124,063 results match your criteria grade medical


The blood neutrophil count after 1 month of treatment predicts the radiological severity of lung disease at treatment end.

Chest 2021 Jul 28. Epub 2021 Jul 28.

Department of Clinical Immunology, Royal Free London NHS Foundation Trust, London NW3 2QG; Institute of Immunity and Transplantation, University College London, Royal Free Campus, London NW3 2QG. Electronic address:

Background: Post-tuberculous lung disease confers significant morbidity. However, the determinants of persistent lung damage in tuberculosis are not well established. We investigated associations between tuberculosis-associated radiological changes and socio-demographic factors, surrogates of bacillary burden and blood inflammatory markers at initiation of therapy and after 1 month. Read More

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Novel Prediction Models for Patients With Oral Squamous Cell Carcinoma at Different Anatomical Sites.

J Oral Maxillofac Surg 2021 Jun 22. Epub 2021 Jun 22.

Professor, Department of Orthodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China; Professor, Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China. Electronic address:

Purpose: The individualized prediction of oral cavity squamous cell carcinoma (OC-SCC) is essential and should be as comprehensive as possible. The aim of this study was to identify new risk factors and develop nomograms comparing all anatomic sites of the oral cavity.

Materials And Methods: We performed a retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) database. Read More

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The real-life efficacy and safety of osimertinib in pretreated advanced non-small cell lung cancer patients with T790M mutation: a Turkish Oncology Group Study.

J Cancer Res Clin Oncol 2021 Jul 31. Epub 2021 Jul 31.

Department of Medical Oncology, Medipol University, Faculty of Medicine, Istanbul, Turkey.

Introduction: Osimertinib, an irreversible third-generation EGFR-TKI, is the standard of care for second-line treatment of T790M-mutant advanced NSCLC patients whose disease progressed after first-line EGFR-TKI therapy. In this multicenter study, we aimed to determine the real-life efficacy and safety of Osimertinib in pretreated advanced NSCLC patients with T790M mutation.

Materials And Methods: This retrospective trial included advanced T790M-mutant pretreated NSCLC patients who received Osimertinib from 24 different centers in Turkey. Read More

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Bortezomib plus dexamethasone as first-line therapy for patients with POEMS syndrome.

Ann Hematol 2021 Jul 31. Epub 2021 Jul 31.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.

POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome is a rare plasma cell dyscrasia without standard front-line treatment. Merely, few studies have reported the responses and outcomes of bortezomib plus dexamethasone (BDex) in POEMS syndrome. In this study, a total of 69 patients (40 males) treated with front-line BDex were included. Read More

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The additional value of weight-bearing and gravity stress ankle radiographs in determining stability of isolated type B ankle fractures.

Eur J Trauma Emerg Surg 2021 Jul 31. Epub 2021 Jul 31.

Department of Trauma Surgery, Haaglanden Medical Center, Hague, The Netherlands.

Goal: The aim of this study is to investigate whether weight-bearing and gravity stress radiographs have additional value in predicting concomitant deep deltoid ligamentous (DDL) injury in case of isolated Weber type B fibular fractures. This may help to make the clinically relevant distinction between unstable fractures and fractures that can be treated conservatively.

Methods: In this prospective cohort study, 90 patients with an isolated type B ankle fracture, without a medial or posterior fracture, and a medial clear space (MCS) < 6 mm on the regular mortise (RM) view were included. Read More

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Early Transient Hypoglycemia and Test Performance in At-Risk Newborns.

Am J Perinatol 2021 Jul 30. Epub 2021 Jul 30.

Departments of Pediatrics (Neonatal-Perinatal Medicine) and Obstetrics and Gynecology, Penn State Health Children's Hospital, Hershey, Pennsylvania.

Objective:  This study aimed to evaluate if early (within the first 3 hours after birth) transient neonatal hypoglycemia (TNH) is associated with poor academic performance in infants at-risk for hypoglycemia.

