3,337 results match your criteria grf


A novel kinematic detection of foot-strike and toe-off events during noninstrumented treadmill running to estimate contact time.

J Biomech 2021 Sep 6;128:110737. Epub 2021 Sep 6.

Institute of Sport Sciences, University of Lausanne, 1015 Lausanne, Switzerland.

Contact time (t) relies upon the accuracy of foot-strike and toe-off events, for which ground reaction force (GRF) is the gold standard. However, force plates are not always available, e.g. Read More

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September 2021

Brain functional alterations in MDD patients with somatic symptoms: A resting-state fMRI study.

J Affect Disord 2021 Sep 4;295:788-796. Epub 2021 Sep 4.

Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan 030001, PR China. Electronic address:

Objective: It has been established that major depressive disorder (MDD) is accompanied by various somatic symptoms that are related to the clinical course and severity of depression. However, the mechanisms of somatic symptoms in MDD have rarely been studied. In this study, we sought to investigate the functional neurological changes in MDD patients with somatic symptoms based off the regional homogeneity (ReHo) and the amplitude of low-frequency fluctuation (ALFF). Read More

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September 2021

Maximal Strength in Relation to Force and Velocity Patterns During Countermovement Jumps.

Int J Sports Physiol Perform 2021 Sep 11:1-7. Epub 2021 Sep 11.

Maximal strength is important for the performance of dynamic athletic activities, such as countermovement jumps (CMJ). Although measures of maximal strength appear related to discrete CMJ variables, such as peak ground reaction forces (GRF) and center-of-mass (COM) velocity, knowledge about the association between strength and the time series patterns during CMJ will help characterize changes that can be expected in dynamic movement with changes in maximal strength.

Purpose: To investigate the associations between maximal strength and GRF and COM velocity patterns during CMJ. Read More

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September 2021

Predictors of short-term impulsive and compulsive behaviour after subthalamic stimulation in Parkinson disease.

J Neurol Neurosurg Psychiatry 2021 Sep 11. Epub 2021 Sep 11.

Department of Neurology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany

Background: The effects of subthalamic stimulation (subthalamic nucleus-deep brain stimulation, STN-DBS) on impulsive and compulsive behaviours (ICB) in Parkinson's disease (PD) are understudied.

Objective: To investigate clinical predictors of STN-DBS effects on ICB.

Methods: In this prospective, open-label, multicentre study in patients with PD undergoing bilateral STN-DBS, we assessed patients preoperatively and at 6-month follow-up postoperatively. Read More

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September 2021

Association of bilateral lower limb coordination while standing with body sway control and aging.

Somatosens Mot Res 2021 Sep 8:1-9. Epub 2021 Sep 8.

Department of Physical Therapy, Yamagata Prefectural University of Health Sciences, Yamagata, Japan.

Purpose: Coordinated movements of both lower limbs may be a clinically important indicator of motor control during quiet standing. From a neurological point of view, it is known that extensive coupling of muscles must be coordinated an upright posture. However, movement coordination between the lower limbs is the final motor output, is unknown. Read More

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September 2021

Ocular Delivery of Predatory Bacteria with Cryomicroneedles Against Eye Infection.

Adv Sci (Weinh) 2021 Sep 8:e2102327. Epub 2021 Sep 8.

Department of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, China.

The development of potent antibiotic alternatives with rapid bactericidal properties is of great importance in addressing the current antibiotic crisis. One representative example is the topical delivery of predatory bacteria to treat ocular bacterial infections. However, there is a lack of suitable methods for the delivery of predatory bacteria into ocular tissue. Read More

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September 2021

The 6-month effect of whole soy and purified isoflavones daidzein on thyroid function-A double-blind, randomized, placebo controlled trial among Chinese equol-producing postmenopausal women.

Phytother Res 2021 Sep 7. Epub 2021 Sep 7.

Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University (North Campus), Guangzhou, China.

The aim of this study was to examine the effect of whole soy and purified daidzein on markers of thyroid function in Chinese postmenopausal women who were equol-producers. Total 270 eligible women were randomized to either one of the three isocaloric supplements: 40 g soy flour (whole soy group), 40 g low-fat milk powder +63 mg daidzein (daidzein group) or 40 g low-fat milk powder (placebo) daily for 6 months. Serum thyroid markers were tested at baseline and 6 months for thyroid stimulating hormone, free triiodothyronine, reverse triiodothyronine and free thyroxine (FT4). Read More

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September 2021

Force-length-velocity behavior and muscle-specific joint moment contributions during countermovement and squat jumps.

