Biomaterials 2021 Dec 30;281:121342. Epub 2021 Dec 30.
Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ontario, M5S 3E5, Canada; Institute of Biomedical Engineering, University of Toronto, 164 College Street, Room 407, Toronto, Ontario, M5S 3G9, Canada. Electronic address:
Islet transplantation is a promising regenerative therapy that would reduce the dependence of type 1 diabetic patients on insulin injections. However, islet transplantation is not yet widely available, in part because there is no ideal transplant site. The subcutaneous space has been highlighted as a promising transplant site, but it does not have the vasculature required to support an islet graft. Read More