7,251 results match your criteria gross cardiac

Notch regulates vascular collagen IV basement membrane through modulation of lysyl hydroxylase 3 trafficking.

Angiogenesis 2021 May 6. Epub 2021 May 6.

Department of Biological Sciences, University of Denver, Denver, CO, 80210, USA.

Collagen type IV (Col IV) is a basement membrane protein associated with early blood vessel morphogenesis and is essential for blood vessel stability. Defects in vascular Col IV deposition are the basis of heritable disorders, such as small vessel disease, marked by cerebral hemorrhage and drastically shorten lifespan. To date, little is known about how endothelial cells regulate the intracellular transport and selective secretion of Col IV in response to angiogenic cues, leaving a void in our understanding of this critical process. Read More

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Precision Medicine Considerations for the Management of Heart Disease and Stroke in East Asians.

Cardiol Plus 2020 Jul-Sep;5(3):101-108. Epub 2020 Sep 30.

Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University, Stanford, California, USA.

Heart disease is the leading cause of death in Asian Americans. Importantly, people of East Asian descent are more likely to carry a loss-of-function point mutation in aldehyde dehydrogenase 2 (ALDH2), ALDH2*2, which reduces ALDH2 enzymatic activity by at least 40% relative to wild type ALDH2. Given the role of ALDH2 in removing toxic aldehydes from the cell, ALDH2 is intimately involved in the cardioprotective mechanisms of ischemic preconditioning and the pathophysiology of ischemia reperfusion injury. Read More

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September 2020

The effects of vibration on efficiency in off-road cyclists.

Turk J Phys Med Rehabil 2021 Mar 4;67(1):69-76. Epub 2021 Mar 4.

Department of Coaching Education, Ege University, Faculty of Sport Sciences, Izmir, Turkey.

Objectives: The aim of this study was to investigate whether vibration significantly affected the efficiency of off-road cyclists.

Patients And Methods: Eight male mountain cyclists (mean age 21.1±1 years; range, 19 to 22 years) between August 2017 and November 2017 were included. Read More

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Benefit of replanning in MR-guided online adaptive radiation therapy in the treatment of liver metastasis.

Radiat Oncol 2021 May 4;16(1):84. Epub 2021 May 4.

Department of Radiation Oncology, University Hospital of Zurich, University of Zurich, Raemistrasse 100, 8091, Zurich, Germany.

Purpose: To assess the effects of daily adaptive MR-guided replanning in stereotactic body radiation therapy (SBRT) of liver metastases based on a patient individual longitudinal dosimetric analysis.

Methods: Fifteen patients assigned to SBRT for oligometastatic liver metastases underwent daily MR-guided target localization and on-table treatment plan re-optimization. Gross tumor volume (GTV) and organs at risk (OARs) were adapted to the anatomy-of-the-day. Read More

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Inappropriate intensification of glucose-lowering treatment in older patients with type 2 diabetes: the global DISCOVER study.

BMJ Open Diabetes Res Care 2021 May;9(1)

Institute for Biometrics and Epidemiology, German Diabetes Center Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Dusseldorf, Germany.

Introduction: Although individualized target glycated hemoglobin (HbA) levels are recommended in older people with type 2 diabetes, studies report high levels of potential overtreatment. We aimed to investigate the proportion of older patients (aged ≥65 years) who potentially received an inappropriately intensive treatment (HbA level <7.0% (53. Read More

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An experimental study to evaluate the effect of (daily consumable) and (daily non-consumable) food items on albino rats.

Ayu 2019 Oct-Dec;40(4):247-255. Epub 2021 Jan 14.

Head of Department, Department of Pharmacology, ITRA, Jamnagar, Gujarat, India.

Background: As per Ayurveda, (NS) food items are recommended for daily intake while (NAS) food items should be avoided for daily intake due to their systemic wholesome and unwholesome effects after consumption, respectively.

Aim And Objectives: The present study was conducted to perform safety evaluation of selected and food items.

Materials And Methods: Thirty rats were randomly divided into five groups-each containing six Charle's Foster strain albino rats. Read More

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January 2021

Hypo-fractionated radiotherapy with concurrent chemotherapy for locoregional recurrence of non-small cell lung cancer after complete resection: A prospective, single-arm, phase II study (GASTO-1017).