Study Design:  This was a retrospective cohort study of at risk-infants (late preterm infants, small and large for gestational age infants, and infants of diabetic mothers [IDMs]) who were born in 1998 and 1999 at the University of Arkansas for Medical Sciences and had ≥1 recorded glucose concentration. The outcome measure was proficiency on 4th grade literacy and mathematics achievement tests. Read More

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Response to the Letter Regarding the Application of Near-Infrared Spectroscopy for the Detection of Delayed Cerebral Ischemia in Poor-Grade Subarachnoid Hemorrhage.

Neurocrit Care 2021 Jul 30. Epub 2021 Jul 30.

Department of Neurosurgery, Hallym University College of Medicine, 77 Sakju-ro, Chuncheon, 24253, Republic of Korea.

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Application of Near-Infrared Spectroscopy for the Detection of Delayed Cerebral Ischemia in Poor-Grade Subarachnoid Hemorrhage.

Neurocrit Care 2021 Jul 30. Epub 2021 Jul 30.

Department of Neuroanaesthesiology and Critical Care, All India Institute of Medical Sciences, New Delhi, India.

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MicroRNA-21 expression in cancer cells is an independent biomarker of progression-free survival of endometrioid endometrial carcinoma.

Virchows Arch 2021 Jul 31. Epub 2021 Jul 31.

Department of Basic Pathology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.

Endometrial carcinoma is one of the most common gynecological cancers. MicroRNA-21 (miR-21) is the most consistently overexpressed miRNA in almost all human cancer types, and it might be a useful clinical biomarker and therapeutic target. However, its precise localization and significance in endometrial carcinoma have not been clarified. Read More

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Resection of vestibular schwannomas after stereotactic radiosurgery: a systematic review.

J Neurosurg 2020 Nov 27:1-9. Epub 2020 Nov 27.

Department of Neurological Surgery, Rush University Medical Center, Chicago.

Objective: Multiple short series have evaluated the efficacy of salvage microsurgery (MS) after stereotactic radiosurgery (SRS) for treatment of vestibular schwannomas (VSs); however, there is a lack of a large volume of patient data available for interpretation and clinical adaptation. The goal of this study was to provide a comprehensive review of tumor characteristics, management, and surgical outcomes of salvage of MS after SRS for VS.

Methods: The Medline/PubMed, Scopus, CINAHL, Cochrane Library, and Google Scholar databases were queried according to PRISMA guidelines. Read More

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November 2020

Bortezomib in combination with fludarabine plus cyclophosphamide for patients with relapsed or refractory mantle-cell lymphoma: results of the LYM-4003 study.

Ann Hematol 2021 Jul 31. Epub 2021 Jul 31.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

This study aimed to identify the maximum-tolerated dose (MTD) of cyclophosphamide when combined with bortezomib and fludarabine (B-FC) in a phase 1b trial, and to assess the efficacy and safety of this combination in a phase 2 trial in patients with relapsed or refractory MCL (rrMCL). Forty patients were enrolled between April 8, 2011, and October 10, 2015. The MTD of cyclophosphamide was identified to be 250 mg/m days 1-2. Read More

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AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing.

Nat Commun 2021 Jul 30;12(1):4624. Epub 2021 Jul 30.

Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA.

AKT-phosphorylated IWS1 regulates alternative RNA splicing via a pathway that is active in lung cancer. RNA-seq studies in lung adenocarcinoma cells lacking phosphorylated IWS1, identified a exon 2-deficient U2AF2 splice variant. Here, we show that exon 2 inclusion in the U2AF2 mRNA is a cell cycle-dependent process that is regulated by LEDGF/SRSF1 splicing complexes, whose assembly is controlled by the IWS1 phosphorylation-dependent deposition of histone H3K36me3 marks in the body of target genes. Read More

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Consideration of antimicrobial resistance and contextual factors in infectious disease guidelines: a systematic survey.

BMJ Open 2021 Jul 30;11(7):e046097. Epub 2021 Jul 30.

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada

Objectives: Guidelines that include antimicrobial recommendations should explicitly consider contextual factors that influence antimicrobial resistance and their downstream effects on resistance selection. The objectives were to analyse (1) how, and to what extent, tuberculosis, gonorrhoea and respiratory tract infection guidelines are considering antimicrobial resistance; (2) are of acceptable quality and (3) if they can be easily contextualised to fit the needs of specific populations and health systems.

