44,456 results match your criteria grade iii

Facial nerve sacrifice in lateral approaches to the skull base: Simultaneous reconstruction by graft interposition.

Am J Otolaryngol 2021 Sep 10;43(1):103210. Epub 2021 Sep 10.

Department of Neuroscience DNS, Otolaryngology Section, Padova University, Padova, Italy.

Purpose: To evaluate the outcome of facial nerve (FN) cable graft interposition in lateral skull base surgery.

Materials And Methods: A group of 16 patients who underwent FN graft interposition procedure was retrospectively considered. Postoperative FN function was evaluated using the House-Brackmann (HB) grading system, the Sunnybrook Facial Grading System (SFGS), the Facial Disability Index (FDI) and the Oral Functioning Scale (OFS) questionnaires. Read More

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September 2021

Polycystic ovary syndrome and cardiovascular risk. Could trimethylamine N-oxide (TMAO) be a major player? A potential upgrade forward in the DOGMA theory.

Biomed Pharmacother 2021 Sep 15;143:112171. Epub 2021 Sep 15.

NGN Healthcare - New Generation Nutraceuticals s.r.l., Torrette Via Nazionale 207, 83013 Mercogliano, Avellino, Italy. Electronic address:

Several studies reported an increase in cardiovascular risk (CVR) in women with polycystic ovary syndrome (PCOS), considered primarily as the result of the combination of all the clinical features that characterize the syndrome, including hyperandrogenism, insulin resistance, diabetes, obesity chronic low-grade inflammation. Interestingly, in 2012 it has been proposed the so-called DOGMA theory, suggesting the pivotal role played by microbiota alteration in the development of PCOS. Subsequently, several authors evidenced the existence in PCOS women of a marked dysbiosis, which is related to the development of metabolic diseases and cardiovascular complications, mainly due to the production of bacteria-derived metabolites that interfere with various pathways. Read More

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September 2021

A prospective, phase II trial of monotherapy with low-dose afatinib for patients with EGFR, mutation-positive, non-small cell lung cancer: Thoracic oncology research group 1632.

Lung Cancer 2021 Aug 31;161:49-54. Epub 2021 Aug 31.

Department of Pulmonary Medicine and Oncology, Nippon Medical School Hospital, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, Japan. Electronic address:

Objectives: Afatinib is an effective treatment for patients with epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC). However, the toxicity associated with this agent often leads to dose modifications. The aim of this study was to assess the efficacy, safety and plasma concentrations of low dose afatinib monotherapy in patients with EGFR mutation-positive NSCLC. Read More

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Resection and extemporaneous coverage of a soft tissue sarcoma with a pedicled groin flap in the trochanteric region: Technical Note.

Orthop Traumatol Surg Res 2021 Sep 15:103054. Epub 2021 Sep 15.

Service de chirurgie orthopédique et traumatologie, groupe hospitalier Cochin-Port Royal, Paris, France.

The main issues pertaining to oncological surgery of the musculoskeletal system are tumour resection with sufficient margins, and the coverage of inherent defects. We report the use of a pedicled cutaneous groin flap as coverage for a trochanteric defect following an oncological resection of a grade III pleomorphic soft tissue sarcoma in a 75-year-old patient. This flap is not routinely used in the coverage of a defect in this region. Read More

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September 2021

Surgical outcomes with anatomic reduction of high-grade spondylolisthesis revisited: an analysis of 101 patients.

J Neurosurg Spine 2021 Sep 17:1-11. Epub 2021 Sep 17.

4Spine Center, Werner-Wicker-Clinic, Bad Wildungen, Germany.

Objective: The ideal strategy for high-grade L5-S1 isthmic spondylolisthesis (HGS) remains controversial. Critical questions include the impact of reduction on clinical outcomes, rate of pseudarthrosis, and postoperative foot drop. The scope of this study was to delineate predictors of radiographic and clinical outcome factors after surgery for HGS and to identify risk factors of foot drop. Read More

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September 2021

A diagnostic tree for differentiation of adult pilocytic astrocytomas from high-grade gliomas.