Comput Methods Biomech Biomed Engin 2021 Sep 7:1-10. Epub 2021 Sep 7.

Joint Department of Biomedical Engineering, University of North Carolina System, Chapel Hill, North Carolina, USA.

The countermovement (CMJ) and squat (SJ) jump are common tasks used to assess neuromuscular performance. While much is known about joint-level differences between both tasks, not much is known about differences in muscle-level biomechanics. The purpose of this study was to calculate the forces, force-length-velocity behavior, and muscle-specific contributions to net joint moments (NJM) during CMJ and SJ. Read More

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September 2021

Gutenberg Gait Database, a ground reaction force database of level overground walking in healthy individuals.

Sci Data 2021 09 2;8(1):232. Epub 2021 Sep 2.

Department of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, Mainz, Germany.

The Gutenberg Gait Database comprises data of 350 healthy individuals recorded in our laboratory over the past seven years. The database contains ground reaction force (GRF) and center of pressure (COP) data of two consecutive steps measured - by two force plates embedded in the ground - during level overground walking at self-selected walking speed. The database includes participants of varying ages, from 11 to 64 years. Read More

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September 2021

Biomechanical characterization of the foot-ground interaction among Service members with unilateral transtibial limb loss performing unconstrained drop-landings: Effects of drop height and added mass.

J Biomech 2021 Aug 20;127:110701. Epub 2021 Aug 20.

Research & Development Section, Department of Rehabilitation, Walter Reed National Military Medical Center, Bethesda, MD, USA; Research & Surveillance Division, DoD-VA Extremity Trauma and Amputation Center of Excellence, Walter Reed National Military Medical Center, Bethesda, MD, USA; Department of Rehabilitation Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Electronic address:

There exist limited data to guide the development of methodologies for evaluating impact resilience of prosthetic ankle-foot systems, particularly regarding human-device interaction in ecologically valid scenarios. The purpose of this study was to biomechanically characterize foot-ground interactions during drop-landings among Service members with and without unilateral transtibial limb loss. Seven males with, and seven males without, unilateral transtibial limb loss completed six drop-landing conditions consisting of all combinations of three heights (20 cm, 40 cm, 60 cm) and two loads (with and without a 22. Read More

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A new approach to modelling the ground reaction force from a runner.

J Biomech 2021 Jul 24;127:110639. Epub 2021 Jul 24.

Department of Mechanical Engineering, UNESP, Ilha Solteira, São Paulo 15385-000, Brazil.

The impact force experienced by a runner when his/her foot makes contact with the ground has been the subject of much research. This force is called the ground reaction force (GRF), and has been measured by several groups. In parallel with this, mathematical models have been developed to simulate GRFs in order to investigate various effects on this, such as the parameters of the human body and types of running shoe soles. Read More

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Information needs on breast cancer genetic and non-genetic risk factors in relatives of women with a BRCA1/2 or PALB2 pathogenic variant.

Breast 2021 Aug 23;60:38-44. Epub 2021 Aug 23.

Institut Curie, Supportive Care Department, Psycho-oncology Unit, PSL University, 26 rue d'Ulm, Paris, 75005 Paris Cedex 05, France; CESP, University Paris-Sud, UVSQ, INSERM, University Paris-Saclay, 16 Avenue Paul Vaillant-Couturier, 94807, Villejuif Cedex, France.

Objectives: Comprehensive breast cancer (BC) risk models integrating effects of genetic (GRF) and non-genetic risk factors (NGRF) may refine BC prevention recommendations. We explored the perceived information received on BC risk factors, and related characteristics, in female relatives of women with a BRCA1/2 or PALB2 pathogenic variant, undergoing BC risk assessment using the CanRisk© prediction tool.

Methods: Of 200 consecutive cancer-free women approached after the initial genetic consultation, 161 (80. Read More

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Ratio of forces during sprint acceleration: A comparison of different calculation methods.

J Biomech 2021 Aug 13;127:110685. Epub 2021 Aug 13.

Univ Savoie Mont Blanc, Interuniversity Laboratory of Human Movement Biology, EA 7424, Chambéry, F-73000, France.

