80,728 results match your criteria graft outcome

Outcomes of Relapsed B-Cell Acute Lymphoblastic Leukemia After Sequential Treatment with Blinatumomab and Inotuzumab.

Blood Adv 2022 Jan 18. Epub 2022 Jan 18.

Department of Medicine, Weill Cornell Medical College of Cornell University, United States.

Novel monoclonal antibody-based therapies (mAbs) targeting CD19 and CD22, i.e. blinatumomab and inotuzumab, have demonstrated high rates of complete remission (CR) and been used as a bridging treatment to potentially curative allogeneic hematopoietic stem cell transplantation (alloHCT) in adults with relapsed or refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL). Read More

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January 2022

Fibrosis-4 Index Can Independently Predict Major Adverse Cardiovascular Events in Nonalcoholic Fatty Liver Disease.

Am J Gastroenterol 2022 Jan 18. Epub 2022 Jan 18.

Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Introduction: Nonalcoholic fatty liver disease (NAFLD) is closely associated with an increased risk of cardiovascular disease. We aimed to determine whether the fibrosis-4 index (FIB-4) can identify patients with NAFLD at highest risk of cardiovascular events.

Methods: We analyzed data from 81,108 patients with (i) a diagnosis of NAFLD, (ii) nonalcoholic steatohepatitis (NASH), or (iii) at risk (RISK) of NASH. Read More

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January 2022

Patient-Reported Outcome, Return to Sport, and Revision Rates 7-9 Years After Anterior Cruciate Ligament Reconstruction: Results From a Cohort of 2042 Patients.

Am J Sports Med 2022 Jan 18:3635465211060333. Epub 2022 Jan 18.

ACL Study Group, Sports Medicine Institute, Hospital for Special Surgery, New York, New York, USA.

Background: Long-term patient-reported outcome measures (PROMs), rates of return to sport, and revision risk after anterior cruciate ligament (ACL) reconstruction (ACLR) are not well understood.

Purpose: To provide long-term follow-up of PROMs, return-to-sport rates, and revision rates after ACLR and to identify predictors for poor outcome.

Study Design: Case-control study; Level of evidence, 3. Read More

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January 2022

Sufficient MRI graft structural integrity at 9 months after anterior cruciate ligament reconstruction with hamstring tendon autograft.

Knee Surg Sports Traumatol Arthrosc 2022 Jan 18. Epub 2022 Jan 18.

Department of Orthopaedics and Traumatology, Clinical Ars Medica, Via Grumo 16, 6929, Gravesano, Ticino, Switzerland.

Purpose: To assess the MRI-measured structural integrity of hamstring autograft at 9 months after anterior cruciate ligament reconstruction (ACLR) surgery.

Methods: A prospective cohort study was conducted including 34 patients (mean age 36.8 ± 11. Read More

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January 2022

Intra-Liver Allograft C3d-Binding Donor-Specific Anti-HLA Antibodies Predict Rejection After Liver Transplantation.

Transplant Proc 2022 Jan 13. Epub 2022 Jan 13.

Wakunaga Pharmaceutical Co, Ltd Molecular Diagnostics Division, 1624 Shimokotachi, Koda-cho, Akitakata, Hiroshima, Japan.

Background: There is no doubt that antibody-mediated rejection (AMR) due to donor-specific anti-HLA antibodies (DSA) brings a poor outcome for liver transplant recipients. However, the relationship between intragraft DSA (g-DSA), complement-binding abilities, and AMR remains unknown.

Materials And Methods: We enrolled a total of 20 liver transplant recipients who underwent protocol or episode graft biopsies in the mid to long term after liver transplant (median 48. Read More

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January 2022

Endovascular treatment of traumatic aortic rupture using iliac extension stent-grafts in patiåents with small aortic diameters.

Interact Cardiovasc Thorac Surg 2022 Jan 17. Epub 2022 Jan 17.

University Heart Center Freiburg - Bad Krozingen, Freiburg, Germany.

Objectives: To evaluate outcomes after thoracic endovascular aortic repair in young patients sustaining traumatic blunt aortic injury (BAI) using iliac extension stent-grafts because of small aortic diameters measuring <24 mm.

