47,276 results match your criteria graft failure

Long-Term Outcomes of Kidney Transplants from Older/Marginal Donors: A Cohort Study.

Nephron 2021 Jun 15:1-11. Epub 2021 Jun 15.

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.

Introduction: To safely expand the donor pool, we introduced a strategy of biopsy-guided selection and allocation to single or dual transplantation of kidneys from donors >60 years old or with hypertension, diabetes, and/or proteinuria (older/marginal donors). Here, we evaluated the long-term performance of this approach in everyday clinical practice.

Methods: In this single-center cohort study, we compared outcomes of 98 patients who received one or two biopsy-evaluated grafts from older/marginal donors ("recipients") and 198 patients who received nonhistologically assessed single graft from ideal donors ("reference-recipients") from October 2004 to December 2015 at the Bergamo Transplant Center (Italy). Read More

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Long-term Kidney Function and Survival in Recipients of Allografts from Living Kidney Donors with Hypertension: A National Cohort Study.

Transpl Int 2021 Jun 15. Epub 2021 Jun 15.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore.

Allografts from living kidney donors with hypertension may carry subclinical kidney disease from the donor to recipient and thus lead to adverse recipient outcomes. We examined eGFR trajectories and all-cause allograft failure in recipients from donors with vs. without hypertension, using mixed-linear and Cox regression models stratified by donor age. Read More

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Incidence, Management, and Prognosis of Graft Failure and Autologous Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation.

J Korean Med Sci 2021 Jun 14;36(23):e151. Epub 2021 Jun 14.

Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: This study presents outcomes of management in graft failure (GF) after allogeneic hematopoietic stem cell transplantation (HCT) and provides prognostic information including rare cases of autologous reconstitution (AR).

Methods: We analyzed risk factors and outcomes of primary and secondary GF, and occurrence of AR in 1,630 HCT recipients transplanted over period of 18 years (January 2000-September 2017) at our center.

Results: Primary and secondary GF occurred in 13 (0. Read More

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Human Induced pluripotent stem cells-derived corneal endothelial-like cells promote corneal transparency in a rabbit model of bullous keratopathy.

Stem Cells Dev 2021 Jun 15. Epub 2021 Jun 15.

First Affiliated Hospital of Harbin Medical University, 74559, Harbin, Heilongjiang, China;

The corneal endothelium(CE) is vital for the cornea to maintain its transparency. However, CE dysfunction occurs due to aging, intraocular surgery, trauma, dystrophy, etc. Corneal transplantation is the only method to clinically treat CE dysfunction; however, this treatment strategy faces the disadvantages of a global cornea shortage, graft failure, and severe side effects. Read More

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Urothelial carcinoma of the graft kidney with molecular analyses: a rare case report.

Diagn Pathol 2021 Jun 14;16(1):53. Epub 2021 Jun 14.

Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: Malignancy after transplantation is a leading cause of death among kidney transplant recipients. However, donor-derived malignancies are rare. We report a case of a high grade papillary urothelial carcinoma arising in a transplanted kidney. Read More

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Relevance of plasma matrix metalloproteinase-9 for bronchiolitis obliterans syndrome after allogeneic hematopoietic cell transplantation: Plasma MMP-9 in BOS.

Transplant Cell Ther 2021 Jun 11. Epub 2021 Jun 11.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Medicine, University of Washington, Seattle, WA.

Background: Bronchiolitis obliterans syndrome (BOS) is a highly morbid form of chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT). Several plasma proteins have been identified as biomarkers for BOS after lung transplantation. Relevance of these biomarkers in BOS patients after allogeneic HCT has not been examined. Read More

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Full dose Cyclophosphamide with the addition of Fludarabine for Matched Sibling transplants in Severe Aplastic Anemia: Flu/Cy conditioning for SAA.

Transplant Cell Ther 2021 Jun 11. Epub 2021 Jun 11.

King Faisal Specialist Hospital and Research Center, KSA.