Methods: We conducted a systematic review and searched Ovid MEDLINE and Embase from 1 January 2007 to 7 June 2019 for tuberculosis, gonorrhoea and respiratory tract infection guidelines published in English. Read More

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Primary diffuse large B cell lymphoma of the optic chiasm in an immunocompetent patient.

BMJ Case Rep 2021 Jul 30;14(7). Epub 2021 Jul 30.

Pathology and Laboratory Medicine, University of Puerto Rico School of Medicine, Río Piedras, Puerto Rico.

Primary lymphoma of the visual pathway is rare, especially at the chiasm. Very few cases have been reported. The lesion is frequently confused with an optic-hypothalamic glioma. Read More

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The prognostic and clinicopathological significance of Tim-3 and PD-1 expression in the prognosis of upper urinary tract urothelial carcinoma.

Urol Oncol 2021 Jul 27. Epub 2021 Jul 27.

Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objective: Upper urinary tract urothelial carcinoma (UTUC) is a relatively uncommon disease with few reported molecular markers. This study evaluated Tim-3 and PD-1 expression in primary UTUC and its impact on patients' clinical outcomes.

Methods: Tim-3 and PD-1 protein expression was detected by immunohistochemistry in paraffin-embedded sections from 101 UTUC patients. Read More

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The effect of race on stage at presentation and survival in upper tract urothelial carcinoma.

Urol Oncol 2021 Jul 27. Epub 2021 Jul 27.

Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada.

Background The effect of racial/ethnic group on survival in upper tract urothelial carcinoma (UTUC) is unknown. We tested this concept in non-metastatic UTUC patients treated with radical nephroureterectomy (RNU) and hypothesized that important differences may exist according to racial/ethnic groups. Material and Methods We relied on the Surveillance Epidemiology and End Results database (2004-2016). Read More

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Gene signatures of autopsy lungs from obese patients with COVID-19.

Clin Nutr ESPEN 2021 Aug 26;44:475-478. Epub 2021 May 26.

Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil; Scientific Platform Pasteur-University of São Paulo, São Paulo, Brazil. Electronic address:

Background & Aims: Obesity is associated with low grade systemic inflammation and insulin resistance. Although metabolic and immunological changes may contribute to the increased risk for COVID-19 mortality in obese, little is known about the impact of obesity in the lungs of patients with COVID-19.

Methods: We analyzed gene expression profiles of autopsy lungs of a cohort of 14 COVID-19 patients and 4 control individuals. Read More

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The Comparison of Predictive Value Among Chemerin, IL-18 and Hormonal Parameters in Assessing the Risk of Metabolic Syndrome in Men.

Am J Mens Health 2021 Jul-Aug;15(4):15579883211034984

Department of Endocrinology, Metabolism and Internal Medicine, Poznań University of Medical Sciences, Poznań, Wielkopolskie, Poland.

Chemerin (CHEM) is a new proinflammatory adipokine involved in the immune, metabolic and reproductive processes. Low-grade state inflammation (LGSI) is a key element in the pathogenesis of metabolic syndrome (MS). Low SHBG is a good marker of male hypogonadism in MS. Read More

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Primary synovial sarcoma of thyroid gland: A case report and review of literature.

Int J Surg Case Rep 2021 Jul 26;85:106245. Epub 2021 Jul 26.

Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Introduction And Importance: Synovial cell sarcoma (SS) is an extremely rare mesenchymal malignancy, representing nearly 10% of all soft-tissue sarcomas. These high-grade soft tissue sarcomas commonly arise in the para-articular regions of lower extremities. However, 15% of Synovial sarcomas has been described at Unusual locations, including head, neck, and trunk. Read More

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Platelet alloimmunization is associated with low grade chronic histiocytic intervillositis - A new link to a rare placental lesion?

Placenta 2021 Jul 23;112:89-96. Epub 2021 Jul 23.

Women's Health and Perinatology Research Group, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway; Department of Obstetrics and Gynecology, University Hospital of North Norway, Tromsø, Norway.

