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Does Higher Self-Reported Cardiorespiratory Fitness Reduce the Odds of Hospitalization From COVID-19?

J Phys Act Health 2021 May 12:1-7. Epub 2021 May 12.

Background: Regular physical activity and higher cardiorespiratory (CR) fitness enhance immune function, possibly reducing coronavirus disease 2019 (COVID-19) infection severity. The aim was to assess the association between physical activity and self-reported CR fitness on COVID-19 infection characteristics.

Methods: Participants formerly testing positive for COVID-19 completed an online questionnaire measuring COVID-19 infection characteristics and complications, self-reported CR fitness level, physical activity, and sociodemographic and health-related characteristics. Read More

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Outcomes and complications following minimally invasive excision of synovial cysts of the lumbar spine: A systematic review and meta-analysis.

Clin Neurol Neurosurg 2021 May 4;206:106667. Epub 2021 May 4.

University Hospitals Cleveland Medical Centre, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Electronic address:

Objective: Lumbar synovial cysts (LSC) are one of the manifestations of spinal degenerative cascade. Spinal stenosis or presence of instability in these patients can lead to various symptoms and surgery is indicated following failure of non-operative management for symptomatic synovial cysts. Surgery when performed consists of either decompression with resection of cyst with our without fusion. Read More

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Fabricating multifunctional low-toxicity ratiometric fluorescent probe for individual detection of Cu/glutamate and continuous sensing for glutamate via Cu-based platform.

Spectrochim Acta A Mol Biomol Spectrosc 2021 May 1;259:119892. Epub 2021 May 1.

College of Chemistry, Liaoning University, 66 Chongshan Middle Road, Shenyang, Liaoning 110036, People's Republic of China. Electronic address:

Herein, a multifunctional ratiometric fluorescent (RF) probe Fe-MIL-88NH@RhB was fabricated for individual detection of CuGlu and continuous sensing of Glu based on unique coordination principle by encapsulating RhB into the porous of metal-organic-framework-Fe-MIL-88NH. Designed Fe-MIL-88NH@RhB platform could selectively identify Cu(II)/Glu accompanying a turn-off/turn-on fluorescent behavior with good linearity. Moreover, if the Fe-MIL-88NH@RhB/Cu is treated with Glu continuously, the quenching fluorescence of this platform (after Cu sensing at blue emission) would be further in turn restored. Read More

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High-throughput fabrication of silk fibroin/hydroxypropyl methylcellulose (SF/HPMC) manofibrous scaffolds for skin tissue engineering.

Int J Biol Macromol 2021 May 10. Epub 2021 May 10.

National Engineering Laboratory for Modern Silk, College of Textile and Engineering, Soochow University, 199 Ren-ai Road, Suzhou 215123, China.

Silk fibroin (SF) is a natural macromolecule material with good biocompatibility, which can be used to prepare a variety of biological materials. In this study, hydroxypropyl methylcellulose (HPMC) was applied to improve the properties of SF nanofibrous scaffolds (NFS) for skin tissue engineering applications. SF/HPMC NFS with varying weight ratios of SF: HPMC were prepared in batches by a modified free surface electrospinning. Read More

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Fabrication of dual layered biocompatible herbal biopatch from biological waste for skin - Tissue regenerative applications.

Int J Biol Macromol 2021 May 10. Epub 2021 May 10.

Department of Biomedical Engineering, K.P.R. Institute of Engineering and Technology, Coimbatore 641048, India.

A dual layered herbal biopolymeric patch (biopatch) with enhanced wound healing efficiency and skin mimicking functions was fabricated for skin-tissue regenerative applications. In this study, hoof keratin (KE) extracted from biological waste and gelatin (GE) was employed for KE-GE biosheet fabrication using a simple casting method. Further, the top layer of the fabricated KE-GE biosheet was coated with bioactive Matricaria recutita (Chamomile flower) extract (CH) with gelatin through an electrospraying method. Read More

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Microneedles for gene and drug delivery in skin cancer therapy.

J Control Release 2021 May 10. Epub 2021 May 10.

School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK. Electronic address:

The success of skin cancer treatment is severely limited in the route of administration because most genes and drugs cannot break through the excellent stratum corneum (SC) barrier of the skin, leading to their inability to reach the tumor tissues at therapeutic doses. As an excellent minimally invasive delivery method, microneedles (MNs) can bypass the SC and enter the skin microcirculation to achieve drug and gene delivery when used to puncture the skin. Compared with traditional administration approaches, MN-assisted gene and drug delivery have obvious advantages, in that they are simple, safe, painless, easily transport genes (such as DNA and siRNA (small interfering RNA)) and macromolecule drugs (including proteins and antibodies), and have good reproducibility. Read More

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Super Stretchable and Durable Electroluminescent Devices Based on Double-Network Ionogels.

