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Neglected Tropical Diseases and the Kidneys.

Contrib Nephrol 2021 Aug 3;199:1-28. Epub 2021 Aug 3.

Medical Sciences Graduate Program, Department of Internal Medicine, Federal University of Ceará, Fortaleza, Brazil.

Clinical Background: Neglected tropical diseases (NTDs), a major public health problem, frequently affect the kidneys. In this chapter, we discuss the NTDs which have been most studied in terms of renal involvement and present a summary of current knowledge regarding kidney disease in all NTDs, through a literature review. Epidemiology: There are more than 1 billion people in the world affected by NTDs. Read More

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Teledentistry and forensic odontology: Cross-sectional observational comparative pilot study.

Forensic Sci Int 2021 Jul 28;326:110932. Epub 2021 Jul 28.

Dental department, University Hospital of Montpellier, Univ Montpellier, Montpellier, France; Systematic Health Care, EA 4129, University of Lyon 1, Lyon, France.

Forensic dentistry is the branch of forensic science concerned with the study of teeth and jaws. To facilitate the work of experts, new comparative identification tools are emerging, with digital techniques such as the intra-oral camera, which are revolutionising current techniques in forensic dentistry.

Objective: The aim of this study is to evaluate the diagnostic quality of the post-mortem odontogram carried out remotely via a video of the oral cavity using an intra-oral camera. Read More

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CT-based radiomics model with machine learning for predicting primary treatment failure in diffuse large B-cell Lymphoma.

Transl Oncol 2021 Jul 30;14(10):101188. Epub 2021 Jul 30.

Jewish General Hospital - McGill University, Canada; Segal Cancer Centre and Lady Davis Institute for Medical Research, Canada.

Biomarkers which can identify Diffuse Large B-Cell Lymphoma (DLBCL) likely to be refractory to first-line therapy are essential for selecting this population prior to therapy initiation to offer alternate therapeutic options that can improve prognosis. We tested the ability of a CT-based radiomics approach with machine learning to predict Primary Treatment Failure (PTF)-DLBCL from initial imaging evaluation. Twenty-six refractory patients were matched to 26 non-refractory patients, yielding 180 lymph nodes for analysis. Read More

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Symptoms of lumbar spinal stenosis in people with knee or hip osteoarthritis or low back pain: a cross-sectional study of 10,234 participants in primary care.

Osteoarthritis Cartilage 2021 Jul 31. Epub 2021 Jul 31.

Centre for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, 5230 Odense, Denmark; Chiropractic Knowledge Hub, 5230 Odense, Denmark. Electronic address:

Objective: The aims of this study were to evaluate: the proportion of people reporting symptoms associated with lumbar spinal stenosis (LSS) in primary care programs for knee or hip osteoarthritis (OA) or persistent low back pain (LBP) and; the prevalence of self-reported clinical LSS in these three cohorts, according to two sets of adapted criteria.

Method: A cross-sectional analysis of baseline data from the Good Life with osteoArthritis in Denmark primary care programs. Self-report LSS symptom questions were administered to participants with knee OA, hip OA, and persistent LBP. Read More

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Stretchable microchannel-on-a-chip: A simple model for evaluating the effects of uniaxial strain on neuronal injury.

J Neurosci Methods 2021 Jul 31:109302. Epub 2021 Jul 31.

Department of Anatomy and Medical Imaging, School of Medical Sciences, Faculty of Medical and Health Sciences and The Centre for Brain Research, University of Auckland, New Zealand. Electronic address:

Background: Axonal injury is a major component of traumatic spinal cord injury (SCI), associated with rapid deformation of spinal tissue and axonal projections. In vitro models enable us to examine these effects and screen potential therapies in a controlled, reproducible manner.

New Method: A customised, stretchable microchannel system was developed using polydimethylsiloxane microchannels. Read More

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Development of a protein assay with copper chelator chromeazurol B, based on the biuret reaction.

Anal Biochem 2021 Jul 31:114320. Epub 2021 Jul 31.

Research Center for Micro Blood Analysis, Leisure, Inc., Japan; Medical Laboratory Sciences, Health Sciences, School of Health Sciences at Narita, International University of Health and Welfare Graduate School, Japan.

