflammatory Response.

J Am Heart Assoc 2021 Sep 17:e020560. Epub 2021 Sep 17.

Department of Clinical, Internal Medicine, Anesthesiology, and Cardiovascular Sciences Sapienza University of Rome Rome Italy.

Background Glutathione is a water-soluble tripeptide with a potent oxidant scavenging activity. We hypothesized that glutathione administration immediately before and after primary angioplasty (primary percutaneous coronary intervention) could be effective in modulating immune cell activation, thereby preventing infarct expansion. Methods and Results One hundred consecutive patients with ST-segment-elevation myocardial infarction, scheduled to undergo primary percutaneous coronary intervention were randomly assigned before the intervention to receive an infusion of glutathione (2500 mg/25 mL over 10 minutes), followed by drug administration at the same doses at 24, 48, and 72 hours elapsing time or placebo. Read More

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September 2021

Chronic opioid use is associated with obstructive and spastic disorders in the esophagus.

Neurogastroenterol Motil 2021 Sep 16:e14233. Epub 2021 Sep 16.

Department of Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA.

Background And Aims: Chronic opioid effects on the esophagus are poorly understood. We investigated whether opioids were associated with increased prevalence of esophageal motility disorders.

Methods: A retrospective study of all patients undergoing high-resolution manometry (HREM) at the Yale Gastrointestinal Motility Lab between January 2014 and August 2019. Read More

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September 2021

Clinical diagnosis and treatment of breast cancer with brain metastases and establishment of a prognostic model: a 10-year, single-center, real-world study of 559 cases.

Ann Transl Med 2021 Aug;9(16):1331

Department of Breast Disease, Henan Breast Cancer Center, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China.

Background: This study involved a retrospective analysis of 559 metastatic breast cancer (MBC) patients with brain metastasis (BM). We aimed to establish the effectiveness of different preferred treatment methods and factors affecting overall survival following BM diagnosis (BMOS) and explore the feasibility of systemic treatment for MBC patients with BM.

Methods: Univariate and multivariate analyses were used to assess the efficacy of different preferred treatments and other factors associated with BMOS, and a nomogram was then established based on the results of the univariate analysis. Read More

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Shotgun-based proteomics of extracellular vesicles in Alzheimer's disease reveals biomarkers involved in immunological and coagulation pathways.

Sci Rep 2021 Sep 16;11(1):18518. Epub 2021 Sep 16.

Department of Basic Medical Sciences, College of Medicine, Qatar University, 2713, Doha, Qatar.

Alzheimer's disease (AD) is the most common form of dementia and without readily available clinical biomarkers. Blood-derived proteins are routinely used for diagnostics; however, comprehensive plasma profiling is challenging due to the dynamic range in protein concentrations. Extracellular vesicles (EVs) can cross the blood-brain barrier and may provide a source for AD biomarkers. Read More

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September 2021

Pedicle Screw Fixation with Percutaneous Vertebroplasty for Traumatic Thoracolumbar Vertebral Compression Fracture.

Niger J Clin Pract 2021 Sep;24(9):1360-1365

Department of Orthopedics and Traumatology, Alanya Alaaddin Keykubat University Alanya Training and Research Hospital, Alanya, Turkey.

Objective: This study aims to evaluate the clinical efficacy of percutaneous pedicle screw fixation (PPSF) combined with percutaneous vertebroplasty (PVP) for the treatment of the thoracolumbar vertebral compression fracture (VCF) without neurologic deficits.

Materials And Methods: This was a prospective observational study. Between January 2015 and December 2018, 62 patients who had suffered from traumatic thoracolumbar (VCF) burst fractures without neurologic deficits were included in this study. Read More

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September 2021

Usefulness of the prostate health index in predicting the presence and aggressiveness of prostate cancer among Korean men: a prospective observational study.

BMC Urol 2021 Sep 16;21(1):131. Epub 2021 Sep 16.