Adv Mater 2021 May 13:e2008849. Epub 2021 May 13.

Graduate Department of Chemical Materials, Institute for Plastic Information and Energy Materials, Sustainable Utilization of Photovoltaic Energy Research Center, Pusan National University, Busan, 46241, Republic of Korea.

Ionogels are good candidates for flexible electronics owing to their excellent mechanical and electrical properties, including stretchability, high conductivity, and stability. In this study, conducting ionogels comprising a double network (DN) of poly(N-isopropylacrylamide-co-N,N'-diethylacrylamide)/chitosan which are further reinforced by the ionic and covalent crosslinking of the chitosan network by tripolyphosphate and glutaraldehyde, respectively, are prepared. Based on their excellent mechanical properties and high conductivity, the developed DN ionogels are envisioned as stretchable ionic conductors for extremely stretchable alternating-current electroluminescent (ACEL) devices. Read More

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Semiconducting α'-boron sheet with high mobility and low all-boron contact resistance: a first-principles study.

Nanoscale 2021 May;13(18):8474-8480

Chemistry Department, Taif University, Taif, Saudi Arabia. and Department of Chemistry, Rice University, Houston, Texas 77005, USA.

Two-dimensional field effect transistors (2D FETs) with high mobility semiconducting channels and low contact resistance between the semiconducting channel and the metallic electrodes are highly sought components of future electronics. Recently, 2D boron sheets (borophene) offer a great platform for realizing ideal 2D FETs but stable semiconducting phases still remain much unexplored. Herein, based on first-principles calculations and tight-binding model, we first clarify that α'-boron is the most stable semiconductor phase of boron sheets, while reveal the mechanism of metal-to-semiconductor transition from α- to α'-boron. Read More

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A comprehensive swarming intelligent method for optimizing deep learning-based object detection by unmanned ground vehicles.

PLoS One 2021 13;16(5):e0251339. Epub 2021 May 13.

College of Automotive Engineering, Jilin University, Changchun, People's Republic of China.

Unmanned ground vehicles (UGVs) are an important research application of artificial intelligence. In particular, the deep learning-based object detection method is widely used in UGV-based environmental perception. Good experimental results are achieved by the deep learning-based object detection method Faster region-based convolutional neural network (Faster R-CNN). Read More

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Ratiometric Detection of Glutathione Based on Disulfide Linkage Rupture between a FRET Coumarin Donor and a Rhodamine Acceptor.

Chembiochem 2021 May 13. Epub 2021 May 13.

Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA.

Abnormal levels of glutathione, a cellular antioxidant, can lead to a variety of diseases. We have constructed a near-infrared ratiometric fluorescent probe to detect glutathione concentrations in biological samples. The probe consists of a coumarin donor, which is connected through a disulfide-tethered linker to a rhodamine acceptor. Read More

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Current Trends in and Indications for Endoscopy-Assisted Breast Surgery for Breast Cancer.

Hyukjai Shin

Adv Exp Med Biol 2021 ;1187:567-590

Hyanyang University College of Medicine, Ansan, Gyeonggi-do, South Korea.

Endoscopic oncoplastic breast surgery represents a minimal invasive approach with the aim of both safe excision of cancer and preserving the breast shape. It has less noticeable scar, excellent cosmetic outcomes, high patient satisfaction rate. Recently, relative long-term follow-up results have been reported to be very safe (Soybir and Fukuma, J Breast Health 11:52-58, 2015; Fan et al. Read More

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January 2021

Treatment of grossly dislocated supracondylar humerus fractures after failed closed reduction: a retrospective analysis of different surgical approaches.

Arch Orthop Trauma Surg 2021 May 13. Epub 2021 May 13.

Department of Trauma and Orthopedic Surgery, BG Unfallklinik Frankfurt Am Main, Friedberger Landstr. 430, 60389, Frankfurt am Main, Germany.

Introduction: The supracondylar humerus fracture (SCHF) is one of the most common pediatric injuries. Highly displaced fractures can be very challenging. If closed reduction fails, the therapy algorithm remains controversial. Read More

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Prospective randomized comparison of bone transport versus Masquelet technique in infected gap nonunion of tibia.