Lung Cancer 2021 Apr 27;156:82-90. Epub 2021 Apr 27.

Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China; Lung Cancer Institute of Sun Yat-sen University, Guangzhou, China; Guangdong Association Study of Thoracic Oncology, Guangzhou, China. Electronic address:

Objectives: To explore the efficacy and toxicities of split-course hypo-fractionated radiotherapy with concurrent chemotherapy (HFRT-CHT) with intensity modulated radiotherapy (IMRT) technique in non-small cell lung cancer (NSCLC) patients with postoperative locoregional recurrence (LRR).

Materials And Methods: NSCLC patients were eligible if confirmed as LRR disease without distant metastasis after complete resection. HFRT-CHT using IMRT technique was administered with 51 Gy in 17 fractions or 40 Gy in 10 fractions as the first course followed by a break. Read More

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Degeneration of Aortic Valves in a Bioreactor System with Pulsatile Flow.

Biomedicines 2021 Apr 23;9(5). Epub 2021 Apr 23.

Department of Cardiac Surgery, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstraße 5, 40225 Düsseldorf, Germany.

Calcific aortic valve disease is the most common valvular heart disease in industrialized countries. Pulsatile pressure, sheer and bending stress promote initiation and progression of aortic valve degeneration. The aim of this work is to establish an ex vivo model to study the therein involved processes. Read More

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Select hyperactivating NLRP3 ligands enhance the T1- and T17-inducing potential of human type 2 conventional dendritic cells.

Sci Signal 2021 Apr 27;14(680). Epub 2021 Apr 27.

Laboratory of Dendritic Cell Biology, Department of Dermatology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg, 91052 Erlangen, Germany.

The detection of microorganisms and danger signals by pattern recognition receptors on dendritic cells (DCs) and the consequent formation of inflammasomes are pivotal for initiating protective immune responses. Although the activation of inflammasomes leading to secretion of the cytokine IL-1β is typically accompanied by pyroptosis (an inflammatory form of lytic programmed cell death), some cells can survive and exist in a state of hyperactivation. Here, we found that the conventional type 2 DC (cDC2) subset is the major human DC subset that is transcriptionally and functionally poised for inflammasome formation and response without pyroptosis. Read More

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Evaluation of supraglottic airway device use during inhalation anesthesia in healthy African pygmy hedgehogs (Atelerix albiventris).

Vet Anaesth Analg 2021 Mar 19. Epub 2021 Mar 19.

Department of Surgical Sciences, University of Wisconsin-Madison, School of Veterinary Medicine, Madison, WI, USA.

Objective: To evaluate a supraglottic airway device (SGAD) designed for rabbits in African pygmy hedgehogs (Atelerix albiventris) during inhalation anesthesia.

Study Design: Prospective, randomized, blinded experimental study.

Animals: A total of 12 adult African pygmy hedgehogs (seven male, five female). Read More

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A Novel Endoscopic Technique for Biopsy and Tissue Diagnosis for a Paraspinal Thoracic Tumor in a Pediatric Patient: A Case Report.

Int J Spine Surg 2021 Feb 29;14(s4):S66-S70. Epub 2020 Dec 29.

Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI.

Background: Conventional approaches to the thoracic spine can require extensive tissue dissection, bony disruption, and instability that may warrant the need for instrumentation and fusion. Furthermore, anterior approaches may require the involvement of various surgeons from multiple disciplines to ensure a successful operation and mitigate complications. Currently, available minimally invasive approaches still require bony removal and usually rely heavily on computed tomography (CT)-guided imaging without direct gross visualization. Read More

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February 2021

Mortality in Common (Sterna hirundo) and Sandwich (Thalasseus sandvicensis) Terns Associated with Bisgaard Taxon 40 Infection on Marco Island, Florida, USA.

J Comp Pathol 2021 Apr 22;184:12-18. Epub 2021 Feb 22.