Methods: Retrospective analysis regarding clinical presentation, trauma management, endovascular techniques and outcome of patients with a small descending aorta involving an iliac extension stent-graft to treat traumatic BAI.

Results: Among 48 patients who suffered a BAI and underwent thoracic endovascular aortic repair, 7 received iliac extension stent-grafts. Read More

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January 2022

Penetrating Keratoplasty With Minimal Endothelial Replacement: A Novel Technique for High-Risk Large-Diameter Corneal Grafting.

Cornea 2022 Feb;41(2):264-268

Department of Ophthalmology, Deenanath Mangeshkar Hospital, Pune, Maharashtra, India.

Purpose: The purpose of this study was to analyze the outcome of large-diameter penetrating keratoplasty with minimal endothelial replacement (PKMER).

Methods: Two eyes (2 patients) with advanced keratoconus and central full-thickness pathology, namely, scar and failed graft, were studied. Both eyes had relatively healthy endothelium in the periphery. Read More

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February 2022

Transverse Weber A fracture atrophic non-union. A single centre case series.

Trauma Case Rep 2022 Feb 4;37:100604. Epub 2022 Jan 4.

Department of Trauma and Orthopaedics, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK.

Introduction: Weber A ankle fractures are isolated fibula fractures distal to the level of the ankle joint line. They are regarded as stable injuries that usually heal successfully without intervention. We have identified several patients that have developed symptomatic atrophic non-union of transverse Weber A fractures that are not simple avulsion fractures of the anterior talo-fibular ligament. Read More

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February 2022

Do Clinical Outcomes and Failure Rates Differ in Patients With Combined ACL and Grade 2 MCL Tears Versus Isolated ACL Tears?: A Prospective Study With 14-Year Follow-up.

Orthop J Sports Med 2022 Jan 7;10(1):23259671211047860. Epub 2022 Jan 7.

II Clinica Ortopedica e Traumatologica, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Background: A combined injury to the anterior cruciate ligament (ACL) and medial collateral ligament (MCL) is a common injury pattern encountered during clinical practice. Recent systematic reviews have found no consensus on the optimal method of managing this combined ligament injury pattern, and no long-term studies with modern techniques are available in the literature.

Purpose: To compare 2 groups of patients who underwent isolated ACL reconstruction in terms of failures and clinical scores at long-term follow-up. Read More

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January 2022

Assessment of hypertension in kidney transplantation by ambulatory blood pressure monitoring: a systematic review and meta-analysis.

Clin Kidney J 2022 Jan 23;15(1):31-42. Epub 2021 Sep 23.

CNR-Institute of Clinical Physiology, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Reggio Calabria, Italy.

Background: Hypertension (HTN) is common following renal transplantation and it is associated with adverse effects on cardiovascular (CV) and graft health. Ambulatory blood pressure monitoring (ABPM) is the preferred method to characterize blood pressure (BP) status, since HTN misclassification by office BP (OBP) is quite common in this population. We performed a systematic review and meta-analysis aimed at determining the clinical utility of 24-h ABPM and its potential implications for the management of HTN in this population. Read More

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January 2022

Surgical Challenges in Multi-Vessel Minimally Invasive Coronary Artery Bypass Grafting.

J Interv Cardiol 2021 29;2021:1195613. Epub 2021 Dec 29.

Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.

Objectives: Minimally invasive coronary artery bypass grafting (MICS CABG) has emerged as an alternative treatment for patients with multi-vessel coronary artery disease, but there are certain surgical challenges inherent in the adoption of this approach. The present study was conducted to provide insight regarding the outcomes associated with our first 118 cases, to discuss the surgical difficulties encountered in these patients, and to outline the potential countermeasures.

Methods: Between January 2017 and January 2020, 118 patients underwent multi-vessel MICS CABG. Read More

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January 2022

Mature naive B cells regulate the outcome of murine acute graft-versus-host disease in an IL-10 independent manner.

Transplant Cell Ther 2022 Jan 12. Epub 2022 Jan 12.

