Cell Immunol 2021 Apr 17;365:104363. Epub 2021 Apr 17.
Department of Basic Oncology, Hacettepe University Cancer Institute, Ankara, Turkey. Electronic address:
The presence of memory T cells in COVID-19 patients has been acknowledged, however the functional potency of memory responses is critical for protection. In this study, naïve, effector, effector memory, and central memory CD4 and CD8 T cells obtained from the COVID-19 survivors were re-exposed to autologous monocyte-derived DCs that were loaded with SARS-CoV-2 spike glycoprotein S1. Proliferation capacity, CD25, 4-1BB, and PD-1 expression, and IFN-γ, IL-6, granzyme, granulysin, and FasL secretion were enhanced in CD4 and CD8 effector memory and central memory T cells. Read More