41,666 results match your criteria granulation tissue

Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing.

Bioact Mater 2022 Feb 23;8:341-354. Epub 2021 Jun 23.

Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, and Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710049, China.

With the increasing prevalence of drug-resistant bacterial infections and the slow healing of chronically infected wounds, the development of new antibacterial and accelerated wound healing dressings has become a serious challenge. In order to solve this problem, we developed photo-crosslinked multifunctional antibacterial adhesive anti-oxidant hemostatic hydrogel dressings based on polyethylene glycol monomethyl ether modified glycidyl methacrylate functionalized chitosan (CSG-PEG), methacrylamide dopamine (DMA) and zinc ion for disinfection of drug-resistant bacteria and promoting wound healing. The mechanical properties, rheological properties and morphology of hydrogels were characterized, and the biocompatibility of these hydrogels was studied through cell compatibility and blood compatibility tests. Read More

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February 2022

Prospective Comparative Observational Study of Safety and Efficacy of Topical Ozone Gas Therapy in Healing of Diabetic Foot Ulcers versus Only Conventional Wound Management.

Surg J (N Y) 2021 Jul 14;7(3):e226-e236. Epub 2021 Sep 14.

Department of Surgery, Seth G.S. Medical College and K.E.M. Hospital, Mumbai, Maharashtra, India.

The prevalence of diabetic foot ulcers (DFUs) in India is 11.6%. DFU accounts for major cost expenditure, morbidity, and mortality. Read More

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Case Report: A Novel Ventilated Thermoplastic Mesh Bandage for Post-operative Management of Large Soft Tissue Defects: A Case Series of Three Dogs Treated With Autologous Platelet Concentrates.

Front Vet Sci 2021 1;8:704567. Epub 2021 Sep 1.

Department of Veterinary Science, University of Parma, Parma, Italy.

A ventilated thermoplastic mesh bandage was used for the post-operative management of large soft tissue defects in three dogs. Once the granulation tissue appeared, the wounds were treated with liquid or jellified autologous platelet concentrates, Platelet Rich Plasma (PRP) and Platelet Lysate (PL), to improve the wound healing process. After cleaning the wound with sterile physiological solution, a dressing was performed with several layers of cotton. Read More

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September 2021

Mycoplasma pneumoniae and Bronchiolitis Obliterans: How a Common Organism Leads to a Rare Pulmonary Disease in Pediatrics.

Cureus 2021 Aug 15;13(8):e17193. Epub 2021 Aug 15.

Department of Pediatrics, University of Puerto Rico School of Medicine, San Juan, PRI.

A rare lung disease, bronchiolitis obliterans (BO) is characterized by airway obstruction and fibrosis of the terminal and respiratory bronchioles. It usually occurs after lung and bone marrow transplants, hematopoietic stem cell transplantation (HSCT), inhalation of toxins, respiratory infections, or in association with several different connective tissue or irritable bowel diseases. When BO is caused by an infection it is referred to as post-infectious bronchiolitis obliterans (PIBO). Read More

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Using systems biology approaches to identify signalling pathways activated during chronic wound initiation.

Wound Repair Regen 2021 Sep 18. Epub 2021 Sep 18.

Department of Molecular, Cell and Systems Biology, UC, Riverside, California, USA.

Chronic wounds are a significant health problem worldwide. However, nothing is known about how chronic wounds initiate and develop. Here we use a chronic wound model in diabetic mice and a Systems Biology Approach using nanoString nCounter technology and weighted gene correlation network analysis (WGCNA), with tissues collected at 6, 12, 24 and 48 h post-wounding, to identify metabolic signalling pathways involved in initiation of chronicity. Read More

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September 2021

Comprehensive Assessment of Fine-Grained Wound Images Using a Patch-Based CNN With Context-Preserving Attention.

IEEE Open J Eng Med Biol 2021 24;2:224-234. Epub 2021 Jun 24.

Foisie Business School, Worcester Polytechnic Institute, Worcester, MA 01609 USA.

Goal: Chronic wounds affect 6.5 million Americans. Wound assessment via algorithmic analysis of smartphone images has emerged as a viable option for remote assessment. Read More

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Foreign body aspiration.

