Genes (Basel) 2021 Mar 25;12(4). Epub 2021 Mar 25.
School of Mathematics, Georgia Institute of Technology, Atlanta, GA 30308, USA.
Minimum free energy prediction of RNA secondary structures is based on the Nearest Neighbor Thermodynamics Model. While such predictions are typically good, the accuracy can vary widely even for short sequences, and the branching thermodynamics are an important factor in this variance. Recently, the simplest model for multiloop energetics-a linear function of the number of branches and unpaired nucleotides-was found to be the best. Read More