13,444 results match your criteria great arteries


Quantifying the Intra-Operative Hemodynamic Effects of Glue Embolization in Vein of Galen Malformations.

Proc IEEE Int Symp Biomed Imaging 2019 11;2019:754-758. Epub 2019 Jul 11.

School of Biomedical Engineering & Imaging Sciences, King's College London, UK.

Vein of Galen malformation is a rare congenital pathological intracranial arteriovenous shunt which carries 30% risk of death before 28 days-of-age. Treatment is by high risk minimally invasive endovascular glue embolization of shunt feeding arteries under angiographic control. A tool to support intra-operative decision making would be useful. Read More

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Occipitocervical instrumented fixation utilising patient-specific C2 3D-printed spinal screw trajectory guides in complex paediatric skeletal dysplasia.

Childs Nerv Syst 2021 Jun 19. Epub 2021 Jun 19.

Department of Neurosurgery, Great Ormond Street Hospital, UCL Great Ormond Street Institute of Child Health, London, UK.

Purpose: Instability of the craniocervical junction in paediatric patients with skeletal dysplasia poses a unique set of challenges including anatomical abnormalities, poor bone quality, skeletal immaturity and associated general anaesthetic risks. Instrumented fixation provides optimal stabilisation and fusion rates. The small vertebrae make the placement of C2 pedicle screws technically demanding with low margins of error between the spinal canal and the vertebral artery. Read More

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Williams syndrome.

Nat Rev Dis Primers 2021 Jun 17;7(1):42. Epub 2021 Jun 17.

Department of Paediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Williams syndrome (WS) is a relatively rare microdeletion disorder that occurs in as many as 1:7,500 individuals. WS arises due to the mispairing of low-copy DNA repetitive elements at meiosis. The deletion size is similar across most individuals with WS and leads to the loss of one copy of 25-27 genes on chromosome 7q11. Read More

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Management of Congenitally Corrected Transposition of the Great Arteries With Intact Ventricular Septum: Anatomic Repair or Palliative Treatment?

Circ Cardiovasc Interv 2021 Jun 18:CIRCINTERVENTIONS120010154. Epub 2021 Jun 18.

Department of Cardiovascular Surgery, Boston Children's Hospital, Harvard Medical School, MA (H.C., B.L.P., G.R.M., C.W.B., P.J.d.N., S.M.E.).

Background: Management of the congenitally corrected transposition of the great arteries (ccTGA) with intact ventricular septum (IVS) is controversial and includes either anatomic repair with systemic left ventricle (morphological left ventricle) or maintenance of a systemic right ventricle (morphological right ventricle). The purpose of this study was to describe outcomes of ccTGA-IVS with either strategy.

Methods: A single-institution, retrospective review of all patients with a diagnosis of ccTGA-IVS who either underwent double switch operation (DSO) or managed with systemic morphological right ventricle (no-DSO). Read More

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Coronary Arteries: Normal Anatomy With Historical Notes and Embryology of Main Stems.

Front Cardiovasc Med 2021 31;8:649855. Epub 2021 May 31.

Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Padua, Italy.

Anatomy of subepicardial coronary arteries became a topic of investigation at autopsy in Florence (Italy) by Banchi in the early twentieth century, with the discovery of dominant and balanced patterns. Thereafter, in the 60's of the same century Baroldi in Milan did post-mortem injection with spectacular three-dimensional casts. Later Sones at the Cleveland Clinic introduced selective coronary arteriography for visualization of coronary arteries. Read More

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Failing systemic right ventricle in a patient with dextrocardia and complex congenitally corrected transposition of the great arteries: a case report of successful transvenous cardiac resynchronization therapy.

Eur Heart J Case Rep 2021 Apr 12;5(4):ytab068. Epub 2021 Apr 12.

Department of Cardiology, Leiden Heart-Lung Center, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.

Background : Patients with congenitally corrected transposition of the great arteries (ccTGA) are prone to the development of advanced atrio-ventricular block requiring chronic ventricular pacing. The morphological right ventricle (RV) often develops systolic dysfunction as it is unable to withstand the chronic pressure overload it is exposed to when supporting the systemic circulation.

Case Summary : A 56-year-old woman with dextrocardia and complex ccTGA with a history of dual-chamber implantable cardioverter-defibrillator (DDD-ICD, high degree atrio-ventricular-block and syncopal ventricular tachycardia), presented with progressive heart failure and symptomatic atrial arrhythmias. Read More

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Left ventricle implantable cardioverter defibrillator: a dextro-transposition of the great arteries case.

Cardiol Young 2021 Jun 14:1-2. Epub 2021 Jun 14.

Department of Cardiology, São João Universitary Hospital, Porto, Portugal.