Laboratório de Pesquisa Sobre o Timo, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro 21040-360, Brazil; Departamento de Imunologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil; Divisão de Medicina Experimental, Instituto Nacional de Câncer, Rio de Janeiro 20231-050, Brazil; Programa FIO-Câncer, Programa FIO-mucosa, Vice Presidência de Pesquisa e Coleções Biológicas/ FIOCRUZ, Rio de Janeiro 21040-360, Brazil. Electronic address:

Graft-versus-host disease (GVHD) is the main complication of bone marrow transplantation (BMT). T CD4+ lymphocytes are the main effector cells for disease development but other cell types can determine disease outcome through cytokine production and antigen presentation. B cells are abundant in BMT products and are involved in chronic GVHD immunopathogenesis. Read More

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January 2022

The Safety and Efficacy of Spreader Grafts and Autospreaders in Rhinoplasty: A Systematic Review and Meta-analysis.

Aesthetic Plast Surg 2022 Jan 14. Epub 2022 Jan 14.

Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, 94305, USA.

Background: The aim of this study was to systematically evaluate the evidence of surgical outcomes and complications of spreader grafts and autospreader flaps in the context of middle vault reconstruction after dorsal hump removal.

Material And Methods: A systematic review was conducted in accordance with the Cochrane Handbook for Systematic Reviews of Interventions. Inclusion and exclusion criteria were based on the population, intervention, comparison, and outcome (PICO) framework. Read More

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January 2022

Clinical Outcomes Using Freestyle Valve/Valsalva Graft Composite Conduit for Aortic Root Replacement.

Ann Thorac Surg 2022 Jan 11. Epub 2022 Jan 11.

Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University School of Medicine, Durham, NC. Electronic address:

Background: We review the clinical outcomes with a novel method of aortic root replacement using a self-constructed tissue valve-conduit comprised of a Freestyle subcoronary valve sewn into a Valsalva graft.

Methods: From 2005 to 2020, 523 patients had aortic root replacement operations using a self-constructed Freestyle Subcoronary-Valsalva graft tissue valve-conduit. Median age was 62 years (IQR 54-70) and 430 (82%) were male patients. Read More

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January 2022

Low posterior tibial slope is associated with increased risk of PCL graft failure.

Knee Surg Sports Traumatol Arthrosc 2022 Jan 14. Epub 2022 Jan 14.

Department of Orthopaedic Surgery, UPMC Freddie Fu Sports Medicine Center, University of Pittsburgh, 3200 S. Water St., Pittsburgh, PA, 15203, USA.

Purpose: To evaluate the effect of posterior tibial slope (PTS) on patient-reported outcomes (PROs) and posterior cruciate ligament (PCL) graft failure after PCL reconstruction.

Methods: Patients undergoing PCL reconstruction with a minimum 2-year follow-up were included in this retrospective cohort study. A chart review was performed to collect patient-, injury-, and surgery-related data. Read More

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January 2022

Influence of anatomical factors related to maxillary sinus on outcomes of transcrestal sinus floor elevation.

J Dent Sci 2022 Jan 26;17(1):438-443. Epub 2021 Aug 26.

Stomatology Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background/purpose: Graft bone maturation and remodeling in the maxillary sinus require adequate angiogenesis and osteoprogenitor cells migration from the surrounding bony walls and Schneiderian membrane. This study aimed to evaluate the influence of anatomical factors related to maxillary sinus on the outcomes of transcrestal sinus floor elevation using cone-beam computed tomography (CBCT).

Materials And Methods: Forty-five patients (63 elevated sites) were included in this study. Read More

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January 2022

Tear pattern after superior capsular reconstruction using an acellular dermal matrix allograft.

J Shoulder Elbow Surg 2022 Jan 10. Epub 2022 Jan 10.

Department of Orthopaedic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: The healing rate and tear pattern of grafts in superior capsular reconstruction (SCR) using acellular dermal matrix (ADM) allograft is poorly understood, and clinical results based on the graft status remain controversial.

Methods: Fifty-one consecutive arthroscopic SCRs using ADM between October 2017 and February 2020 were enrolled. The range-of-motion, strength, Visual Analog Scale for pain (PVAS), American Shoulder and Elbow Surgeons (ASES) score, and Constant score were evaluated preoperatively and at the last follow-up. Read More

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January 2022

The utilization of hyperbaric oxygenation therapy in hypospadias repair: a systematic review and meta-analysis.

Int Urol Nephrol 2022 Jan 13. Epub 2022 Jan 13.

Division of Urology, Hospital for Sick Children, Toronto, ON, Canada.

