171,840 results match your criteria graft function

Deep sequencing of DNA from urine of kidney allograft recipients to estimate donor/recipient-specific DNA fractions.

PLoS One 2021 15;16(4):e0249930. Epub 2021 Apr 15.

Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Doha, Qatar.

Kidney transplantation is the treatment of choice for patients with end-stage kidney failure, but transplanted allograft could be affected by viral and bacterial infections and by immune rejection. The standard test for the diagnosis of acute pathologies in kidney transplants is kidney biopsy. However, noninvasive tests would be desirable. Read More

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Targeted Peripheral Nerve Interface: Case Report with Literature Review.

Plast Reconstr Surg Glob Open 2021 Apr 8;9(4):e3532. Epub 2021 Apr 8.

Division of Plastic Surgery, Department of Surgery, University of Washington, Seattle, Wash.

Nerve transection injuries can result in painful neuromas that adversely affect patient recovery. This is especially significant following amputation surgeries in the setting of prosthetic wear and function. Targeted Muscle Reinnervation and Regenerative Peripheral Nerve Interface (RPNI) are 2 modern surgical techniques that provide neuromuscular targets for these transected nerve endings to reinnervate. Read More

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Long-Term Immunosuppression Management: Opportunities and Uncertainties.

Clin J Am Soc Nephrol 2021 Apr 14. Epub 2021 Apr 14.

Centura Transplant, Denver, Colorado

The long-term management of maintenance immunosuppression in kidney transplant recipients remains complex. The vast majority of patients are treated with the calcineurin inhibitor tacrolimus as the primary agent in combination with mycophenolate, with or without corticosteroids. A tacrolimus trough target 5-8 ng/ml seems to be optimal for rejection prophylaxis, but long-term tacrolimus-related side effects and nephrotoxicity support the ongoing evaluation of noncalcineurin inhibitor-based regimens. Read More

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Cyclosporine A and IFNγ licencing enhances human mesenchymal stromal cell potency in a humanised mouse model of acute graft versus host disease.

Stem Cell Res Ther 2021 Apr 14;12(1):238. Epub 2021 Apr 14.

Cellular Immunology Laboratory, Department of Biology, Maynooth University, Maynooth, Co. Kildare, Ireland.

Immunosuppressive ability in human MSC donors has been shown to be variable and may be a limiting factor in MSC therapeutic efficacy in vivo. The importance of cytokine activation of mesenchymal stromal cells (MSCs) to facilitate their immunosuppressive function is well established. This study sought to further understand the interactions between MSCs and the commonly used calcineurin inhibitor cyclosporine A (CsA). Read More

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Right Ventricular Dysfunction and Adverse Outcomes after Renal Transplantation.

Cardiorenal Med 2021 Apr 14:1-10. Epub 2021 Apr 14.

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School and Michigan Medicine, Ann Arbor, Michigan, USA.

Introduction: Pulmonary hypertension is common among patients with end-stage renal disease, although data regarding the impact of right ventricular (RV) failure on postoperative outcomes remain limited. We hypothesized that echocardiographic findings of RV dilation and dysfunction are associated with adverse clinical outcomes after renal transplant.

Methods: A retrospective review of adult renal transplant recipients at a single institution from January 2008 to June 2010 was conducted. Read More

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Bilateral neglected posterior dislocation of the shoulder treated by reverse arthroplasty and contralateral osteochondral autograft. A case report.

Trauma Case Rep 2021 Jun 11;33:100455. Epub 2021 Mar 11.

Orthopaedic and Trauma Unit, Hospital "Maggiore della Carità", Novara, Italy.

Bilateral posterior dislocation of the glenohumeral joint is an uncommon event, that can be missed at the initial presentation. We report the case of a 76-year old woman, who suffered a traumatic bilateral posterior dislocation, that was diagnosed three months later. She underwent surgical treatment on both shoulders in a single stage. Read More

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Early rehabilitation after lung transplantation with extracorporeal membrane oxygenation (ECMO) of COVID-19 patient: a case report.

Ann Transl Med 2021 Mar;9(6):512

Department of Rehabilitation Medicine, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.

