1,019 results match your criteria gondii increase


Comparative analysis of ketone body metabolism in BALB/c mice infected with Trypanosoma evansi and Toxoplasma gondii.

Res Vet Sci 2021 Dec 20;143:134-141. Epub 2021 Dec 20.

Key Laboratory of Livestock Infectious Diseases, Ministry of Education, China; College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China. Electronic address:

KBs (ketone bodies), i.e., acetoacetate, acetone, and (R)-3-Hydroxybutanoate, constitute the intermediate products of the incomplete oxidative degradation of fatty acids. Read More

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December 2021

Protective Effect Against Toxoplasmosis in Mice Vaccinated With Recombinant MIF, CDPK3, and 14-3-3 Protein Cocktail Vaccine.

Front Immunol 2021 22;12:755792. Epub 2021 Dec 22.

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.

can infect almost all endotherm organisms including humans and cause life-threatening toxoplasmosis in immunocompromised individuals, which leads to serious public health problems. Developing an excellent vaccine against this disease is impending. In present study, we formulated a cocktail protein vaccine including the TgMIF, TgCDPK3, and Tg14-3-3 proteins, which play critical roles in infection. Read More

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December 2021

First report on molecular epidemiology, seasonality and phylogeny of Toxoplasma gondii infecting goats from Khanewal district in Punjab, Pakistan.

Acta Trop 2022 Jan 6;228:106304. Epub 2022 Jan 6.

Zoology Division, Institute of Pure and Applied Biology, Bahauddin Zakariya University Multan, 60800, Pakistan. Electronic address:

Raising small ruminants is the main source of income for farmers in Pakistan. Economic losses caused by Toxoplasma gondii to small ruminants have been reported worldwide, however reports on molecular detection of T. gondii are lacking in Pakistan despite a large goat population. Read More

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January 2022

Reversible myocardial injury aggravated by complex arrhythmias in three Toxoplasma gondii-positive dogs.

J Vet Med Sci 2021 Dec 27. Epub 2021 Dec 27.

Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of Bologna.

Although Toxoplasma gondii represents an oft-cited cause of myocarditis in veterinary medicine, the existing literature on the pre-mortem demonstration of T. gondii-associated myocardial injury (MI) in dogs is scant. In this case series, we provide detailed clinical, laboratory, echocardiographic and electrocardiographic description of three T. Read More

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December 2021

Gene-Environment Interactions in Schizophrenia: A Literature Review.

Genes (Basel) 2021 Nov 23;12(12). Epub 2021 Nov 23.

Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Schizophrenia is a devastating mental illness with a strong genetic component that is the subject of extensive research. Despite the high heritability, it is well recognized that non-genetic factors such as certain infections, cannabis use, psychosocial stress, childhood adversity, urban environment, and immigrant status also play a role. Whenever genetic and non-genetic factors co-exist, interaction between the two is likely. Read More

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November 2021

Blood-brain barrier-restricted translocation of from cortical capillaries.

Elife 2021 12 8;10. Epub 2021 Dec 8.

Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.

The cellular barriers of the central nervous system proficiently protect the brain parenchyma from infectious insults. Yet, the single-celled parasite commonly causes latent cerebral infection in humans and other vertebrates. Here, we addressed the role of the cerebral vasculature in the passage of to the brain parenchyma. Read More

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December 2021

In vitro and in vivo Anti- Effects of Essential Oil Against RH Strain.

Infect Drug Resist 2021 30;14:5057-5068. Epub 2021 Nov 30.

Department of Medical Laboratories Sciences, College of Applied Medical Sciences in Al-Quwayiyah, Shaqra University, Riyadh, Saudi Arabia.

Background: Since no effective vaccine has been developed for toxoplasmosis, prophylaxis in seronegative pregnant women and immunocompromised patients with a CD4 <100 cells/μL is highly recommended as an ideal strategy to prevent this disease. This study aimed to assess the chemical composition, in vitro, and in vivo effects of essential oil (ASEO) against RH strain.

Methods: The in vitro anti- effects of different concentrations of ASEO (32. Read More

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November 2021

Comparison of serum creatine kinase and aspartate aminotransferase activity in dogs with Neospora meningoencephalitis and noninfectious meningoencephalitis.

J Vet Intern Med 2021 Dec 3. Epub 2021 Dec 3.

Department of Neurology and Neurosurgery, Langford Vets Small Animal Hospital, Bristol, United Kingdom.

Background: Creatine kinase (CK) and aspartate aminotransferase (AST) activity can be increased with myositis associated with Toxoplasma and Neospora infection in dogs.

Hypothesis/objectives: Serum activity of CK and AST can be used as a rapid screen for predicting positive serology in meningoencephalitis caused by Toxoplasma gondii or Neospora caninum in dogs compared to dogs with noninfectious meningoencephalitis.

Animals: Eighty dogs with meningoencephalitis based on magnetic resonance imaging and cerebrospinal fluid analysis. Read More

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December 2021

Thiosemicarbazone Copper Chelator BLT-1 Blocks Apicomplexan Parasite Replication by Selective Inhibition of Scavenger Receptor B Type 1 (SR-BI).

Microorganisms 2021 Nov 17;9(11). Epub 2021 Nov 17.

Institute of Parasitology, Biomedical Research Center Seltersberg, Justus Liebig University Giessen, 35392 Giessen, Germany.

Coccidian parasites are obligate intracellular pathogens that affect humans and animals. Apicomplexans are defective in de novo synthesis of cholesterol, which is required for membrane biosynthesis and offspring formation. In consequence, cholesterol has to be scavenged from host cells. Read More

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November 2021

Infection Causes an Atypical Abundance of Oxytocin and Its Receptor in the Female Rat Brain.

