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Long-term Safety and Efficacy of Avalglucosidase Alfa in Patients With Late-Onset Pompe Disease.

Neurology 2022 May 26. Epub 2022 May 26.

Friedrich-Baur-Institut, Department of Neurology Klinikum München, München, Germany.

Background And Objectives: Pompe disease is a rare, progressive neuromuscular disorder caused by deficiency of lysosomal acid α-glucosidase (GAA) and subsequent glycogen accumulation. Avalglucosidase alfa, a recombinant human GAA enzyme replacement therapy designed for increased cellular uptake and glycogen clearance, has been studied for long-term efficacy and safety in patients with late-onset Pompe disease (LOPD). Here we report up to 6. Read More

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Genome-wide Association and Meta-analysis of Age-at-Onset in Parkinson Disease: Evidence From COURAGE-PD Consortium.

Neurology 2022 May 26. Epub 2022 May 26.

Sorbonne Université (SU) Unité Mixte de Recherche (UMR) 1127, INSERM U1127, CNRS UMR 7225, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France.

Background And Objectives: Considerable heterogeneity exists in the literature concerning genetic determinants of the age of onset (AAO) of Parkinson's disease (PD), which could be attributed to lack of well-powered replication cohorts. The previous largest GWAS identified nd loci on chromosome (Chr) 4 with a significant influence on AAO of PD, these have not been independently replicated. The present study aims to conduct a meta-analysis of GWAS of PD AAO and validate previously observed findings in worldwide populations. Read More

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Volumetric Measurement of Relative CBV Using T1-Perfusion-Weighted MRI with High Temporal Resolution Compared with Traditional T2*-Perfusion-Weighted MRI in Postoperative Patients with High-Grade Gliomas.

AJNR Am J Neuroradiol 2022 May 26. Epub 2022 May 26.

From the Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, the Catholic University of Korea, Seoul, Republic of Korea.

Background And Purpose: T1-PWI with high temporal resolution may provide a reliable relative CBV value as a valid alternative to T2*-PWI under increased susceptibility. The purpose of this study was to assess the technical and clinical performance of T1-relative CBV in patients with postoperative high-grade gliomas.

Materials And Methods: Forty-five MRIs of 34 patients with proved high-grade gliomas were included. Read More

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Microinfarcts in the Deep Gray Matter on 7T MRI: Risk Factors, MRI Correlates, and Relation to Cognitive Functioning-The SMART-MR Study.

AJNR Am J Neuroradiol 2022 May 26. Epub 2022 May 26.

Julius Center for Health Sciences and Primary Care (R.G., I.R., M.I.G.)

Background And Purpose: The clinical relevance of cortical microinfarcts has recently been established; however, studies on microinfarcts in the deep gray matter are lacking. We examined the risk factors and MR imaging correlates of microinfarcts in the deep gray matter on 7T MR imaging and their relation to cognitive functioning.

Materials And Methods: Within the Second Manifestations of ARTerial disease-Magnetic Resonance (SMART-MR) study, 213 patients (mean age, 68 [SD, 8] years) had a risk-factor assessment, 7T and 1. Read More

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Diagnostic Accuracy of High-Resolution 3D T2-SPACE in Detecting Cerebral Venous Sinus Thrombosis.

AJNR Am J Neuroradiol 2022 May 26. Epub 2022 May 26.

From the University Institute of Diagnostic and Interventional Neuroradiology (A.H., C.K., K.P., M.E.).

Background And Purpose: Assessment of cerebral venous sinus thrombosis on MR imaging can be challenging. The aim of this study was to evaluate the diagnostic accuracy of high-resolution 3D T2 sampling perfection with application-optimized contrasts by using different flip angle evolution (SPACE) in patients with cerebral venous sinus thrombosis and to compare its performance with contrast-enhanced 3D T1-MPRAGE.

Materials And Methods: We performed a blinded retrospective analysis of T2-SPACE and contrast-enhanced MPRAGE sequences from patients with cerebral venous sinus thrombosis and a control group. Read More

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Views about Primary Care health checks for autistic adults: UK survey findings.

BJGP Open 2022 May 26. Epub 2022 May 26.

Cumbria Northumberland Tyne and Wear NHS Foundation Trust, Morpeth, UK.