Even when severe acute respiratory syndrome coronavirus 2-related coronavirus disease 2019 (COVID-19) is treated with first-line drugs, it progresses and leads to irreversible loss of lung function in some critically ill patients, and lung transplantation is an effective treatment for end-stage chronic pulmonary disease. This case report mainly describes the rehabilitation of a 66-year-old female patient with severe COVID-19 after bilateral lung transplantation. The old patient had a body mass index of 31. Read More

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Clinical application and accuracy analysis of 3D printing guide plate based on polylactic acid in mandible reconstruction with fibula flap.

Ann Transl Med 2021 Mar;9(6):460

Department of Stomatology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.

Background: Due to the special anatomy morphology and physiological function of the mandible, it has always become a challenge to accurately reconstruct the mandibular defect in maxillofacial surgery. Digital three dimensions (3D) printing surgical guide, as the effective method for individual and accurate surgery, is a hotspot of clinical research at present. In this study, 3D printing PLA surgical guide plate was applied to reconstruct the mandibular defect with fibula flap, its clinical effect and accuracy were evaluated, which aimed to improve the accurate reconstruction of mandibular defects. Read More

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Perfect outcome of kidney recipients with ureteral stenosis after treatment with open surgery under magnetic resonance urography localization.

Transl Androl Urol 2021 Mar;10(3):1160-1169

Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Background: To evaluate the outcome of kidney recipients with ureteral stenosis after treatment with open surgery under magnetic resonance urography (MRU) localization.

Methods: We assessed 2,256 consecutive kidney transplant recipients between October 2010 and December 2018. Ureteral stenosis was detected by ultrasound, confirmed and positioned by Magnetic Resonance Urography. Read More

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Thrombotic Microangiopathy Associated with Pazopanib in a Kidney Transplant Recipient.

J Kidney Cancer VHL 2021 24;8(1):25-31. Epub 2021 Mar 24.

Department of Nephrology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Thrombotic microangiopathy (TMA) is characterised by abnormalities in the walls of arterioles and capillaries, precipitated by hereditary or acquired characteristics, and culminating in microvascular thrombosis because of dysregulated complement activity. A number of drugs can precipitate TMA, including vascular endothelial growth factor (VEGF) inhibitors, because of their effects on endothelial repair. Pazopanib is a VEGF inhibitor used for the treatment of renal cell carcinoma (RCC); it is uncommonly associated with TMA. Read More

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Iatrogenic common peroneal nerve injury during harvesting of semitendinosus tendon for anterior cruciate ligament reconstruction.

BMJ Case Rep 2021 Apr 13;14(4). Epub 2021 Apr 13.

Orthopedisch Centrum Oost Nederland, Hengelo, The Netherlands.

We present a case of iatrogenic injury to the common peroneal nerve (CPN) occurring due to harvesting of a hamstring graft, using a posterior mini-incision technique. A twitch of the foot was noted on retraction of the tendon stripper. After clinically diagnosing a CPN palsy proximal to the knee, the patient was referred to a neurosurgeon within 24 hours. Read More

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Among-genotype responses of the coral Pocillopora acuta to emersion: implications for the ecological engineering of artificial coastal defences.

Mar Environ Res 2021 Mar 26;168:105312. Epub 2021 Mar 26.

Experimental Marine Ecology Laboratory, Department of Biological Sciences, National University of Singapore, 16 Science Drive 4, 117558, Singapore. Electronic address:

Stony corals are promising transplant candidates for the ecological engineering of artificial coastal defences such as seawalls as they attract and host numerous other organisms. However, seawalls are exposed to a wide range of environmental stressors associated with periods of emersion during low tide such as desiccation and changes in salinity, temperature, and solar irradiance. All of these variables have known deleterious effects on coral physiology, growth, and fitness. Read More

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Tumor necrosis factor-alpha and interferon-gamma induce inflammasome-mediated corneal endothelial cell death.