Introduction: This study aimed to evaluate the efficacy and safety of Hyperbaric Oxygen Therapy (HBOT) use in hypospadias repair through systematic review and meta-analysis of comparative studies.

Methods: A systematic literature search was performed in May 2021. Comparative studies assessing the surgical outcome of hypospadias repair between control versus HBOT utilization were identified and evaluated according to Cochrane collaboration recommendations. Read More

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January 2022

Relapse and Disease-Free Survival in Patients With Myelodysplastic Syndrome Undergoing Allogeneic Hematopoietic Cell Transplantation Using Older Matched Sibling Donors vs Younger Matched Unrelated Donors.

JAMA Oncol 2022 Jan 13. Epub 2022 Jan 13.

Division of Hematology-Oncology, Blood and Marrow Transplantation Program, Mayo Clinic, Jacksonville, Florida.

Importance: Matched sibling donors (MSDs) are preferred for allogeneic hematopoietic cell transplantation (allo-HCT) in myelodysplastic syndrome even if they are older. However, whether older MSDs or younger human leukocyte antigen-matched unrelated donors (MUDs) are associated with better outcomes remains unclear.

Objective: To investigate whether allo-HCT for myelodysplastic syndrome using younger MUDs would be associated with improved disease-free survival and less relapse compared with older MSDs. Read More

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January 2022

Could plasma based therapies still be considered in selected cases with atypical hemolytic uremic syndrome?

Turk J Pediatr 2021 ;63(6):986-993

Department of Pediatric Nephrology, Gazi University Faculty of Medicine, Ankara, Turkey.

Background: Atypical hemolytic uremic syndrome (aHUS) occurs due to defective regulation of the alternative complement pathway (ACP) on vascular endothelial cells. Plasma based therapy (PT) was the mainstay of the treatment for aHUS for many years until the introduction of therapies targeting blockage of the complement system. The aim of this study was to evaluate patients with aHUS who had been treated with plasma based therapies alone. Read More

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January 2021

Graft function and pregnancy outcomes after kidney transplantation.

BMC Nephrol 2022 Jan 12;23(1):27. Epub 2022 Jan 12.

Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany.

Background: After kidney transplantation, pregnancy and graft function may have a reciprocal interaction. We evaluated the influence of graft function on the course of pregnancy and vice versa.

Methods: We performed a retrospective observational study of 92 pregnancies beyond the first trimester in 67 women after renal transplantation from 1972 to 2019. Read More

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January 2022

Bridging patients in cardiogenic shock with a paracorporeal pulsatile biventricular assist device to heart transplantation-a single-centre experience.

Eur J Cardiothorac Surg 2022 Jan 10. Epub 2022 Jan 10.

Department of Cardiac Surgery, Ludwig Maximilian University Munich, Munich, Germany.

Objectives: We evaluated the outcome of patients in cardiogenic shock receiving a paracorporeal pulsatile biventricular assist device as a bridge to transplantation.

Methods: We performed a retrospective single-centre analysis of all patients who received a Berlin Heart Excor® at our institution between 2004 and 2019.

Results: A total of 97 patients (90 adults, 7 paediatric) were analysed. Read More

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January 2022

Recurrence and Visual Outcomes of Phototherapeutic Keratectomy in Lattice Corneal Dystrophy: A Cohort Study.

J Refract Surg 2022 Jan 1;38(1):43-49. Epub 2022 Jan 1.

Purpose: To evaluate recurrence and visual outcomes of phototherapeutic keratectomy (PTK) in lattice corneal dystrophy.

Methods: Kaplan-Meier survival analyses were retrospectively performed. Recurrence was defined as central biomicroscopic findings of recurrence with decreased visual acuity: loss of at least two lines or visual acuity ≤ 20/40) at any time during the follow-up. Read More

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January 2022

Skin ulcers caused by ruxolitinib in a patient with chronic cutaneous graft-versus-host disease.

J Oncol Pharm Pract 2022 Jan 12:10781552211073881. Epub 2022 Jan 12.

146995Ankara Oncology Training and Research Hospital, Department of Hematology and Bone Marrow Transplantation Center, University of Health Sciences, Ankara, Turkey.

