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Deep attributed graph clustering with self-separation regularization and parameter-free cluster estimation.

Neural Netw 2021 Jul 15;142:522-533. Epub 2021 Jul 15.

Beijing Municipal Key Laboratory of Multimedia and Intelligent Software Technology, Faculty of Information Technology, Beijing University of Technology, Beijing, 100124, China; Beijing Artificial Intelligence Institute, Beijing University of Technology, Beijing, 100124, China. Electronic address:

Detecting clusters over attributed graphs is a fundamental task in the graph analysis field. The goal is to partition nodes into dense clusters based on both their attributes and structures. Modern graph neural networks provide facilitation to jointly capture the above information in attributed graphs with a feature aggregation manner, and have achieved great success in attributed graph clustering. Read More

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J Vasc Surg 2021 Jul 24. Epub 2021 Jul 24.

Department of Surgery, Division of Vascular Surgery, University of Arizona.

Introduction: Over the last decade, multidisciplinary "toe and flow" programs have gained great popularity with proven benefits in limb salvage. Many vascular surgeons have incorporated podiatrists into their practices. The viability of this practice model requires close partnership, hospital support, and financial sustainability. Read More

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A Legislative/Legal History of Prescription Drug Advertising and Promotion Regulation.

J Pharm Pharm Sci 2021 ;24:381-389

Gibbs Pharma Solutions, Cambridge, MA, USA.

Purpose: The communication by pharmaceutical companies of promotional messages about their products has long been controversial, but deemed to be necessary by the pharmaceutical industry so that health care professionals and in some cases patients/consumers can be made aware of the latest developments through the communication vehicles they are accustomed to seeing - in the case of health care professionals, through medical advertising, direct mail, visits by company representatives, and attendance at medical meetings, and in case of patients, through the news media and television advertising. On the other hand, critics argue that such promotion, which sometimes reduces complex medical issues to advertising slogans, is inappropriate for products intended to treat and cure diseases, and that health care professionals should learn about new products from peer-reviewed medical literature.  Consequently, advertising, and promotional programs are heavily regulated by the U. Read More

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January 2021

Mini-Mental State Examination (MMSE) for the early detection of dementia in people with mild cognitive impairment (MCI).

Cochrane Database Syst Rev 2021 Jul 27;7:CD010783. Epub 2021 Jul 27.

Department of Psychological Medicine, University of Auckland, Auckland, New Zealand.

Background: Dementia is a progressive global cognitive impairment syndrome. In 2010, more than 35 million people worldwide were estimated to be living with dementia. Some people with mild cognitive impairment (MCI) will progress to dementia but others remain stable or recover full function. Read More

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Rational Design of Nonbonded Point Charge Models for Divalent Metal Cations with Lennard-Jones 12-6 Potential.

J Chem Inf Model 2021 Jul 27. Epub 2021 Jul 27.

Department of Biological Science and Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.

Exploring a metal-involved biochemical process at a molecular level often requires a reliable description of metal properties in aqueous solution by classical nonbonded models. An additional term for considering ion-induced dipole interactions was previously proposed to supplement the widely used Lennard-Jones 12-6 potential (known as the 12-6-4 LJ-type model) with good accuracy. Here, we demonstrate an alternative to modeling divalent metal cations (M) with the traditional 12-6 LJ potential by developing nonbonded point charge models for use with 11 water models: TIP3P, SPC/E, SPC/E, TIP4P-Ew, TIP4P-D, and TIP4P/2005 and the more recent OPC3, TIP3P-FB, OPC, TIP4P-FB, and a99SB-. Read More

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Crystallization-Induced Enhanced Electrochemiluminescence from Tetraphenyl Alkene Nanocrystals for Ultrasensitive Sensing.

Anal Chem 2021 Jul 27. Epub 2021 Jul 27.

Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China.

Organic materials with diverse structures and brilliant glowing colors have been attracting extensive attention in optical electronic devices and electrochemiluminescence (ECL) fields and are currently faced with the issue of low ECL efficiency. Herein, a series of tetraphenyl alkene nanocrystals (TPA NCs) with an ordered molecular structure were synthesized to explore regularities in the crystallization-induced enhanced (CIE) ECL emission effects by altering the number and position of vinyl on the backbone of TPA molecules. Among those TPA NCs, tetraphenyl-1,3-butadiene (TPB) NCs exhibit the brightest ECL emission via a coreactant pathway, with the relative ECL efficiency of up to 31. Read More

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Effects of rotation grazing time on the characteristics of soil seed bank in desert steppe.