Exp Eye Res 2021 Apr 10:108574. Epub 2021 Apr 10.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

Purpose: Chronic corneal endothelial cell (CEC) loss results in corneal edema and vision loss in conditions such as pseudophakic bullous keratopathy (PBK), Fuchs' dystrophy, and corneal graft failure. Low CEC density has been associated with an elevation of intraocular pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α and interferon (INF)-γ. These cytokines are capable of triggering pyroptosis, a programmed cell death mechanism mediated by the inflammasome, prompting the activation of the pro-inflammatory cytokine interleukin (IL)-1β, the perpetuation of inflammation, and subsequent damage of corneal endothelial tissue. Read More

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Atelectasis in Primary Graft Dysfunction Survivors after Lung Transplantation.

Clin Transplant 2021 Apr 13:e14315. Epub 2021 Apr 13.

Department of Medicine, University of Alberta, Edmonton, Canada.

Background: Primary graft dysfunction (PGD) is an important contributor to early mortality in lung transplant recipients and is associated with impaired lung function. The radiographic sequelae of PGD on computed tomography (CT) have not been characterized.

Methods: We studied adult double lung transplant recipients from 2010-2016 for whom protocol 3-month post-transplant CT scans were available. Read More

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The Benefits of Complement Measurements for the Clinical Practice.

Methods Mol Biol 2021 ;2227:1-20

INSERM, UMRS 1138, Inflammation, Complement and Cancer Team, Centre de Recherche des Cordelier, Sorbonne Universités, Université de Paris, Paris, France.

The complement cascade is an evolutionary ancient innate immune defense system, playing a major role in the defense against infections. Its function in maintaining host homeostasis on activated cells has been emphasized by the crucial role of its overactivation in ever growing number of diseases, such as atypical hemolytic uremic syndrome (aHUS), autoimmune diseases as systemic lupus erythematosus (SLE), C3 glomerulopathies (C3GN), age-related macular degeneration (AMD), graft rejection, Alzheimer disease, and cancer, to name just a few. The last decade of research on complement has extended its implication in many pathological processes, offering new insights to potential therapeutic targets and asserting the necessity of reliable, sensitive, specific, accurate, and reproducible biomarkers to decipher complement role in pathology. Read More

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January 2021

Innate lymphoid cell recovery and occurrence of GvHD after hematopoietic stem cell transplantation.

J Leukoc Biol 2021 Apr 13. Epub 2021 Apr 13.

APHM, Hôpital de la Timone, Service d'Immunologie, Marseille-Immunopole, Marseille, France.

Lymphocytes are essential for microbial immunity, tumor surveillance, and tissue homeostasis. However, the in vivo development and function of helper-like innate lymphoid cells (ILCs) in humans remain much less well understood than those of T, B, and NK cells. We monitored hematopoietic stem cell transplantation (HSCT) to determine the kinetics of ILC development in both children and adults. Read More

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Graft-versus-host disease prophylaxis with posttransplantation bendamustine (PTB) in patients with refractory acute leukemia: a dose-ranging study: Category of manuscript: Regular Manuscript.

Transplant Cell Ther 2021 Apr 9. Epub 2021 Apr 9.

RM Gorbacheva Research Institute, Pavlov University, Saint-Petersburg, Russian Federation. Electronic address:

Background: The prognosis of acute leukemia refractory to induction chemotherapy or immunotherapy is dismal. Salvage allogeneic hematopoietic stem cell transplantation (HSCT) is widely used option for these patients, but only 10-15% of patients are cured by the procedure. Preclinical studies indicate that substitution of posttransplantation cyclophosphomide (PTCY) with bendamustine (PTB) in a prophylaxis regimen may be associated with augmented graft-versus-leukemia (GVL) reaction. Read More

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Computational Fluid Dynamics Study of Cerebral Thromboembolism Risk in Ventricular Assist Device Patients: Effects of Pulsatility and Thrombus Origin.

J Biomech Eng 2021 Apr 12. Epub 2021 Apr 12.

Arnold Palmer Children's Hospital, 1222 S. Orange Ave., Orlando, 32806 Florida; College of Medicine, University of Central Florida, 6850 Lake Nona Blvd, Orlando, FL 32827.

Purpose: This study investigates the hypothesis that by surgically manipulating the outflow graft implantation during ventricle assist device placement, it may be possible to reduce the risk of cerebral embolism.

