29,783 results match your criteria granulomatous mastitisconclusion


Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets.

J Clin Invest 2021 Jun 15. Epub 2021 Jun 15.

School of Clinical and Experimental Sciences, University of Southampton, Faculty of Medicine, Southampton, United Kingdom.

Tuberculosis (TB) is a persistent global pandemic and standard treatment has not changed for thirty years. Mycobacterium tuberculosis (Mtb) has undergone prolonged co-evolution with humans, and patients can control Mtb even after extensive infection, demonstrating the fine balance between protective and pathological host responses within infected granulomas. We hypothesised that whole transcriptome analysis of human TB granulomas isolated by laser capture microdissection could identify therapeutic targets, and that comparison with a non-infectious granulomatous disease, sarcoidosis, would identify disease-specific pathological mechanisms. Read More

View Article and Full-Text PDF

Is vaccination a viable method to control Johne's disease caused by Mycobacterium avium subsp. paratuberculosis? Data from 12 million ovine vaccinations and 7.6 million carcass examinations in New South Wales, Australia from 1999-2009.

PLoS One 2021 14;16(6):e0246411. Epub 2021 Jun 14.

James J. Peters VAMC, Bronx, New York, United States of America.

Background: Mycobacterium avium subsp. paratuberculosis (MAP) causes Johne's disease (or paratuberculosis), a chronic wasting disease of ruminants and other animals resulting from granulomatous enteritis. There are increasing concerns that MAP is zoonotic. Read More

View Article and Full-Text PDF

Clinical variants of mycosis fungoides in a cohort.

Gac Med Mex 2021 ;157(1):41-46

Centro Dermatológico "Dr. Ladislao de la Pascua", Mexico City, Mexico.

Introduction: Mycosis fungoides (MF) is the most common primary skin T-cell lymphoma, which is characterized for a heterogeneous clinical expressivity.

Objective: To report clinical variants and sociodemographic characteristics in patients with MF under the care of a dermatological hospital.

Methods: 290 patients with MF clinical and histopathological diagnosis attended to over the course of 11 years were included. Read More

View Article and Full-Text PDF
January 2021

"Post Coronavirus Disease (COVID-19) Reactivation of a Quiescent Unilateral Anterior Uveitis".

SN Compr Clin Med 2021 Jun 7:1-5. Epub 2021 Jun 7.

Department of Neuro-ophthalmology, Cornea and Refractive Surgery, Narayana Nethralaya, Bangalore, India.

Coronavirus disease (COVID-19) can be associated with ophthalmic manifestations like conjunctivitis, retinal haemorrhages, retinal vascular occlusions, papillophlebitis, and Adie's syndrome. We herein report for a case of a unilateral acute anterior uveitis which was quiescent for 13 years and was reactivated post COVID-19 infection in a 43-year-old Asian Indian male. He had a past history of recurrent unilateral granulomatous anterior and intermediate uveitis in the right eye (RE), and all the investigations done 14 years ago were negative and had been on treatment with topical and oral steroids. Read More

View Article and Full-Text PDF

Invasive Mediastinal Mucormycosis with Pulmonary and Cardiac Involvement in an Adult with Chronic Granulomatous Disease: Case Report and Review of the Literature.

Eur J Case Rep Intern Med 2021 5;8(5):002435. Epub 2021 May 5.

Department of Critical Care Medicine at King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Mucormycosis is a rare fungal infection that often causes rhinocerebral disease. However, there have been rare cases of mediastinal involvement. These patients remain a therapeutic challenge and mortality in this group is very high. Read More

View Article and Full-Text PDF

Adolescent with severe granulomatosis with polyangiitis: a case report.

Pan Afr Med J 2021 18;38:285. Epub 2021 Mar 18.

Department of Respiratory Diseases, Hospital 20 Août 1953, University of Hassan II, University Hospital Center Ibn Rochd, Casablanca, Morocco.