Background: Compared to the general population, autistic adults experience higher rates of physical and mental health conditions, premature morbidity and mortality, and barriers to healthcare. A health check for autistic people may improve their health outcomes.

Aim: To establish the views of autistic people toward a primary care health check for autistic people. Read More

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Campus Food Pantry Use Is Linked to Better Health Among Public University Students.

J Nutr Educ Behav 2022 Jun;54(6):491-498

Department of Psychiatry, University of Arizona, Tucson, AZ.

Objective: To examine retrospectively whether access to a campus food pantry (CFP) is related to improvements in sleep, mental health, and physical health among college students in a public university system.

Design: Retrospective, cross-sectional study of student CFP users who completed an online survey in the summer of 2019.

Setting: Ten-campus University of California system. Read More

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Early language intervention improves behavioral adjustment in school: Evidence from a cluster randomized trial.

J Sch Psychol 2022 Jun 7;92:334-345. Epub 2022 May 7.

University of Oxford, UK; University of Oslo, Norway.

Oral language skills are critical for psychosocial development and children with language difficulties are more likely than peers to experience behavioral problems. This study investigated the effects of an oral language intervention on behavioral adjustment. We collected teacher ratings of behavioral adjustment for 1173 children taking part in a cluster randomized trial of the Nuffield Early Language Intervention (NELI) program in 193 primary schools. Read More

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A test of the maintenance of the effects of imagined contact framed with supportive social norms as a teacher-led field intervention.

J Sch Psychol 2022 Jun 6;92:324-333. Epub 2022 May 6.

Migration and Diversity Research Lab, Department of Psychology, University of Limerick, Ireland.

As the arrival of refugees and asylum seekers continues to increase, schools continue to become a vital center for children to develop positive intergroup attitudes. Teacher-led activities can become useful tools in sustainable prejudice reduction. A field intervention incorporated normative in-group influence with imagined intergroup contact to reduce children's anti-refugee bias. Read More

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A cost-effectiveness analysis of four approaches to universal screening for reading risk in upper elementary and middle school.

J Sch Psychol 2022 Jun 27;92:246-264. Epub 2022 Apr 27.

Gibson Consulting Group, Austin, TX, United States of America.

Research on universal screening in reading has primarily focused on the psychometric adequacy of screening procedures without critically considering costs and value. Educators in upper elementary and middle school have access to a great deal of extant student achievement data, which makes the evaluation of the costs associated with collecting new data for screening purposes paramount. We conducted a retrospective analysis of four approaches to reading screening using cost-effectiveness analysis. Read More

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Reading fluency intervention dosage: A novel meta-analysis and research synthesis.

J Sch Psychol 2022 Jun 13;92:148-165. Epub 2022 Apr 13.

University of Florida, USA.

Reading fluency is a fundamental component of reading proficiency, and yet, it is a common area of need for students demonstrating reading difficulties. In response, reading fluency interventions have been researched and implemented relatively extensively, but how much intervention is needed to affect reading fluency growth is not clear. The purpose of this study was to meta-analyze and synthesize the research base regarding targeted reading fluency interventions for kindergarten through 12th grade students and to examine how intervention dosage is conceptualized and measured in these interventions. Read More

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Impact of State Laws: CPR Education in High Schools.

J Am Coll Cardiol 2022 May;79(21):2140-2143

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA; Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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Disruption of Circadian Rhythms by Shift Work Exacerbates Reperfusion Injury in Myocardial Infarction.

J Am Coll Cardiol 2022 May;79(21):2097-2115

State Key Laboratory for Oncogenes and Related Genes, Division of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai, China. Electronic address:

Background: Shift work is associated with increased risk of acute myocardial infarction (AMI) and worsened prognosis. However, the mechanisms linking shift work and worsened prognosis in AMI remain unclear.

Objectives: This study sought to investigate the impact of shift work on reperfusion injury, a major determinant of clinical outcomes in AMI. Read More

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Gender Differences in Takotsubo Syndrome.

J Am Coll Cardiol 2022 May;79(21):2085-2093

University of Foggia, Department of Medical and Surgical Sciences, Foggia, Italy.

Background: Male sex in takotsubo syndrome (TTS) has a low incidence and it is still not well characterized.

Objectives: The aim of the present study is to describe TTS sex differences.

Methods: TTS patients enrolled in the international multicenter GEIST (GErman Italian Spanish Takotsubo) registry were analyzed. Read More

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Fracture Risk of Sodium-Glucose Cotransporter-2 Inhibitors in Chronic Kidney Disease.