J Thorac Dis 2021 Aug;13(8):5159-5175

Department of Respiratory Medicine, Dr. RML Hospital & Atal Bihari Vajpayee Institute of Medical Sciences, New Delhi, India.

The clinical manifestations of foreign body (FB) aspiration can range from an asymptomatic presentation to a life-threatening emergency. Patients may present with acute onset cough, chest pain, breathlessness or sub-acutely with unexplained hemoptysis, non-resolving pneumonia and at times, as an incidental finding on imaging. Patients with iatrogenic FB such as an aspirated broken tooth during difficult intubation or a broken instrument are more common scenarios in the intensive care unit (ICU). Read More

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Efficacy of Collagen Membrane Graft in Intraoral Surgery - An Evaluative Study.

Ann Maxillofac Surg 2021 Jan-Jun;11(1):42-48. Epub 2021 Jul 24.

Department of Oral and Maxillofacial Surgery, Karnavati School of Dentistry, Gandhinagar, Gujarat, India.

Introduction: Bovine-derived collagen membrane is usually and regularly used as a temporary cover or dressing for extraoral wounds and burns. It has wide applications because of its usefulness and biocompatibility. This has provoked us to do a study with the use of collagen membrane even for minor intraoral surgical defects. Read More

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Less-invasive Treatment for Group A Streptococcal Fasciitis with Rapid Antigen Detection Test and Collagen/Gelatin Sponge.

Plast Reconstr Surg Glob Open 2021 Sep 13;9(9):e3793. Epub 2021 Sep 13.

Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Patients with severe group A Streptococcus (GAS) induced necrotizing soft tissue infection sometimes develop Streptococcal toxic shock syndrome, which is a life-threatening condition with an extremely high fatality rate. Obtaining survival is the most important goal; however, an early diagnosis for debridement surgery and quick granulation formation for skin grafting surgery can better preserve the extremity functions. The patient was a 47-year-old man with a history of atopic dermatitis who presented with GAS-induced necrotizing soft tissue infection in his left lower extremity. Read More

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September 2021

Bioglass promotes wound healing by inhibiting endothelial cell pyroptosis through regulation of the connexin 43/reactive oxygen species (ROS) signaling pathway.

Lab Invest 2021 Sep 14. Epub 2021 Sep 14.

Institute of Life Sciences, Engineering Laboratory of Zhejiang province for pharmaceutical development of growth factors, Biomedical Collaborative Innovation Center of Wenzhou, Wenzhou University, Zhejiang, China.

Bioactive glass (BG) has recently shown great promise in soft tissue repair, especially in wound healing; however, the underlying mechanism remains unclear. Pyroptosis is a novel type of programmed cell death that is involved in various traumatic injury diseases. Here, we hypothesized that BG may promote wound healing through suppression of pyroptosis. Read More

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September 2021

The natural history of laryngo-onycho-cutaneous syndrome: A case series of six pediatric patients and literature review.

Pediatr Dermatol 2021 Sep 13. Epub 2021 Sep 13.

Department of Dermatology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.

Background/objectives: Laryngo-onycho-cutaneous syndrome (LOC) is a rare subtype of junctional epidermolysis bullosa (JEB), featuring aberrant granulation tissue formation in the skin, larynx, and eyes. So far, three mutations including the specific (founder) mutation in exon 39 of LAMA3 (c.151dup) have been identified, but sparse data exists regarding the natural history, the genotype-phenotype correlation, and its differentiation from other JEB types. Read More

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September 2021

A Ventral Hernia-repair-related Mesh Infection Treated with NPWT without Mesh Removal.

Plast Reconstr Surg Glob Open 2021 Sep 7;9(9):e3799. Epub 2021 Sep 7.

Division of Plastic Surgery, Nara Medical University Hospital, Kashihara, Nara, Japan.

Abdominal hernias are often repaired using prosthetic mesh, which is susceptible to infections. Normally, it is necessary to remove the mesh. However, successful mesh salvation with negative-pressure wound therapy (NPWT) has recently been reported. Read More

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September 2021

Comparison of Rat Connective Tissue Response to BioMTA, Angelus MTA, and Root MTA.