Granulomatosis with polyangiitis (GPA) is a rare vasculitis among adolescents. Its pulmonary manifestations may mimic tuberculosis. We report the case of a 16-years-old female patient with multiple excavated lung nodules revealed by a chronic cough, hemoptysis, epistaxis and weight loss. Read More

View Article and Full-Text PDF

Oesophageal Obstruction in a Donkey Due to Mediastinal Lymphadenitis Caused by Mycobacterium avium Complex.

J Comp Pathol 2021 May 25;185:66-71. Epub 2021 May 25.

Department of Pathobiology and Population Sciences, Royal Veterinary College, Hatfield, Hertfordshire, UK.

Mycobacterial infections are rare in horses, donkeys and mules. Although there are a few reports in horses, mycobacterial disease is poorly documented in the donkey. Mycobacterial infection of equine species typically affects the alimentary tract, causing granulomatous enterocolitis resulting in diarrhoea and chronic weight loss, while lymph nodes and liver may also be affected. Read More

View Article and Full-Text PDF

Frequency of detection and load of amastigotes in the pancreas of Leishmania infantum-seropositive dogs: clinical signs and histological changes.

Parasit Vectors 2021 Jun 12;14(1):321. Epub 2021 Jun 12.

Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Av. Brasil, 4365, Rio de Janeiro, RJ, 21040-360, Brazil.

Background: Zoonotic visceral leishmaniasis is caused by the protozoan Leishmania infantum and is highly lethal in humans and dogs if left untreated. The frequency of this parasite and associated histological changes in the pancreas of dogs are poorly studied. Therefore, the objectives of this study were to evaluate the frequency of detection and load of amastigotes in the pancreas of L. Read More

View Article and Full-Text PDF

Interstitial granuloma annulare triggered by Lyme disease.

Dermatol Online J 2021 May 15;27(5). Epub 2021 May 15.

Division of Dermatology, The Ohio State University Wexner Medical Center, Columbus, OH.

Granuloma annulare is a non-infectious granulomatous skin condition with multiple different associations. We present a case of a man in his 60s with a three-week history of progressive targetoid plaques on his arms, legs, and trunk. Skin biopsy demonstrated interstitial granuloma annulare. Read More

View Article and Full-Text PDF

Macroscopic identification of visceral titanium pigment in an intravenous drug user.

J Forensic Sci 2021 Jun 12. Epub 2021 Jun 12.

Forensic Science SA, Adelaide, SA, Australia.

Autopsy findings in intravenous drug addicts are quite variable and may involve a number of organ systems. Reports of the macroscopic identification at autopsy of components of tablets that have been crushed and injected are, however, exceedingly rare. The case of 34-year-old man who died of zolpidem toxicity on a background of pulmonary hypertension attributed to intravenous injections of crushed tablets is described. Read More

View Article and Full-Text PDF

Extirpation of Recurrent Petrous Apex Cholesterol Granuloma Through the Zygomatic Approach: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Jun 10. Epub 2021 Jun 10.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Petrous apex cholesterol granulomas are believed to result from blockage of the normal aeration of the petrous air cells, resulting in a repetitive cycle of mucosal engorgement, hemorrhage, and granuloma formation.1 The lesion usually progressively expands causing compressive symptoms. The thick granulomatous wall envelopes various ages of breakdown products, including a cholesterol-containing fluid, which is typically hyperintense on T1 and T2 weighted magnetic resonance imaging. Read More

View Article and Full-Text PDF

A Conservative Management Approach for Unusual Presentation of Oral Actinomycosis.

Authors:
Qamar Hashem

Case Rep Dent 2021 18;2021:5570758. Epub 2021 May 18.

Clinical Dental Sciences Department/Endodontic Division College of Dentistry, Princes Noura Bint Abdulrahman University, Riyadh, Saudi Arabia.

Actinomycosis is gram-positive saprophytic infection that is characterized by chronic suppurative and granulomatous lesion. It could be found in the oral cavity, lungs, colon, and genital area. In the oral cavity, it is commonly associated with infected root canals presented as persistent infections. Read More

View Article and Full-Text PDF

Cryopyrin-associated periodic syndrome: a treatable genetic inflammatory condition.