This study aimed to provide a novel and highly sensitive protein assay based on the biuret reaction and using chromeazurol B, a metal chelate compound. The method consists of two reagents and an automated analyzer. First, a complex of copper and protein (biuret reaction) is formed. Read More

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Medicines management at home during the COVID-19 pandemic: a qualitative study exploring the UK patient/carer perspective.

Int J Pharm Pract 2021 Aug 3. Epub 2021 Aug 3.

Imperial College Healthcare NHS Trust, London, UK.

Objectives: To explore home medicine practices and safety for people shielding and/or over the age of 70 during the COVID-19 pandemic and to create guidance, from the patient/carer perspective, for enabling safe medicine practices for this population.

Methods: Semi-structured interviews were carried out with 50 UK participants who were shielding and/or over the age of 70 and who used medicines for a long-term condition, using telephone or video conferencing. Participants were recruited through personal/professional networks and through patient/carer organisations. Read More

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The 21-Gene Recurrence Score in Special Histologic Subtypes of Breast Cancer: A Population-Based Study.

Arch Pathol Lab Med 2021 Aug 3. Epub 2021 Aug 3.

the Department of Internal Medicine, Division of Epidemiology (Stoddard), University of Utah Health, Salt Lake City.

Context.—: Recurrence score (RS) testing was developed and validated in invasive ductal and rare lobular carcinomas, although it is used for all special types of breast cancers.

Objective. Read More

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Cannabis-Related Perceptions as Mediators of the Association Between Trait Impulsivity and Cannabis Outcomes.

J Stud Alcohol Drugs 2021 Jul;82(4):522-535

Universidad Nacional de Córdoba, Facultad de Psicología, Córdoba, Argentina.

Objective: Normative perceptions have been shown to mediate the effect of personality traits on cannabis outcomes. We examined descriptive norms, injunctive norms, and the role of cannabis in college life as possible mediators of the association between impulsivity-related traits (i.e. Read More

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Effect of telephone counselling on the knowledge, attitude and practices of contacts of confirmed COVID-19 cases in Egypt.

Afr J Prim Health Care Fam Med 2021 Jul 12;13(1):e1-e10. Epub 2021 Jul 12.

Department of Family Medicine, Faculty of Medicine, Zagazig University, Zagazig.

Background: The coronavirus disease 2019 (COVID-19) is an emerging respiratory illness. The World Health Organization declared it a public health emergency of international concern on 30 January 2020 and called for collaborative efforts, such as contact tracing and promoting the public awareness about COVID-19, and recommended prevention and control measures.

Aim: The aim of this study was to assess the effect of telephone counselling on the knowledge, attitude and practices (KAPs) of contacts of COVID-19 confirmed cases towards COVID-19 epidemiology and infection prevention and control measures. Read More

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Predicting imminent fractures in patients with a recent fracture or starting oral bisphosphonate therapy: development and international validation of prognostic models.

J Bone Miner Res 2021 Aug 3. Epub 2021 Aug 3.

Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Orthopaedic Centre, University of Oxford, UK.

The availability of anti-osteoporosis medications with rapid onset and high potency requires tools to identify patients at high imminent fracture risk (IFR). There are few tools that predict a patient's IFR. We aimed to develop and validate tools for target patients with a recent fracture or initiating oral bisphosphonate therapy. Read More

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Evaluation of Three anti-SARS-CoV-2 Serologic Immunoassays for Post-Vaccine Response.

J Appl Lab Med 2021 Aug 3. Epub 2021 Aug 3.

Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.

Background: In North America, both mRNA vaccines, Pfizer-BioNTech BNT162b2, and Moderna mRNA-1273, each utilizing a two-dose regimen, have started to be administered to individuals.

Methods: We evaluated the quantitative serologic antibody response following administration of either a single dose or both doses of an mRNA SARS-CoV-2 vaccine in a cohort of 98 participants (88 healthcare workers [HCW] and 10 solid organ transplant [SOT] recipients). Antibody levels were compared across three immunoassays: Elecsys Anti-SARS-CoV-2 S (Roche Diagnostics), SARS-CoV-2 TrimericS IgG (DiaSorin), and SARS-CoV-2 IgG II Quant (Abbott). Read More

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Studying Microtemporal, Within-Person Processes of Diet, Physical Activity, and Related Factors Using the APPetite-Mobile-App: Feasibility, Usability, and Validation Study.