The orientation of the ground reaction force (GRF) vector is a key determinant of human sprint acceleration performance and has been described using ratio of forces (RF) which quantifies the ratio of the antero-posterior component to the resultant GRF. Different methods have previously been used to calculate step-averaged RF, and this study therefore aimed to compare the effects of three calculation methods on two key "technical" ability measures: decline in ratio of forces (D) and theoretical maximal RF at null velocity (RF). Twenty-four male sprinters completed maximal effort 60 m sprints from block and standing starts on a fully instrumented track (force platforms in series). Read More

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Differential Retinal Protein Expression in Primary and Secondary Retinal Ganglion Cell Degeneration Identified by Integrated SWATH and Target-Based Proteomics.

Int J Mol Sci 2021 Aug 10;22(16). Epub 2021 Aug 10.

Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong 999077, China.

To investigate the retinal proteins associated with primary and secondary retinal ganglion cell (RGC) degeneration and explore their molecular pathways, SWATH label-free and target-based mass spectrometry was employed to identify the proteomes in various retinal locations in response to localized optic nerve injury. Unilateral partial optic nerve transection (pONT) was performed on adult Wistar rats and their retinas were harvested 2 weeks later. To confirm the separation of primary and secondary RGC degeneration, immunohistochemistry of RNA binding protein with multiple splicing (RBPMS) and glial fibrillary acidic protein (GFAP) was performed on retinal whole-mounts. Read More

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Recovery of Metals from Heat-Treated Printed Circuit Boards via an Enhanced Gravity Concentrator and High-Gradient Magnetic Separator.

Materials (Basel) 2021 Aug 14;14(16). Epub 2021 Aug 14.

Key Laboratory of Coal Processing and Efficient Utilization of Ministry of Education, China University of Mining and Technology, Xuzhou 221116, China.

The recovery and reuse of waste printed circuit boards (PCBs) has attracted more and more attention from global researchers, as recycling of waste PCB metals is of great significance to the rational utilization of metal material resources. This study puts forward a clean and economical method in which enhanced gravity separation and wet high-gradient magnetic separation were combined to recover waste PCBs with heat treatment at a temperature of 240 °C. The heat treatment could improve the metal liberation effect of the PCBs, and the thermal behavior was measured by thermogravimetric analysis (TGA). Read More

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Regional and remote connectivity patterns in focal extratemporal lobe epilepsy.

Ann Transl Med 2021 Jul;9(14):1128

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.

Background: Focal epilepsy accounts for most epilepsy cases, and frontal lobe epilepsy (FLE) accounts for the largest proportion of cases of extratemporal epilepsy syndrome. The epileptogenic zone is usually not easy to locate, contributing to a lack of imaging studies. The objective of this study was to evaluate functional connectivity patterns to explore the underlying pathological mechanisms of this disorder. Read More

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Characteristics of ground reaction force and frontal body movement during failed trials of single-leg lateral drop jump-landing task.

Asia Pac J Sports Med Arthrosc Rehabil Technol 2021 Oct 2;26:8-14. Epub 2021 Aug 2.

Clinical Center for Sports Medicine and Sports Dentistry, Tokyo Medical and Dental University, Tokyo, Japan.

Background: /objectives: For biomechanical studies using jump-landing tasks, many researchers set the criteria for judging success or failure of the trial. Failed trials are usually removed from the analysis. However, the kinetics and kinematics during tasks included in failed trials might be important for understanding the mechanisms and risk factors of non-contact sports injuries. Read More

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October 2021

Descriptive and Kinetic Analysis of Two Different Vertical Jump Tests Among Youth and Adolescent Male Basketball Athletes Using a Supervised Machine Learning Approach.

J Strength Cond Res 2021 Aug 19. Epub 2021 Aug 19.

Minnesota Timberwolves, Sports Science and Performance, Minneapolis, Minnesota; University of Houston Clear Lake, School of Human Sciences and Humanities, Houston, Texas; School of Kinesiology, Applied Health, and Human Performance, Oklahoma State University, Stillwater, Oklahoma; and Trinity University, Strength & Conditioning, San Antonio, Texas.

Abstract: Gillett, J, De Witt, J, Stahl, CA, Martinez, D, and Dawes, JJ. Descriptive and kinetic analysis of two different vertical jump tests among youth and adolescent male basketball athletes using a supervised machine learning approach. J Strength Cond Res XX(X): 000-000, 2021-The countermovement jump (CMJ) is a functional movement in basketball and is also frequently used as an assessment of lower-body power. Read More

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Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage.