Arch Orthop Trauma Surg 2021 May 13. Epub 2021 May 13.

Department of Sports Medicine, PGIMS, Pt. B. D. Sharma, Health University, Rohtak, 124001, Haryana, India.

Aim: The present prospective randomized study compared the bone transport technique (BT) and Masquelet technique (MT) in the treatment of infected gap non-union of the tibia.

Patients And Methods: Total 25 patients with infected gap non-union of the tibia with bone gap upto 6 cm were randomised into BT group (group I, 13 patients) and MT (group II, 12 patients). The mean age was 31. Read More

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Pd-Catalyzed Enantioselective Dicarbofunctionalization of Alkene to Access Disubstituted Dihydroisoquinolinone.

Org Lett 2021 May 13. Epub 2021 May 13.

Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai, 200438, China.

A Pd/Xu-Phos-catalyzed asymmetric Heck/Suzuki domino reaction has been developed that shows high functional group tolerance and enables coupling with various aryl/alkenyl borates. A series of chiral disubstituted dihydroisoquinolinones could be obtained in good yields and excellent enantioselectivities. Read More

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Exploring glycosyl sulphates as donors for chemical glycosylation.

Org Biomol Chem 2021 May 13. Epub 2021 May 13.

Università del Piemonte Orientale, Dipartimento di Scienze del Farmaco, L.go Donegani 2, 28100 Novara, Italy.

The preparation of anomeric tetrabutylammonium sulphates of glucose and galactose derivatives is reported and their role as donors in glycosylation reactions is studied. Metal triflates showed good performance in activating sulphate as a leaving group. Among them, ytterbium triflate in stoichiometric amounts gave the best results. Read More

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Cu(I)-Catalyzed asymmetric -selective synthesis of substituted pyrrolidines a 1,3-dipolar cycloaddition reaction.

Org Biomol Chem 2021 May 13. Epub 2021 May 13.

Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh 208 016, India.

An (R)-DM-BINAP/Cu(CH3CN)4BF4 complex catalyzed exo-selective asymmetric 1,3-dipolar cycloaddition (1,3-DCA) reaction of imino esters with α,β-unsaturated pyrazoleamides has been developed. A series of highly functionalized pyrrolidines with multiple stereogenic centers were obtained with good yields and diastereoselectivities and excellent enantioselectivities (up to 99% ee). Read More

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Synthesis of 2-isoxazolyl-2,3-dihydrobenzofurans palladium-catalyzed cascade cyclization of alkenyl ethers.

Chem Commun (Camb) 2021 May;57(39):4799-4802

State Key Laboratory of Pulp and Paper Engineering, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.

A novel palladium-catalyzed cascade cyclization reaction of alkenyl ethers with alkynyl oxime ethers for the construction of poly-heterocyclic scaffolds has been developed, in which the electron-rich alkene moiety functions as a three-atom unit, simultaneously dealing well with the coordination and regioselectivity of electron-rich olefins under metal catalysis. The strategy features excellent regio- and chemoselectivities as well as good functional group tolerance. Moreover, the newly formed 2-isoxazolyl-2,3-dihydrobenzofuran products can be further transformed to diverse complex heterocycles, demonstrating their potential applications in organic synthesis and medicinal chemistry. Read More

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Two-Photon Near-Infrared AIE Luminogens as Multifunctional Gene Carriers for Cancer Theranostics.

ACS Appl Mater Interfaces 2021 May 13. Epub 2021 May 13.

China National Institute for Food and Drug Control, Institute of Chemical Drug Control, Tian Tan XiLi 2, Beijing 100050, China.

Construction of multifunctional nonviral gene vectors to execute defined tasks holds great potential for the precise and effective treatment of gene-associated diseases. Herein, we have developed four large π-conjugation triphenylamine derivatives bearing two polar [12]aneN heads and a lipophilic tail for applications in gene delivery, one/two-photon-triggered near-infrared (NIR) fluorescence bioimaging, and combined photodynamic therapy (PDT) and gene therapy of cancer. These compounds possess typical NIR aggregation-induced emission characteristics, mega Stokes shifts, strong two-photon excitation fluorescence, and excellent DNA condensation abilities. Read More

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Synergistic Ir/Cu Catalysis for Asymmetric Allylic Alkylation of Oxindoles: Enantio- and Diastereoselective Construction of Quaternary and Tertiary Stereocenters.

Chemistry 2021 May 12. Epub 2021 May 12.