Pract Neurol 2021 Jun 10. Epub 2021 Jun 10.

Department of Neurology, Royal Hobart Hospital, Hobart, Tasmania, Australia

A 20-year-old man presented with recurrent subdural haemorrhages on a background of progressive sensorineural hearing loss, juvenile idiopathic arthritis and intracranial hypertension of unknown cause. His mother had a similar previous history. They both had a persistently mildly elevated serum C reactive protein. Read More

View Article and Full-Text PDF

Pulmonary Hypertension in Patients with Common Variable Immunodeficiency.

J Clin Immunol 2021 Jun 10. Epub 2021 Jun 10.

Assistance Publique - Hôpitaux de Paris (AP-HP), Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Center, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

Purpose: Common variable immunodeficiency (CVID) is known to cause infectious, inflammatory, and autoimmune manifestations. Pulmonary hypertension (PH) is an unusual complication of CVID with largely unknown characteristics and mechanisms.

Methods: We report the clinical, functional, hemodynamics, radiologic and histologic characteristics, and outcomes of CVID-associated PH patients from the French PH Network. Read More

View Article and Full-Text PDF

in a Maine Coon cat: case report and literature review.

J Vet Diagn Invest 2021 Jun 10:10406387211022298. Epub 2021 Jun 10.

BluePearl Pet Hospital, Auburn Hills, MI, USA.

A 15-y-old castrated male Maine Coon cat was evaluated for an ulcerated soft tissue mass on the right hindlimb that had been observed for 4 mo and had grown rapidly. A 3 × 3 cm soft, raised, amorphous, and ulcerated subcutaneous mass was observed on the lateral right metatarsus. In-house cytology via fine-needle aspiration was nondiagnostic. Read More

View Article and Full-Text PDF

Spectrum of childhood interstitial and diffuse lung diseases at a tertiary hospital in Egypt.

ERJ Open Res 2021 Apr 7;7(2). Epub 2021 Jun 7.

Dept of Paediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Background: Childhood interstitial and diffuse lung diseases (chILD) encompass a broad spectrum of rare pulmonary disorders. In most developing Middle Eastern countries, chILD is still underdiagnosed. Our objective was to describe and investigate patients diagnosed with chILD in a tertiary university hospital in Egypt. Read More

View Article and Full-Text PDF

Case report of osteolytic lesions in a patient with multisystem granulomatous disease.

BMJ Case Rep 2021 Jun 9;14(6). Epub 2021 Jun 9.

School of Medicine, University of Notre Dame, Fremantle, Western Australia, Australia.

We present a case of a 70-year-old Caucasian woman with multisystem granulomatous disease involving her lungs, bones and lymph nodes. The patient initially presented with cervical lymphadenopathy and subsequently developed progressive breathlessness. Imaging revealed extensive mediastinal, hilar and intra-abdominal lymphadenopathy as well as bilateral pulmonary parenchymal infiltrates. Read More

View Article and Full-Text PDF

Adaptive immune system in pulmonary sarcoidosis - comparison of peripheral and alveolar biomarkers.

Clin Exp Immunol 2021 Jun 9. Epub 2021 Jun 9.

Respiratory Diseases and Lung Transplantation, Department of Medical and Surgical Sciences & Neurosciences, Siena University Hospital, Siena, 53100, Italy.

Sarcoidosis is a multisystemic granulomatous disease of unknown origin. Recent research has focused on the role of autoimmunity in its development and progression. This study aimed to determine and define disturbance and distribution of T- and B-cell subsets in the alveolar and peripheral compartments. Read More

View Article and Full-Text PDF

Bovine tuberculosis due to Mycobacterium bovis and other mycobacteria among water buffalo (Bubalus bubalis) from the Brazilian Amazon.

J Infect Dev Ctries 2021 May 31;15(5):736-741. Epub 2021 May 31.