Eur J Radiol 2021 Sep 8;143:109946. Epub 2021 Sep 8.

Department of Radiology and Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: To develop a diagnostic tree analysis (DTA) model based on demographical information and conventional MRI for differential diagnosis of adult pilocytic astrocytomas (PAs) and high-grade gliomas (HGGs; World Health Organization grade III-IV).

Methods: A total of 357 adult patients with pathologically confirmed PA (n = 65) and HGGs (n = 292) who underwent conventional MRI were included. The patients were randomly divided into training (n = 250) and validation (n = 107) datasets to assess the diagnostic performance of the DTA model. Read More

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September 2021

Radiation-Free myeloablative allogeneic hematopoietic stem cell transplantation for adult acute lymphoblastic leukemia: A comparison of outcomes between patients with and without central nervous system involvement.

Leuk Res 2021 Sep 14;111:106703. Epub 2021 Sep 14.

Pediatric Cell and Gene Therapy Research Center, Gene, Cell & Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Pediatric Stem Cell Transplantation, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

For patients with acute lymphoblastic leukemia (ALL) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT), total body irradiation (TBI) has been particularly advocated as a part of the conditioning regimen in case of extramedullary involvement in sanctuary sites such as the central nervous system (CNS), to ensure greater tissue penetration. In resource-limited countries lacking TBI facilities; however, ALL patients undergo radiation-free myeloablative conditioning, though its impacts on post-HSCT outcomes of the patients with pre-HSCT CNS involvement have not been analyzed. In this 14-year series of 278 adult (> 18 y) ALL patients undergoing TBI-free busulfan/cyclophosphamide conditioning allo-HSCT, we found that the long-term probabilities of overall survival, disease free survival, relapse and non-relapse mortality were not significantly different between CNS-involved and CNS-spared patients. Read More

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September 2021

[Urogenital Injury in Polytrauma Patients: a Five-year Epidemiological Study].

Acta Chir Orthop Traumatol Cech 2021 ;88(4):307-312

Urologická klinika 3. lékařské fakulty Univerzity Karlovy a Fakultní nemocnice Královské Vinohrady, Praha.

INTRODUCTION The authors present an overview of polytrauma patients with urinary tract injuries managed in the Level I trauma centre. The purpose of this study was to evaluate the frequency of injuries to the urinary system, the mechanism of their injury and the method of treatment in the cohort of polytrauma patients treated in the trauma centre. MATERIAL AND METHODS Between 2012 and 2016, a total of 231 polytrauma patients were treated, of whom 47 (20. Read More

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January 2021

Panitumumab Plus Fluorouracil and Folinic Acid Versus Fluorouracil and Folinic Acid Alone as Maintenance Therapy in Wild-Type Metastatic Colorectal Cancer: The Randomized PANAMA Trial (AIO KRK 0212).

J Clin Oncol 2021 Sep 17:JCO2101332. Epub 2021 Sep 17.

Zentrum für Tumorbiologie und Integrative Medizin, Klinikum Wilhelmshaven, Wilhelmshaven, Germany.

Purpose: The randomized PANAMA trial investigated the efficacy of panitumumab (Pmab) when added to maintenance therapy with fluorouracil and folinic acid (FU/FA) in patients with wild-type metastatic colorectal cancer.

Methods: Following first-line induction therapy with six cycles of FU/FA and oxaliplatin plus Pmab, responding patients (stable disease or partial or complete remission) were randomly assigned (1:1, open-label) to maintenance treatment with either FU/FA plus Pmab or FU/FA alone. The primary objective was to demonstrate superiority of progression-free survival (PFS, time from random assignment until progression or death) in favor of FU/FA plus Pmab with a hazard ratio (HR) of 0. Read More

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September 2021

SPOP and CHD1 alterations in prostate cancer: Relationship with PTEN loss, tumor grade, perineural infiltration, and PSA recurrence.