Background: The recommended therapy for severe aplastic anemia (SAA) in younger patients with a matched sibling donor (MSD) is allogeneic hematopoietic cell transplantation (allo-HCT). A number of conditioning regimens and protocols have been utilized. Here we report a homogeneous cohort of SAA patients receiving a uniform transplant protocol. Read More

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Bone marrow transplantation without myeloablative conditioning in a mouse model for Diamond-Blackfan Anemia corrects the disease phenotype.

Exp Hematol 2021 Jun 11. Epub 2021 Jun 11.

Division of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Lund, Sweden. Electronic address:

Diamond-Blackfan Anemia (DBA) is a congenital erythroid hypoplasia caused by a functional haploinsufficiency of genes coding for ribosomal proteins. Among these genes, the ribosomal protein S19 (RPS19) gene is the most frequently mutated. Previously, a mouse model deficient in RPS19 was developed by our laboratory, which recapitulates the hematopoietic disease phenotype by displaying pathological features and clinical symptoms of DBA. Read More

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Does a combined screw and dowel construct improve tibial fixation during anterior cruciate ligament reconstruction?

Eur J Orthop Surg Traumatol 2021 Jun 14. Epub 2021 Jun 14.

Department of Orthopaedics, Children's Hospital, CHU de Toulouse, Toulouse, France.

Purpose: The aims of the present study were to compare the biomechanical properties of tibial fixation in hamstring-graft ACL reconstruction using interference screw and a novel combination interference screw and dowel construct.

Material And Methods: We compared the fixation of 30 (2- and 4-stranded gracilis and semitendinosis tendons) in 15 fresh-frozen porcine tibiae with a biocomposite resorbable interference screw (Group 1) and a screw and dowel construct (Group 2). Each graft was subjected to load-to-failure testing (50 mm/min) to determine maximum load, displacement at failure and pullout strength. Read More

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Karnofsky Performance Score-Failure to Thrive as a Frailty Proxy?

Transplant Direct 2021 Jul 8;7(7):e708. Epub 2021 Jun 8.

Department of Medicine, Division of Nephrology, Stanford University School of Medicine, Palo Alto, CA.

Among patients listed for kidney transplantation, the Karnofsky Performance Status (KPS) Scale has been used as a proxy for frailty and proposed as a predictor of long-term posttransplant outcomes. The KPS is required by the Organ Procurement and Transplantation Network for all transplants; however, the interrater reliability of KPS reporting in kidney transplant candidates has not been well investigated, and there is concern regarding limitations of using KPS that may influence transplant eligibility.

Methods: We performed an observational study using existing Scientific Registry of Transplant Recipients data from 2006 to 2020 to examine the variability, reliability, and trends in the KPS among patients on the kidney transplant waitlist. Read More

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"Raising HOPE": Improved Outcomes for HIV/HCV-coinfected Liver Transplant Recipients in the Direct-acting Antiviral Era.

Transplant Direct 2021 Jul 8;7(7):e707. Epub 2021 Jun 8.

Division of Digestive and Liver Disease, UT Southwestern Medical Center, Dallas, TX.

The 2013 HIV Organ Policy Equity Act has increased liver transplantation (LT) in HIV patients; however, transplant centers may remain reluctant to perform LT in HIV/hepatitis C virus (HCV)-coinfected patients due to inferior outcomes. We aimed to assess how direct-acting antivirals (DAAs) have impacted HIV/HCV-coinfected LT recipient outcomes.

Methods: national data including 70 125 adult LT recipients between 2008 and 2019 were analyzed. Read More

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Incidence Rate and Predictors of Delayed Graft Function Among Adult Kidney Transplant Recipients at a Tertiary Care Hospital in Riyadh, Saudi Arabia.

Cureus 2021 May 12;13(5):e14985. Epub 2021 May 12.

Department of Transplantation and Hepatobiliary Surgery, Ministry of the National Guard Health Affairs, Riyadh, SAU.