Introduction: Maternal alloimmunization against human platelet antigen (HPA)-1a has been implied to mediate both reduced birth weight and chronic placental inflammation. Fetal growth restriction is associated with different types of chronic inflammation in the placenta, mainly chronic histiocytic intervillositis and chronic villitis. The aim of this prospective study was to do a systematic examination of placentas from HPA-1a alloimmunized pregnancies, with focus on the histopathological and immunohistochemical diagnosis of variants of chronic inflammation. Read More

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Olaparib in combination with pegylated liposomal doxorubicin for platinum-resistant ovarian cancer regardless of BRCA status: a GEICO phase II trial (ROLANDO study).

ESMO Open 2021 Jul 27;6(4):100212. Epub 2021 Jul 27.

Department of Medical Oncology Department, Clínica Universidad de Navarra, Madrid, Spain.

Background: There is limited evidence for the benefit of olaparib in platinum-resistant ovarian cancer (PROC) patients with BRCA wild-type tumors. This study investigated whether this combination of a DNA-damaging chemotherapy plus olaparib is effective in PROC regardless BRCA status.

Patients And Methods: Patients with high-grade serous or endometrioid ovarian carcinoma and one previous PROC recurrence were enrolled regardless of BRCA status. Read More

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Ki-67 immunoexpression and radiological assessment of necrosis improves accuracy of conventional and modified core biopsy systems in predicting the final grade assigned to adult-soft tissue sarcomas. An international collaborative study.

Pathol Res Pract 2021 Jul 22;225:153562. Epub 2021 Jul 22.

Pathology Department, University of Valencia, Valencia, Spain.

Based on the French Federation Nationale des Centers de Lutte Contre le Cancer (FNCLCC) grading system, this study assesses the accuracy of conventional and modified core biopsy (CB) systems in predicting the final grade (low vs high) assigned to the resected specimen. Substituting Ki-67 immunoexpression for mitotic count, and radiological for histological assessment of necrosis, we used two modified FNCLCC CB grading systems: (1) Ki-67 immunoexpression alone, and (2) Ki-67 plus radiological assessment of necrosis. We graded 199 soft tissue sarcomas (STS) from nine centers, and compared the results for the conventional (obtained from local histopathology reports) and modified CB systems with the final FNCLCC grading of the corresponding resected specimens. Read More

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DICER1-associated malignancies mimicking germ cell neoplasms: Report of two cases and review of the literature.

Pathol Res Pract 2021 Jul 16;225:153553. Epub 2021 Jul 16.

Pathology Unit, Department of Laboratories, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy 00165. Electronic address:

DICER1 syndrome is characterized by a unique combination of features and a growing list of associated rare tumors. Traditionally, gonadal or extra-gonadal teratomas have not been considered part of this spectrum, with only rare DICER1-related teratoid neoplasms recently reported. Besides, their methylation profiles remain elusive. Read More

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The influence of severe radiation-induced lymphopenia on overall survival in solid tumors: a systematic review and meta-analysis.

Int J Radiat Oncol Biol Phys 2021 Jul 27. Epub 2021 Jul 27.

Department of Radiation Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Background: Emerging evidence suggests a detrimental prognostic association between radiation-induced lymphopenia (RIL) and pathologic response, progression-free and overall survival (OS) in patients who undergo radiotherapy for cancer. The aim of this study was to systematically review and meta-analyze the prognostic impact of RIL on OS in patients with solid tumors.

Methods: PubMed/MEDLINE and Embase were systematically searched. Read More

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Pulse therapy with vincristine and dexamethasone for childhood acute lymphoblastic leukaemia (CCCG-ALL-2015): an open-label, multicentre, randomised, phase 3, non-inferiority trial.

Lancet Oncol 2021 Jul 27. Epub 2021 Jul 27.

Department of Hematology/Oncology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology & Oncology, Shanghai, China.

Background: Vincristine plus dexamethasone pulses are generally used throughout maintenance treatment for childhood acute lymphoblastic leukaemia. However, previous studies remain inconclusive about the benefit of this maintenance therapy and the absence of randomised, controlled trials in patients with low-risk or high-risk acute lymphoblastic leukaemia provides uncertainty. We therefore aimed to determine if this therapy could be safely omitted beyond 1 year of treatment without leading to an inferior outcome in any risk subgroup of childhood acute lymphoblastic leukaemia. Read More

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Dose-dense brentuximab vedotin plus ifosfamide, carboplatin, and etoposide for second-line treatment of relapsed or refractory classical Hodgkin lymphoma: a single centre, phase 1/2 study.

