346,225 results match your criteria graft substitutes


ROTEM Testing for Direct Oral Anticoagulants.

Semin Thromb Hemost 2021 Jun 15. Epub 2021 Jun 15.

Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic.

Direct oral anticoagulants (DOACs) are increasingly used worldwide for the prevention of stroke in patients with atrial fibrillation and to prevent or treat venous thromboembolism. In situations such as serious bleeding, the need for urgent surgery/intervention or the management of a thromboembolic event, the laboratory measurement of DOACs levels or anticoagulant activity may be required. Rotational thromboelastometry (ROTEM) is a viscoelastic hemostatic assay (VHA) which has been used in emergencies (trauma and obstetrics), and surgical procedures (cardiac surgery and liver transplants), but experience with this assay in DOACs-treated patients is still limited. Read More

View Article and Full-Text PDF

Abdominal Panniculectomy Can Simplify Kidney Transplantation in Obese Patients.

Urol Int 2021 Jun 15:1-8. Epub 2021 Jun 15.

Department of Plastic and Hand Surgery and Laboratory for Tissue Engineering and Regenerative Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Background: Obesity is frequently present in patients suffering from end-stage renal disease (ESRD). However, overweight kidney transplant candidates are a challenge for the transplant surgeon. Obese patients tend to develop a large abdominal panniculus after weight loss creating an area predisposed to wound-healing disorders. Read More

View Article and Full-Text PDF

Long-Term Outcomes of Kidney Transplants from Older/Marginal Donors: A Cohort Study.

Nephron 2021 Jun 15:1-11. Epub 2021 Jun 15.

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.

Introduction: To safely expand the donor pool, we introduced a strategy of biopsy-guided selection and allocation to single or dual transplantation of kidneys from donors >60 years old or with hypertension, diabetes, and/or proteinuria (older/marginal donors). Here, we evaluated the long-term performance of this approach in everyday clinical practice.

Methods: In this single-center cohort study, we compared outcomes of 98 patients who received one or two biopsy-evaluated grafts from older/marginal donors ("recipients") and 198 patients who received nonhistologically assessed single graft from ideal donors ("reference-recipients") from October 2004 to December 2015 at the Bergamo Transplant Center (Italy). Read More

View Article and Full-Text PDF

In vivo evaluation of deer antler trabecular bone as a reconstruction material for bone defects.

Res Vet Sci 2021 Jun 11;138:116-124. Epub 2021 Jun 11.

Department of Clinical Sciences, FARAH, Faculty of Veterinary Medicine, University of Liège, Quartier Vallée 2, Avenue de Cureghem 1 - B67, Liège, Belgium.

Availability of graft materials to fill up osseous defects has always been a concern in orthopaedic surgeries. Deer antler material is a primary bone structure that is easy to collect and could serve as a xenograft. This study examines the behaviour of red deer antler trabecular cylinders in critical size distal femoral epiphyseal defects in 11 rabbits, and evaluates the effect of the decellularization protocols. Read More

View Article and Full-Text PDF

Effects of Macrophage Regulation on Fat Grafting Survival: Improvement, Mechanisms, and Potential Application A Review.

J Cosmet Dermatol 2021 Jun 15. Epub 2021 Jun 15.

Department of Cosmetic and Plastic Surgery, Oral and Maxillofacial Surgery, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Background: Autologous fat grafting has become a popular tool in plastic surgery to solve soft tissue defects and achieve skin rejuvenation, but the volume loss after transplantation remains a disturbing problem. In recent years, some new strategies have improved the outcome to some extent, but the fat graft retention is still far from ideal, so there remains a wide development prospect in this field. Macrophages are closely related to the local microenvironment and tissue regeneration, and their role in fat grafting has been increasingly highlighted. Read More

View Article and Full-Text PDF

Critical care and ventilatory management of deceased organ donors impacts lung use and recipient graft survival.

Am J Transplant 2021 Jun 15. Epub 2021 Jun 15.

Department of Surgery, Division of Trauma, Critical Care and Acute Care Surgery, Oregon Health & Science University, Portland, OR, USA.