We present a case of a patient with dextro-transposition of the great arteries palliated with a Senning procedure and a long-term arrhythmic complication that required an intervention, with an Implantable Cardioverter Defibrillator (ICD) implantation in the sub-pulmonary ventricle (morphologically left). This case highlights the need to perform off-label procedures to deal with the long-term complications of these complex patients. Read More

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Fetal double outlet right ventricle without heterotaxy syndrome: diagnostic spectrum, associated extracardiac pathology and clinical outcomes.

Prenat Diagn 2021 Jun 12. Epub 2021 Jun 12.

Fetal & Neonatal Cardiology Program, Division of Pediatric Cardiology, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

Objectives: To document the clinical spectrum and outcomes of fetal DORV without heterotaxy in a recent diagnostic era.

Methods: Prenatal cases of DORV consecutively diagnosed from 2007-2018 were retrospectively identified. Clinical records, including details regarding genetic testing and pre and postnatal imaging were reviewed. Read More

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Tetra ostial coronary arterial anatomy-A rare pattern in transposition.

J Card Surg 2021 Jun 12. Epub 2021 Jun 12.

Pediatric Cardiac Surgery, Madras Medical Mission, Chennai, India.

Background: Meticulous transfer of coronary arteries is of crucial importance in transposition and determines the success of the switch procedure. This report describes a coronary arterial anatomy consisting of four separate ostia from the two facing sinuses in a 6-month-old infant presenting with transposition and ventricular septal defect.

Conclusion: Being a rare coronary arterial pattern not described in previous coding systems, the surgeon would do well to be aware of this possibility while performing the switch procedure. Read More

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HOXA5 induces M2 macrophage polarization to attenuate carotid atherosclerosis by activating MED1.

IUBMB Life 2021 Jun 11. Epub 2021 Jun 11.

Department of Vascular Surgery, The First Hospital of China Medical University, Shenyang, China.

Macrophage polarization is of great importance in the formation of atherosclerotic plaque. Homeobox A5 (HOXA5), one of the homeobox transcription factors, has been revealed to be closely associated with macrophage phenotype switching. This study aims to investigate the role of HOXA5 in carotid atherosclerosis (CAS). Read More

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Assessing Early Cardiac Outflow Tract Adaptive Responses Through Combined Experimental-Computational Manipulations.

Ann Biomed Eng 2021 Jun 11. Epub 2021 Jun 11.

Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, 304 Weill Hall, Ithaca, NY, 14853-7202, USA.

Mechanical forces are essential for proper growth and remodeling of the primitive pharyngeal arch arteries (PAAs) into the great vessels of the heart. Despite general acknowledgement of a hemodynamic-malformation link, the direct correlation between hemodynamics and PAA morphogenesis remains poorly understood. The elusiveness is largely due to difficulty in performing isolated hemodynamic perturbations and quantifying changes in-vivo. Read More

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Corrigendum to "Congenitally Corrected Transposition of the Great Arteries: Anatomic, Physiologic Repair, and Palliation" [Semin Thorac Cardiovasc Surg Pediatr Card Surg Ann 2019;22:32-42].

Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2021 ;24:95-96

Pediatric Congenital Heart Surgery, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas.

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January 2021

How and When Should Tetralogy of Fallot be Palliated Prior to Complete Repair?

Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2021 ;24:77-84

Hospital for Sick Children, Department of Surgery, Division of Cardiovascular Surgery, Toronto, Ontario, Canada.

The controversy regarding the best or ideal surgical management of Tetralogy of Fallot (ToF) stems from the recognition of there being a spectrum of morphology and associated lesions, each of which require a different approach to achieve the three goals of minimizing mortality preserving right ventricular function long-term and minimizing reinterventions. A one-size-fits-all approach to ToF needs to be replaced by a considered and personalized approach in order to yield the best outcomes possible for individual patients. The great majority of patients with ToF undergo primary complete repair between age 3-9 months with excellent outcomes. Read More

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January 2021

Panoramic imaged carotid atheromas are associated with increased neutrophil count: both validated, independent predictors of near-term myocardial infarction.

Dentomaxillofac Radiol 2021 Jun 16:20210045. Epub 2021 Jun 16.

Maxillofacial Surgery & Medicine, Dental Service, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.

Objectives: Panoramic images (PXs) demonstrating calcified carotid artery atheromas (CCAAs) are associated with heightened risk of near-term myocardial infarction (MI). Elevated neutrophil counts (NC) within normal range 2,500-6,000 per mm are likewise associated with future MI signaling the role neutrophils play in the chronic inflammation process underlying coronary artery atherogenesis. We determined if CCAAs on PXs are associated with increased NC. Read More

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Congenitally corrected transposition of the great arteries (CCTGA).

BMJ Case Rep 2021 Jun 9;14(6). Epub 2021 Jun 9.