Lancet Haematol 2021 Aug;8(8):e562-e571

Department of Medicine, Division of Medical Oncology, University of Washington, Seattle, WA, USA; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address:

Background: Relapsed or refractory classical Hodgkin lymphoma could be treated with multiagent salvage chemotherapy followed by autologous haematopoietic stem-cell transplantation. The aim of this study is to establish the safety and activity of dose-dense brentuximab vedotin combined with ifosfamide, carboplatin, and etoposide (BV-ICE) chemotherapy in second-line treatment of classical Hodgkin lymphoma.

Methods: We conducted a single-arm, open-label, phase 1/2 study of dose-dense BV-ICE at the Seattle Cancer Care Alliance, University of Washington (Seattle, WA, USA). Read More

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Intimal aortic atherosclerosis in cardiac surgery: surgical strategies to prevent embolic stroke.

Eur J Cardiothorac Surg 2021 Jul 30. Epub 2021 Jul 30.

Cardiothoracic Surgery, Erasmus Medical Center, Rotterdam, Netherlands.

Objectives: Although the incidence of perioperative stroke after cardiac surgery gradually decreased over the last decades, there is much variation between centres. This review aimed to create a concise overview of the evidence on possible surgical strategies to prevent embolic stroke in patients with intimal aortic atherosclerosis.

Methods: The PubMed and EMBASE databases were searched for studies on surgical management of aortic atherosclerosis and the association with perioperative stroke in cardiac surgery, including specific searches on the most common types of surgery. Read More

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Assessing national cervical cancer screening guidelines: Results from an HIV testing clinic also screening for cervical cancer and HPV in Soweto, South Africa.

PLoS One 2021 30;16(7):e0255124. Epub 2021 Jul 30.

Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa.

Objective: A screening centre in Soweto, South Africa (SA), investigated high-risk human papillomavirus (HR-HPV), HIV, cervical cancer risk amongst women.

Methods: This cross-sectional study (June 2018-March 2019) describes screening results (Roche Linear Array HPV test and Pap smear liquid based cytology) and history of screening (known HIV status, antiretroviral therapy [ART] use, previous Pap smears). Data were stratified by age group (18-29, 30+ years), HIV status, Pap smear results and tested for statistical significance. Read More

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Wearable Electronics Based on the Gel Thermogalvanic Electrolyte for Self-Powered Human Health Monitoring.

ACS Appl Mater Interfaces 2021 Jul 30. Epub 2021 Jul 30.

Micro Nano System Research Center, College of Information and Computer & Key Lab of Advanced Transducers and Intelligent Control System of the Ministry of Education, Taiyuan University of Technology, Taiyuan 030024, China.

There is always a temperature difference of more than 10 degrees between the human body, as a sustainable heat source, and the ambient temperature. Converting body heat into electricity that in turn is used to drive personal medical electronics is of significance in smart wearable medicine. To avoid the frangibility and complex preparation of traditional thermoelectric materials, we fabricated a gel electrolyte-based thermogalvanic generator with Fe/Fe as a redox pair, which presents not only moderate thermoelectric performance but also excellent flexibility. Read More

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Clinical Management of Adult Patients with COVID-19 Outside Intensive Care Units: Guidelines from the Italian Society of Anti-Infective Therapy (SITA) and the Italian Society of Pulmonology (SIP).

Infect Dis Ther 2021 Jul 30. Epub 2021 Jul 30.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.

Introduction: The Italian Society of Anti-Infective Therapy (SITA) and the Italian Society of Pulmonology (SIP) constituted an expert panel for developing evidence-based guidance for the clinical management of adult patients with coronavirus disease 2019 (COVID-19) outside intensive care units.

Methods: Ten systematic literature searches were performed to answer ten different key questions. The retrieved evidence was graded according to the Grading of Recommendations Assessment, Development, and Evaluation methodology (GRADE). Read More

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