Current risk-adjusted models for donor lung use and lung graft survival do not include donor critical care data. We sought to identify modifiable donor physiologic and mechanical ventilation parameters that predict donor lung use and lung graft survival. This is a prospective observational study of donors after brain death (DBDs) managed by 19 organ procurement organizations from 2016 to 2019. Read More

View Article and Full-Text PDF

Poly(lactide-co-ε-caprolactone) scaffold promotes equivalent tissue integration and supports skin grafts compared to a predicate collagen scaffold.

Wound Repair Regen 2021 Jun 15. Epub 2021 Jun 15.

Division of Plastic and Reconstructive Surgery, Department of Surgery, School of Medicine, Duke University, Durham, North Carolina, USA.

Dermal scarring from motor vehicle accidents, severe burns, military blasts, etc. is a major problem affecting over 80 million people worldwide annually, many of whom suffer from debilitating hypertrophic scar contractures. These stiff, shrunken scars limit mobility, impact quality of life, and cost millions of dollars each year in surgical treatment and physical therapy. Read More

View Article and Full-Text PDF

Long-term Kidney Function and Survival in Recipients of Allografts from Living Kidney Donors with Hypertension: A National Cohort Study.

Transpl Int 2021 Jun 15. Epub 2021 Jun 15.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore.

Allografts from living kidney donors with hypertension may carry subclinical kidney disease from the donor to recipient and thus lead to adverse recipient outcomes. We examined eGFR trajectories and all-cause allograft failure in recipients from donors with vs. without hypertension, using mixed-linear and Cox regression models stratified by donor age. Read More

View Article and Full-Text PDF

Early implant placement with or without alveolar ridge preservation in single tooth gaps renders similar esthetic, clinical and patient-reported outcome measures: one-year results of a randomized clinical trial.

Clin Oral Implants Res 2021 Jun 15. Epub 2021 Jun 15.

Department of Oral & Maxillofacial Surgery, Erasmus University Medical Center Rotterdam, the Netherlands.

Objectives: To test whether early implant placement with alveolar ridge preservation (ARP) results in different esthetic, clinical and patient-reported outcome measures (PROMs) compared to early implant placement without ARP.

Material And Methods: Seventy-five patient requiring single tooth extraction in the anterior maxilla were recruited. Following tooth extraction, the patients were randomly allocated to three groups: 1) ARP using demineralized bovine bone mineral containing 10% collagen (DBBM-C) covered by a collagen matrix (CM) (n = 25), 2) ARP using DBBM-C covered with a palatal graft (PG) (n = 25), 3) spontaneous healing (control) (n = 25). Read More

View Article and Full-Text PDF

Predicting ACL Reinjury from Return to Activity Assessments at 6-months Post-Surgery: A Prospective Cohort Study.

J Athl Train 2021 Jun 15. Epub 2021 Jun 15.

Department of Kinesiology. University of Virginia, Charlottesville, VA.

Context: Return to activity(RTA) assessments are commonly administered following ACL-Reconstruction(ACLR) to manage post-operative progressions back to activity. To date, there is little knowledge on the clinical utility of these assessments to predict patient outcomes such as secondary ACL injury once returned to activity.

Objective: To identify what measures of patient function at 6-months post-ACLR best predict return to activity and second ACL injury at a minimum of 2-years following ACLR. Read More

View Article and Full-Text PDF

Clarithromycin As an Alternative and Prophylactic Agent in a Hematopoietic Stem Cell Transplantation Patient.

Am J Case Rep 2021 Jun 15;22:e931731. Epub 2021 Jun 15.

Medical Mycology Research Center, Chiba University, Chiba, Japan.

BACKGROUND Nocardia infections have rarely been reported in hematopoietic stem cell transplantation (HSCT) patients, who usually receive the prophylactic use of sulfamethoxazole/trimethoprim (ST) against Pneumocystis jiroveci. However, the ST prophylaxis, sensitive to Nocardia species, sometimes induces renal toxicities. Therefore, alternative prophylactic or therapeutic drugs are required for nocardiosis in HSCT patients. Read More

View Article and Full-Text PDF

Mangiferin Promotes Bregs Level, Activates Nrf2 Antioxidant Signaling, and Inhibits Proinflammatory Cytokine Expression in Murine Splenic Mononuclear Cells In Vitro.

Curr Med Sci 2021 Jun 15. Epub 2021 Jun 15.

Department of Cardiovascular Surgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China.