Department of Cardiology, Mater Dei Hospital, Msida, Malta.

A 33-year-old man presented with a 3-week history of breathlessness and cough. He disclosed that he was informed regarding a heart defect as a child in his home country but was unaware of its nature and was never followed up. Examination revealed a pansystolic murmur (loudest at the apex), a hyperdynamic, displaced apex, and pulmonary oedema. Read More

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Artificial intelligence and guidance of medicine in the bubble.

Cell Biosci 2021 Jun 9;11(1):108. Epub 2021 Jun 9.

Institute for Immunity and Transplantation, Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Palo Alto, CA, 94304, USA.

Microbubbles are nanosized gas-filled bubbles. They are used in clinical diagnostics, in medical imaging, as contrast agents in ultrasound imaging, and as transporters for targeted drug delivery. They can also be used to treat thrombosis, neoplastic diseases, open arteries and vascular plaques and for localized transport of chemotherapies in cancer patients. Read More

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Is arterial switch operation possible with neonatology-focused intensive care unit modality.

Turk Gogus Kalp Damar Cerrahisi Derg 2021 Apr 26;29(2):136-142. Epub 2021 Apr 26.

Department of Pediatric Cardiology, Health Sciences University, Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey.

Background: In this study, we aimed to examine the feasibility of arterial switch operation and its perioperative management with neonatology-focused intensive care modality in a region of Turkey where the birth rate and the number of asylum seekers who had to leave their country due to regional conflicts are high.

Methods: Between December 2017 and June 2020, a total of 57 patients (48 males, 9 females; median age: 12.2 days; range, 2 to 50 days) who were diagnosed with transposition of the great arteries in our clinic and underwent arterial switch operation were retrospectively analyzed. Read More

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Transposition of the great arteries with total anomalous pulmonary venous connection in a 1½year-old child: Pulmonary arterial hypertension - An advantage.

Ann Pediatr Cardiol 2021 Apr-Jun;14(2):235-238. Epub 2021 Feb 16.

Sri Sathya Sai Sanjeevani International Paediatric Cardiac Centre, Raipur, Chhattisgarh, India.

Transposition of the great arteries with total anomalous pulmonary venous connection is a rare anomaly with varied management approach depending on the time of presentation; the management of cases which present early is usually by anatomical surgical approach while late presentation is by physiologic approach. This is due to early left ventricular mass regression as a result of the absence of volume and pressure load to the left ventricle (LV). We report a late presentation (at 1½ years of age) that had a successful anatomic surgical correction because the LV was "prepared" by both pressure and volume load from pulmonary arterial hypertension and large ostium secundum atrial septal defect. Read More

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February 2021

Recent advancements in the bioprinting of vascular grafts.

Biofabrication 2021 Jun 8. Epub 2021 Jun 8.

IMP, The University of Edinburgh, Sanderson Building, Edinburgh, EH8 9YL, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Occlusive artery disease and cardiovascular disease are the major causes of death globally. These diseases are caused by the blockage in the arteries, which results in a decreased blood flow to the tissues of major organs in the body, such as the heart. Bypass surgery is often performed using a vascular graft to re-route the blood flow. Read More

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From textbook to patient: a practical guide to train the end-to-side microvascular anastomosis.

Br J Neurosurg 2021 Jun 7:1-5. Epub 2021 Jun 7.

Far East Neurosurgical Institute, Sapporo Teishinkai Hospital, Sapporo, Japan.

Microvascular anastomosis is one of the most challenging neurosurgical techniques. Mastering this technique allows to perform intracranial bypass with arteries of small caliber usually placed in deep narrow surgical fields. The aim of this paper is to describe step by step end-to-side microanastomosis training method by using polyvinyl alcohol (PVA) hydrogel tubing as it is easily reproducible. Read More

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Opposing responses of the rat pulmonary artery and vein to phenylephrine and other agents in vitro.

BMC Pulm Med 2021 Jun 5;21(1):189. Epub 2021 Jun 5.

Department of Anaesthesia, Obstetrics and Gynecology Hospital, Fudan University, 128 Shenyang road, Shanghai, 200090, China.

Background: Different from current cognition, our study demonstrated that adrenergic receptors agonist phenylephrine significantly relaxed isolated pulmonary artery but constricted pulmonary veins. Through comparing differences in the effects of commonly used vasoactive drugs on pulmonary artery and veins, the study aimed to improve efficiency and accuracy of isolated pulmonary vascular experiments, and to provide experimental basis for clinical drug use.

Methods: The contractile responses of pulmonary arteries and veins from twelve-week-old Male Sprague-Dawley rats to phenylephrine, arginine vasopressin (AVP), U46619, endothelin-1, and potassium chloride (KCl) were recorded, as well as the relaxation in response to phenylephrine, AVP, acetylcholine. Read More

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Role of Computed Tomography in Pre- and Postoperative Evaluation of a Double-Outlet Right Ventricle.