Clin J Am Soc Nephrol 2022 May 26. Epub 2022 May 26.

Institute for Clinical and Evaluative Sciences (ICES), London, Ontario, Canada.

Background And Objectives: Sodium-glucose cotransporter-2 (SGLT2) inhibitors have been associated with a higher risk of skeletal fractures in some randomized, placebo-controlled trials. Secondary hyperparathyroidism and increased bone turnover (also common in CKD) may contribute to the observed fracture risk. We aimed to determine if SGLT2 inhibitor use associates with a higher risk of fractures compared with dipeptidyl peptidase-4 (DPP-4) inhibitors, which have no known association with fracture risk. Read More

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Affective disorders: eliminate WArning signs and REstore functioning-AWARE-a randomised controlled multimodule intervention study, presentation of design and intervention.

BMJ Open 2022 May 26;12(5):e058839. Epub 2022 May 26.

Research Unit, North Zealand Psychiatric Center, Hillerod, Copenhagen, Denmark.

Introduction: Affective disorders are associated with impaired overall functioning and quality of life (QoL). Despite different medical and psychological treatment options, the prognosis remains largely unchanged. Consequently, the field needs new intervention strategies especially targeting patient groups with impaired functioning. Read More

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Mediator or moderator? The role of obesity in the association between age at menarche and blood pressure in middle-aged and elderly Chinese: a population-based cross-sectional study.

BMJ Open 2022 May 26;12(5):e051486. Epub 2022 May 26.

Department of Emergency and Critical Care Nursing, School of Nursing, Wannan Medical College, Wuhu, Anhui, China.

Objective: We investigated the moderation/mediation between the age of menarche and obesity parameters in predicting blood pressure (BP) in middle-aged and elderly Chinese.

Design: Our study is a population-based cross-sectional study.

Setting: Participants in this study came from the China Health and Retirement Longitudinal Study (CHARLS). Read More

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Randomised controlled monocentric trial to compare the impact of using professional actors or peers for communication training in a competency-based inverted biochemistry classroom in preclinical medical education.

BMJ Open 2022 May 26;12(5):e050823. Epub 2022 May 26.

Institute of Biochemistry and Molecular Biolog, Ulm University, Ulm, Germany

Objective: In medical education, biochemistry topics are usually knowledge based, and students often are unaware of their clinical relevance. To improve students' awareness of the relevance, we integrated communication skills training into biochemistry education. No studies before have examined the difference between peer and standardised patient (SP) role plays where students explain the biochemical background of a disease in patient-centred language. Read More

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Meditation and yoga for irritable bowel syndrome: study protocol for a randomised clinical trial (MY-IBS study).

BMJ Open 2022 May 26;12(5):e059604. Epub 2022 May 26.

Department of Medicine, University of Calgary, Calgary, Alberta, Canada

Introduction: When delivered in person, yoga has been shown to be effective in managing irritable bowel syndrome (IBS) symptoms. Research is needed to test the feasibility and effectiveness of yoga as a therapeutic option when delivered virtually. The primary aim of the mind and yoga for IBS randomised controlled trial is to determine the effects of an 8-week virtual meditation and yoga intervention on IBS symptom severity compared with an advice-only active control group. Read More

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Remote versus face-to-face home-based exercise programme in people with amyotrophic lateral sclerosis: protocol for a randomised clinical trial.

BMJ Open 2022 May 26;12(5):e056323. Epub 2022 May 26.

Department of Physical Therapy, Federal University of Rio Grande do Norte, Natal, Brazil.

Introduction: Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease with variable and complex clinical manifestations that requires a multidisciplinary approach. However, face-to-face treatment in this population may experience barriers, such as difficulty accessing physical therapists or other professionals. As a result, strategies (eg, telerehabilitation) emerged to facilitate treatment and physical therapy monitoring. Read More

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The parent-reported ADHD symptom infrequency scale (PRASIS): a parent report measure of ADHD symptom exaggeration.

Child Neuropsychol 2022 May 26:1-21. Epub 2022 May 26.

Department of Psychology, Central Michigan University, Mount Pleasant, MI, USA.