Recent studies indicated that regulatory B cells (Bregs) and nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant signaling pathway play important roles in the pathogenesis of chronic graft-versus-host disease (cGVHD). Mangiferin (MA), a polyphenol compound, has been reported to activate Nrf2/antioxidant-responsive element (ARE) signaling pathway. This study was aimed to investigate the effects of MA on Bregs and Nrf2 antioxidant signaling in murine splenic mononuclear cells (MNCs) in vitro. Read More

View Article and Full-Text PDF

Combined impact of HLA-allele matching and the CD34-positive cell dose on optimal unit selection for single-unit cord blood transplantation in adults.

Leuk Lymphoma 2021 Jun 15:1-10. Epub 2021 Jun 15.

Central Japan Cord Blood Bank, Seto, Japan.

The combined effects of HLA-allele matching at six-loci (HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1) and CD34 cell dose on clinical outcomes were analyzed in 1,226 adult cases with single-unit unrelated cord blood transplantation. In the six-loci analysis, low HLA-allele matches did not significantly increase the overall mortality compared to higher matches, whereas in the five-loci analysis excluding HLA-DPB1, they caused a higher overall mortality (HR 1.42,  = . Read More

View Article and Full-Text PDF

Incidence, Management, and Prognosis of Graft Failure and Autologous Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation.

J Korean Med Sci 2021 Jun 14;36(23):e151. Epub 2021 Jun 14.

Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: This study presents outcomes of management in graft failure (GF) after allogeneic hematopoietic stem cell transplantation (HCT) and provides prognostic information including rare cases of autologous reconstitution (AR).

Methods: We analyzed risk factors and outcomes of primary and secondary GF, and occurrence of AR in 1,630 HCT recipients transplanted over period of 18 years (January 2000-September 2017) at our center.

Results: Primary and secondary GF occurred in 13 (0. Read More

View Article and Full-Text PDF

Human Induced pluripotent stem cells-derived corneal endothelial-like cells promote corneal transparency in a rabbit model of bullous keratopathy.

Stem Cells Dev 2021 Jun 15. Epub 2021 Jun 15.

First Affiliated Hospital of Harbin Medical University, 74559, Harbin, Heilongjiang, China;

The corneal endothelium(CE) is vital for the cornea to maintain its transparency. However, CE dysfunction occurs due to aging, intraocular surgery, trauma, dystrophy, etc. Corneal transplantation is the only method to clinically treat CE dysfunction; however, this treatment strategy faces the disadvantages of a global cornea shortage, graft failure, and severe side effects. Read More

View Article and Full-Text PDF

The Influence of Low- and High-Negative-Pressure Liposuction and Different Harvesting Sites on the Viability and Yield of Adipocytes and Other Nucleated Cells.

Aesthetic Plast Surg 2021 Jun 14. Epub 2021 Jun 14.

General Surgery Department, Hand Unit, Locarno's Regional Hospital, Via Ospedale 1, 6600, Locarno, Switzerland.

Background: The volume effect of fat grafting is highly dependent on the presence of viable adipocytes and other nucleated cells within the lipoaspirate. We suspected that one of the crucial factors influencing cell viability is the negative pressure applied during the fat graft harvesting and the suitability of various harvest sites when compared to others. Despite much discussion, there is no consensus on the optimal negative pressure or the best site for harvesting so we designed an experiment to test this. Read More

View Article and Full-Text PDF

Osteobiologics.

Oper Neurosurg (Hagerstown) 2021 Jun;21(Supplement_1):S2-S9

Center for Spine Health, Department of Neurosurgery, Neurologic Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Background: Osteobiologics are engineered materials that facilitate bone healing and have been increasingly used in spine surgery. Autologous iliac crest bone grafts have been used historically, but morbidity associated with graft harvesting has led surgeons to seek alternative solutions. Allograft bone, biomaterial scaffolds, growth factors, and stem cells have been explored as bone graft substitutes and supplements. Read More

View Article and Full-Text PDF

Cryopreservation of unrelated donor hematopoietic stem cells: the right answer for transplantations during the COVID-19 pandemic?

Bone Marrow Transplant 2021 Jun 14. Epub 2021 Jun 14.

Banc de Sang i Teixits, Barcelona, Spain.