Prostate 2021 Sep 17. Epub 2021 Sep 17.

Departament of Health and Experimental Sciences, Universitat Pompeu Fabra, Barcelona, Spain.

Background: In the non-ETS fusion of prostate cancer (PCa) pathway, SPOP mutations emerge as a distinct oncogenic driver subclass. Both SPOP downregulation and mutation can lead to SPOP target stabilization promoting dysregulation of key regulatory pathways. CHD1 gene is commonly deleted in PCa. Read More

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September 2021

[[18F]Fluorothymidine Positron Emission Tomography Imaging in Primary Brain Tumours: A Systematic Review.

Curr Med Imaging 2021 Sep 17. Epub 2021 Sep 17.

Nuclear Medicine Unit, Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, University of Messina, Messina, Italy.

Purpose: This review aimed to summarize the available literature on the clinical application of [18F]FLT PET imaging in primary brain tumours.

Methods: A comprehensive search strategy based on Pubmed/Medline, Scopus, Web of Science, Cochrane Library, Google Scholar, and the Embase databases was carried on using the following search string: ('3` Fluorothymidine'/exp OR 'FLT' OR '[18F]-FLT' OR '[18F]Fluorothymidine') AND ('pet'/exp OR 'pet' OR 'positron emission tomography') AND ('glioma'/exp OR 'glioma' OR 'brain tumour'/exp OR 'brain tumour'). The search was updated till March 2021 and only articles in English and studies investigating the clinical applications of [18F]FLT PET and PET/CT in primary brain tumours were considered eligible for inclusion. Read More

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September 2021

Safety profile of poly (ADP-ribose) polymerase (PARP) inhibitors in cancer: a network meta-analysis of randomized controlled trials.

Ann Transl Med 2021 Aug;9(15):1229

Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: Poly (ADP-ribose) polymerase (PARP) inhibitors, which are among the most important breakthroughs in precision medicine, have played a crucial role in cancer treatment. Understanding the toxicity profiles of the different PARP inhibitors will improve strategic treatment in clinical practice.

Methods: PubMed, Cochrane Library, and Web of Science were systematically searched to include related studies published in English between January 2009 and February 2020. Read More

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Is there an interdependence between paraspinal muscle mass and lumbar disc degeneration? A MRI based study at 2520 levels in 504 patients.

J Clin Orthop Trauma 2021 Nov 2;22:101576. Epub 2021 Sep 2.

Department of Spine Surgery, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

Introduction: Low back pain is one of the most common cause for outpatient visits. Though few studies have shown the vital role of paraspinal muscles in lumbar spine pathology, literature is scarce regarding the influence of the paraspinal muscles in disc degeneration. We aimed to analyse the correlation between paraspinal muscles and disc degeneration. Read More

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November 2021

Overexpressed GNAZ predicts poor outcome and promotes G0/G1 cell cycle progression in hepatocellular carcinoma.

Feng Tian Daxia Cai

Gene 2021 Sep 13:145964. Epub 2021 Sep 13.

Key Laboratory of Imaging Diagnosis and Minimally Invasive Research, Lishui Central Hospital, Zhejiang University Lishui Hospital, The Fifth Affiliated Hospital of Wenzhou Medical College, Lishui, Zhejiang, China. Electronic address:

Aims: We aimed to investigate the role of G protein subunit alpha Z(GNAZ) in the progression and prognosis of patients with hepatocellular carcinoma (HCC).

Methods: Oncomine, GEO, TCGA, GEPIA2, Kaplan-Meier Plotter, TIMER2, Metascape, CCLE, LinkedOmics, and UALCAN databases were used to analyze the differential expression of GNAZ in HCC and normal liver tissues, relationship between GNAZ expression and prognosis of patients with HCC, and expression of GNAZ in common human HCC cell lines. Western blotting was performed to analyze GNAZ expression, while the Cell Counting Kit 8 assay was used to determine cell proliferation, and flow cytometry was used to evaluate the cell cycle and apoptosis. Read More

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September 2021

The impact of lymph node ratio on overall survival in patients with colorectal cancer.