The present article outlines the development of the parent-reported ADHD symptom infrequency scale (PRASIS), a novel stand-alone questionnaire designed to discriminate between parents exaggerating ratings of ADHD symptoms of their child from parents more accurately reporting symptoms. The PRASIS includes an Infrequency scale (INF) to measure infrequently reported symptoms of ADHD and a clinical scale to measure Diagnostic and Statistical Manual of Mental Disorders-5 Edition (DSM-5) defined ADHD symptoms (ADHD Total). An initial list of infrequency and clinical items was revised over the course of three studies, each conducted on a different sample of participants ( = 154,  = 203,  = 167) recruited via CloudResearch and consisting of mothers of children 4-12 years old. Read More

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Parametric mapping CMR for the measurement of inflammatory reactions of the pericardium.

Open Heart 2022 May;9(1)

Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland

Objectives: Although cardiovascular magnetic resonance (CMR) is increasingly used to diagnose pericardial inflammation, imaging can still be challenging using conventional CMR techniques. Parametric mapping (T1/T2 mapping) techniques have emerged as novel methods to quantify focal and global changes of the myocardium without contrast agent. The aim of the present study was to implement parametric mapping to facilitate diagnostic decision-making in pericardial inflammation. Read More

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Assessing the burden of COVID-19 in developing countries: systematic review, meta-analysis and public policy implications.

BMJ Glob Health 2022 May;7(5)

Western Sydney Diabetes, Western Sydney Local Health District, Blacktown, New South Wales, Australia

Introduction: The infection fatality rate (IFR) of COVID-19 has been carefully measured and analysed in high-income countries, whereas there has been no systematic analysis of age-specific seroprevalence or IFR for developing countries.

Methods: We systematically reviewed the literature to identify all COVID-19 serology studies in developing countries that were conducted using representative samples collected by February 2021. For each of the antibody assays used in these serology studies, we identified data on assay characteristics, including the extent of seroreversion over time. Read More

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Postural Control Adaptations in Yoga Single-Leg Support Postures: Comparison Between Practitioners and Nonpractitioners.

Motor Control 2022 May 26:1-18. Epub 2022 May 26.

Biomedical Engineering Program, COPPE, Federal University of Rio de Janeiro, Rio de Janeiro, RJ,Brazil.

This paper investigates whether a group of regular Yoga practitioners shows postural control differences compared with healthy controls while performing single-leg Yoga postures. Ten Yoga practitioners were compared with a control group of 10 nonpractitioners performing two single-leg support Yoga postures: Vrksasana (tree posture) and Natarajasana (dancer posture). Rambling and trembling decomposition of the center of pressure trajectories was implemented using a genetic algorithm spectral optimization that avoids using horizontal forces and was validated with bipedal posture data. Read More

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Association of Ankle Sprain Frequency With Body Mass and Self-Reported Function: A Pooled Multisite Analysis.

J Sport Rehabil 2022 May 26:1-6. Epub 2022 May 26.

School of Health and Kinesiology, University of Nebraska, Omaha, NE,USA.

Context: Ankle sprains result in pain and disability. While factors such as body mass and prior injury contribute to subsequent injury, the association of the number of ankle sprains on body anthropometrics and self-reported function are unclear in this population. Therefore, the purpose of this investigation was to assess differences in anthropometric measurements and self-reported function between the number of ankle sprains utilizing a large, pooled data set. Read More

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The Effects of a Physical Education Intervention Program on the Bone Properties of Second- and Third-Grade Pupils: A Cluster Randomized Controlled Trial.

J Phys Act Health 2022 May 26:1-11. Epub 2022 May 26.

School of Education, The Academic College at Wingate, Netanya,Israel.

Background: Many young children do not participate in sufficient physical activity for promoting optimal bone growth. The objective of this study was to investigate the effect of young children who participated in a school-based intervention program on bone properties. The program included structured physical activity, with a focus on the application of mechanical loads on the upper and lower limbs. Read More

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Efficacy of pembrolizumab in patients with advanced cancer of unknown primary (CUP): a phase 2 non-randomized clinical trial.

J Immunother Cancer 2022 May;10(5)

Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Background: Cancer of unknown primary (CUP) is an aggressive rare malignancy with limited treatment options. Data regarding clinical activity of immune checkpoint inhibitors in CUP is lacking. Therefore, we evaluated the efficacy of pembrolizumab, a programmed cell death-1 inhibitor, in patients with CUP. Read More

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