Cryopreservation was recommended to ensure continuity of unrelated donor (UD) hematopoietic stem cell transplantation (HSCT) during COVID-19 pandemic. However, its impact on clinical outcomes and feasibility was not well known. We compared 32 patients who underwent UD HSCT using cryopreserved peripheral blood stem cells (PBSC) during the COVID-19 pandemic with 32 patients who underwent UD HSCT using fresh PBSC in the previous period. Read More

View Article and Full-Text PDF

Lysyl oxidase inhibitors attenuate cyclosporin A-induced nephropathy in mouse.

Sci Rep 2021 Jun 14;11(1):12437. Epub 2021 Jun 14.

Renal Medicine, Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, NSW, Australia.

Calcineurin inhibitors, such as Cyclosporin (CsA), are the mainstay of anti-rejection therapy in solid organ transplants but can paradoxically induce progressive nephropathy characterised by renal dysfunction and interstitial fibrosis. Lysyl oxidases (LOXs), a group of enzymes that catalyse extracellular matrix (ECM) crosslinking, were shown to implicate in tissue scarring. It is hypothesized that inhibition of these enzymes may render therapeutic effects against CsA-induced nephropathy. Read More

View Article and Full-Text PDF

Palliative Radiotherapy for Diffuse Large B-cell Lymphoma.

Clin Lymphoma Myeloma Leuk 2021 May 19. Epub 2021 May 19.

Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.

Recent improvements in chemoimmunotherapies, targeted agents, hematopoietic stem cell transplants, and cellular therapies have revolutionized treatment paradigms for patients with diffuse large B-cell lymphoma (DLBCL). Even in the relapsed or refractory setting, contemporary treatment options are delivered with curative intent and can lead to lasting remissions. Although such therapies have improved overall outcomes, they have increasingly led to a wide variety of presentations of recurrent tumors in need of palliation. Read More

View Article and Full-Text PDF

Polyphosphate (PolyP) for alveolar cleft repair: study protocol for a pilot randomized controlled trial.

Trials 2021 Jun 14;22(1):393. Epub 2021 Jun 14.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University, Makassar, 90425, Indonesia.

Objective: Bone grafting is an important surgical procedure to restore missing bone in patients with alveolar cleft lip/palate, aiming to stabilize either sides of the maxillary segments by inducing new bone formation, and in bilateral cleft cases also to stabilize the pre-maxilla. Polyphosphate (PolyP), a physiological polymer composed of orthophosphate units linked together with high-energy phosphate bonds, is a naturally existing compound in platelets which, when complexed with calcium as Ca-polyP microparticles (Ca-polyP MPs), was proven to have osteoinductive properties in preclinical studies.

Aim: To evaluate the feasibility, safety, and osteoinductivity of Ca-polyP MPs as a bone-inducing graft material in humans. Read More

View Article and Full-Text PDF

Urothelial carcinoma of the graft kidney with molecular analyses: a rare case report.

Diagn Pathol 2021 Jun 14;16(1):53. Epub 2021 Jun 14.

Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: Malignancy after transplantation is a leading cause of death among kidney transplant recipients. However, donor-derived malignancies are rare. We report a case of a high grade papillary urothelial carcinoma arising in a transplanted kidney. Read More

View Article and Full-Text PDF

Long-Term Prognostic Value of Stress Cardiovascular Magnetic Resonance in Patients With History of Percutaneous Coronary Intervention.

Circ Cardiovasc Imaging 2021 Jun 15;14(6):e012374. Epub 2021 Jun 15.

Hôpital Privé Jacques Cartier, Institut Cardiovasculaire Paris Sud, Cardiovascular Magnetic Resonance Laboratory, Ramsay Santé, Massy, France (T.P., T.H., M.K., F.S., S.C., T.U., P.G., J.G.).

Background: Recurrence of cardiovascular events remains a substantial cause of mortality and morbidity among patients with previous coronary revascularization. The aim was to assess the prognostic value of stress cardiovascular magnetic resonance (CMR) parameters in patients with history of percutaneous coronary intervention.

Methods: Between 2011 and 2014, consecutive patients with history of percutaneous coronary intervention referred for stress perfusion CMR were followed for the occurrence of major adverse cardiovascular events (MACEs), defined by cardiovascular death or nonfatal myocardial infarction. Read More

View Article and Full-Text PDF

Composite femoro-tibial bypass as alternative solution in complicated revascolarization: Case report.