J Cancer Res Ther 2021 Jul-Sep;17(4):1069-1074

Department of Medical Oncology, University of Health Sciences, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Ankara, Turkey.

Background: Lymph node metastasis is a predominant prognostic indicator in colorectal cancer. Number of lymph nodes removed surgically was demonstrated to correlate with staging accuracy and oncological outcomes. However, number of lymph nodes removed depends on uncontrolled variables. Read More

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September 2021

Prognostic factors and clinical nomogram predicting survival in high-grade glioma.

J Cancer Res Ther 2021 Jul-Sep;17(4):1052-1058

Department of Surgery, Division of Neurosurgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Background: Genomic-based tools have been used to predict poor prognosis high-grade glioma (HGG). As genetic technologies are not generally available in countries with limited resources, clinical parameters may be still necessary to use in predicting the prognosis of the disease. This study aimed to identify prognostic factors associated with survival of patients with HGG. Read More

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September 2021

Expression of astrocyte-elevated gene-1 indicates prognostic value of fluoropyrimidine-based adjuvant chemotherapy in resectable stage III colorectal cancer.

Pathol Int 2021 Sep 15. Epub 2021 Sep 15.

Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan.

It is unclear which prognostic factor such as pathological features and gene mutation are majorly relevant for stage III disease and whether they aid in determining patients who will be benefit from postoperative adjuvant chemotherapy. The expression of astrocyte-elevated gene-1 (AEG-1), thymidylate synthase (TS), excision repair cross-complementation group 1 (ERCC1), epidermal growth factor receptor (EGFR), and vascular endothelial growth factor (VEGF) was examined to investigate their role in adjuvant chemotherapy for patients with resectable stage III colorectal cancer (CRC). A significant positive correlation was observed between AEG-1, TS, ERCC1, EGFR, and VEGF gene expression levels in CRC cell lines, and low AEG-1 and TS expression were highly sensitive to 5-fluorouracil treatment. Read More

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September 2021

Multi-Organ Dysfunction Scoring in Neonatal Encephalopathy (MODE Score) and Neurodevelopmental Outcomes.

Acta Paediatr 2021 Sep 16. Epub 2021 Sep 16.

National Children's Research Centre, Crumlin, Dublin.

Aim: Neonatal Encephalopathy (NE) is associated with increased risk of multi-organ injury. The lack of standardized definitions for multi-organ dysfunction in NE hinders accurate quantification of these complications.

Methods: A simple Multi-Organ Dysfunction in neonatal Encephalopathy scoring (MODE) system was created to include the cardiovascular, respiratory, gastrointestinal, haematological and neurological systems with a maximum score of 15. Read More

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September 2021

A Prospective Phase II Study of Safety and Efficacy of Sorafenib Followed by Y Glass Microspheres for Patients with Advanced or Metastatic Hepatocellular Carcinoma.

J Hepatocell Carcinoma 2021 9;8:1129-1145. Epub 2021 Sep 9.

Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Purpose: The most common cause of death in advanced/metastatic hepatocellular carcinoma (HCC) is liver failure due to tumor progression. While retrospective studies and meta-analyses of systemic therapy combined with liver-directed therapy have been performed, prospective studies of safety/efficacy of antiangiogenesis followed by intra-arterial therapies are lacking. We tested our hypothesis that sorafenib followed by yttrium 90 glass microspheres (Y GMs) is safe and that survival outcomes may improve by controlling hepatic tumors. Read More

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September 2021

DNA methylation of the glucocorticoid receptor gene predicts substance use in adolescence: longitudinal data from over 1000 young individuals.