Ying Yong Sheng Tai Xue Bao 2021 Jul;32(7):2378-2388

Institute of Agriculture and Animal Husbandry Science, Science and Technology Bureau of Yanchi County, Ningxia 751500, China.

Exploring the characteristics of soil seed bank under seasonal grazing plays an important role in the reasonable use of desert steppe. We examined seed bank species composition, density, vertical distribution, diversity in the soil of 0-5, 5-10, 10-15 cm soil layers and the relationship with vegetation and soil environmental factors in Ningxia desert steppe. The treatments included enclosure (FY), traditional time rotation grazing (FG), delayed to start rotation grazing (YG), early to end rotation grazing (TG), delayed to start and early to end rotation grazing (YT) and free grazing (ZY). Read More

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Constructing multicomponent cooperative functional systems using metal complexes of short flexible peptides.

Ryosuke Miyake

Chem Commun (Camb) 2021 Jul 27. Epub 2021 Jul 27.

Department of Chemistry and Biochemistry, Graduate School of Humanities and Sciences, Ochanomizu University, 2-1-1, Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan.

The construction of cooperative systems comprising several units is an essential challenge for artificial systems toward the development of sophisticated functions comparable to those found in biological systems. Flexible frameworks possessing various functional groups that can form weak intra/intermolecular interactions similar to those observed in biological systems have promising design features for artificial systems used to control cooperative systems. However, it is difficult to construct multiple component systems >1 nm using these flexible units by controlling the arrangement of functional units, beginning with the precise control of the cooperative switching of multiple units. Read More

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9-Cyanopyronin probe palette for super-multiplexed vibrational imaging.

Nat Commun 2021 07 26;12(1):4518. Epub 2021 Jul 26.

Department of Chemistry, Columbia University, New York, NY, USA.

Multiplexed optical imaging provides holistic visualization on a vast number of molecular targets, which has become increasingly essential for understanding complex biological processes and interactions. Vibrational microscopy has great potential owing to the sharp linewidth of vibrational spectra. In 2017, we demonstrated the coupling between electronic pre-resonant stimulated Raman scattering (epr-SRS) microscopy with a proposed library of 9-cyanopyronin-based dyes, named Manhattan Raman Scattering (MARS). Read More

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Biofilm associated genotypes of multiple antibiotic resistant Pseudomonas aeruginosa.

BMC Genomics 2021 Jul 26;22(1):572. Epub 2021 Jul 26.

Faculty of Science and Engineering, Manchester Metropolitan University, Chester Street, Manchester, United Kingdom.

Background: Pseudomonas aeruginosa is a ubiquitous environmental microorganism and also a common cause of infection. Its ability to survive in many different environments and persistently colonize humans is linked to its presence in biofilms formed on indwelling device surfaces. Biofilm promotes adhesion to, and survival on surfaces, protects from desiccation and the actions of antibiotics and disinfectants. Read More

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The ability of modern therapy to improve the prognosis of patients with HF: role of angiotensin neprilysin inhibitors and sodium-glucose cotransporter inhibitors.

Kardiologiia 2021 Jul 1;61(6):4-10. Epub 2021 Jul 1.

Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia Faculty of Fundamental Medicine, Lomonosov Moscow State University, Russia.

Major principles for treatment of chronic heart failure with reduced left ventricular ejection fraction <40% (HFrEF) include a "triple neurohormonal blockade" as a main approach. However, in recent 6 years, two new classes of drugs for the treatment of HFrEF have appeared, which beneficially influence the prognosis. These drugs are angiotensin receptor neprilysin inhibitors (ARNI) and type 2 sodium-glucose cotransporter 2 (SGLT2) inhibitors. Read More

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Toward the Development of Disposable Electrodes Based on Holmium Orthovanadate/-Boron Nitride: Impacts and Electrochemical Performances of Emerging Inorganic Contaminants.

Inorg Chem 2021 Jul 26. Epub 2021 Jul 26.