Department of Laboratory Medicine, Sanggye Paik Hospital, Inje University College of Medicine, 1342 Dongil-ro, Nowon-gu, Seoul, 01757, Republic of Korea.

Background: We aimed to evaluate the usefulness of the Beckman Coulter prostate health index (PHI) and to compare it with total prostate-specific antigen (PSA) levels and related derivatives in predicting the presence and aggressiveness of prostate cancer (PCa) in the Korean population.

Methods: A total of 140 men who underwent their first prostate biopsy for suspected PCa were included in this prospective observational study. The diagnostic performance of total PSA, free PSA, %free PSA, [-2] proPSA (p2PSA), %p2PSA, and PHI in detecting and predicting the aggressiveness of PCa was estimated using the receiver operating characteristic curve (ROC) and logistic multivariate regression analyses. Read More

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September 2021

[Efficacy of combined treatment with mechanical circulation support devices and immunomodulation therapy for patients with fulminant myocarditis].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 Sep;49(9):894-899

Department of Cardiac Care Unit, Henan Provincial People's Hospital, Department of Cardiac Care Unit of Central China Fuwai Hospital,Central China Fuwai Hospital of Zhengzhou University, Zhengzhou 450003, China.

To summarize the efficacy of combined treatment strategy of mechanical circulation support devices and immunomodulation therapy for patients with fulminant myocarditis. We retrospectively analyzed the clinical data and outcomes of 37 fulminant myocarditis patients complicating cardiogenic shock, who were hospitalized from October 2017 to December 2019 in our department. Patients received guideline therapy according to "Chinese expert consensus statement on clinical diagnosis and treatment of fulminant myocarditis in adults"issued by Chinese Society of Cardiology of Chinese Medical Association. Read More

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September 2021

The Renaissance of Unicompartmental Knee Arthroplasty appears rational - A radiograph-based comparative Study on adverse Events and patient-reported Outcomes in 353 TKAs and 98 UKAs.

Authors:
Magnus Tveit

PLoS One 2021 16;16(9):e0257233. Epub 2021 Sep 16.

Department of Orthopedics, Skåne University Hospital, Clinical Sciences, Lund University, Lund, Sweden.

Purpose: Total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA) are both considered suitable for antero-medial osteoarthritis and spontaneous osteonecrosis of the knee. National registry data are consistent in showing higher revision rates for UKA. Adequately adjusted, these findings may be challenged by differences in adverse events and patient-reported outcomes, as both can have serious long-term implications. Read More

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September 2021

Disaggregating Data to Measure Racial Disparities in COVID-19 Outcomes and Guide Community Response - Hawaii, March 1, 2020-February 28, 2021.

MMWR Morb Mortal Wkly Rep 2021 Sep 17;70(37):1267-1273. Epub 2021 Sep 17.

Native Hawaiian and Pacific Islander populations have been disproportionately affected by COVID-19 (1-3). Native Hawaiian, Pacific Islander, and Asian populations vary in language; cultural practices; and social, economic, and environmental experiences, which can affect health outcomes (4). However, data from these populations are often aggregated in analyses. Read More

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September 2021

Impact of CYP2D6 Polymorphism on Equilibrium Concentration of Fluoxetine in Patients Diagnosed With Major Depressive Disorder and Comorbid Alcohol Use Disorders.

J Psychiatr Pract 2021 Sep 16;27(5):372-379. Epub 2021 Sep 16.

Introduction: Fluoxetine is used in the treatment of patients with recurrent depressive disorder. Some of these patients do not achieve an adequate response to a treatment regimen containing fluoxetine, and many of these patients experience dose-dependent adverse drug reactions. The cytochrome P450 enzyme CYP2D6 is involved in the biotransformation of fluoxetine, the activity of which is quite dependent on the polymorphism of the gene encoding this enzyme. Read More

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September 2021

Improving Practices of Mental Health Professionals in Recommending More Physical Activity and Less Sedentary Behaviour to Their Clients: An Intervention Trial.