Transl Psychiatry 2021 Sep 15;11(1):477. Epub 2021 Sep 15.

Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.

Early life stress has been linked to increased methylation of the Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1) gene, which codes for the glucocorticoid receptor. Moreover, early life stress has been associated with substance use initiation at a younger age, a risk factor for developing substance use disorders. However, no studies to date have investigated whether NR3C1 methylation can predict substance use in young individuals. Read More

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September 2021

Efficacy, safety and prognostic factors affecting overall survival among metastatic prostate cancer patients undergoing treatment with Lu-PSMA-617: A single center study.

Rev Esp Med Nucl Imagen Mol (Engl Ed) 2021 Sep 12. Epub 2021 Sep 12.

Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background: Determining the efficacy, safety, and prognostic factors affecting overall survival (OS) among metastatic prostate cancer patients undergoing PSMA-targeted radioligand therapy (PRLT).

Method: In this retrospective study, from November 2016 and December 2019, 43 heavily pretreated (90.7% on 1st line androgen deprivation therapy (ADT), 53. Read More

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September 2021

Isolated pancreatic injury in an adolescent treated with Roux-en-Y pancreatojejunostomy: a case report and review of the literature.

J Med Case Rep 2021 Sep 16;15(1):474. Epub 2021 Sep 16.

Department of Gastrointestinal and Hepato-Pancreatic-Biliary Surgery, Ibn Sina Specialized Hospital, Khartoum, Sudan.

Background: Pancreatic injury presented as isolated injury in the pediatric population is exceptionally rare, with a conveyed incidence of less than 2% of all abdominal trauma injuries cases and a very controversial management approach for grade III injuries.

Case Presentation: A 16-year-old adolescent Sudanese boy was referred to our emergency department with a 5-day history of upper and left hypochondrial pain after blunt abdominal trauma to the epigastric region with a solid object. Grade III pancreatic body trauma with major duct involvement can be successfully treated operatively. Read More

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September 2021

Ultrasound-based evaluation revealed reliable postoperative knee stability after combined acute ACL and MCL injuries.

J Exp Orthop 2021 Sep 15;8(1):76. Epub 2021 Sep 15.

Department for Orthopedic Sports Medicine, Technical University Munich, Ismaningerstrasse 22, 81675, Munich, Germany.

Purpose: Anterior cruciate ligament (ACL) injuries are often combined with lesions of the medial collateral ligament (MCL). The aim of this study was to evaluate treatment outcome of combined acute ACL and MCL lesions using functional US and clinical examination.

Methods: Patients aged > 18 years undergoing primary ACL reconstruction with concomitant operative (group 1) or non-operative treatment of the MCL (group 2) between 2014 and 2019 were included after a minimum follow-up of 12 months. Read More

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September 2021

[Retroperitoneal soft tissue sarcoma: role of radiotherapy].

Chirurg 2021 Sep 15. Epub 2021 Sep 15.

Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Campus Großhadern, LMU Klinikum, Marchioninistraße 15, 81377, München, Deutschland.

Background: Retroperitoneal soft tissue sarcomas (RPS) include tumors of mesenchymal origin with overall well-defined histological subtypes and heterogenic prognosis. For the first time with the publication of the STRASS study, which investigated the value of neoadjuvant radiotherapy in primary RPS, there is phase III evidence for the use of radiotherapy.

Objective: The primary objective of the present article is to present the role of neoadjuvant radiotherapy in RPS since the publication of the STRASS study. Read More

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September 2021

Inflammatory markers are associated with quality of life, physical activity, and gait speed but not sarcopenia in aged men (40-79 years).

J Cachexia Sarcopenia Muscle 2021 Sep 15. Epub 2021 Sep 15.

Geriatrics and Gerontology, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.