Institute of Animal Health and Production, Federal Rural University of Amazonia, Belém, Brazil.

Introduction: Zoonotic tuberculosis is a disease of public health importance worldwide, especially in developing countries. The present study aimed to investigate the role played by Mycobacterium bovis and other mycobacteria as etiologic agents of bubaline tuberculosis (TB) in the Brazilian Amazon region.

Methodology: Granulomatous lesions suggestive of TB obtained from 109 buffaloes (n =109) during sanitary inspection at slaughter were subjected to histopathological evaluation, immunohistochemical (IHC) detection of Mycobacterium antigens, and to molecular tests (PCR) to detect hsp65, IS6110 and RD4 genes, which are specific to Mycobacterium spp. Read More

View Article and Full-Text PDF

Clinical characteristics and predictive factors of erythema nodosum in granulomatous lobular mastitis.

Australas J Dermatol 2021 Jun 9. Epub 2021 Jun 9.

Department of Mammary Disease, The Second affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.

Background/objectives: In recent years, there is a growing incidence of granulomatous lobular mastitis (GLM), but studies about the coexistence of erythema nodosum (EN) and GLM are rare. In this study, we assess the clinical characteristics and predictive factors of EN in GLM.

Methods: A total of 303 patients diagnosed with GLM were enrolled from January 2012 to October 2018 at the second affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, including 78 patients with EN. Read More

View Article and Full-Text PDF

Langerhans cell histiocytosis: Version 2021.

Hematol Oncol 2021 Jun;39 Suppl 1:15-23

Texas Children's Hospital Cancer and Hematology Center, Houston, Texas, USA.

Children with Langerhnans cell histiocytosis (LCH) develop granulomatous lesions with characteristic clonal CD207+ dendritic cells that can arise as single lesions or life-threatening disseminated disease. Despite the wide range of clinical presentations, LCH lesions are histologically indistinguishable based on severity of disease, and uncertain classification as an immune versus neoplastic disorder has historically challenged the development of optimal clinical strategies for patients with LCH. Recently, activating somatic mutations in MAPK pathway genes, most notably BRAFV600E, have been discovered in almost all cases of LCH. Read More

View Article and Full-Text PDF

Kocuria varians meningitis in a child with chronic granulomatous disease.

Turk Arch Pediatr 2021 1;56(3):278-279. Epub 2021 May 1.

2 Pediatric Clinic, Department of Mother and Child, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, Romania; Emergency Clinical Hospital for Children, Cluj-Napoca, Romania.

View Article and Full-Text PDF

A case of nontuberculous mycobacteria-associated thyroiditis mimicking subacute thyroiditis.

Acta Radiol Open 2021 May 31;10(5):20584601211021504. Epub 2021 May 31.

Department of Otolaryngology-Head & Neck Surgery, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.

We describe a case of nontuberculous mycobacteria infection in the thyroid gland in a 54-year-old woman who had painful thyroid enlargement. Ultrasonography showed ill-defined hypoechoic lesions without increased vascularity in both upper lobes of the thyroid gland. Fine needle aspiration biopsy was performed, and pathology showed granulomatous inflammation with necrotic debris that the pathologist suspected was subacute granulomatous thyroiditis or tuberculosis of the thyroid gland. Read More

View Article and Full-Text PDF

Granuloma after breast conserving surgery-a report of three cases.

J Surg Case Rep 2021 Jun 4;2021(6):rjab199. Epub 2021 Jun 4.

Department of Breast Oncology, Saitama Medical University International Medical Center, Saitama, Japan.

Granulomatous mastitis is a rare breast disease that is categorized as a benign tumor with chronic inflammation. Since the cause of the chronic inflammation is usually unknown, it is sometimes called idiopathic granulomatous mastitis (IGM). Although imaging modalities, such as ultrasound, magnetic resonance imaging and mammography can detect tumors, they are sometimes unable to differentiate between benign and malignant tumors. Read More

View Article and Full-Text PDF

Pulmonary sarcoidosis masquerading as metastatic breast cancer: a case report.

