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Assessment of genetic diversity and population structure of oil palm (Elaeis guineensis Jacq.) field genebank: A step towards molecular-assisted germplasm conservation.

PLoS One 2021 29;16(7):e0255418. Epub 2021 Jul 29.

Plant Breeding Section, Advanced Agriecological Research Sdn. Bhd. (AAR), Paloh, Johor, Malaysia.

Oil palm (Elaeis guineensis) germplasm is exclusively maintained as ex situ living collections in the field for genetic conservation and evaluation. However, this is not for long term and the maintenance of field genebanks is expensive and challenging. Large area of land is required and the germplasms are exposed to extreme weather conditions and casualty from pests and diseases. Read More

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Effects of screen-based retinal light stimulation measured with a novel contrast sensitivity test.

PLoS One 2021 29;16(7):e0254877. Epub 2021 Jul 29.

Institute for Ophthalmic Research, Eberhard Karls University Tübingen, Tübingen, Germany.

Myopia is increasing worldwide hence it exists a pressing demand to find effective myopia control strategies. Previous studies have shown that light, spectral composition, spatial frequencies, and contrasts play a critical role in refractive development. The effects of light on multiple retinal processes include growth regulation, but also visual performance and perception. Read More

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Does Exercise Prevent Gestational Diabetes Mellitus in Pregnant Women? A Clin-IQ.

J Patient Cent Res Rev 2021 19;8(3):281-285. Epub 2021 Jul 19.

Department of Family and Preventive Medicine, University of Oklahoma College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK.

Excessive weight gain during pregnancy has been on the rise globally, leading to increased prevalence of gestational diabetes mellitus (GDM). A diagnosis of GDM often leads to pregnancy and infant-related complications. Regular exercise may have the potential to prevent GDM. Read More

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Telemedicine Improves the Short-Term Medical Care of Acute ST-Segment Elevation Myocardial Infarction After Primary Percutaneous Coronary Intervention.

Front Cardiovasc Med 2021 12;8:693731. Epub 2021 Jul 12.

Department of Cardiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Telemedicine appears to be a promising tool for healthcare professionals to deliver remote care to patients with cardiovascular diseases especially during the COVID-19 pandemic. We aimed in this study to evaluate the value of telemedicine added to the short-term medical care of acute ST-segment elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (PCI). Two hundred acute STEMI patients after primary PCI were randomly divided into two groups. Read More

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Effectiveness of data auditing as a tool to reinforce good research data management (RDM) practice: a Singapore study.

BMC Med Ethics 2021 Jul 28;22(1):103. Epub 2021 Jul 28.

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

Background: Institutions, funding agencies and publishers are placing increasing emphasis on good research data management (RDM). RDM lapses in medical science can result in questionable data and cause the public's confidence in the scientific community to crumble. A fledgling medical school in a young university in Singapore has mandated every funded research project to have a data management plan (DMP). Read More

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A Biofeedback App for Migraine: Development and Usability Study.

JMIR Form Res 2021 Jul 28;5(7):e23229. Epub 2021 Jul 28.

Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.

Background: Biofeedback is effective in treating migraines. It is believed to have a beneficial effect on autonomous nervous system activity and render individuals resilient to stressors that may trigger a migraine. However, widespread use of biofeedback is hampered by the need for a trained therapist and specialized equipment. Read More

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Prognosis and treatment of 46 Chinese pediatric cystic fibrosis patients.

BMC Pediatr 2021 Jul 28;21(1):329. Epub 2021 Jul 28.

Department No. 2 of Respiratory Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

Background: Since public awareness of cystic fibrosis (CF) has increased, more children have been diagnosed with CF in China. This study aimed to investigate medical and other challenges faced by pediatric CF patients in China.

Method: Treatments and treatment outcomes were retrospectively analyzed for 46 pediatric CF patients diagnosed from August 2009 to June 2019. Read More

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Efficacy of a Smart Insulin Pen Cap for the Management of Patients with Uncontrolled Type 2 Diabetes: A Randomized Cross-Over Trial.