Southeastern Cooperative Wildlife Disease Study, Departments of Pathology and Population Health, University of Georgia, Athens, Georgia, USA. Electronic address:

Widely distributed aquatic species such as terns are highly dependent on, and can serve as indicators of, the global health of marine and other aquatic environments. Documented mass mortality events in terns have been associated with anthropogenic, weather-related and, less commonly, infectious causes. This study describes a multispecies mortality event associated with brevetoxicosis and Bisgaard taxon 40-induced sepsis involving common (Sterna hirundo) and sandwich (Thalasseus sandvicensis) terns off the southwest coast of Florida, USA, in November and December 2018. Read More

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B-cell lymphoma invading and compressing the heart base and pericardium in a cat.

J Vet Cardiol 2021 Mar 24;35:84-89. Epub 2021 Mar 24.

The Animal Medical Center, 510 East 62nd Street, New York, NY 10065, USA. Electronic address:

A 3-year-old, 3.5-kg, neutered male, domestic shorthair cat presented with progressive lethargy, anorexia, coughing, and acute respiratory distress of two-week duration. Auscultation detected diffuse pulmonary crackles. Read More

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Physiological responses and cycle characteristics during double-poling versus diagonal-stride roller-skiing in junior cross-country skiers.

Eur J Appl Physiol 2021 Apr 24. Epub 2021 Apr 24.

Swedish Winter Sports Research Centre, Department of Health Sciences, Mid Sweden University, Östersund, Sweden.

Purpose: This study aimed to compare physiological factors and cycle characteristics during cross-country (XC) roller-skiing at matched inclines and speeds using the double-poling (DP) and diagonal-stride (DS) sub-techniques in junior female and male XC skiers.

Methods: Twenty-three well-trained junior XC skiers (11 women, 12 men; age 18.2 ± 1. Read More

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A genome-wide analysis of cardiac lesions of pigs that die during transport: Is heart failure of in-transit-loss pigs associated with a heritable cardiomyopathy?

Can J Vet Res 2021 Apr;85(2):119-126

Department of Population Medicine, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1 (Zurbrigg, Friendship, O'Sullivan); Department of Animal Science, Iowa State University, Ames, Iowa 50011, USA (Bertolini, Walugembe, Rothschild); National Institute of Aquatic Resources, Technical University of Denmark, Lyngby, Denmark (Bertolini); Veterinary Pathology Consultant, Ontario (van Dreumel), Veterinary Epidemiology Consultant, Elora, Ontario (Alves).

While heart failure is a primary cause of death for many in-transit-loss (ITL) pigs, the underlying cause of these deaths is not known. Cardiomyopathies are considered a common cause of heart failure in humans and often have a genetic component. The objective of this study was to determine if genes associated with cardiomyopathies could be identified in ITL pigs. Read More

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The Effectiveness of a 30-Week Concurrent Strength and Endurance Training Program in Preparation for an Ultra-Endurance Handcycling Challenge: A Case Study.

Int J Sports Physiol Perform 2021 Apr 21:1-7. Epub 2021 Apr 21.

Purpose: The aim of the following case study was to evaluate the effectiveness of a 30-week concurrent strength and endurance training program designed to prepare a trained H4 male handcyclist (aged 28 y, bilateral, above knee amputee, and body mass 65.6 kg) for a 1407-km ultra-endurance handcycling challenge.

Methods: This observational case study tracked selected physiological measures, training intensity distribution, and total training load over the course of a 30-week concurrent training protocol. Read More

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ATS Core Curriculum 2020. Pediatric Pulmonary Medicine.

ATS Sch 2020 Dec 30;1(4):456-475. Epub 2020 Dec 30.

Beth Israel Deaconess Medical Center, Boston, Massachusetts.

The American Thoracic Society Core Curriculum updates clinicians annually in adult and pediatric pulmonary disease, medical critical care, and sleep medicine, in a 3- to 4-year recurring cycle of topics. These topics will be presented at the 2020 International Conference. Below is the pediatric pulmonary medicine core, including pediatric hypoxemic respiratory failure; modalities in noninvasive management of chronic respiratory failure in childhood; surgical and nonsurgical management of congenital lung malformations; an update on smoke inhalation lung injury; an update on vaporizers, e-cigarettes, and other electronic delivery systems; pulmonary complications of sarcoidosis; pulmonary complications of congenital heart disease; and updates on the management of congenital diaphragmatic hernia. Read More

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December 2020

The economic impact of sudden cardiac arrest.

Resuscitation 2021 Apr 15;163:49-56. Epub 2021 Apr 15.