J Cardiovasc Imaging 2021 Mar 8. Epub 2021 Mar 8.

Department of Radiodiagnosis and Imaging, Fortis Escort Heart Institute, New Delhi, India.

Double-outlet right ventricle (DORV) is a type of ventriculoarterial connection in which both great arteries arise entirely or predominantly from the right ventricle. The morphology of DORV is characterized by a ventricular septal defect (location and relationship with the semilunar valve); bilateral coni and aortomitral continuity; the presence or absence of outflow tract obstruction; tricuspid-pulmonary annular distance; and associated cardiac anomalies. The surgical approach varies with the type of DORV and is based on multiple variables. Read More

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Variant Arterial Supply of the Descending Colon by the Coeliac Trunk: A Case Report.

Medicina (Kaunas) 2021 May 12;57(5). Epub 2021 May 12.

University Medical Center, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg-University, 55131 Mainz, Germany.

: Knowledge of arterial variations of the intestines is of great importance in visceral surgery and interventional radiology. : An unusual variation in the blood supply of the descending colon was observed in a Caucasian female body donor. : In this case, the left colic artery that regularly derives from the inferior mesenteric artery supplying the descending colon was instead a branch of the common hepatic artery. Read More

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Adverse functional remodelling of the subpulmonary left ventricle in patients with a systemic right ventricle is associated with clinical outcome.

Eur Heart J Cardiovasc Imaging 2021 May 31. Epub 2021 May 31.

Congenital andStructural Cardiology, University Hospitals Leuven, Herestraat 49, B-3000 Leuven, Belgium.

Aims: Early recognition of adverse remodelling is important since outcome is unfavorable once patients with a systemic right ventricle (sRV) become symptomatic. We aimed assessing prognostic markers linked to short-term clinical evolution in this population.

Methods And Results: Thirty-three patients (76% male) with sRV (atrial switch repair for D-transposition of the great arteries and congenitally corrected transposition of the great arteries) underwent detailed phenotyping including exercise cardiac magnetic resonance and were followed over mean follow-up time of 3 years. Read More

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Surgery for severe congenital heart diseases in children from developing nations.

J Thorac Cardiovasc Surg 2021 May 14. Epub 2021 May 14.

Mécénat Chirurgie Cardiaque Foundation, Paris, France.

Background: Children with severe congenital heart disease (CHD) are rarely treated in developing countries and have very little to no chance to survive in their local environment. Mécénat Chirurgie Cardiaque (MCC) flies to France children with CHD from developing countries. This report focuses on the early, mid, and late outcomes of 531 children with severe CHD sent to MCC for surgery from 1996 to 2019. Read More

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Reliability of Fetal Echocardiography in Predicting Postnatal Critical Hypoxia in Patients with Transposition of Great Arteries and Intact Ventricular Septum.

Pediatr Cardiol 2021 May 29. Epub 2021 May 29.

Perinatal Cardiology Unit, Department of Medical and Surgical for Fetus-Neonate, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.

Critical hypoxemia soon after birth is the most critical preoperative determinant of neurological outcomes and survival in newborns with Dextro Transposition of the Great Arteries and Intact Ventricular Septum (D-TGAIVS). Our study aimed to define fetal echocardiographic aspects that can better predict neonates with D-TGAIVS at risk for restricted interatrial communication after birth. 31 fetuses with a prenatal diagnosis of D-TGAIVS were included in our study. Read More

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A Murine Bone Metastasis Model Using Caudal Artery Injection and Bioluminescence Imaging.

Methods Mol Biol 2021 ;2274:37-42

Life Science and Technology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan.

The current standard murine model of bone metastasis by using intracardiac injection (IC) has some limitations despite the great utility of this model. This fact emphasizes the need for a new murine model to accelerate basic research of bone metastasis. The present protocol provides instructions on caudal artery (CA) injection that is an easy-to-use method to reliably construct a murine bone metastasis model with a variety type of cancer cell lines. Read More

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Allogeneic Mesenchymal Stromal Cell Injection to Alleviate Ischemic Heart Failure Following Arterial Switch Operation.

JACC Case Rep 2021 May;3(5):724-727

Department of Cardiac Surgery, Bristol Heart Institute and Bristol Royal Hospital for Children, Bristol, United Kingdom.

Cell therapy is a promising tool to prevent and treat heart failure in congenital heart disease. We report the first case of intramyocardial injection of allogeneic mesenchymal stromal cells as rescue therapy in a neonate with ischemic heart failure following arterial switch procedure for isolated transposition of the great arteries. (). Read More

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