Introduction: Graft-versus-host disease (GVHD) is a common complication of allogeneic hematopoietic cell transplantation (HCT). In the treatment of chronic GVHD, skin directed therapy, systemic corticosteroids, calcineurin inhibitors (such as cyclosporine (CsA) and tacrolimus), rituximab, mycophenolate mofetil (MMF), extracorporeal photopheresis (ECP) and ruxolitinib are used.

Case Report: We present an 18 year old male with Philadelphia chromosome positive acute B lymphoblastic leukemia, treated with allogeneic HCT from a full matched sibling donor. Read More

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January 2022

Liver Transplantation in Recipients With Class III Obesity: Posttransplant Outcomes and Weight Gain.

Transplant Direct 2022 Feb 5;8(2):e1242. Epub 2022 Jan 5.

Division of Transplantation, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN.

Background: There has been a dramatic increase in obesity in the United States. Several studies have reported conflicting results for the impact of obesity on outcomes of liver transplantation (LT). This study aims to assess the impact of obesity on LT and changes in body mass index (BMI) after transplantation. Read More

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February 2022

Bone Regenerative Biomaterials in Periapical Surgery: A Systemic Review and Meta-Analysis.

J Pharm Bioallied Sci 2021 Nov 10;13(Suppl 2):S933-S937. Epub 2021 Nov 10.

BDS, PGDHHM, MPH, Final Year Student, Parul Univeristy, Limda, Waghodia, Vadodara, Gujrat, India.

Introduction: Successful treatment in the endodontics and periodontics depends on the periapical status. Hence, in the present meta-analysis, we evaluate the various bone regenerative materials in the periapical surgeries.

Materials And Methods: Online data were collected from the search engines of EBSCO, PubMed, Google Scholar, and Scopus. Read More

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November 2021

Induced membrane technique for reconstruction of a 25 cm humerus diaphyseal defect secondary to chronic osteomyelitis in an adolescent.

Afr J Paediatr Surg 2022 Apr-Jun;19(2):112-114

Paediatric Surgery Unit, University Teaching Hospital of Yopougon, Abidjan, Côte d'Ivoire.

The surgical treatment of long bone defects in septic environments remains a challenge for any orthopedic surgeon. The two-stage reconstruction technique described by Masquelet AC is a better alternative in our regions where expertise in microsurgical techniques is rare. We report our first experience with this technique through the reconstruction of the humeral diaphyseal bone defect. Read More

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January 2022

Urinary tract infection in renal transplant recipient: A clinical comprehensive review.

Saudi J Kidney Dis Transpl 2021 Mar-Apr;32(2):307-317

Department of Nephrology, Institute of Renal Science, Sir Gangaram Hospital, New Delhi, India.

Since the initial times of renal transplantation in the 1950s, understanding various aspects influencing graft survival and outcome have been progressively improving. However, infections especially urinary tract infections (UTIs), are an important factor leading to an increase in morbidity and graft failure. UTI degrades the health-related quality of life and can potentially impair graft function. Read More

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January 2022

Oral vancomycin for clostridioides difficile prophylaxis in allogenic hematopoietic cell transplant.

Transpl Infect Dis 2022 Jan 11. Epub 2022 Jan 11.

The University of Kansas Health System, Kansas City, Kansas.

Background: Neutropenia and antibiotic use put patients at risk for Clostridioides difficile infection (CDI) following allogenic hematopoietic cell transplant (alloHCT). CDI following alloHCT has been associated with acute graft versus host disease (aGVHD), a significant cause of morbidity and mortality in this population. We sought to evaluate if prophylactic oral vancomycin reduces the incidence of CDI in alloHCT recipients. Read More

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January 2022

A comparative study of suction blister epidermal grafting and automated blister epidermal micrograft in stable vitiligo.

Sci Rep 2022 Jan 10;12(1):393. Epub 2022 Jan 10.

Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, No.5, Fushin Street, Taoyuan, Keelung Branch, Linkou, Taipei, Taiwan.

The automated blister epidermal micrograft (ABEM) is a newly introduced surgical transplantation for refractory vitiligo. Comparative analysis of other surgical methods is lacking. We conducted a retrospective study to compare the efficacy, safety, and experience of ABEM with conventional suction blister epidermal graft (SBEG). Read More

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January 2022