Nat Biomed Eng 2021 Aug 19. Epub 2021 Aug 19.

Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.

The progression of osteoarthritis is associated with inflammation triggered by the enzymatic degradation of extracellular matrix in injured cartilage. Here we show that a locally injected depot of nanoparticles functionalized with an antibody targeting type II collagen and carrying small interfering RNA targeting the matrix metalloproteinase 13 gene (Mmp13), which breaks down type II collagen, substantially reduced the expression of MMP13 and protected cartilage integrity and overall joint structure in acute and severe mouse models of post-traumatic osteoarthritis. MMP13 inhibition suppressed clusters of genes associated with tissue restructuring, angiogenesis, innate immune responses and proteolysis. Read More

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Different effects of the DRD4 genotype on intrinsic brain network connectivity strength in drug-naïve children with ADHD and healthy controls.

Brain Imaging Behav 2021 Aug 18. Epub 2021 Aug 18.

Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.

The dopamine D4 receptor gene (DRD4) has been consistently reported to be associated with attention-deficit/hyperactivity disorder (ADHD). Recent studies have linked DRD4 to functional connectivity among specific brain regions. The current study aimed to compare the effects of the DRD4 genotype on functional integrity in drug-naïve ADHD children and healthy children. Read More

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AtHDA6 functions as an H3K18ac eraser to maintain pericentromeric CHG methylation in Arabidopsis thaliana.

Nucleic Acids Res 2021 Aug 17. Epub 2021 Aug 17.

School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region.

Pericentromeric DNA, consisting of high-copy-number tandem repeats and transposable elements, is normally silenced through DNA methylation and histone modifications to maintain chromosomal integrity and stability. Although histone deacetylase 6 (HDA6) has been known to participate in pericentromeric silencing, the mechanism is still yet unclear. Here, using whole genome bisulfite sequencing (WGBS) and chromatin immunoprecipitation-sequencing (ChIP-Seq), we mapped the genome-wide patterns of differential DNA methylation and histone H3 lysine 18 acetylation (H3K18ac) in wild-type and hda6 mutant strains. Read More

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More than Sports Participation: The Role of Ground Reaction Force, Osteocalcin and Lean Soft Tissue on Bone Density Accrual in Adolescents: ABCD Growth Study.

J Clin Densitom 2021 Jul 24. Epub 2021 Jul 24.

Post-Graduation Program in Movement Sciences, Sao Paulo State University (UNESP), Presidente Prudente, Brazil; Laboratory of InVestigation in Exercise LIVE, Department of Physical Education, Sao Paulo State University (UNESP), Presidente Prudente, Brazil.

The objective of this study was to identify predictors of 12-mo areal bone density accrual in different body segments, lean soft tissue, and osteogenic characteristics attributed to sports participation among adolescent girls and boys. Adolescents (Girls [n = 64], [aged = 14.7]); Boys [n = 129], [aged = 14. Read More

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Graded bulk-heterojunction enables 17% binary organic solar cells via nonhalogenated open air coating.

Nat Commun 2021 Aug 10;12(1):4815. Epub 2021 Aug 10.

Department of Electronic and Information Engineering, Research Institute for Smart Energy (RISE), The Hong Kong Polytechnic University, Hong Kong, China.

Graded bulk-heterojunction (G-BHJ) with well-defined vertical phase separation has potential to surpass classical BHJ in organic solar cells (OSCs). In this work, an effective G-BHJ strategy via nonhalogenated solvent sequential deposition is demonstrated using nonfullerene acceptor (NFA) OSCs. Spin-coated G-BHJ OSCs deliver an outstanding 17. Read More

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Correlation between Levels of Vitamins D and E in Type 2 Diabetes Mellitus: A Case-Control Study in Serdang, Selangor, Malaysia.

Nutrients 2021 Jul 1;13(7). Epub 2021 Jul 1.

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.

An overview of vitamins D and E suggests micronutrient deficiency contributes to type 2 diabetes mellitus (T2DM). A case-control study was conducted to determine the status of plasma vitamins D and E isomers amongst diabetic Malaysians. Two groups were recruited for participation, one comprising fifty diabetic subjects (DM) and one comprising fifty non-diabetic (non-DM) subjects, in order to assess their plasma vitamin D, calcium and vitamin E status. Read More

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Increased Loading Rates During Gait Correlate With Morphology of Unaffected Hip in Juveniles With Treated Developmental Hip Dysplasia.