Background Delayed graft function (DGF) is the most common early postoperative complication of renal transplantation. The occurrence of DGF can lead to both early and late devastating consequences on the allograft's survival. The risk of developing this complication can increase with certain factors that are related to both the donor and the recipient. Read More

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Massive Chondrolysis and Joint Destruction after Artificial Anterior Cruciate Ligament Repair.

Case Rep Orthop 2021 26;2021:6634935. Epub 2021 May 26.

Department of Orthopaedics, Bathurst Hospital, Bathurst, NSW 2795, Australia.

The Ligament Augmentation Reconstruction System (LARS) is an artificial ligament made of polyethylene terephthalate (PET) used for anterior cruciate ligament (ACL) reconstruction in Australia. Poor results with previous generations of synthetic grafts causing synovitis, graft failure, and premature osteoarthritis have encouraged the production of the newer LARS ligament with good results. We present a case of massive chondrolysis and joint destruction after LARS implantation requiring total knee replacement in a 23-year-old male. Read More

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Pediatric heart-liver transplant outcomes in the United States: A 25-year National Cohort Study.

Pediatr Transplant 2021 Jun 13:e14066. Epub 2021 Jun 13.

Section of Pediatric Cardiology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.

Background: Pediatric HLT remains uncommon in the United States and criteria for HLT are unclear. The objectives of this study were to review the indications, and outcomes of pediatric HLT.

Methods: Data from the Scientific Registry of Transplant Recipients heart and liver databases were used to identify 9245 pediatric isolated heart transplants (PHT), 14 134 pediatric isolated liver transplant (PLT), and 20 pediatric HLT (16 patients underwent sHLT [same organ donor] and four patients with a history of PHT followed by PLT [different organ donors]; age ≤21 years) between 1992 and 2017. Read More

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Long-term follow-up of ruxolitinib in the treatment of steroid-refractory chronic graft-versus-host disease (GVHD).

Transplant Cell Ther 2021 Jun 9. Epub 2021 Jun 9.

Bone Marrow Transplant, Hospital Sirio Libanes, São Paulo, Brazil; Division of Hematology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.

Chronic graft-versus-host disease (cGVHD) remains a major barrier to a successful hematopoietic stem cell transplantation (HSCT); in cases refractory to first-line therapy with steroids, there is no standard of care for second-line therapy. As such, ruxolitinib is a promising drug in this scenario. We retrospectively analyzed its efficacy and safety as treatment of steroid-refractory cGVHD in 35 patients from two transplant centers, with the longest follow-up described to date. Read More

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Cardiac amyloidosis: Watching the tip of the iceberg emerging from the "heart of the sea".

Int J Cardiol 2021 Jun 9. Epub 2021 Jun 9.

Inherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 80131 Naples, Italy.

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Successful Reuse of Kidney Graft After Early Recurrence of Primary Focal and Segmental Glomerulosclerosis.

Am J Kidney Dis 2021 Jun 9. Epub 2021 Jun 9.

Department of Nephrology, Dialysis, Transplantation, and Apheresis, Lille University, Regional and University Hospital Center of Lille, F-59037 Lille, France.

Primary focal and segmental glomerulosclerosis (pFSGS) frequently recurs after transplantation and is associated with a poor prognosis. We describe here the successful kidney graft reuse in an adult recipient, eight months after early pFSGS recurrence resistant to all available therapeutics. Patient 1, a 23-year-old man, followed for kidney failure secondary to pFSGS, was first transplanted in 2018 with a deceased donor graft. Read More

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Letermovir in lung transplant recipients with cytomegalovirus infection: A retrospective observational study.

Am J Transplant 2021 Jun 12. Epub 2021 Jun 12.

Department of Internal Medicine V, University Hospital, LMU, Comprehensive Pneumology Center (CPC-M), German Center for Lung Research (DZL), Germany.