Methods: We investigate this hypothesis using a computational approach on a patient specific basis under fully-pulsatile hemodynamics with a multi-scale computational fluid dynamics model incorporating a coupled Eulerian-Lagrangian scheme that effectively tracks emboli in the fluid domain. Blood is modeled as a non-Newtonian fluid based on the hematocrit level. Read More

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Pediatric Challenges in Robot-Assisted Kidney Transplantation.

Front Surg 2021 25;8:649418. Epub 2021 Mar 25.

Department of Urology, ERN eUROGEN Accredited Centre, Ghent University Hospital, Ghent University, Ghent, Belgium.

Kidney transplantation is universally recognized as the gold standard treatment in patients with End-stage Kidney Disease (ESKD, or according to the latest nomenclature, CKD stage 5). Robot-assisted kidney transplantation (RAKT) is gradually becoming preferred technique in adults, even if applied in very few centra, with potentially improved clinical outcomes compared with open kidney transplantation. To date, only very few RAKT procedures in children have been described. Read More

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Machine Perfusion of the Liver: A Review of Clinical Trials.

Front Surg 2021 26;8:625394. Epub 2021 Mar 26.

Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, United States.

Although efforts have been made by transplant centers to increase the pool of available livers by extending the criteria of liver acceptance, this practice creates risks for recipients that include primary non-function of the graft, early allograft dysfunction and post-operative complications. Donor liver machine perfusion (MP) is a promising novel strategy that not only decreases cold ischemia time, but also serves as a method of assessing the viability of the graft. In this review, we summarize the data from liver machine perfusion clinical trials and discuss the various techniques available to date as well as future applications of machine perfusion. Read More

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Extensor mechanism failure in total knee arthroplasty.

EFORT Open Rev 2021 Mar 1;6(3):181-188. Epub 2021 Mar 1.

Nottingham Elective Orthopaedic Services, Nottingham University Hospitals NHS Trust, Nottingham, UK.

Extensor mechanism failure in total knee arthroplasty (TKA) can present as quadriceps tendon rupture, patella fracture or patella tendon rupture.Component malrotation, excessive joint line elevation and previous lateral release are some of the risk factors contributing to extensor mechanism failure in TKA.Partial quadriceps tendon rupture and undisplaced patella fracture with intact extensor mechanism function can be treated conservatively. Read More

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Pregnancies in kidney transplant recipients with complement gene variant-mediated thrombotic microangiopathy.

Clin Kidney J 2021 Apr 20;14(4):1255-1260. Epub 2020 Aug 20.

Department of Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria.

Background: Pregnancies in patients with complement gene variant-mediated thrombotic microangiopathy (cTMA) are challenging, and pregnancies in such patients after kidney transplantation (KTX) are even more so.

Methods: We identified nine pregnancies following KTX of three genetically high-risk cTMA patients enrolled in the Vienna thrombotic microangiopathy cohort. Preventive plasma therapy was used in three pregnancies, and one patient had ongoing eculizumab (ECU) therapy during two pregnancies. Read More

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Activation of final complement components after kidney transplantation as a marker of delayed graft function severity.

Clin Kidney J 2021 Apr 10;14(4):1190-1196. Epub 2020 Oct 10.

Department of Nephrology, Hospital del Mar, Barcelona, Catalunya, Spain.

Background: Ischaemia-reperfusion (I/R) damage is a relevant cause of delayed graft function (DGF). Complement activation is involved in experimental I/R injury, but few data are available from kidney transplant (KT) patients. We studied the dynamics of membrane attack complex (C5b-9) as a soluble fraction (SC5b-9) and the histological deposit pattern of C3b, complement Factor H (FH) and C5b-9 in DGF patients. Read More

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Kidney transplantation outcomes from elderly donors after circulatory death: a comparison with elderly brain-dead donors.

Clin Kidney J 2021 Apr 10;14(4):1181-1189. Epub 2020 Sep 10.

Department of Nephrology, Hospital del Mar, Barcelona, Spain.