Baker Heart and Diabetes Institute, 75 Commercial Rd, Prahran, VIC, 3181, Australia; Alfred Hospital, 55 Commercial Rd, Prahran, VIC, 3181, Australia; St Vincent's Hospital Melbourne, 41 Victoria Pde, Fitzroy, VIC, 3065, Australia.

Background: There are 20,000 sudden cardiac arrests (SCAs) in Australia annually, with 90% case-fatality.

Objective: The present study calculated both the health and economic impact of SCAs in Victoria, Australia.

Methods: Data on all SCAs attended by Ambulance Victoria from July 2017 to June 2018 were collected regarding age, gender, and survival to hospital, discharge and 12 months. Read More

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Impact of heat stress on broilers with varying body weights: Elucidating their interactive role through physiological signatures.

J Therm Biol 2021 Apr 20;97:102840. Epub 2021 Jan 20.

Division of Avian Genetics and Breeding, ICAR-Central Avian Research Institute, Izatnagar, 243122, Uttar Pradesh, India.

Physiological determinants of different body weight (BW) broiler chickens under heat stressed conditions were investigated to compare the performance at market age considering medium body weight group as standard. At 5 weeks, broilers were categorized randomly into 3 treatments (N = 24 per group) as high (HBW) (>1050 g), medium (MBW) (900-1050 g) and low (LBW) (<900 g) followed by simultaneous exposure to normal and heat stress (HS) conditions at 40 ± 1 °C and 45 ± 5% RH for 4 h/day for a period of 7 days (D) and sample collection was employed at D0, D3 and D7. Physiological and stress responses, haematological and biochemical profile, intestinal gross and histological aspects were estimated using standard protocols. Read More

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Infectious bronchitis associated with infection in commercial broiler chickens: a case report.

J Adv Vet Anim Res 2021 Mar 5;8(1):101-104. Epub 2021 Mar 5.

Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Pengkalan Chepa, 16100 Kota Bharu, Kelantan, Malaysia.

Objective: In this case report, we have investigated the infectious bronchitis (IB) virus (IBV) outbreak with the co-infection of in 28-33-day-old broiler chickens in Malaysia.

Materials And Methods: A farmer complained that Cobb 500 chickens, raised in the open house, were having bloody diarrhea, open mouth breathing, non-uniform growth, and ruffled feathers. The mortality was about 100 birds (from about 7000 birds) per day. Read More

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Men's Health: Benign Prostatic Hyperplasia.

Robert C Langan

FP Essent 2021 Apr;503:18-22

St. Luke's Family Medicine Residency Program at St. Luke's Hospital - Sacred Heart Campus, 421 West Chew St, Allentown, PA, 18102.

Benign prostatic hyperplasia (BPH) commonly causes lower urinary tract symptoms (LUTS) through narrowing of the urethra and disruption of innervation of the gland. BPH is common in older men. Risk factors include Black race, Hispanic ethnicity, obesity, type 2 diabetes, high levels of alcohol consumption, physical inactivity, and a family history of BPH. Read More

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The left ventricular assist device as a patient monitoring system.

Ann Cardiothorac Surg 2021 Mar;10(2):221-232

Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.

Technological progress of left ventricular assist devices (LVADs) towards rotary blood pumps and the optimization of medical management contributed to the significant improvements in patient survival as well as LVAD support duration. Even though LVAD therapy is now well-established for end-stage heart failure patients, the long-term occurrence of adverse events (AE) such as bleeding, infection or stroke, still represent a relevant burden. An early detection of AE, before onset of major symptoms, can lead to further optimization of patient treatment and thus mitigate the burden of AE. Read More

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Invasive Aortic Valve Endocarditis: Clinical and Tissue Findings from a Prospective Investigation.

Ann Thorac Surg 2021 Apr 8. Epub 2021 Apr 8.

Department of Thoracic and Cardiovascular Surgery, Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:

Background: Advanced aortic valve infective endocarditis (IE) with progression and destruction beyond the valve cusps-invasive IE-is incompletely characterized. We aimed to further characterize invasive disease extent, location, and stage and correlate macroscopic operative findings with microscopic disease patterns and progression.