Int J Biomater 2021 31;2021:7415302. Epub 2021 Aug 31.

Master of Science in Statistics, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

Due to the widespread use of MTA in dentistry and various brands of this product, we decided to compare the three brands available in the country market by their biocompatibility. We divided 20 male Wistar rats into four groups. After local anesthesia and washing, we made two incisions on both sides (4 incisions in total). Read More

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MRI of the Meniscus.

Clin Sports Med 2021 Oct;40(4):641-655

Musculoskeletal Radiology, Department of Radiology, DC069.10, University of Missouri, Columbia, MO, USA.

The menisci of the knee are accurately evaluated by MRI. Knowledge of normal anatomy, imaging parameters, imaging appearance of the normal and torn meniscus, and common anatomic variants and pitfalls are essential in obtaining the correct imaging diagnosis. There are multiple imaging signs of meniscal tear, including linear signal intensity extending to an articular surface on at least 2 images, altered meniscal shape, displaced meniscal flap, ghost meniscus, meniscal extrusion, and parameniscal cyst. Read More

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October 2021

Scar Pregnancy a Diagnostic Conundrum: A Case Report.

JNMA J Nepal Med Assoc 2021 Mar 31;59(235):288-291. Epub 2021 Mar 31.

Department of Obstetrics and Gynecology, Kathmandu Medical College and Teaching Hospital, Kathmandu, Nepal.

Cesarean scar pregnancy is a rare form of ectopic pregnancy which may lead to uterine rupture and catastrophic hemorrhage. We report a case of cesarean scar pregnancy in a 35-year-old female with the past history of cesarean section presented with complaints of amenorrhoea for 6 weeks and non-specific  pain. Two Transvaginal sonography was done 48 hours apart which suggested a cesarean scar pregnancy in one and cervical pregnancy on the other. Read More

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The Clinical and Epidemiological Profile of Adult Female Acne Vulgaris in Lagos, Nigeria.

E L Anaba I R Oaku

West Afr J Med 2021 08;38(8):785-790

Department of Medicine, Lagos State University Teaching Hospital, 1-5 Oba Akinjobi Way, Ikeja, Lagos, Nigeria. Email: +2348030495911.

Background And Aims: Studies of adult female acne vulgaris are few despite its increasing presentation in dermatology clinics. Adult female acne is classified as either late onset, persistent acne or return acne with a mixed pattern of inflammation in most females. The aim of this study was to document the socio-demographic characteristics (late onset, persistent acne, age, pre-menstrual flare) and clinical profile (severity, pattern, type of lesions, scarring and type of scars) of adult female acne patients. Read More

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Effect of Silver Nitrate Application on the Success of Endoscopic Dacryocystorhinostomy.

Am J Rhinol Allergy 2021 Sep 9:19458924211042786. Epub 2021 Sep 9.

Van Yüzüncü Yıl University, Van, Turkey.

Objectives: To compare the clinical outcomes of patients undergoing additional procedures in endoscopic endonasal dacryocystorhinostomy (End-DCR) surgery and discuss the factors affecting the success of End-DCR surgery in light of relevant literature.

Methods: The study included 155 patients who underwent End-DCR surgery in our clinic due to epiphora. This was a prospective randomized, single-blind, controlled trial. Read More

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September 2021

Varicella gangrenosa: A rare chickenpox complication.

Indian J Dermatol Venereol Leprol 2021 Aug 1:1-3. Epub 2021 Aug 1.

Department of Dermatology, Government T. D. Medical College, Alappuzha, Kerala, India.

Varicella gangrenosa is a rare but life-threatening dermatological complication of infection with varicella-zoster virus. A healthy 37-year-old male who had been diagnosed with varicella 20 days back was admitted to our hospital with complaints of fever and painful necrotic skin lesions. Physical examination revealed multiple round to oval ulcers covered with eschar predominantly over arms, lower limbs, back of trunk and flanks. Read More

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Fluorodeoxyglucose Positron-Emission Tomography/Computed Tomography and Magnetic Resonance Imaging for Adverse Local Tissue Reactions near Metal Implants after Total Hip Arthroplasty: A Preliminary Report.