J Diabetes Sci Technol 2021 Jul 22:19322968211033837. Epub 2021 Jul 22.

Emory University School of Medicine, Division of Endocrinology and Diabetes, Grady Memorial Hospital, Atlanta, GA, USA.

Background: We studied a smart insulin pen cap that can be plugged to several brand of insulin pens, to track insulin administration via smart-phone Bluetooth technology, with alarm/reminder system aiming.

Methods: This pilot randomized, cross-over design study assessed the use of a smart insulin pen cap in improving adherence, glycemic control and patient satisfaction in insulin-treated patients with poorly controlled type 2 diabetes. Eighty patients on basal insulin ± oral agents with hemoglobin A1C (HbA1c) between 7. Read More

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Field evaluation of a prototype tuberculosis lipoarabinomannan lateral flow assay on HIV-positive and HIV-negative patients.

PLoS One 2021 26;16(7):e0254156. Epub 2021 Jul 26.

Global Good Fund, Intellectual Ventures, Bellevue, Washington, United States of America.

Detection of tuberculosis at the point-of-care (POC) is limited by the low sensitivity of current commercially available tests. We describe a diagnostic accuracy field evaluation of a prototype urine Tuberculosis Lipoarabinomannan Lateral Flow Assay (TB-LAM LFA) in both HIV-positive and HIV-negative patients using fresh samples with sensitivity and specificity as the measures of accuracy. This prototype combines a proprietary concentration system with a sensitive LFA. Read More

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Feasibility, Efficacy, and Efficiency of eHealth-Supported Pediatric Asthma Care: Six-Month Quasi-Experimental Single-Arm Pretest-Posttest Study.

JMIR Form Res 2021 Jul 26;5(7):e24634. Epub 2021 Jul 26.

Biomedical Signals and Systems, University of Twente, Enschede, Netherlands.

Background: Early detection of loss of asthma control can effectively reduce the burden of the disease. However, broad implementation in clinical practice has not been accomplished so far. We are in need of research investigating the operationalization of eHealth pediatric asthma care in practice, which can provide the most potential benefits in terms of adoption, efficiency, and effectiveness. Read More

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Understanding COVID-19 dynamics and the effects of interventions in the Philippines: A mathematical modelling study.

Lancet Reg Health West Pac 2021 Sep 14;14:100211. Epub 2021 Jul 14.

School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.

Background: COVID-19 initially caused less severe outbreaks in many low- and middle-income countries (LMIC) compared with many high-income countries, possibly because of differing demographics, socioeconomics, surveillance, and policy responses. Here, we investigate the role of multiple factors on COVID-19 dynamics in the Philippines, a LMIC that has had a relatively severe COVID-19 outbreak.

Methods: We applied an age-structured compartmental model that incorporated time-varying mobility, testing, and personal protective behaviors (through a "Minimum Health Standards" policy, MHS) to represent the first wave of the Philippines COVID-19 epidemic nationally and for three highly affected regions (Calabarzon, Central Visayas, and the National Capital Region). Read More

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September 2021

Adherence to the Mediterranean diet in health personnel from the province of Las Palmas.

Rev Clin Esp (Barc) 2021 Jul 22. Epub 2021 Jul 22.

Servicio de Medicina Interna, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain; Departamento de Ciencias Médicas y Quirúrgicas, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.

Introduction And Objectives: Given the proven protective effect of the Mediterranean Diet, adherence to it by healthcare personnel and the influence of different factors on dietary compliance were evaluated.

Methods: A cross-sectional study was conducted on healthcare personnel, obtaining the data through anonymous surveys that collected demographic characteristics, professional activity, history of cardiovascular risk factors, alcohol, and tobacco consumption, physical activity, and adherence to the Mediterranean Diet, using the 14-point Mediterranean Diet Adherence Score (MEDAS). Adherence and related factors were measured. Read More

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Adherence to treatment with tofacitinib in patients with rheumatoid arthritis in daily clinical practice.