Background: Age-related chronic low-grade inflammation (inflammaging) is one of the proposed mechanisms behind sarcopenia. However, findings regarding inflammatory markers in sarcopenic older adults are conflicting. This study aimed to determine the association between inflammatory markers, prevalent as well as incident sarcopenia, sarcopenia-defining parameters, quality of life (QoL), and physical activity in middle-aged and older men. Read More

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September 2021

Comparison of carbon ion and photon reirradiation for recurrent glioblastoma.

Strahlenther Onkol 2021 Sep 14. Epub 2021 Sep 14.

Klinik für Strahlentherapie und Radioonkologie, Universitätsklinikum Marburg, Marburg, Germany.

Purpose: Purpose of this study was to investigate overall survival in recurrent glioblastoma treated with either carbon ion reirradiation or photon reirradiation.

Materials And Methods: In this retrospective study we evaluated 78 consecutive patients with recurrent IDH (Isocitrate dehydrogenase)-wildtype glioblastoma (38 patients carbon ion re-radiotherapy, 40 patients photon re-radiotherapy) treated with either carbon ion reirradiation or stereotactic photon reirradiation. 45 Gy (RBE; 15 fractions) carbon ion reirradiation (CIRT) or 39 Gy (13 fractions) photon reirradiation (FSRT) was administered, respectively. Read More

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September 2021

Straight nail insertion through a laterally shifted entry for diaphyseal atypical femoral fractures with bowing: good indications and limitations of this technique.

Int Orthop 2021 Sep 15. Epub 2021 Sep 15.

Department of Orthopaedic Surgery, Deagu Fatima Hospital, Daegu, Korea.

Purpose: Inserting a straight (piriformis fossa entry) nail through the tip of the greater trochanter has been used for treating atypical femoral fractures (AFFs) with bowing. This study aimed to determine what degree of bowing can be successfully treated using a laterally shifted entry technique.

Methods: Twenty-three complete and six incomplete diaphyseal AFFs treated using the shifted entry technique were retrospectively analysed. Read More

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September 2021

Portal Vein Tumor Thrombosis and Hepatocellular Carcinoma - The Changing Tides.

J Hepatocell Carcinoma 2021 7;8:1089-1115. Epub 2021 Sep 7.

Department of Hepatobiliary and Pancreatic Surgery, The Center for Integrated Oncology and Precision Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, People's Republic of China.

Portal vein involvement is considered one of the most fearful complications of hepatocellular carcinoma (HCC). Portal vein tumor thrombosis (PVTT) is associated with aggressive tumor biology (high grade), high tumor burden (number and size of lesions), high levels of serum markers (AFP), poor liver function (deranged LFT), and poor performance status of patients. The Barcelona Clinic Liver Cancer staging system places HCC patients with PVTT in advanced stage (BCLC Stage-C). Read More

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September 2021

Chondrosarcoma of Maxilla - A Rare Case Report.

Ann Maxillofac Surg 2021 Jan-Jun;11(1):140-143. Epub 2021 Jul 24.

Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, Dharmsinh Desai University, Nadiad, Gujarat, India.

Rationale: Chondrosarcoma, although being a rare entity in jaws, may turn fatal if left untreated or inadequately excised. Prognosis in terms of 5-year survival rate ranges from 90% for Grade I, 81% for Grade II and 43% for Grade III respectively.

Patient Concerns: A 35-year-old male patient reported with a gradually progressive hard painless growth over right maxillary molar region. Read More

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Effects of surgery, chemotherapy, and radiation on hepatocellular carcinoma patients: A SEER-based study.

Ann Med Surg (Lond) 2021 Sep 4;69:102782. Epub 2021 Sep 4.

University of Buckingham Medical School, Buckingham, Buckinghamshire, UK.

Background: Hepatocellular carcinoma (HCC) is a major global health issue, accounting for 75%-85% of primary liver cancer cases. HCC has huge molecular heterogeneity, and the treatment varies among the patients. The aim of this study is assess the effect of surgery, chemotherapy, and radiation on the mortality risk in hepatocellular carcinoma (HCC) patients. Read More

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September 2021