Clin Orthop Surg 2021 Sep 17;13(3):320-328. Epub 2021 Aug 17.

Department of Orthopedic Surgery, Faculty of Medicine, Oita University, Yufu, Japan.

Background: Plain computed tomography (CT) and magnetic resonance imaging (MRI) are useful for diagnosing adverse local tissue reactions after metal-on-metal total hip arthroplasty (THA), but metal artifacts can hamper radiological assessments near the implants. We sought to clarify the usefulness of 18F-fluorodeoxyglucose positron-emission tomography (18F-FDG-PET) CT and MRI in the periprosthetic region, which is difficult to assess after THA due to metal artifacts.

Methods: We performed preoperative 18F-FDG-PET/CT and 18F-FDG-PET/MRI, as well as plain CT and MRI, in 11 metal-on-metal THA patients who underwent revision surgery. Read More

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September 2021

Effects of Cyanoacrylate in Rabbits with Induced Achilles Tendon Rupture.

Med Sci Monit 2021 Sep 6;27:e929709. Epub 2021 Sep 6.

Department of Orthopaedics and Traumatology, Faculty of Medicine, University of Bolu Abant Izzet Baysal, Bolu, Turkey.

BACKGROUND In this study, we aimed to investigate the effects of N-butyl-2-cyanoacrylate (cyanoacrylate) on the biomechanical and histopathological aspects of tendon healing in a rabbit model of Achilles tendon injury. MATERIAL AND METHODS In total, 36 rabbits were randomized to experimental (cyanoacrylate) and control groups (n=36 tendons in each group). A simple suture was used in the control group and a simple suture plus cyanoacrylate was used in the experimental group. Read More

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September 2021

Review on novel targets and therapies for Keloids.

P P Naik

Clin Exp Dermatol 2021 Sep 4. Epub 2021 Sep 4.

Department of dermatology, Saudi German hospitals and clinics, Opposite of American School, Hessa Street 331 West, Al Barsha 3, Exit 36 Sheikh Zayed Road, Dubai, United Arab Emirates.

Keloids are aberrant tissue scarring typically occurring in the injured skin, caused by the overgrowth of granulation tissue or collagen type III during the healing process. Keloid has a genetic component, and therefore, it can be genetically transmitted. Keloids are difficult to treat because of their post-excisional recurrence and impact the quality of life due to psychological stress on cosmetic concerns and functional disability. Read More

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September 2021

[Endoscopic treatment of bronchial complications after lung transplantation].

Khirurgiia (Mosk) 2021 (9):12-18

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia.

Objective: To analyze the incidence and structure of bronchial complications following lung transplantation and evaluate an effectiveness of endoscopic treatment of these events.

Material And Methods: The study enrolled 50 patients after bilateral lung transplantation (24 men and 26 women). Mean age of patients was 35. Read More

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September 2021

[Treatment of extensive cervicomandibular scar in children and adolescent patients with bilateral expanded scapular flaps: report of 7 consecutive cases].

Shanghai Kou Qiang Yi Xue 2021 Jun;30(3):332-336

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200011, China. E-mail:

Purpose: To explore the feasibility of applying bilateral free expanded scapular flaps to treat extensive cervicomandibular scar in children and adolescents.

Methods: This study reviewed 7 children and adolescent patients who received bilateral expanded scapular flaps to treat extensive cervicomandibular scars in the Pediatric Plastic Surgery Ward from August 2018 to December 2020. The scars in all patients involved neck, mandible, and anterior chest. Read More

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SkinTE for the Treatment of a Complicated Wound after Synovial Sarcoma Resection: A Case Report.

Plast Reconstr Surg Glob Open 2021 Aug 23;9(8):e3764. Epub 2021 Aug 23.

Division of Plastic and Reconstructive Surgery, Children's National Hospital, Washington, D.C.

Radiation therapy following oncologic resection can result in incisional breakdown, delay or cessation of wound healing, and exposure of structures. Impaired wound healing often mandates free tissue transfer for definitive closure and preservation of function. We present the case of a 16-year-old male patient who had a major incisional dehiscence following resection of a synovial sarcoma of the lower leg after postoperative irradiation. Read More

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Healing Effects of Human Amniotic Membrane and Burned Wool on the Second-degree Burn in Rats.