Department of Chemistry, Stella Maris College, Affiliated to the University of Madras, Chennai, Tamil Nadu 600086, India.

Rare-earth metal orthovanadates have great technological relevance in the family of rare-earth compounds owing to their excellent physical and chemical properties. A significant number of studies have been carried out on this class of compounds to exploit their electrochemical properties in virtue of variable oxidation states. But holmium vanadate (HoV) and its morphology selective synthesis have not been considered, which can have potential applications similar to the rest of the family. Read More

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Laser Printing of Multilayered Alternately Conducting and Insulating Microstructures.

ACS Appl Mater Interfaces 2021 Jul 23. Epub 2021 Jul 23.

Department of Chemistry, Bar-Ilan University, Ramat Gan 5290002, Israel.

Production of multilayered microstructures composed of conducting and insulating materials is of great interest as they can be utilized as microelectronic components. Current proposed fabrication methods of these microstructures include top-down and bottom-up methods, each having their own set of drawbacks. Laser-based methods were shown to pattern various materials with micron/sub-micron resolution; however, multilayered structures demonstrating conducting/insulating/conducting properties were not yet realized. Read More

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Review: Genetic selection of high-yielding dairy cattle toward sustainable farming systems in a rapidly changing world.

Animal 2021 Jul 19:100292. Epub 2021 Jul 19.

Centre for Genetic Improvement of Livestock, Department of Animal Biosciences, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada.

The massive improvement in food production, as a result of effective genetic selection combined with advancements in farming practices, has been one of the greatest achievements of modern agriculture. For instance, the dairy cattle industry has more than doubled milk production over the past five decades, while the total number of cows has been reduced dramatically. This was achieved mainly through the intensification of production systems, direct genetic selection for milk yield and a limited number of related traits, and the use of modern technologies (e. Read More

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Two-Branch 3D Convolutional Neural Network for Motor Imagery EEG decoding.

J Neural Eng 2021 Jul 26. Epub 2021 Jul 26.

Shien-Ming Wu School of Intelligent Engineering, South China University of Technology, 777 Xingye Avenue, Panyu District, Guangzhou, Guangdong, 510460, CHINA.

Objective: The original motor imagery electroencephalography (MI-EEG) data contains not only temporal features but also a large number of spatial features related to the distribution of electrodes on the brain. However, in the process of MI-EEG decoding, most of the current convolutional neural network (CNN) based methods do not make the utmost of the spatial features related to electrode distribution.

Approach: In this study, we adopt a concise 3D representation for the MI-EEG data to take full advantage of the spatial features and propose a two-branch 3D CNN (TB-3D CNN) for the 3D representation of MI-EEG data. Read More

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Application of Machine Learning for eutrophication analysis and algal bloom prediction in an urban river: A 10-year study of the Han River, South Korea.

Sci Total Environ 2021 Jul 17;797:149040. Epub 2021 Jul 17.

Department of Environment and Energy, Sejong University, Seoul 05006, South Korea. Electronic address:

The increasing release of nutrients to aquatic environments has led to great concern regarding eutrophication and the risk of unwanted algal blooms. Based on observational data of 20 water quality parameters measured on a monthly basis at 40 stations from 2011 to 2020, this study applied different Machine Learning (ML) algorithms to suggest the best option for algal bloom prediction in the Han River, a large river in South Korea. Eight different ML algorithms were categorized into several groups of statistical learning, regression family, and deep learning, and were then compared for their suitability to predict the chlorophyll-derived trophic index (TSI-Chla). Read More

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MicroRNA-based host response to toxicant exposure is influenced by the presence of gut microbial populations.

Sci Total Environ 2021 Jul 20;797:149130. Epub 2021 Jul 20.

Center for Microbial Ecology, Michigan State University, East Lansing, MI 48824, USA; Department of Plant, Soil, and Microbial Sciences, Michigan State University, East Lansing, MI 48824, USA; Department of Civil and Environmental Engineering, East Lansing, MI 48824, USA. Electronic address:

Segmented filamentous bacteria (SFB) and Bacteroides fragilis are known to interact with the host immune response through the aryl hydrocarbon receptor (Ahr). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), an environmental toxicant and a high-affinity Ahr ligand has the potential to modify the effect of SFB and B. fragilis. Read More

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Understanding mechanisms of drug resistance in epilepsy and strategies for overcoming it.

