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Protuberant fibro-osseous lesion of the temporal bone: report of four cases and review of the literature.

Int J Oral Maxillofac Surg 2021 Apr 14. Epub 2021 Apr 14.

Service de Chirurgie Maxillo-faciale et Chirurgie Plastique, Hôpital Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris, Université de Paris, Paris, France.

'Bullough lesions', also referred to as protuberant fibro-osseous lesions (PFOL), are rare temporal bone lesions initially described in 1999. Since only 12 cases have been reported, several key issues, such as their origin and recommended management strategies, remain unresolved. This article reports the largest cohort included in the literature to date, comprising four patients with PFOL. Read More

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Invasive urothelial carcinoma of urinary bladder presenting with annular constriction and mimicking proctitis observed by colonoscopy: A case report.

Int J Surg Case Rep 2021 Mar 16;82:105785. Epub 2021 Mar 16.

Division of Colon and Rectal Surgery, Department of Surgery, Tri-Service General Hospital, No. 325, Sec. 2, Chenggong Rd., Neihu District, Taipei City, 11490, Taiwan, ROC.

Introduction: Bladder urothelial carcinoma rarely spreads to the gastrointestinal tract, and its presentation in the rectum varies. We report a case of a patient who presented with an annular constriction of the rectum.

Presentation Of Case: A 60-year-old man was referred to our hospital with chief complaints of anal stricture and partial obstruction for about 1 month. Read More

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Mast cell activation during suspected perioperative hypersensitivity: a need for paired samples analysis.

J Allergy Clin Immunol Pract 2021 Apr 13. Epub 2021 Apr 13.

University of Antwerp, Faculty of Medicine and Health Sciences, Department of Immunology, Allergology, Rheumatology and the Infla-Med Centre of Excellence, Antwerp (Belgium) and Immunology, Allergology, Rheumatology, Antwerp University Hospital, Antwerp, Belgium; AZ Jan Palfijn Gent, Department of Immunology and Allergology, Ghent, Belgium.

Background: Perioperative hypersensitivity (POH) reactions constitute a significant clinical and diagnostic challenge. A transient increase in serum tryptase during POH reflects mast cell activation (MCA) and helps to recognize an underlying hypersensitivity mechanism.

Objective: This study aims to determine the diagnostic performance of different tryptase decision thresholds based upon single and paired measurements to document MCA in suspected POH. Read More

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The IMPACT trial: human papillomavirus, cervical cytology and histopathological results from the baseline and 1-year follow-up phase.

Am J Obstet Gynecol 2021 Apr 11. Epub 2021 Apr 11.

Ventana Medical Systems Inc./Roche Tissue Diagnostics, Tucson, AZ.

Background: An increase in human papillomavirus (HPV) test volumes is expected in the near future as HPV-based screening protocols are expected to become more broadly adopted.

Objective: The IMproving Primary screening And Colposcopy Triage (IMPACT) trial, a prospective, multicenter US cervical cancer screening trial, was conducted to obtain FDA approvals for the new high-throughput cobas HPV for use on the cobas 6800/8800 Systems (cobas HPV) for detecting cervical precancer and cancer (cervical intraepithelial neoplasia of grade 2 or worse [≥CIN2] and grade 3 or worse, [≥CIN3]). Here the baseline demographics, HPV, cervical cytology and histolpathologic results are presented. Read More

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Impact of a Virtual Multidisciplinary Sarcoma Case Conference on Treatment Plan and Survival in a Large Integrated Healthcare System.

JCO Oncol Pract 2021 Apr 14:OP2001078. Epub 2021 Apr 14.

Department of Musculoskeletal Oncology, Kaiser Permanente, South San Francisco, CA.

Purpose: Quantifying the impact of a multidisciplinary cancer case conference on patient outcome and care quality remains challenging.

Patients And Methods: We prospectively investigated the impact of our virtual multidisciplinary sarcoma case conference (VMSCC) on treatment plan in patients presented to the VMSCC from July to October 2020 (prospective cohort) and retrospectively in patients with metastatic or locally advanced high-grade soft-tissue sarcoma (STS) reviewed in the VMSCC in 2016 and 2017 (high-grade STS cohort). We also investigated the factors related to the nonadherence to the VMSCC-recommended plan in both cohorts. Read More

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Patterns of disease detection using [F]DCFPyL PET/CT imaging in patients with detectable PSA post prostatectomy being considered for salvage radiotherapy: a prospective trial.