Front Bioeng Biotechnol 2021 21;9:704266. Epub 2021 Jul 21.

Department of Biomedical Engineering, National Taiwan University, Taipei, Taiwan.

Long-term follow-up studies on children with surgically treated developmental dysplasia of the hip (DDH) have shown that not only the affected side progresses to premature osteoarthritis, but the unaffected side may also suffer from insidious hip dysplasia or osteonecrosis. The current gait analysis study identified the loading and unloading rates of the ground reaction forces (GRF) and lower limb joint axial forces during gait, and their correlations with the hip morphology in twenty juvenile patients with surgically treated unilateral DDH during toddlerhood. In a gait laboratory, each subject walked at preferred speed on a 10-m walkway while the kinematics and the GRF were measured. Read More

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New Insights in Mechanisms and Therapeutics for Short- and Long-Term Impacts of Hepatic Ischemia Reperfusion Injury Post Liver Transplantation.

Authors:
Hui Liu Kwan Man

Int J Mol Sci 2021 Jul 30;22(15). Epub 2021 Jul 30.

Department of Surgery, HKU-SZH & Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Liver transplantation has been identified as the most effective treatment for patients with end-stage liver diseases. However, hepatic ischemia reperfusion injury (IRI) is associated with poor graft function and poses a risk of adverse clinical outcomes post transplantation. Cell death, including apoptosis, necrosis, ferroptosis and pyroptosis, is induced during the acute phase of liver IRI. Read More

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The Mechanistic Action of Biosynthesised Silver Nanoparticles and Its Application in Aquaculture and Livestock Industries.

Animals (Basel) 2021 Jul 14;11(7). Epub 2021 Jul 14.

Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia UPM, Serdang 43400, Selangor, Malaysia.

Nanotechnology is a rapidly developing field due to the emergence of various resistant pathogens and the failure of commercial methods of treatment. AgNPs have emerged as one of the best nanotechnology metal nanoparticles due to their large surface-to-volume ratio and success and efficiency in combating various pathogens over the years, with the biological method of synthesis being the most effective and environmentally friendly method. The primary mode of action of AgNPs against pathogens are via their cytotoxicity, which is influenced by the size and shape of the nanoparticles. Read More

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Symmetry function - An effective tool for evaluating the gait symmetry of trans-femoral amputees.

Gait Posture 2021 Aug 2;90:9-15. Epub 2021 Aug 2.

Department of Physiotherapy, Faculty of Health Sciences, Wroclaw Medical University, 50-367, Wrocław, Poland.

Background: Prostheses can help persons with trans-femoral amputation (TFA) regain normal function, but such individuals still exhibit gait deviations expressed in gait asymmetries. We apply a specialised tool, the Symmetry Function (SF), to evaluate the symmetry of walking in terms of kinematic and dynamic variables and to identify areas with large side deviations (exceeding defined ±5% threshold) in the movement cycle.

Research Question: Which movements and joints or GRF components revealed the most significant side deviations in the movement cycle? When exactly are they located in the gate cycle?

Methods: In this retrospective observational study, an instrumented motion analysis system was used to register the gait of fourteen patients after unilateral TFA. Read More

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Stress analysis of intervertebral disc during occupational activities.

Comput Methods Programs Biomed 2021 Sep 23;208:106298. Epub 2021 Jul 23.

Department of Mechanical Engineering, Korea University, 145, Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea. Electronic address:

Background And Objective: Manual material handling activities cause large compression of the intervertebral disc of the lumbar spine. Intradiscal pressure (IDP) has generally been employed to predict the risk of low back injury. As an alternative to in vivo measurements, either motion analysis or finite element (FE) analysis has been used to estimate IDP. Read More

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September 2021

Instability and results after non-operative treatment of large anterior glenoid rim fractures: is there a correlation between fragment size or displacement and recurrence?

Arch Orthop Trauma Surg 2021 Aug 2. Epub 2021 Aug 2.

Department of General and Trauma Surgery, University Bergmannsheil Bochum, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.

Introduction: There is little data available on non-operative treatment of anterior glenoid rim fractures (GRF). Nothing is known about fracture size and displacement in comparison to clinical outcomes and instability in a mainly middle-aged patient population. The aim of this study was to demonstrate the results of non-operative treatment in anterior glenoid rim fractures with the special focus on potential instability/recurrence. Read More

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