Expert Opin Drug Metab Toxicol 2021 Jul 26. Epub 2021 Jul 26.

Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8b, 20-090 Lublin, Poland.

Introduction: The present evidence indicates that approximately 70% of patients with epilepsy can be successfully treated with antiepileptic drugs (AEDs). A significant proportion of patients are not under sufficient control and pharmacoresistant epilepsy is clearly associated with poor quality of life and increased morbidity and mortality. There is a great need for newer therapeutic options able to reduce the percentage of drug-resistant patients. Read More

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A Novel Nanomedicine Ameliorates Acute Inflammatory Bowel Disease by Regulating Macrophages and T-Cells.

Mol Pharm 2021 Jul 26. Epub 2021 Jul 26.

Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, P. R. China.

polysaccharide (RMP), one of the most important active components of , has been attracting increasing interest because of its potent bioactive properties, including anti-inflammatory, antitumor, and antidiabetic effects. Despite the great therapeutic potential of RMP, its inherent properties of low bioavailability and brief biological half-life have limited its applications to the clinic. Thus, RMP was packaged by poly(lactic--glycolic acid) (PLGA) nanoparticles to develop a novel anti-inflammatory nanomedicine (PLGA-RMP) in this study. Read More

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Long-term blood pressure trajectories and associations with age and body mass index among urban women in South Africa.

Cardiovasc J Afr 2021 Jul 26;32:1-7. Epub 2021 Jul 26.

MRC Developmental Pathways for Health Research Unit (DPHRU), Department of Paediatrics, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Blood pressure (BP) is known to increase inevitably with age. Understanding the different ages at which great gains could be achieved for intervention to prevent and control BP would be of public health importance.

Methods: Data collected between 2003 and 2014 from 1 969 women aged 22 to 89 years were used in this study. Read More

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First Report of Enterobacter cloacae Causing Bulb Decay on Garlic in China.

Plant Dis 2021 Jul 26. Epub 2021 Jul 26.

Beijing, China;

Enterobacter cloacae is a symbiotic bacterium, which is one of the species in intestinal microbiota in many humans and animals. In some cases, it causes harmful diseases in humans. More and more studies showed that E. Read More

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Sputnik V Vaccine Elicits Seroconversion and Neutralizing Capacity to SARS CoV-2 after a Single Dose.

Cell Rep Med 2021 Jul 9:100359. Epub 2021 Jul 9.

Hospital Interzonal Especializado de Agudos y Crónicos San Juan de Dios, Provincia de Buenos Aires, Argentina.

Massive vaccination offers great promise for halting the global COVID-19 pandemic. However, limited supply and uneven vaccine distribution create an urgent need to optimize vaccination strategies. We evaluate SARS-CoV-2-specific antibody responses after Sputnik V vaccination of healthcare workers in Argentina, measuring IgG anti-spike titers and neutralizing capacity after one and two doses in a cohort of naïve or previously infected volunteers. Read More

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Comparison of Cardiothoracic Surgical Training Before and During the COVID Pandemic in the United Kingdom.

JTCVS Open 2021 Jul 16. Epub 2021 Jul 16.

Department of Cardiothoracic Surgery, Barts Heart Centre, St Bartholomew's Hospital, London, UK.

Objectives: Cardiothoracic training during the COVID-19 pandemic witnessed a dramatic change in the UK, resulting in changes in surgical provisions, centralisation of services and reduced surgical case volume. The aim of this study is to assess the impact COVID-19 on surgical training and seek opinions regarding the future role of surgical simulation in cardiothoracic training.

Methods: A cross sectional survey was designed and distributed amongst cardiothoracic national and non-national trainees in the UK. Read More

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Rapid Separation and Efficient Removal of Cd Based on Enhancing Surface Precipitation by Carbonate-Modified Biochar.

ACS Omega 2021 Jul 8;6(28):18253-18259. Epub 2021 Jul 8.

Hunan Province Key Laboratory of Coal Resources Clean Utilization and Mine Environment Protection, Hunan University of Science and Technology, Xiangtan, Hunan 411201, China.