Reumatol Clin (Engl Ed) 2021 Jul 20. Epub 2021 Jul 20.

Instituto de Rehabilitación Psicofísica (IREP), Ciudad de Buenos Aires, Argentina. Electronic address:

Objectives: To evaluate the adherence to treatment with Tofacitinib in patients with Rheumatoid Arthritis (RA) using two versions of the self-questionnaire Compliance Questionnaire Rheumatology, CQR19 and CQR5, to determine the variables associated with adherence to Tofacitinib and to compare the performance of both questionnaires.

Material And Methods: A cross-sectional study was carried out. We included patients ≥18 years old, with RA (ACR/EULAR criteria 2010) under treatment with Tofacitinib. Read More

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The Contribution of Machine Learning in the Validation of Commercial Wearable Sensors for Gait Monitoring in Patients: A Systematic Review.

Sensors (Basel) 2021 Jul 14;21(14). Epub 2021 Jul 14.

Univ Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1294, F-69621 Villeurbanne, France.

Gait, balance, and coordination are important in the development of chronic disease, but the ability to accurately assess these in the daily lives of patients may be limited by traditional biased assessment tools. Wearable sensors offer the possibility of minimizing the main limitations of traditional assessment tools by generating quantitative data on a regular basis, which can greatly improve the home monitoring of patients. However, these commercial sensors must be validated in this context with rigorous validation methods. Read More

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Adherence to Lipid-Lowering Medication in People Living with HIV: An Outpatient Clinic Drug Direct Distribution Experience.

J Res Pharm Pract 2021 Jan-Mar;10(1):10-16. Epub 2021 May 13.

Clinic of Infectious Diseases, Azienda Ospedaliero-Universitaria Di Modena, Modena, Italy.

Objective: Adherence to lipid-lowering drugs could be challenging in our patients as it is in the general population, which is described as low as 25%. Our aim was to evaluate adherence to statins and to investigate clinical event impact on it.

Methods: This retrospective study on HIV+ patients attending to Clinic of Modena (Italy) was conducted in order to evaluate characteristics, clinical events, and adherence on lipid-lowering drugs. Read More

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Occupational Contact Dermatitis: Return to Work Using a Multidisciplinary Clinic Model.

Contact Dermatitis 2021 Jul 22. Epub 2021 Jul 22.

Department of Medicine, University of Toronto, Toronto, CANADA.

Background: Occupational contact dermatitis often results in work disruption. Return-to-work (RTW) is an important outcome.

Objective: The objective of this study was to determine RTW outcomes and factors associated with such outcomes using a multidisciplinary clinic model. Read More

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PrEP monitoring and HIV incidence after PrEP initiation in France: 2016-18 nationwide cohort study.

J Antimicrob Chemother 2021 Jul 22. Epub 2021 Jul 22.

INSERM U1259, Université de Tours, France.

Background: Clinical trials have demonstrated that oral pre-exposure prophylaxis (PrEP) has high efficacy in preventing HIV transmission. In many countries, HIV testing is recommended prior to PrEP initiation, 1 month after and quarterly thereafter. We assessed the uptake of HIV testing and estimated the incidence of HIV infections after oral PrEP initiation, by using the French national health database (SNDS). Read More

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Exploring Behavioral Typologies to Inform COVID-19 Health Campaigns: A Person-Centered Approach.

J Health Commun 2021 Jul 22:1-11. Epub 2021 Jul 22.

Department of Medicine, Pennsylvania State College of Medicine, Hershey, Pennsylvania.

As the United States continues to be ravaged by COVID-19, it becomes increasingly important to implement effective public health campaigns to improve personal behaviors that help control the spread of the virus. To design effective campaigns, research is needed to understand the current mitigation intentions of the general public, diversity in those intentions, and theoretical predictors of them. COVID-19 campaigns will be particularly challenging because mitigation involves myriad, diverse behaviors. Read More

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Effectiveness and acceptability of a multidisciplinary approach in improving the care of patients with advanced chronic kidney disease: a pilot study.