Eur J Nucl Med Mol Imaging 2021 Apr 14. Epub 2021 Apr 14.

GenesisCare, St Vincent's Hospital, Melbourne, Australia.

Purpose: Prostate-specific membrane antigen (PSMA) PET/CT is increasingly used in patients with biochemical recurrence post prostatectomy to detect local recurrence and metastatic disease at low PSA levels. The aim of this study was to assess patterns of disease detection, predictive factors and safety using [F]DCFPyL PET/CT versus diagnostic CT in patients being considered for salvage radiotherapy with biochemical recurrence post prostatectomy.

Methods: We conducted a prospective trial recruiting 100 patients with detectable PSA post prostatectomy (PSA 0. Read More

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En bloc resection and reconstruction of a huge chondrosarcoma involving multilevel upper thoracic spine and chest wall: case report.

BMC Musculoskelet Disord 2021 Apr 12;22(1):348. Epub 2021 Apr 12.

Musculoskeletal Tumor Center, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.

Background: En bloc resection of malignant tumors involving upper thoracic spine is technically difficult. We surgically treated a patient with grade 2 chondrosarcoma involving T1-5, left upper thoracic cavity, and chest wall.

Case Presentation: A 37 years old, male patient was referred to our hospital for a huge lump involved left shoulder and chest wall. Read More

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High-Throughput and Automated Acoustic Trapping of Extracellular Vesicles to Identify microRNAs With Diagnostic Potential for Prostate Cancer.

Front Oncol 2021 25;11:631021. Epub 2021 Mar 25.

Department of Laboratory Medicine, Lund University, Lund, Sweden.

Molecular profiling of extracellular vesicles (EVs) offers novel opportunities for diagnostic applications, but the current major obstacle for clinical translation is the lack of efficient, robust, and reproducible isolation methods. To bridge that gap, we developed a microfluidic, non-contact, and low-input volume compatible acoustic trapping technology for EV isolation that enabled downstream small RNA sequencing. In the current study, we have further automated the acoustic microfluidics-based EV enrichment technique that enables us to serially process 32 clinical samples per run. Read More

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Aggressive anaplastic ovarian carcinoma in a young nulliparous patient.

BMJ Case Rep 2021 Apr 9;14(4). Epub 2021 Apr 9.

Department of Gynaecology Oncology, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UK

Ovarian tumours harbouring foci of anaplastic carcinoma are extremely rare. With just a handful of cases reported in the literature, understanding of the disease and optimal management remains limited. A 38-year-old woman was referred to the gynaeoncologists with a multiloculated complex ovarian mass. Read More

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Polymorphous Adenocarcinoma: A Rare Case Report with Unique Radiographic Appearance on CBCT.

Case Rep Dent 2021 24;2021:8853649. Epub 2021 Mar 24.

Dept. of Oral Medicine and Radiology, Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka 576104, India.

Background: Polymorphous low-grade adenocarcinoma (PLGA) is a slow growing malignant tumor of minor salivary glands and is generally of indolent nature. However, according to the most recent WHO Classification of Salivary Gland Tumors (2017), the cancer is classified as Polymorphous AdenoCarcinoma (PAC). PAC presents as a less aggressive tumor, though it could on rare occasions demonstrate distant metastasis. Read More

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A cross-sectional study exploring triage of human papillomavirus (HPV)-positive women by visual assessment, manual and computer-interpreted cytology, and HPV-16/18-45 genotyping in Cameroon.

Int J Gynecol Cancer 2021 Apr 8. Epub 2021 Apr 8.

Department of Pediatrics, Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland.

Background: High-risk human papillomavirus (HPV)-positive women require triage to identify those at higher risk of cervical intraepithelial neoplasia grade 2 or worse (CIN2+). We aimed to compare visual assessment of the cervix, manual cytology and automated cytology as triage tests to screen HPV-positive women, and to assess over-treatment rates after visual assessment and over-referral rates to colposcopy after cytology.

Methods: The present cross-sectional study is nested in a large prospective screening trial in Cameroon. Read More

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Percutaneous management of postoperative Bile leak after hepato-pancreato-biliary surgery: a multi-center experience.

HPB (Oxford) 2021 Mar 19. Epub 2021 Mar 19.