Letermovir is a new antiviral drug approved for the prophylaxis of CMV infection in allogeneic stem cell transplants. The aim of the study was to assess the therapeutic efficacy of letermovir in difficult to treat CMV infections in lung transplant recipients. All lung transplant recipients between March 2018 and August 2020, who have been treated with letermovir for ganciclovir-resistant or refractory CMV infection were included in the study and analysed retrospectively. Read More

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Treg cells in atherosclerosis.

Mol Biol Rep 2021 Jun 12. Epub 2021 Jun 12.

Department of Translational Research, Western University of Health Sciences, 309 E. Second Street, Pomona, CA, 91766-1854, USA.

Atherosclerosis involves both innate and adaptive immunity. Here, we provide an overview of the role of regulatory T (Treg) cells in atherosclerotic diseases. Treg cells and their inhibitory cytokines, IL-10 and TGF-β, have been identified in atherosclerotic lesions and to inhibit progression through lipoprotein metabolism modulation. Read More

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DSAEK or DMEK for failed penetrating keratoplasty: a systematic review and single-arm meta-analysis.

Int Ophthalmol 2021 Jun 12. Epub 2021 Jun 12.

Department of Ophthalmology, the Third Medical Centre, Chinese PLA General Hospital, Fuxing Road 28, Beijing, 100853, China.

Purpose: To review the published literature on indications and outcomes of DSAEK/DSEK and DMEK for the treatment of failed penetrating keratoplasty.

Design: This is a systematic review and single-arm meta-analysis.

Methods: Literature searches were conducted in PubMed, Embase, Web of Science, and the Cochrane Database of Systematic Reviews. Read More

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Autologous Matrix-Induced Chondrogenesis (AMIC) for Isolated Retropatellar Cartilage Lesions: Outcome after a Follow-Up of Minimum 2 Years.

Cartilage 2021 Jun 11:19476035211021908. Epub 2021 Jun 11.

Department of Orthopedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

Purpose: To evaluate autologous matrix-induced chondrogenesis (AMIC) for isolated focal retropatellar cartilage lesions and the influence of patellofemoral (PF) anatomy on clinical outcomes at a minimum of 2-year follow-up.

Methods: Twenty-nine consecutive patients (31 knees) who underwent retropatellar AMIC with a mean age of 27.9 ± 11. Read More

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Corneal Allograft Rejection Associated With Herpes Zoster Recombinant Adjuvanted Vaccine.

Alice Matoba

Cornea 2021 Jun 9. Epub 2021 Jun 9.

Department of Ophthalmology, Baylor College of Medicine, Houston, TX.

Purpose: The purpose of this article is to report 3 cases of corneal allograft rejection that occurred in temporal proximity to administration of the zoster subunit vaccine (RZV).

Methods: Three cases of corneal transplant rejection that developed after RZV administration were identified. Clinical history, including existence of other risk factors, timing of rejection, corticosteroid therapy at the time of onset of rejection, and course were reviewed. Read More

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Evolving trends in risk profiles and outcomes in older adults undergoing kidney re-transplantation.

Transplantation 2021 Jun 2. Epub 2021 Jun 2.

1 Division of Nephrology, Department of Medicine, McGill University Health Centre, Montreal, Quebec 2 Research Institute of the McGill University Health Centre, Montreal, Quebec 3 Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 4 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

Background: In older adults (≥65) access to and outcomes following kidney transplantation (KT) have improved over the past three decades. It is unknown if there were parallel trends in re-KT. We characterized the trends, changing landscape, and outcomes of re-KT in older adults. Read More

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Kidney transplantation from expanded criteria donors: an increased risk of urinary complications. The UNyCORT* study.

BJU Int 2021 Jun 11. Epub 2021 Jun 11.

Clinique urologique, Hôpital Hôtel Dieu, CHU de Nantes, Nantes, France.

Objectives: To assess the impact of ECD (expanded criteria donors) on urinary complications in kidney transplantation.