Int Urol Nephrol 2021 Jul 22. Epub 2021 Jul 22.

Duke-NUS Medical School, Health Services and Systems Research, Singapore, Singapore.

Objective: This study aimed at determining the feasibility of conducting a large-scale pragmatic effectiveness study on the implementation of multidisciplinary care (MDC) program for patients with advanced chronic kidney disease (CKD).

Methods: This is a single-arm pre-post intervention design pilot study over 12 months. Participants with an estimated glomerular filtration rate (eGFR) between 11 and 20 ml/min/1. Read More

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The COVID-19 Lockdown and CPAP Adherence: The More Vulnerable Ones Less Likely to Improve Adherence?

Nat Sci Sleep 2021 12;13:1097-1108. Epub 2021 Jul 12.

Department of Neuroscience, University of Split School of Medicine, Split, Croatia.

Purpose: Due to the possible interplay of factors predisposing to severe COVID-19 outcomes and negative health consequences of poorly controlled OSA, adherence to continuous positive airway pressure (CPAP) therapy among OSA patients might be crucial during COVID-19 pandemics. Lockdown-related changes in CPAP adherence were investigated in CPAP users willing to participate in this study. Pre-lockdown adherence, age, gender, comorbidities and anxiety were analyzed as predictors of COVID-19 lockdown adherence. Read More

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Ultra-processed food consumption and its correlates among Italian children, adolescents and adults from the Italian Nutrition & Health Survey (INHES) cohort study.

Public Health Nutr 2021 Jun 24:1-14. Epub 2021 Jun 24.

Department of Epidemiology and Prevention, IRCCS NEUROMED, Via dell'Elettronica, 86077 Pozzilli (IS), Italy.

Objective: To assess ultra-processed food (UPF) consumption and its socio-demographic, psychosocial and behavioural correlates in a general population of Italian children, adolescents and adults.

Design: Cross-sectional telephone-based survey.

Setting: Italy, 2010-2013. Read More

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Patient activation and patient-reported outcomes of men from a community pharmacy lifestyle intervention after prostate cancer treatment.

Support Care Cancer 2021 Jul 21. Epub 2021 Jul 21.

School of Health Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.

Purpose: To report patient activation, which is the knowledge, skills, and confidence in self-managing health conditions, and patient-reported outcomes of men after prostate cancer treatment from a community pharmacy lifestyle intervention.

Methods: The 3-month lifestyle intervention was delivered to 116 men in nine community pharmacies in the UK. Patient Activation Measure (PAM) was assessed at baseline, 3 and 6 months. Read More

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The Impact of Adherence to Disease-Modifying Therapies on Functional Outcomes in Veterans with Multiple Sclerosis.

J Cent Nerv Syst Dis 2021 6;13:11795735211028769. Epub 2021 Jul 6.

Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center (Statistician), Oklahoma, UK.

Background: Patients who adhere to their DMTs have lower rate of MS-related relapses and disability.

Objective: We sought to determine the adherence rate to disease-modifying therapies (DMTs) and its impact on functional outcome(s) in veterans with multiple sclerosis (MS).

Method: We reviewed the electronic records of 279 veterans with MS who were periodically followed in our MS clinic. Read More

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Care bundles to reduce unplanned extubation in critically ill children: a systematic review, critical appraisal and meta-analysis.

Arch Dis Child 2021 Jul 20. Epub 2021 Jul 20.

Health Technologies Assessment Center, Federal University of Sao Paulo Paulista School of Medicine, Sao Paulo, Brazil.

Objective: To assess the current evidence for the efficacy of care bundles in reducing unplanned extubations (UEs) in critically ill children.

Design: Systematic review according to the Cochrane guidelines and meta-analysis using random-effects modelling.

Methods: We searched MEDLINE, EMBASE, CINAHL, Web of Science, Scopus, Cochrane and SciELO databases from inception until April 2021. Read More

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Suppression of hyphal formation and virulence of by natural and synthetic compounds.