Department of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, 40138, Bologna, Italy.

Background: Bile leak (BL) after hepato-pancreato-biliary (HPB) surgery is associated with significant morbidity and mortality. Aim of this study was to evaluate effectiveness and safety of percutaneous transhepatic approach (PTA) to drainage BL after HPB surgery.

Methods: Between 2006 and 2018, consecutive patients who were referred to interventional radiology units of three tertiary referral hospitals were retrospectively identified. Read More

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Feasibility of peripheral OCT imaging using a novel integrated SLO ultra-widefield imaging swept-source OCT device.

Int Ophthalmol 2021 Apr 8. Epub 2021 Apr 8.

Vitreous Retina Macula Specialists of Toronto, 3280 Bloor St. West. Suite 310, Etobicoke, ON, M8X 2X3, Canada.

Purpose: To describe the feasibility of peripheral OCT imaging in retinal diseases using a novel full-field device.

Methods: A total of 134 consecutive eyes were referred and imaged on the Optos Silverstone swept-source OCT (SS-OCT) (Optos PLC; Dunfermline, UK). Scanning laser ophthalmoscope (SLO) images and the associated SS-OCT images were obtained in the posterior pole, mid-periphery or far periphery based on the nature of the referral and on new areas of interest observed in the optomap images at the time of imaging. Read More

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Case Report: Peripheral Retinal Ischemia and Retinal Neovascularization in von Willebrand Disease.

Optom Vis Sci 2021 04;98(4):418-424

The University of Chicago Medical Center, Chicago, Illinois.

Significance: Although von Willebrand disease is the most common inherited bleeding disorder, there are only a few published reports of ocular complications. To our knowledge, this is the first case of peripheral retinal ischemia and retinal neovascularization in a patient with von Willebrand disease.

Purpose: This study aimed to demonstrate the value of multispecialty care when exploring a diagnosis for bilateral retinopathy. Read More

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Motion Characteristics of the 'Functional Spinal Unit' During Lumbar Disc Injection (Discography) including Comparison between Normal and Degenerative Levels.

Pain Med 2021 Apr 5. Epub 2021 Apr 5.

Department or Biostatistics, Graduate School of Public Health, University of Pittsburgh, 7123, Public Health, 130 DeSoto Street, Pittsburgh, PA.

Objective: While Provocation Lumbar Discography has been used to identify discs responsible for low back pain, the biomechanical effects of disc injection have received little attention. The purpose of this study was to assess the motion of the Functional Spinal Unit including the Endplate and Facet/Pedicle region during disc injection including comparison between normal and degenerative discs.

Subjects: 91 consecutive patients referred for Discography with chronic low back pain. Read More

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Comparing the cerebro-placental to umbilico-cerebral Doppler ratios for the prediction of adverse neonatal outcomes in pregnancies complicated by fetal growth restriction.

J Matern Fetal Neonatal Med 2021 Apr 5:1-5. Epub 2021 Apr 5.

Department of Obstetrics and Gynecology, University of South Florida Morsani College of Medicine, Tampa, FL, USA.

Objective: The cerebroplacental ratio (CPR) has shown utility as a surrogate marker for fetal growth restriction and can be used to stratify the risk for adverse perinatal outcomes in affected pregnancies. However, recent studies suggest that its inverse, the umbilico-cerebral ratio (UCR), may be a better predictor of such outcomes. The aim of this study was to compare the prognostic accuracy of CPR to that of UCR Doppler in predicting short-term adverse perinatal outcomes in growth-restricted fetuses. Read More

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Papanicolaou smear: A diagnostic aid in sexually transmitted infections.

Indian J Sex Transm Dis AIDS 2020 Jul-Dec;41(2):143-148. Epub 2020 Jul 31.

Department of Dermatology and Venereology, Government Medical College, Thiruvananthapuram, Kerala, India.

Background: Sexually transmitted infections (STIs) are a major public health problem in developing countries, and treatment with the right medicine at the right time is necessary to reduce transmission and improve sexual and reproductive health. Laboratory diagnosis has undergone changes in the recent years. The new generation tests are not cost-effective in resource-poor settings. Read More

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Clinical Benefits of Conversion Surgery for Unresectable Pancreatic Ductal Adenocarcinoma: A Single-Institution, Retrospective Analysis.