Shanghai Jiao Tong University, School of Chemistry and Chemical Engineering, 800 Dongchuan Road, 200240, Shanghai, CHINA.

3,3-Disubstituted oxindoles bearing quaternary and tertiary stereogenic centers are privileged structural motifs, which widely exist in pharmaceutical and natural products. Herein, we describe a highly regio-, enantio-, and diastereoselective allylic alkylation of 3-alkyl oxindoles through synergistic iridium and copper catalysis, providing a series of 3,3-disubstituted oxindole derivatives containing adjacent quaternary and tertiary stereogenic centers in excellent yields, enantiomeric excess, and diastereomeric ratio (for 30 examples, up to 97% yield, >99% ee, and >20:1 dr). This method provides exclusive branched selectivity, excellent enantio- and diastereoselectivities, and good functional compatibility. Read More

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Study of the permeability of tubular mineral membranes: application to wastewater treatment.

Heliyon 2021 Apr 19;7(4):e06837. Epub 2021 Apr 19.

Laboratory of Materials, Membranes and Nanotechnology, Department of Chemistry, Faculty of Sciences, Moulay Ismail University, PB 11201, Zitoune, Meknes, Morocco.

This research work opens up the possibility of developing tubular mineral membranes from Moroccan clay powders and their use in water permeability tests and wastewater treatment. The aim is to show the possibility of using clay as a low-cost raw material for the production of ceramic membranes with high mechanical and chemical performances. In a first step, we developed ceramic membranes by extruding a prepared plastic paste with the addition of an optimized amount of wood powder as organic matter (OM) to improve the porosity characteristics of the final products after firing. Read More

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Fruit as a Source of Bioactive Compounds with Good Quality Traits.

Biomed Res Int 2021 23;2021:6683877. Epub 2021 Apr 23.

Multidisciplinary Agroindustry Research Laboratory, Instituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca, Chile.

Since the intake of fruits and vegetables displays important effects on the incidence of several chronic diseases in humans, consumers' attention worldwide is focused on the identification of functional foods. In this sense, (murtilla or murta fruit) is an important source of molecules with a strong antioxidant capacity that is widely used as a medicinal plant in Southern Argentina-Chile. Research on murtilla berries showed that this fruit and its leaves can be an excellent source of polyphenols and bioactive compounds with antibacterial and antioxidant capacity. Read More

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Development and Psychometric Properties of the Test of Passive Aggression.

Front Psychol 2021 26;12:579183. Epub 2021 Apr 26.

Clinical Psychology and Psychotherapy, Department of Psychology, Saarland University, Saarbruecken, Germany.

To date, most research on aggression in mental disorders focused on active-aggressive behavior and found self-directed and other-directed active aggression to be a symptom and risk-factor of psychopathology. On the other hand, passive-aggressive behavior has been investigated less frequently and only in research on psychodynamic defense mechanisms, personality disorders, and dysfunctional self-control processes. This small number of studies primarily reflects a lack of a reliable and valid clinical assessment of passive-aggressive behavior. Read More

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Multivendor comparison of global and regional 2D cardiovascular magnetic resonance feature tracking strains vs tissue tagging at 3T.

J Cardiovasc Magn Reson 2021 May 13;23(1):54. Epub 2021 May 13.

Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St. Luc UCL, Av Hippocrate 10/2806, 1200, Woluwe St. Lambert, Belgium.

Background: Cardiovascular magnetic resonance (CMR) 2D feature tracking (FT) left ventricular (LV) myocardial strain has seen widespread use to characterize myocardial deformation. Yet, validation of CMR FT measurements remains scarce, particularly for regional strain. Therefore, we aimed to perform intervendor comparison of 3 different FT software against tagging. Read More

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Unsupported Nanoporous Platinum-Iron Bimetallic Catalyst for the Chemoselective Hydrogenation of Halonitrobenzenes to Haloanilines.

ACS Appl Mater Interfaces 2021 May 13. Epub 2021 May 13.

State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China.

An unsupported nanoporous platinum-iron bimetallic catalyst (PtFeNPore) was prepared with an electrochemical dealloying technique. Its structure and composition were characterized through various measurement methods, such as X-ray absorption fine structure (XAFS) and X-ray photoelectron spectroscopy (XPS). An intermetallic compound and iron oxide species were both found in the PtFeNPore catalyst. Read More

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Sex differences in weight perception and weight gain among Black college students in the USA.

Osong Public Health Res Perspect 2021 Apr 29;12(2):96-104. Epub 2021 Apr 29.