Galen Med J 2020 18;9:e1759. Epub 2020 Dec 18.

Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: This study aimed to compare sheep burnt wool and human amniotic membrane (AM) on second-degree burn wound healing in rats.

Materials And Methods: Seventy-two adult male rats of Sprague Dawley underwent general anesthesia, and a deep second-degree burn was created on their skin by a hot iron plate. Afterward, human AM, silver sulfadiazine ointment (SSD), and sheep burned wool were used on wound area for burn treatment. Read More

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December 2020

Safety and effectiveness of endoluminal vacuum-assisted closure for esophageal defects: Systematic review and meta-analysis.

Endosc Int Open 2021 Sep 16;9(9):E1371-E1380. Epub 2021 Aug 16.

Division of Gastroenterology and Hepatology, University of Toledo, Toledo, Ohio, United States.

Esophageal defects (leaks, fistulas, and perforations) are associated with significant morbidity and mortality. Endoluminal vacuum-assisted closure (EVAC) is a novel intervention that entails the use of sponges in the defect along with negative pressure to achieve granulation tissue formation and healing and has been gaining popularity. We performed a systematic review and pooled analysis of available literature to assess the safety and effectiveness of EVAC for esophageal defects. Read More

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September 2021

Evaluation of the Effect of Pomegranate Seed Oil on Healing in a Rat Wound Model With Antioxidant, Vascular, and Histopathological Parameters.

Int J Low Extrem Wounds 2021 Aug 31:15347346211040593. Epub 2021 Aug 31.

Vocational School, Nişantaşı University, Istanbul, Turkey.

The study aimed to evaluate the efficiency of pomegranate () seed oil in wound healing in excised rats. Sixteen female young Wistar Albino Rats weighing approximately 300 to 320 g were randomly divided into 2 groups as the treatment (=pomegranate seed oil group) and control groups in this experiment. Six different wounds 1 cm apart from the midline and each other were formed with a 6 mm punch biopsy instrument. Read More

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Comparing levonorgestrel intrauterine system versus hysteroscopic resection in patients with postmenstrual spotting related to a niche in the caesarean scar (MIHYS NICHE trial): protocol of a randomised controlled trial.

BMJ Open 2021 08 30;11(8):e045770. Epub 2021 Aug 30.

Department of Obstetrics and Gynecology, Amsterdam Reproduction and Development Research institute, Amsterdam University Medical Centre, location AMC and VUmc, Amsterdam, Netherlands.

Introduction: Recently, the rate of caesarean sections (CS) worldwide has risen and CS-associated complications such as niche have increased substantially. Until now, evidence-based clinical guidelines for the treatment of niche-related symptoms remain absent. In patients with postmenstrual spotting, it has not been studied if the effect of levonorgestrel 52 mg intrauterine system (LNG-IUS 52 mg) is superior to that of hysteroscopy. Read More

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Predicting hyperbaric oxygen therapy success using the decision tree approach.

Ann Med Surg (Lond) 2021 Sep 16;69:102725. Epub 2021 Aug 16.

Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.

Introduction: Hyperbaric oxygen therapy (HBOT), a procedure that involves the patient inhaling 100% oxygen gas under pressure, is currently used as an adjunctive treatment option for certain inflammatory conditions. HBOT can improve wound healing by increasing the rate of angiogenesis in injured tissue by increasing levels of vascular endothelial growth factor (VEGF). VEGF causes re-epithelialization, the migration of endothelial cells, and the formation of granulation tissue, which are involved in the wound healing process. Read More

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September 2021

In vitro and in vivo biological performance of hydroxyapatite from fish waste.

J Mater Sci Mater Med 2021 Aug 28;32(9):109. Epub 2021 Aug 28.

Department of Biosciences, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil.

The aim of this study was to evaluate biocompatibility of hydroxyapatite (HAP) from fish waste using in vitro and in vivo assays. Fish samples (whitemouth croaker - Micropogonias furnieri) from the biowaste was used as HAP source. Pre-osteoblastic MC3T3-E1 cells were used in vitro study. Read More

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