J Med Internet Res 2021 Jul 5;23(7):e25850. Epub 2021 Jul 5.

Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt, Germany.

Background: Diet and physical activity (PA) have a major impact on physical and mental health. However, there is a lack of effective strategies for sustaining these health-protective behaviors. A shift to a microtemporal, within-person approach is needed to capture dynamic processes underlying eating behavior and PA, as they change rapidly across minutes or hours and differ among individuals. Read More

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Cost-effectiveness analysis of superabsorbent wound dressings in patients with moderate-to-highly exuding leg ulcers in Germany.

Int Wound J 2021 Aug 2. Epub 2021 Aug 2.

Institute of Public Health, Medical Decision Making and Health Technology Assessment, UMIT, Hall, Tirol, Austria.

The study aims to estimate the cost-effectiveness of superabsorbent wound dressings compared to the standard-of-care (SoC) dressings mix for treatment of patients with moderate-to-highly exuding leg ulcers in the German healthcare settings. A model-based cost-effectiveness analysis was conducted from the German statutory health insurance perspective, following German specific and international recommendations of good research practice. An individual-level (microsimulation) state-transition model has been used with a cycle length of 1 week and time horizon of 6 months. Read More

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'The pine tree, my good friend': The other as more-than-human.

Nurs Philos 2021 Aug 2:e12366. Epub 2021 Aug 2.

Division of Nursing and Medical Technology, Department of Health, Education and Technology, Luleå University of Technology, Luleå, Sweden.

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Temozolomide in grade III gastroenteropancreatic neuroendocrine neoplasms (G3 GEPNENs): A multicentre retrospective review.

Oncologist 2021 Aug 3. Epub 2021 Aug 3.

Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Canada.

Background: G3 GEPNENs are often aggressive, and the optimal treatment is unclear for this subgroup of NENs. Temozolomide (TEM)-based regimens have been increasingly used to treat grade 1-2 NENs, but their efficacy in G3 NENs remains undetermined. We aimed to assess the clinical efficacy of TEM-containing regimens in advanced grade 3 GEPNENs. Read More

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The relationship between obsessions and the self: Feared and actual self-descriptions in a clinical OCD sample.

Clin Psychol Psychother 2021 Aug 3. Epub 2021 Aug 3.

Departament de Personalitat, Avaluació i Tractaments Psicològics. Facultat de Psicologia, Universitat de València, Valencia, Spain.

Cognitive models of obsessive-compulsive disorder (OCD) posit the relevance of the self in OCD, although the nature of this association is still unclear. We aimed to explore actual and feared selves and its association with obsessions and intrusions in a group of OCD patients. A group of 58 patients with OCD identified their most upsetting obsession and intrusion (non-clinical obsession) experienced in the past three months. Read More

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Development and Preliminary Evaluation of a Quality-of-Life Questionnaire for Adults with Neurofibromatosis Type 1 (NF1-AdQOL).

Clin Exp Dermatol 2021 Aug 2. Epub 2021 Aug 2.

Faculty of Medicine and Child Health, University of Sydney, Sydney, NSW, Australia.

Background: Neurofibromatosis type 1 (NF1) is a variable and unpredictable multisystem genetic disorder which predisposes to medical complications, cognitive impairment and disfigurement, of all which can impact negatively upon the health related quality of life (HRQOL) of affected adults.

Objectives: To develop and validate a disease specific HRQOL adult questionnaire to evaluate effects of NF1 from the patient's viewpoint.

Methods: The NF1 adult HRQOL questionnaire (NF1-AdQOL) was developed based on patient interviews (n=8), survey of clinicians and piloting of the questionnaire. Read More

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The possible association of clusterin fucosylation changes with male fertility disorders.

Sci Rep 2021 Aug 2;11(1):15674. Epub 2021 Aug 2.