Background: The use of kidneys from elderly controlled donation after circulatory death (cDCD) donors has increased significantly in recent years. Concerns about outcomes achieved with these elderly cDCD kidneys have arisen. We aimed to compare outcomes from elderly cDCD kidney transplant recipients (KTrs) and elderly donation after brain death donors (DBDs) in KTrs. Read More

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Calcium and phosphate levels after kidney transplantation and long-term patient and allograft survival.

Clin Kidney J 2021 Apr 22;14(4):1106-1113. Epub 2020 May 22.

Department of Nephrology and Transplantation, Beaumont Hospital, Dublin, Ireland.

Background: Non-traditional cardiovascular risk factors, including calcium and phosphate derangement, may play a role in mortality in renal transplant. The data regarding this effect are conflicting. Our aim was to assess the impact of calcium and phosphate derangements in the first 90 days post-transplant on allograft and recipient outcomes. Read More

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Early Graft Dysfunction Following Kidney Transplantation: Can Thermographic Imaging Play a Predictive Role?

Semin Cardiothorac Vasc Anesth 2021 Apr 12:10892532211007270. Epub 2021 Apr 12.

Azienda Sanitaria Universitaria Friuli Centrale, University-Hospital of Udine, Udine, Italy.

The shortage of organs and the growing need for them over recent years have led to the adoption of less stringent donor acceptance criteria, resulting in the approval of marginal organs for transplant, especially from elderly donors. This implies a higher risk of graft dysfunction, a higher frequency of immunological and vascular complications, and shorter graft survival. Several strategies have been implemented in clinical practice to assess graft quality and suitability for transplantation. Read More

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A vascularized bone graft harvested from the dorsal base of the third metacarpal bone for the treatment of scaphoid nonunion.

Hand Surg Rehabil 2021 Apr 8. Epub 2021 Apr 8.

Department of Hand Surgery, Third Hospital of Hebei Medical University, Zhiqiang Road 139, Shijiazhuang, Hebei, 050051, China.

The purpose of this retrospective study was to introduce the use of an alternative vascularized bone graft for treating scaphoid non-union. The vascularized bone graft was harvested from the dorsal base of the third metacarpal bone. From May 2014 to September 2017, 29 patients with scaphoid non-union were treated. Read More

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The early impact of preformed angiotensin II type 1 receptor antibodies on graft function in a low immunological risk cohort of kidney transplant recipients.

Transpl Immunol 2021 Apr 7;66:101389. Epub 2021 Apr 7.

Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Center for Uronephrology and Kidney Transplantation, Fundeni Clinical Institute, Bucharest, Romania.

Intruduction and aim: Angiotensin II type 1 receptor antibodies (AT1R-Ab) are associated with graft rejection and poor graft outcomes in kidney transplantation (KT). We aimed to assess the frequency of preformed AT1R-Ab and their impact on graft function and survival at 1 year after KT in a low immunological risk cohort.

Methods: We performed a prospective, observational cohort study in 67 adult KT recipients, transplanted between 2018 and 2019. Read More

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Chronic active T cell-mediated rejection is variably responsive to immunosuppressive therapy.

Kidney Int 2021 Apr 7. Epub 2021 Apr 7.

Division of Nephrology, Department of Medicine, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048 USA.

Chronic active T cell-mediated rejection (CA TCMR) is a newly described variant of kidney allograft rejection associated with long-term graft loss. Whether this form of rejection is related to under immunosuppression is debated and the benefit of immunosuppressive therapy in CA TCMR is unknown. Here we investigate the amenability of CA TCMR to treatment and examine the impact of clinical, histologic, and molecular parameters on outcomes. Read More

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Donor Left Ventricular Function Assessed by Echocardiographic Strain is a Novel Predictor of Primary Graft Failure After Orthotopic Heart Transplantation.

J Cardiothorac Vasc Anesth 2021 Mar 17. Epub 2021 Mar 17.

Thoracic Organ Transplants, Institute of Heart and Lung Transplantation, Gleneagles Global Health City, Chennai, India.

Objectives: This study sought to determine the utility of donor left ventricular function assessment by echocardiographic left ventricular global longitudinal strain (LV GLS) in predicting primary graft failure (PGF) after orthotopic heart transplantation (HT).

Design: Retrospective, observational study.

Setting: Tertiary referral hospital. Read More

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