Cancers (Basel) 2021 Mar 2;13(5). Epub 2021 Mar 2.

Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1, Kagoshima 890-8520, Japan.

Background: Unresectable pancreatic ductal adenocarcinoma (UR-PDAC) has a poor prognosis. Conversion surgery is considered a promising strategy for improving the prognosis of UR-PDAC. This study aimed to investigate the clinical benefits of conversion surgery in patients with UR-PDAC. Read More

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Image-Guided Brachytherapy for Salvage Reirradiation: A Systematic Review.

Cancers (Basel) 2021 Mar 11;13(6). Epub 2021 Mar 11.

Department of Radiation Oncology, Gustave Roussy, Paris-Saclay University, 94800 Villejuif, France.

Background: Local recurrence in gynecological malignancies occurring in a previously irradiated field is a challenging clinical issue. The most frequent curative-intent treatment is salvage surgery. Reirradiation, using three-dimensional image-guided brachytherapy (3D-IGBT), might be a suitable alternative. Read More

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Colposcopic Impression Has a Key Role in the Estimation of the Risk of HSIL/CIN3.

Cancers (Basel) 2021 Mar 11;13(6). Epub 2021 Mar 11.

Institute Clinic of Gynecology, Obstetrics, and Neonatology, Hospital Clínic, University of Barcelona, 08036 Barcelona, Spain.

Recently published guidelines stratify the risk of high-grade squamous intraepithelial lesion/grade 3 cervical intraepithelial neoplasia (HSIL/CIN3) based on hrHPV detection and Pap smear results. However, colposcopic impression could also provide valuable information for risk estimation. We aimed to analyze the value of adding colposcopic impression to screening tests for the diagnosis of HSIL/CIN3 in 302 women referred for colposcopy due to an abnormal Pap smear. Read More

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An outcome-based comparison of two international guidelines for defining fetal growth restriction.

Ultrasound Obstet Gynecol 2021 Apr 2. Epub 2021 Apr 2.

Departments of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of South Florida, Morsani College of Medicine, Tampa, FL.

Objective: Predicting fetal growth restriction (FGR) is a challenge and recent international guidelines by the Society of Maternal Fetal Medicine (SMFM) and the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) differ in their definitions of FGR. Our objective was to compare the prediction of small for gestational age (SGA) and a composite neonatal outcome using the SMFM and ISUOG definitions.

Methods: This was a secondary analysis using data from a prospective study of women referred for growth ultrasound examinations. Read More

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Quantification of mitral regurgitation using transthoracic echocardiography and cardiac magnetic resonance imaging.

Rev Cardiovasc Med 2021 Mar;22(1):215-223

Cardiology Department, Faculty of Medicice, AlFayoum University, 63514 AlFayoum, Egypt.

Both Transthoracic echocardiography (TTE) and cardiac magnetic resonance (CMR) have well-established role in mitral regurgitation (MR) quantification for optimal management strategy. We assessed the correlation between TTE and CMR in the quantification of MR. Participants with isolated MR and echocardiographic mitral regurgitant volume (RVol) ≥ 30 mL/beat were included. Read More

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External evaluations for dyslexia: do the data support parent concerns?

Ann Dyslexia 2021 Mar 31. Epub 2021 Mar 31.

Middle Tennessee State University, Murfreesboro, TN, USA.

A grassroots movement of parents who fear that their children's reading struggles are going unrecognized at school has led to dyslexia laws in all but three states in the U.S. The current study was undertaken to provide data relevant to this topic by characterizing the reading profiles of 71 children referred for testing at a center specializing in the assessment of reading disabilities. Read More

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The Clinical Outcomes and Toxicities of Induction Chemotherapy Followed by Concurrent Chemoradiotherapy Plus Adjuvant Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma.

Front Oncol 2020 26;10:619625. Epub 2021 Feb 26.

Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Purpose: To analyze the outcomes and toxicities of induction chemotherapy (ICT) followed by concurrent chemoradiotherapy (CCRT) plus adjuvant chemotherapy (ACT) in patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC).

Methods: Retrospective analysis of 163 patients with LA-NPC referred from August 2015 to December 2018 was carried out. All patients underwent platinum-based ICT followed by CCRT plus ACT. Read More

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February 2021

Changes in Mode of Oxygen Delivery and Physiological Parameters with Physiotherapy in COVID-19 Patients: A Retrospective Study.