Int J Surg Case Rep 2021 Jun 10;84:106103. Epub 2021 Jun 10.

Vascular Surgery Unit, AOUP Policlinico 'P. Giaccone', Palermo, Italy; Department of Surgical, Oncological and Oral Sciences, University of Palermo, Italy.

Introduction: Peripheral Arterial Disease (PAD) in diabetic patients is a significant cause of Morbility. Long arterial occlusion in patient previously treated can require unusual and complex solution. Herein we report a case of complicated bypass in diabetic patient with history of bypass for bilateral popliteal aneurysm. Read More

View Article and Full-Text PDF

Relevance of plasma matrix metalloproteinase-9 for bronchiolitis obliterans syndrome after allogeneic hematopoietic cell transplantation: Plasma MMP-9 in BOS.

Transplant Cell Ther 2021 Jun 11. Epub 2021 Jun 11.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Medicine, University of Washington, Seattle, WA.

Background: Bronchiolitis obliterans syndrome (BOS) is a highly morbid form of chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT). Several plasma proteins have been identified as biomarkers for BOS after lung transplantation. Relevance of these biomarkers in BOS patients after allogeneic HCT has not been examined. Read More

View Article and Full-Text PDF

Full dose Cyclophosphamide with the addition of Fludarabine for Matched Sibling transplants in Severe Aplastic Anemia: Flu/Cy conditioning for SAA.

Transplant Cell Ther 2021 Jun 11. Epub 2021 Jun 11.

King Faisal Specialist Hospital and Research Center, KSA.

Background: The recommended therapy for severe aplastic anemia (SAA) in younger patients with a matched sibling donor (MSD) is allogeneic hematopoietic cell transplantation (allo-HCT). A number of conditioning regimens and protocols have been utilized. Here we report a homogeneous cohort of SAA patients receiving a uniform transplant protocol. Read More

View Article and Full-Text PDF

Autograft long head biceps tendon can be used as a scaffold for biologically augmenting rotator cuff repairs.

Arthroscopy 2021 Jun 11. Epub 2021 Jun 11.

Laboratory of Orthopaedic Tissue Regeneration & Orthobiologics, Department of Bioengineering, Clemson University, Clemson, SC; Frank H. Stelling and C. Dayton Riddle Orthopaedic Education and Research Laboratory, Clemson University Biomedical Engineering Innovation Campus, Greenville, SC.

Purpose: To create a viable, mechanically expanded autograft long head biceps tendon (LHBT) scaffold for biologically augmenting the repair of torn rotator cuffs.

Methods: The proximal aspect of the tenotomized LHBTs were harvested from patients during rotator cuff repair surgery and were mechanically formed into porous scaffolds using a surgical graft expander. LHBT scaffolds were evaluated for change in area, tensile properties, and tenocyte viability before and after expansion. Read More

View Article and Full-Text PDF

Bone marrow transplantation without myeloablative conditioning in a mouse model for Diamond-Blackfan Anemia corrects the disease phenotype.

Exp Hematol 2021 Jun 11. Epub 2021 Jun 11.

Division of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Lund, Sweden. Electronic address:

Diamond-Blackfan Anemia (DBA) is a congenital erythroid hypoplasia caused by a functional haploinsufficiency of genes coding for ribosomal proteins. Among these genes, the ribosomal protein S19 (RPS19) gene is the most frequently mutated. Previously, a mouse model deficient in RPS19 was developed by our laboratory, which recapitulates the hematopoietic disease phenotype by displaying pathological features and clinical symptoms of DBA. Read More

View Article and Full-Text PDF

Operational tolerance after pediatric composite liver-pancreas-intestine transplantation following severe graft-versus-host disease.

Pediatr Transplant 2021 Jun 14:e14069. Epub 2021 Jun 14.

Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Background: While operational tolerance has been previously described in isolated intestinal transplant, reports of this phenomenon in combined liver-intestine transplant are lacking.

Case Description: We detail a unique case of a patient who received a composite allograft including liver, pancreas, and small bowel due to short gut syndrome secondary to gastroschisis complicated by volvulus. The indication for transplantation was permanent dependence on total parenteral nutrition, end-stage liver disease, recurrent sepsis, and persistent stomal variceal hemorrhage. Read More

View Article and Full-Text PDF