Department of Laboratory Diagnostics, Division of Laboratory Diagnostics, Faculty of Pharmacy, Wroclaw Medical University, Borowska Street 211A, 50-556, Wrocław, Poland.

In the seminal plasma (n = 118) and serum (n = 90) clusterin (CLU) the fucosylation and the expression of selected fucosyltransferases (FUTs) were analyzed. Samples from infertile men were divided into groups based on the results of the standard semen analysis: normozoospermic (N), teratozoospermic (T), asthenoteratozoospermic (AT) and oligoasthenoteratozoospermic (OAT). The CLU fucosylation was analyzed using lectin-ELISAs with biotinylated lectins specific to α1,3-, α1,2-linked antennary fucose, and α1,6-linked core fucose (LTA, UEA, and LCA, respectively). Read More

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Paediatric neck masses in Zaria: A review of clinical profile and treatment outcome.

Afr J Paediatr Surg 2021 Oct-Dec;18(4):205-209

Department of Pathology, Faculty of Basic Clinical Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria.

Background: A neck mass is any abnormal lesion in the neck that can be seen, palpated, or identified on imaging. It is one of the most common reasons for presentation to the surgical clinics.

Aim: the aim is to analyse the clinical presentation and treatment outcome in children who were diagnosed and managed for neck masses in a tertiary centre in Northwestern Nigeria. Read More

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Chairside endodontic management of a child with fibrodysplasia ossificans progressiva.

J Indian Soc Pedod Prev Dent 2021 Apr-Jun;39(2):221-224

Department of Pedodontics and Preventive Dentistry, KAHER's KLE VK Institute of Dental Sciences, Belagavi, Karnataka, India.

Fibrodysplasia ossificans progressiva (FOP) is an exceptionally atypical genetic disorder characterized by heterotopic bone formation within skeletal muscles, ligaments, tendons, and other connective tissues that affects one in 2 million people. A 4-year-old girl with FOP was referred to our practice with complaints of pain and discomfort in both sides of the lower jaw. Clinical examination revealed deep multiple caries and buccal gingival abscess in relation to multiple teeth. Read More

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Severe Acute Respiratory Syndrome Coronavirus 2 and Dentistry: A Summative Review of Guidelines issued by National Health Authorities.

J Indian Soc Pedod Prev Dent 2021 Apr-Jun;39(2):120-131

Department of Pediatric Dentistry, Faculty of Dental Medicine, University of Monastir, Monastir University, Monastir, Tunisia.

COVID-19 was first reported in China, in November 2019 and since then the spread of this disease was so rapid that on March 11, 2020, it was declared a pandemic by the World Health Organization. Due to the high transmissibility of the COVID virus and the associated morbidity and mortality, various International and National health authorities released different guidelines for day-to-day living, laying down "new norms" which has impacted our lives enormously. Although these guidelines seem to be convoluted but owing to some differences in the guidelines, it raises an ambiguity in the minds of dentists. Read More

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An assessment of compliance with the provisions of Cigarettes and Other Tobacco Products Act 2003: Is Shimla a smoke-free city?

Natl Med J India 2020 Nov-Dec;33(6):335-339

Department of Obstetrics and Gynaecology, Indira Gandhi Medical College, Shimla 171001, Himachal Pradesh, India.

Background: . Tobacco consumption in any form is a major contributor to non-communicable diseases, and it is the leading preventable cause of death worldwide. Secondhand smoke is also harmful. Read More

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SUpporting wellbeing through PEeR-Befriending (SUPERB) feasibility trial: fidelity of peer-befriending for people with aphasia.

BMJ Open 2021 08 2;11(8):e047994. Epub 2021 Aug 2.

Centre for Language and Communication Science Research, City University of London, London, UK

Objective: To evaluate systematically the fidelity of a peer-befriending intervention for people with aphasia.

Design: SUpporting wellbeing through Peer-befriending (SUPERB) was a feasibility randomised controlled trial comparing usual care to usual care +peer-befriending. This paper reports on the fidelity of all intervention aspects (training and supervision of providers/befrienders; intervention visits) which was evaluated across all areas of the Behaviour Change Consortium framework. Read More

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Trainee perspective of the causes of stress and burnout in surgical training: a qualitative study from Wales.