Issues Ment Health Nurs 2021 Sep 16:1-7. Epub 2021 Sep 16.

Institute for Health and Sport, Victoria University, Melbourne, Australia.

We investigated the effects of increasing physical activity (PA) and reducing sedentary behaviour (SB) of mental health professionals on their attitudes towards and practices in recommending more PA and less SB to their clients. A 4-week pre-post intervention trial was conducted involving 17 mental health professionals. The participants who increased their own physical activity during the intervention increased the frequency of recommending more PA ( = 0. Read More

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September 2021

Antimicrobial action of photodynamic therapy on Enterococcus faecalis biofilm using curing light, curcumin and riboflavin.

Aust Endod J 2021 Sep 16. Epub 2021 Sep 16.

Laser Research Center of Dentistry, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

The aim of this study was to assess the effect of antimicrobial photodynamic therapy (aPDT) with curcumin and riboflavin on three-week Enterococcus faecalis biofilm. At first the 15-mm root canals of 65 single rooted extracted human teeth (including maxillary incisors, mandibular and maxillary canines and mandibular premolars) were separated from the crown and were prepared with ProTaper instruments. After autoclave sterilisation, samples were inoculated with E. Read More

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September 2021

Evaluation of hematological parameters and inflammatory markers in children with COVID-19.

Ir J Med Sci 2021 Sep 16. Epub 2021 Sep 16.

Department of Biochemistry, Selcuk University Faculty of Medicine, Konya, Turkey.

Background: The aim of this study was to evaluate hematological parameters in children with COVID-19 and determine the effects of inflammatory biomarkers on the assessment of hospitalization.

Methods: This retrospective single-center study was performed on 633 children with COVID-19 between March 2020 and January 2021. The study population was separated into two groups: inpatients (n = 83) and outpatients (n = 550). Read More

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September 2021

Trabecular bone score and bone mineral density in acromegalic osteopathy assessment: a cross-sectional study.

Arch Osteoporos 2021 Sep 16;16(1):134. Epub 2021 Sep 16.

CI Parhon National Institute of Endocrinology, Bucharest, Romania.

Purpose: The evaluation of acromegalic osteopathy is a subject of current interest as there is a lack of evidence concerning proper evaluation techniques and clear diagnostic criteria. The aim of this study was to evaluate lumbar spine trabecular bone score (TBS) and bone mineral density (BMD) in acromegaly patients compared to healthy controls.

Methods: We conducted a cross-sectional study on 43 acromegaly patients recruited between 2018 and 2020 and a healthy control group matched 1:1 for age, gender, and body mass index (BMI). Read More

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September 2021

Linking Macroinvertebrates and Physicochemical Parameters for Water Quality Assessment in the Lower Basin of the Volta River in Ghana.

Environ Manage 2021 Sep 16. Epub 2021 Sep 16.

Aquatic Ecology and Water Quality Management Group, Wageningen University, P.O. Box 47, 6700 AA, Wageningen, The Netherlands.

The health of the lower basin of the Volta River in Ghana was evaluated in January-February and May-June 2016 using physicochemical parameters and benthic macroinvertebrates sampled at 10 locations. Selected environmental variables were compared to accepted environmental water quality standard values where applicable. Principal component analysis (PCA) and redundancy analysis (RDA) were used to analyse the association between the benthic macroinvertebrates distribution and physicochemical variables. Read More

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September 2021

Clinical and Structural Results of Rotator Cuff Repair Compared With Rotator Cuff Debridement in Arthroscopic Treatment of Calcifying Tendinitis of the Shoulder.

Am J Sports Med 2021 Sep 16:3635465211037690. Epub 2021 Sep 16.

Department of Orthopaedic Surgery, Saarland University, Homburg (Saar), Germany.