The high buoyancy of biochar makes its application difficult in Cd removal. In this paper, the content of minerals was increased by modifying carbonate on the biochar surface using the vacuum impregnation method. Enhancing surface precipitation between minerals and Cd introduced a correspondingly great number of Cd precipitates on the biochar surface, leading to the rapid precipitation and separation of buoyant biochar. Read More

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Childhood Idiopathic Nephrotic Syndrome: Does the Initial Steroid Treatment Modify the Outcome? A Multicentre, Prospective Cohort Study.

Front Pediatr 2021 8;9:627636. Epub 2021 Jul 8.

Pediatric Nephrology, Dialysis and Transplant Unit, Fondazione Ca' Granda Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore Policlinico, Milan, Italy.

A great majority of children with idiopathic nephrotic syndrome will relapse after successful treatment of the initial episode. The possibility that different steroid dosing regimens at onset, adjusted for risk factors, can reduce the rate of relapse represents an interesting option to investigate. To evaluate the effect of the initial steroid regimen, adjusted for time to remission (TTR), on the frequency of relapses and steroid dependence, and to verify the influence of prognostic factors on disease course. Read More

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Effects of fake and original perfumes on the presence, numbers, and distribution of mast cells in selected tissues in rats.

Open Vet J 2021 Apr-Jun;11(2):277-282. Epub 2021 Jun 6.

Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Background: Perfumes, whether original or fake, are considered of great economic value. However, overzealous use of perfumes could be associated with local or systemic side effects.

Aim: This study was conducted to investigate the effects of daily use of original and fake perfumes on numbers and distribution of mast cells in several organs and tissues of Wistar rats. Read More

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Clinical application of mesenchymal stem cells therapy in musculoskeletal injuries in dogs-a review of the scientific literature.

Open Vet J 2021 Apr-Jun;11(2):188-202. Epub 2021 Apr 12.

Department of Veterinary Sciences, ECAV, UTAD, Vila Real, Portugal.

Mesenchymal stem cells (MSCs) are multipotent, which is defined by their ability to self-renew while maintaining the capacity to differentiate into a certain number of cells, presumably from their own germinal layer. MSCs therapy is based on their anti-inflammatory, immunomodulatory (immunosuppressive), and regenerative potential. This review aims to provide a clinical overview of the MSCs potential as a therapeutic option for orthopedic diseases in dogs. Read More

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Clinical significance of combined detection of anti-Mullerian hormone and follicular output rate in women of late reproductive age.

Am J Transl Res 2021 15;13(6):6270-6278. Epub 2021 Jun 15.

Department of Reproductive Medicine, Hengshui People's Hospital Hengshui 053000, Hebei Province, China.

Objective: This study was designed to explore the clinical significance of anti-Mullerian hormone (AMH) combined with follicular output rate (FORT) in women of late reproductive age.

Methods: A total of 258 women (age range: 35-45 years old) who underwent pre-pregnancy examination in our hospital were collected as the research group (RG), among whom 184 were treated with fertilization-embryo transfer (IVF-ET). Concurrently, 126 women aged 24-30 years who came to our hospital for pre-pregnancy examination were enrolled as the control group (CG). Read More

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A Study of the Brain Network Connectivity in Visual-Word Pairing Associative Learning and Episodic Memory Reactivating Task.

Comput Intell Neurosci 2021 8;2021:5579888. Epub 2021 Jul 8.

Computational Engineering Applications Unit, Head Office for Information Systems and Cybersecurity, RIKEN, Wako-Shi, Japan.

Episodic memory allows a person to recall and mentally reexperience specific episodes from one's personal past. Studies of episodic memory are of great significance for the diagnosis and the exploration of the mechanism of memory generation. Most of the current studies focus on certain brain regions and pay less attention to the interrelationship between multiple brain regions. Read More

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The Expression Profiles of mRNAs and lncRNAs in Buffalo Muscle Stem Cells Driving Myogenic Differentiation.

Front Genet 2021 7;12:643497. Epub 2021 Jul 7.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Animal Reproduction Institute, Guangxi University, Nanning, China.

Buffalo breeding has become an important branch of the beef cattle industry. Hence, it is of great significance to study buffalo meat production and meat quality. However, the expression profiles of mRNA and long non-coding RNAs (lncRNA) molecules in muscle stem cells (MuSCs) development in buffalo have not been explored fully. Read More

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