BMJ Open 2021 08 2;11(8):e045150. Epub 2021 Aug 2.

School of Surgery, NHS Wales Health Education and Improvement Wales, Nantgarw, UK.

Objectives: Stress and burn-out among surgical trainees has been reported most prevalent in core surgical trainees (CST) and female trainees in particular. This study aimed to identify factors perceived by CSTs to be associated with stress and burnout in those at risk.

Design: An open-ended questionnaire was distributed to 79 CSTs and two researchers categorised responses independently, according to Michie's model of workplace stress. Read More

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Subcutaneous fat necrosis associated with hypercalcemia in neonates with neonatal encephalopathy treated with therapeutic hypothermia.

Semin Fetal Neonatal Med 2021 Jul 14:101269. Epub 2021 Jul 14.

Department of Neonatology and Intensive Care, University Children's Hospital Zurich, Steinwiesstrasse 37, 8075, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, Steinwiesstrasse 37, 8075, Zurich, Switzerland; University of Zurich, Zurich, Switzerland. Electronic address:

Subcutaneous fat necrosis of the newborn (SFNN) is a rare, self-resolving panniculitis. The onset of skins lesions occurs within the first week of life, with a median age of onset around day 6 of life (range 1-70). About 50% of neonates with SFNN will develop hypercalcemia in the first month though some present later. Read More

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Do degree of coronal plane deformity and patient related factors affect union and outcome of Arthroscopic versus Open Ankle Arthrodesis?

Foot Ankle Surg 2021 Jul 24. Epub 2021 Jul 24.

Leicester General Hospital, University Hospitals of Leicester, Gwendolen Road, Leicester LE5 4PW, United Kingdom.

Background: This study aimed to analyse if union and outcome of Arthroscopic Ankle Arthrodesis (AAA) versus Open Ankle Arthrodesis (OAA) were influenced by the extent of coronal plane deformity and to report if patient related factors influence union.

Methods: A total of 122 ankle arthrodesis procedures were included in the study. These were divided into two groups; Group A (n = 99) with deformity less than 15° and Group B (n = 23) with deformity greater than or equal to 15°. Read More

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Pediatric Resuscitation.

Crit Care Nurs Clin North Am 2021 Sep 7;33(3):287-302. Epub 2021 Jul 7.

Pediatric Intensive Care Unit, UF Health Shands Children's Hospital, 1600 SW Archer Rd., Gainesville FL 32608, USA.

This article describes evidence-based nursing practices for detecting pediatric decompensation and prevention of cardiopulmonary arrest and outlines the process for effective and high-quality pediatric resuscitation and postresuscitation care. Primary concepts include pediatric decompensation signs and symptoms, pediatric resuscitation essential practices, and postresuscitation care, monitoring, and outcomes. Pediatric-specific considerations for family presence during resuscitation, ensuring good outcomes for medically complex children in community settings, and the role of targeted temperature management, continuous electroencephalography, and the use of extracorporeal membrane oxygenation in pediatric resuscitation are also discussed. Read More

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September 2021

Cardiovascular Health and African-American Women: A Qualitative Analysis.

Am J Health Behav 2021 Jul;45(4):735-745

Sara C. Folta, PhD, Associate Professor, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, United States;, Email:

There are disparities in cardiovascular disease (CVD) among African-American women and culturally adapted interventions are needed for this population. The purpose of this study was to conduct qualitative research to inform a cultural adaptation of the evidence-based intervention for midlife and older African-American women. Eligible participants were African-American women age ≥ 40 years, BMI ≥ 25, and sedentary. Read More

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Chinese Parental Awareness of Children's COVID-19 Protective Measures.

Am J Health Behav 2021 Jul;45(4):657-664

BiRong Wei, Professor, School of Nursing, Putian University, Putian Nursing University, Putian, Fujian Province, P.R. China.

In this research our aim was to investigate Chinese parents' awareness of pediatric COVID-19 in relation to protecting their children. A cross-sectional study was conducted in Fujian provinces in China using a Web-based questionnaire to survey parents of children aged 6 to 16 years old. The sample included 1222 participants. Read More

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