Background: Arthroscopic treatment of calcifying tendinitis of the shoulder reveals good to excellent results. However, whether the tendon needs to be repaired after removal of the calcific deposit or simply debrided remains unclear.

Purpose: To evaluate the structural and clinical results after arthroscopic calcific deposit removal with additional rotator cuff repair or rotator cuff debridement. Read More

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September 2021

A relative quantitation method for measuring DNA methylation and hydroxymethylation using guanine as an internal standard.

Anal Methods 2021 Sep 16. Epub 2021 Sep 16.

MS Metabolomics Research Group, Centre for Structural Study, Research Centre for Natural Sciences, Eötvös Loránd Research Network, Magyar tudósok krt. 2, H-1117 Budapest, Hungary.

Global DNA methylation and hydroxymethylation play an important role in gene expression. They can be connected with several diseases. The modification status could be a biomarker to determine the status of disease. Read More

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September 2021

Self-esteem, metacognition, and coping strategies in cancer patients: A case-control study.

J Cancer Res Ther 2021 Jul-Sep;17(4):956-962

Department of Family Medicine, Karabuk University, Karabuk, Turkey.

Background: Self-esteem refers to a person's positive and negative attitudes towards the self, and metacognition is an upper system providing awareness and direction of events and mental functions. Coping refers to the specific and psychological efforts used to deal with stressful events or the negative effects of the agents of these. The aim of this study was to evaluate self-esteem, metacognition status and coping attitudes in patients with cancer, which is known to have severely destructive psychological effects. Read More

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September 2021

Evaluation of intraocular pressure change and anterior segment parameters after intravitreal bevacizumab injection - Cannula size matters.

Saudi J Ophthalmol 2020 Oct-Dec;34(4):247-250. Epub 2021 Jul 29.

Department of Ophthalmology, Uludağ University Hospital, Bursa, Turkey.

Purpose: To determine the changes in intraocular pressure (IOP) and anterior chamber parameters following intravitreal bevacizumab injection with different sizes of cannulas.

Methods: This clinical trial was conducted with 70 eyes of 70 patients who received an intravitreal injection of bevacizumab with 26 G (Group 1) or 30 G (Group 2) needle. Preinjection and postinjection 30-min IOP and pentacam measurements were obtained. Read More

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Cardioprotecive Properties of Known Agents in Rat Ischemia-Reperfusion Model Under Clinically Relevant Conditions: Only the NAD Precursor Nicotinamide Riboside Reduces Infarct Size in Presence of Fentanyl, Midazolam and Cangrelor, but Not Propofol.

Front Cardiovasc Med 2021 30;8:712478. Epub 2021 Aug 30.

Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, Netherlands.

Cardioprotective strategies against ischemia-reperfusion injury (IRI) that remain effective in the clinical arena need to be developed. Therefore, maintained efficacy of cardioprotective strategies in the presence of drugs routinely used clinically (e.g. Read More

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Does Mammotome biopsy affect surgery option and margin status of breast conserving surgery in breast cancer?

Gland Surg 2021 Aug;10(8):2428-2437

Department of Breast Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

Background: The Mammotome, an image-guided, usually ultrasound-guided vacuum-assisted breast biopsy (US-VABB) system, has been widely used in the early diagnosis of breast disease and the complete excision of benign lesions. However, in some malignant lesions underestimated by U.S. Read More

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Transfer factor treatment in management of peritonitis condition: An experimental study in rat.

Ann Med Surg (Lond) 2021 Sep 25;69:102755. Epub 2021 Aug 25.

Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.

Background: There is a role for the immune system in improving the outcome of peritonitis cases in children. Transfer factors are one immunomodulatory treatment that can increase the activity of natural killer (NK) cells to produce interferon-gamma (IFN-γ), which is thought to increase the phagocytic activity of macrophages. This study analyzed the effects of transfer factors on the phagocytic activity of macrophages in the intraperitoneal fluid of a Wistar rat model of peritonitis. Read More

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September 2021