Department of Human Development and Family Science, University of Georgia, Athens, GA, USA.

Objective: The aims of this study were to examine the prevalence of overweight/obesity and to explore sex differences in body weight perceptions and correlates of weight gain among Black students at 2 historically Black colleges and universities (HBCUs) in the USA.

Methods: Participants completed a paper-based survey, and their height and weight were measured (67% completion rate).

Results: The overweight and obesity rates were 33. Read More

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Assessing Agreement between Frequency-Specific Chirp Auditory Steady-State Response and Pure Tone Audiometry in Adults by Intraclass Correlation Coefficient.

ORL J Otorhinolaryngol Relat Spec 2021 May 12:1-9. Epub 2021 May 12.

Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Introduction: Chirp auditory steady-state response (ASSR) can be used to assess frequency-specific hearing thresholds. However, its reliability has not been confirmed yet. The purpose of this proposed study is to analyze the agreement of thresholds measured by chirp-ASSR and pure tone audiometry (PTA) to investigate the value of chirp-ASSR in hearing threshold evaluation. Read More

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Advanced Li-S Batteries Enabled by a Biomimetic Polysulfide-Engulfing Net.

ACS Appl Mater Interfaces 2021 May 12. Epub 2021 May 12.

Beijing Key Laboratory of Environmental Science and Engineering, School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081, P.R. China.

Lithium-sulfur batteries are attractive because of their high specific capacity and energy density, but issues with the polysulfide dissolution and shuttling intrinsically hinder their wide application. Here, hydroxylate multiwalled carbon nanotubes (MWCNT-OH) were grafted with a supramolecular polymer (heptakis(6-amino-6-deoxy)-β-cyclodextrin) to form a polysulfide-engulfing net, which was coated on a separator. Such a molecular microarray structure of a polymer can block the polysulfides and have biomimetic cellular behavior for engulfing polysulfides. Read More

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Side-Chain-Type Anion Exchange Membranes Based on Poly(arylene ether sulfone)s Containing High-Density Quaternary Ammonium Groups.

ACS Appl Mater Interfaces 2021 May 12. Epub 2021 May 12.

Laboratory of High Performance Plastics (Jilin University), Ministry of Education, National & Local Joint Engineering Laboratory for Synthesis Technology of High Performance Polymer, College of Chemistry, Jilin University, Changchun 130012, People's Republic of China.

To obtain anion exchange membranes with both high ionic conductivity and good dimensional stability, a series of side-chain-type poly(arylene ether sulfone)s (PAES-QDTPM-) were designed and synthesized. Quaternary ammonium (QA) groups were densely aggregated and grafted onto the main chain via flexible hydrophobic spacers. Well-defined microphase separation was confirmed by small-angle X-ray scattering. Read More

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Reliability of iCare ic100 Rebound Tonometry and agreement with Goldmann Applanation Tonometry in Healthy and Post-myopic LASIK Patients.

J Glaucoma 2021 May 12. Epub 2021 May 12.

Optometry Department, Oftalvist. Valencia, Spain Department of Optics & Optometry & Vision Sciences, University of Valencia. Valencia, Spain Alcocer Medical Centre. Valencia, Spain Avanza Vision Ophthalmology Clinic. Valencia, Spain.

Prcis: Rebound tonometry offers excellent reliability for obtaining IOP measurements in healthy and post-myopic LASIK patients regardless of corneal parameters and axial length and regardless of the instillation of ocular topical anesthesia.

Purpose: To assess the reliability of rebound tonometry, its agreement with Goldmann applanation tonometry (GAT) and its concordance after topical anesthesia in a group of non-operated healthy patients and a group of post-myopic laser-assisted in situ keratomileusis (LASIK) patients.

Patients And Methods: Fifty-four patients were included in this prospective observational, case-control study. Read More

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Supported Cu(II)-Schiff base: novel heterogeneous catalyst with extremely high activity for eco-friendly, one-pot and multi-component C-S bond-forming reaction toward a wide range of thioethers as biologically active cores.

Mol Divers 2021 May 12. Epub 2021 May 12.

Department of Chemistry, College of Sciences, Shiraz University, 71454, Shiraz, Iran.

An effective and proficient process for the synthesis of a variety of thioethers via the one-step reaction of benzyl halides, aryl halides, and thiourea is presented. This strategy is a one-pot procedure to achieve a variety of thioethers without the requirement to thiols as starting compounds. A range of thioethers containing electron donating/electron-withdrawing functional groups were obtained with good to excellent yields under mild conditions. Read More

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