Biofouling 2021 Jul 20:1-30. Epub 2021 Jul 20.

Research Center for Marine Integrated Bionics Technology, Pukyong National University, Busan, South Korea.

undergoes a morphological yeast-to-hyphal transition during infection, which plays a significant role in its pathogenesis. The filamentous morphology of the hyphal form has been identified as a virulence factor as it facilitates surface adherence, intertwining with biofilm, invasion, and damage to host tissues and organs. Hence, inhibition of filamentation in addition to biofilm formation is considered a viable strategy against infections. Read More

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Adherence of obstructive sleep apnoea syndrome patients to positive airway pressure therapy - 10-year follow-up.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2021 Jul 2. Epub 2021 Jul 2.

Department of Respiratory Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic.

Purpose: Continuous positive airway pressure (CPAP) is the most effective therapy for obstructive sleep apnoea syndrome (OSAS). Long-term adherence is necessary; however, it may be widely variable based on current literature, where the predicting factors are also not well defined. The aim of this study was to assess ten-year adherence to CPAP and to define factors influencing it. Read More

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Over-the-counter protein supplement resulting in impaired thyroxine absorption in a hypothyroid patient.

Endocrinol Diabetes Metab Case Rep 2021 Jul 19;2021(21-0070). Epub 2021 Jul 19.

Diabetes and Endocrinology Unit, National Hospital Kandy, Kandy, Sri Lanka.

Summary: Whey protein is a popular dietary supplement that is claimed to provide multiple health benefits. It has been shown to delay gastric emptying and impair ileal nutrient absorption. Additionally, some of the other additives like papain enzyme, soy lecithin in these protein supplements could interfere with L-thyroxine absorption. Read More

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Efficacy of vitamin D supplementation among persons living with HIV/AIDS in São Paulo city, Brazil.

Braz J Infect Dis 2021 Jul 16:101598. Epub 2021 Jul 16.

Universidade de São Paulo, Hospital das Clínicas da Faculdade de Medicina, Departamento de Dermatologia, São Paulo, SP, Brazil. Electronic address:

Hypovitaminosis D is now considered a pandemic, especially among more vulnerable populations and in HIV-infected subjects, with 80% presenting levels below 30 ng/mL. As there is no consensus on the more adequate dosage needed to correct such deficiency, the objective of this study was to evaluate 25 (OH) vitamin D supplementation in HIV-1 patients deficient of vitamin D. A total of 73 HIV-1-infected patients were included, drawn from a cohort of 435 patients; 37 patients were randomized to the active group, supplemented once a week with 50,000 UI vitamin D by mouth (group 1) and 36 to the placebo group (group 2). Read More

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Overcoming the challenges of treating hemophilia in resource-limited nations: a focus on medication access and adherence.

Expert Rev Hematol 2021 Jul 29:1-10. Epub 2021 Jul 29.

Clinical Biochemistry, Tata Memorial Hospital and Homi Bhaba National Institute, Mumbai, India.

Background: Hemophilia is a high cost low volume disease. Resource limited nations (RLN) usually spend very little on health budget and most of it is spent in dealing with common ailments. Clotting products constitute more than 90% of the total cost of hemophilia care. Read More

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Test-Retest Reliability of Remote ImPACT Administration.

Arch Clin Neuropsychol 2021 Jul 16. Epub 2021 Jul 16.

Neuromechanics Laboratory, School of Community Health Sciences, University of Nevada, Reno, Nevada, 89557, USA.

Objective: To evaluate the performance and test-retest reliability obtained when administering a computerized baseline neurocognitive exam to NCAA Division I student-athletes in a controlled laboratory setting versus an uncontrolled remote location.

Method: A sample of 129 (female = 100) Division I student-athletes completed Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) pre-season assessments for two distinct and respective sports seasons in a controlled laboratory environment and an uncontrolled remote environment. Depending on the environment, participants were given verbal (controlled) or written (uncontrolled) guidelines for taking the test. Read More

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