Methods: Forty-three patients with invasive aortic valve IE were prospectively enrolled from 8/2017 to 7/2018. Read More

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SARS-CoV 2 Infection (Covid-19) and Cardiovascular Disease in Africa: Health Care and Socio-Economic Implications.

Glob Heart 2021 03 15;16(1):18. Epub 2021 Mar 15.

Hatter Institute for Cardiovascular Research in Africa, University of Cape Town, Cape Town, ZA.

The current pandemic of SARS-COV 2 infection (Covid-19) is challenging health systems and communities worldwide. At the individual level, the main biological system involved in Covid-19 is the respiratory system. Respiratory complications range from mild flu-like illness symptoms to a fatal respiratory distress syndrome or a severe and fulminant pneumonia. Read More

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Assessment of a Contralateral Esophagus-Sparing Technique in Locally Advanced Lung Cancer Treated With High-Dose Chemoradiation: A Phase 1 Nonrandomized Clinical Trial.

JAMA Oncol 2021 Apr 8. Epub 2021 Apr 8.

Department of Radiation Oncology, Massachusetts General Hospital, Boston.

Importance: Severe acute esophagitis occurs in up to 20% of patients with locally advanced lung cancer treated with chemoradiation therapy to at least 60 Gy once daily and represents a dose-limiting toxic event associated with poor outcomes.

Objective: To assess whether formalized sparing of the contralateral esophagus (CE) is associated with reduced risk of severe acute esophagitis.

Design, Setting, And Participants: This single-center phase 1 nonrandomized clinical trial assessing an empirical CE-sparing technique enrolled patients from July 2015 to January 2019. Read More

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Review of MR-Guided Radiotherapy for Esophageal Cancer.

Front Oncol 2021 22;11:628009. Epub 2021 Mar 22.

Department of Radiation Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.

In this review, we outline the potential benefits and the future role of MRI and MR-guided radiotherapy (MRgRT) in the management of esophageal cancer. Although not currently used in most clinical practice settings, MRI is a useful non-invasive imaging modality that provides excellent soft tissue contrast and the ability to visualize cancer physiology. Chemoradiation therapy with or without surgery is essential for the management of locally advanced esophageal cancer. Read More

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Haploinsufficiency of PRR12 causes a spectrum of neurodevelopmental, eye, and multisystem abnormalities.

Genet Med 2021 Apr 6. Epub 2021 Apr 6.

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Purpose: Proline Rich 12 (PRR12) is a gene of unknown function with suspected DNA-binding activity, expressed in developing mice and human brains. Predicted loss-of-function variants in this gene are extremely rare, indicating high intolerance of haploinsufficiency.

Methods: Three individuals with intellectual disability and iris anomalies and truncating de novo PRR12 variants were described previously. Read More

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Comparison of identifiable and non-identifiable data linkage: health technology assessment of MitraClip using registry, administrative and mortality datasets.

BMJ Health Care Inform 2021 Apr;28(1)

Northern Medical Physics and Clinical Engineering, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle Upon Tyne, Tyne and Wear, UK

Objectives: The UK MitraClip registry was commissioned by National Health Service (NHS) England to assess real-world outcomes from percutaneous mitral valve repair for mitral regurgitation using a new technology, MitraClip. This study aimed to determine longitudinal patient outcomes by linking to routine datasets: Hospital Episode Statistics (HES) Admitted Patient Care (APC) and Office of National Statistics.

Methods: Two methods of linkage were compared, using identifiable (NHS number, date of birth, postcode, gender) and non-identifiable data (hospital trust, age in years, admission, discharge and operation dates, operation and diagnosis codes). Read More

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Piezo1 Channels Contribute to the Regulation of Human Atrial Fibroblast Mechanical Properties and Matrix Stiffness Sensing.

Cells 2021 Mar 16;10(3). Epub 2021 Mar 16.

Institute for Experimental Cardiovascular Medicine, University Heart Center Freiburg Bad Krozingen, and Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany.

The mechanical environment of cardiac cells changes continuously and undergoes major alterations during diseases. Most cardiac diseases, including atrial fibrillation, are accompanied by fibrosis which can impair both electrical and mechanical function of the heart. A key characteristic of fibrotic tissue is excessive accumulation of extracellular matrix, leading to increased tissue stiffness. Read More

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