Pan Afr Med J 2021 8;38:245. Epub 2021 Mar 8.

Department of Radiology, Alexis Multispecialty Hospital, Nagpur, Maharashtra, India.

Pulmonary lesions on imaging are presumed to be metastatic lesions in patients with breast cancer. Here, we report an interesting case of a 63-year-old lady with breast carcinoma showing pulmonary lesions on imaging suggestive of pulmonary metastases. Detailed evaluation of pulmonary lesions confirmed the presence of co-existing pulmonary sarcoidosis. Read More

View Article and Full-Text PDF

Sarcoidosis: An Occupational Disease?

Chest 2021 Jun 5. Epub 2021 Jun 5.

The Occupational Health Clinics for Ontario Workers, Sudbury, Ontario, CA; Laurentian University, Sudbury, Ontario, CA; Center for Research in Occupational Safety and Health, Sudbury, Ontario, CA.

Sarcoidosis is an important member of the family of granulomatous lung diseases. Since its recognition in the late 19 century, sarcoidosis has been thought of as a disease of unknown cause. Over the past 20 years this paradigm has been shifting, more rapidly in the past 10 years. Read More

View Article and Full-Text PDF

Fracture of the Dens Axis Due to Spinal Manifestation of Sarcoidosis: Treatment Option and Review of the Literature.

Spine (Phila Pa 1976) 2021 Jul;46(13):E743-E749

Department of Orthopedics, Trauma Surgery and Hand Unit, Helios Klinikum Krefeld, Krefeld, Germany.

Study Design: Case report and literature review.

Objective: We present a case of a pathologic unstable fracture of the odontoid process due to vertebral osseous sarcoidosis. The surgical management of this unreported pathology is described and a review of the literature is given. Read More

View Article and Full-Text PDF

Acute arthritis, skin rash and Lofgren's syndrome.

BMJ Case Rep 2021 Jun 7;14(6). Epub 2021 Jun 7.

Department of Radiotherapy and Oncology, IGMC, Shimla, Himachal Pradesh, India.

Sarcoidosis is an autoimmune multisystem granulomatous disorder of unknown aetiology, which mainly affects the adults in the age group of 20-39 years. The disease can affect any organ in the body but mainly presents as bilateral hilar lymphadenopathy, pulmonary infiltrates, cutaneous lesions, ocular manifestations and arthropathy. Lofgren's syndrome is an uncommon initial presentation of sarcoidosis which is recognised by the classical triad of acute arthritis, erythema nodosum and bilateral hilar lymphadenopathy. Read More

View Article and Full-Text PDF

Challenging diagnosis of leprosy in a psychotic homeless patient with atypical clinical manifestations: an interesting case report.

BMC Infect Dis 2021 Jun 7;21(1):540. Epub 2021 Jun 7.

Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin General Hospital, Jl. Pasteur No. 38, Bandung, 40161, Indonesia.

Background: A decision to diagnose certain skin diseases in patient undergoing psychotic break is challenging; this includes establishing the diagnosis of leprosy. Diagnosis of leprosy is established if there is at least one of the three cardinal signs of leprosy. Histopathological examination is not a gold standard, but remains useful in atypical or clinically suspicious cases. Read More

View Article and Full-Text PDF

Hematopoietic Stem Cell Transplantation Cures Therapy-refractory Aspergillosis in Chronic Granulomatous Disease.

Pediatr Infect Dis J 2021 Jul;40(7):649-654

From the Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité Universitätsmedizin.

Background: Pulmonary invasive aspergillosis is a frequent and life-threatening complication for patients with chronic granulomatous disease (CGD). Despite combined treatment with several groups of antifungal agents, conservative treatment of invasive aspergillosis often remains refractory. Pulmonary invasive aspergillosis is often treated by surgical resection of consolidated lobes or segments, donor granulocyte transfusions and allogeneic hematopoietic stem cell transplantation (HSCT). Read More

View Article and Full-Text PDF