Indian J Crit Care Med 2021 Mar;25(3):317-321

Topiwala National Medical College & BYL Nair Ch Hospital, Mumbai, Maharashtra, India.

Coronavirus disease (COVID-19) is an infectious disease caused by SARS-CoV-2, clinically presenting with common symptoms of fever, dry cough, and breathlessness within 14 days of exposure. Its severity ranges from mild to severe, latter manifesting into severe acute respiratory syndrome. As a part of multidisciplinary team, physiotherapy along with medical management was administered to patients with COVID-19 in an acute care setup. Read More

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[A Case of Transverse Colon Cancer with Metastatic Recurrence in Bilateral Inguinal Lymph Nodes].

Gan To Kagaku Ryoho 2021 Mar;48(3):431-433

Dept. of Surgery, Saiseikai Senri Hospital.

A woman in the 60s. She was referred to our hospital because the fecal occult blood test was positive. Colonoscopy was performed. Read More

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Real-World Performance Assessment of Xpert MTB/RIF Assay for Detecting Pulmonary Tuberculosis and Rifampin Resistance in a Single Tertiary Care Hospital in Korea.

Jpn J Infect Dis 2021 Mar 31. Epub 2021 Mar 31.

Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Korea.

This study aimed at evaluating performance of Xpert MTB/RIF (Xpert) regarding detection of pulmonary tuberculosis compared to acid-fast bacilli (AFB) smear and culture, and concordance of rifampin resistance with drug susceptibility test. Specimens simultaneously referred for AFB smear, culture, and Xpert during April 2015 to March 2018 were retrospectively reviewed. Sensitivity, specificity, and mean cycle-threshold (C) values of Xpert and rifampin resistance results were analyzed. Read More

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Tumor detection of F-PSMA-1007 in the prostate gland in patients with prostate cancer using prostatectomy specimens as reference method.

J Nucl Med 2021 Mar 31. Epub 2021 Mar 31.

Lund university and Skåne University Hospital, Lund, Sweden.

Prostate-specific membrane antigen (PSMA) radiopharmaceuticals used with positron emission tomography/computed tomography (PET-CT) are a promising tool for managing patients with prostate cancer. This study aimed to determine the accuracy of F-PSMA-1007 PET-CT for detecting tumors in the prostate gland using radical prostatectomy (RP) specimens as a reference method and to determine whether a correlation exists between F-PSMA-1007 uptake and the International Society of Urological Pathology (ISUP) grade and prostate specific antigen (PSA) levels at diagnosis. Thirty-nine patients referred for F-PSMA-1007 PET-CT for initial staging and who underwent RP within four months were retrospectively included. Read More

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[Periodontal rehabilitation in a deaf patient with symptomatic epilepsy in Sturge-Weber syndrome - a case report].

Swiss Dent J 2021 Apr;131(4):327-338

Klinik für Zahnerhaltung und Präventivzahnmedizin, Zentrum für Zahnmedizin, Universität Zürich, Zürich, Schweiz.

When a syndrome forms the background of a systemic involvement of periodontal disease, it is necessary to fully exploit the resources outside, which soon reaches its limits in private practice. In the patient's environment, it must be checked whether support for the patient can be guaranteed. Without support, as in this presented case, the patient's oral hygiene could hardly be maintained. Read More

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First-line palliative systemic therapy alternated with electrostatic pressurised intraperitoneal aerosol chemotherapy (oxaliplatin) for isolated unresectable colorectal peritoneal metastases: protocol of a multicentre, single-arm, phase II study (CRC-PIPAC-II).

BMJ Open 2021 Mar 30;11(3):e044811. Epub 2021 Mar 30.

Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands

Introduction: Despite its increasing use, first-line palliative systemic therapy alternated with electrostatic pressurised intraperitoneal aerosol chemotherapy with oxaliplatin (ePIPAC-OX), hereinafter referred to as first-line bidirectional therapy, has never been prospectively investigated in patients with colorectal peritoneal metastases (CPM). As a first step to address this evidence gap, the present study aims to assess the safety, feasibility, antitumour activity, patient-reported outcomes, costs and systemic pharmacokinetics of first-line bidirectional therapy in patients with isolated unresectable CPM.

Methods And Analysis: In this single-arm, phase II study in two Dutch tertiary referral centres, 20 patients are enrolled. Read More

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