Materials And Methods: UNyCORT is a cohort study based on the French prospective DIVAT cohort (Données Informatisées et VAlidées en Transplantation /Computerized and VAlidated Data in Transplantation). Data were extracted between January 1, 2002 and January 1, 2018 with one-year minimum follow-up, in relation to 44 pre-and post-operative variables. Read More

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Transplant Hepatectomy With Portacaval Shunt and MARS Therapy for Perioperative Catastrophe: A Series of Four Liver Transplant Cases.

Transplant Direct 2021 Mar 18;7(3):e674. Epub 2021 Feb 18.

University of Maryland School of Medicine, Baltimore, MD.

Increased worldwide focus on maximal donor utilization and transplantation of patients once considered too ill to survive liver transplantation may increase the otherwise rare frequency of catastrophic graft failure. Although the deleterious effects of an acutely failing allograft have been established for decades, the optimal strategy in this patient population in the perioperative period remains ill-defined.

Methods: A retrospective review of all liver transplant recipients with perioperative failure leading to transplant hepatectomy between January 1, 2014 and June 30, 2017 was performed. Read More

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Heparanase inhibition preserves the endothelial glycocalyx in lung grafts and improves lung preservation and transplant outcomes.

Sci Rep 2021 Jun 10;11(1):12265. Epub 2021 Jun 10.

Division of Lung Transplant and Lung Failure, Department of Cardiothoracic Surgery, University of Pittsburgh, UPMC Presbyterian C-900, 200 Lothrop St., Pittsburgh, PA, 15213, USA.

The endothelial glycocalyx (eGC) is considered a key regulator of several mechanisms that prevent vascular injury and disease. Degradation of this macromolecular layer may be associated with post-transplant graft dysfunction. In this study, we aimed to demonstrate the benefits of eGC protection via heparanase inhibition on graft quality. Read More

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Sequential Organ Failure Assessment (SOFA) Score-Based Factors Predict Early Mortality in High-Risk Patients with Living Donor Liver Transplant.

Ann Transplant 2021 Jun 11;26:e931045. Epub 2021 Jun 11.

Department of Liver and Transplantation Surgery, Chang-Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.

BACKGROUND Patients with a Sequential Organ Failure Assessment (SOFA) score >7 on post-transplant day (POD) 7 have been reported to have a higher risk of short-term mortality after living donor liver transplant (LDLT). We sought to identify factors that were associated with early mortality in this high-risk population. MATERIAL AND METHODS A total of 102 patients with a high SOFA score (>7) on POD 7 were enrolled, of which 72 (70. Read More

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Immunotherapy using IgE or CAR T cells for cancers expressing the tumor antigen SLC3A2.

J Immunother Cancer 2021 Jun;9(6)

St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, England, UK

Background: Cancer immunotherapy with monoclonal antibodies and chimeric antigen receptor (CAR) T cell therapies can benefit from selection of new targets with high levels of tumor specificity and from early assessments of efficacy and safety to derisk potential therapies.

Methods: Employing mass spectrometry, bioinformatics, immuno-mass spectrometry and CRISPR/Cas9 we identified the target of the tumor-specific SF-25 antibody. We engineered IgE and CAR T cell immunotherapies derived from the SF-25 clone and evaluated potential for cancer therapy. Read More

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SOX9 inactivation affects the proliferation and differentiation of human lung organoids.

Stem Cell Res Ther 2021 Jun 10;12(1):343. Epub 2021 Jun 10.

State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.

Background: The regulation of the transcription factor sex-determining region Y-box transcription factor 9 (SOX9) in lung development has been described in mouse, but the same principles apply to human lung development is unknown due to a lack of appropriate experimental approaches and models.

Methods: Here, we used gene editing technology to inactivate SOX9 in human embryonic stem cells that were then induced to differentiate into lung organoids to investigate the role of SOX9 in human lung epithelium development.

Results: Complete knockout of the transactivation domain of SOX9 by gene editing resulted in indels in both alleles of SOX9. Read More

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