Pathogens 2021 Nov 17;10(11). Epub 2021 Nov 17.

School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.

Infection with the protozoan causes loss of innate fear of cat odors in both male and female rats. This behavioral change is presumed to reflect a parasitic manipulation that increases transmission of the parasite from its intermediate to definitive host. The host behavioral change in male rats is dependent on gonadal steroids. Read More

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November 2021

High Seroprevalence of in Slovenian Wild Boars ().

Animals (Basel) 2021 Nov 3;11(11). Epub 2021 Nov 3.

Veterinary Faculty, University of Ljubljana, Gerbičeva ulica 60, SI-1115 Ljubljana, Slovenia.

is a zoonotic parasite of great public health concern. Wild boars could be considered an emerging source of toxoplasmosis in humans due to the popularity of venison and their increasing population. The aim of this study was to determine the seroprevalence of in the Slovenian wild boar population and evaluate risk factors for human infection. Read More

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November 2021

Effect of spiramycin versus aminoguanidine and their combined use in experimental toxoplasmosis.

J Parasit Dis 2021 Dec 26;45(4):1014-1025. Epub 2021 Apr 26.

Department of Medical Parasitology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Toxoplasmosis is one of the widest spread parasitic infections which is caused by protozoon. Many experimental studies have evaluated the effect of aminoguanidine upon parasitic load and inflammatory process. However, few reports have illustrated the impact of combining aminoguanidine with spiramycin in the treatment of toxoplasmosis. Read More

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December 2021

Modulation of mRNA Expression of Monoacylglycerol Lipase, Diacylglycerol Lipase and Cannabinoid Receptor-1 in Mice Experimentally Infected with .

Int J Mol Cell Med 2021 1;10(2):149-155. Epub 2021 Sep 1.

Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

, an obligate intracellular parasite, infects more than 30% of world's population. This parasite is considered to be neurotropic, and has high tropism for the central nervous system, and potentially induces cryptogenic epilepsy by no clear mechanism. The current study aimed to investigate the alteration of the main components of the endocannabinoid signaling systems in -infected mice. Read More

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September 2021

Effect of alginate nanoparticles on the immunogenicity of excretory-secretory antigens against acute toxoplasmosis in murine model.

Acta Trop 2022 Jan 21;225:106215. Epub 2021 Oct 21.

Medical Parasitology Department, Faculty of Medicine, Alexandria University, Egypt.

Efficacy of alginate nanoparticles (Alg-NPs) as vaccine delivery for the excretory-secretory antigens (ESAs) against the virulent strain of Toxoplasma gondii was evaluated. Swiss albino mice were intraperitoneally immunized with three doses of either in vivo and in vitro-prepared ESA vaccines, 20 µg each, at 2-week intervals, then were challenged with 2500 tachyzoites of the RH HXGPRT (-) Toxoplasma gondii strain, four weeks later. Mice mortality, tachyzoite number in both peritoneal fluid and impression smear, and viability, ultrastructural tachyzoite changes, measuring immunological markers, and histopathological changes of both liver and spleen were studied, in comparison to alum adjuvanted ESAs and infected control subgroups. Read More

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January 2022

Human density is associated with the increased prevalence of a generalist zoonotic parasite in mammalian wildlife.

Proc Biol Sci 2021 Oct 20;288(1961):20211724. Epub 2021 Oct 20.

Ottawa Research Development Centre, Agriculture and Agri-Food Canada, Ottawa, Ontario, Canada K1A 0C6.

Macroecological approaches can provide valuable insight into the epidemiology of globally distributed, multi-host pathogens. is a zoonotic protozoan that infects any warm-blooded animal, including humans, in almost every ecosystem worldwide. There is substantial geographical variation in prevalence in wildlife populations and the mechanisms driving this variation are poorly understood. Read More

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October 2021

Analogs of marinopyrrole A show enhancement to observed potency against acute infection.

Antimicrob Agents Chemother 2021 Oct 18:AAC0079421. Epub 2021 Oct 18.

Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA.

The apicomplexan parasite is the causative agent of toxoplasmosis, a globally distributed infection with severe clinical consequences for immunocompromised individuals and developing fetuses. There are few available treatments, and these are associated with potentially severe adverse effects. Marinopyrrole A, a compound discovered in a marine species, has previously been found to exhibit potent antimicrobial activity, prompting our interest in exploring efficacy against . Read More

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October 2021

Revisiting the Role of Toxoplasma gondii ERK7 in the Maintenance and Stability of the Apical Complex.

mBio 2021 10 5;12(5):e0205721. Epub 2021 Oct 5.

Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Genevagrid.8591.5, Geneva, Switzerland.

Toxoplasma gondii extracellular signal-regulated kinase 7 (ERK7) is known to contribute to the integrity of the apical complex and to participate in the final step of conoid biogenesis. In the absence of ERK7, mature parasites lose their conoid complex and are unable to glide, invade, or egress from host cells. In contrast to a previous report, we show here that the depletion of ERK7 phenocopies the depletion of the apical cap protein AC9 or AC10. Read More

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October 2021

Seroprevalence of toxoplasmosis in Kermanshah City, west of Iran.

Ann Parasitol 2021 ;67(2):229-236

Department of Laboratory Sciences, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.

It is estimated that one-third of the world's population is infected with Toxoplasma gondii. The purpose of this study was to evaluate the latest status of toxoplasmosis seroprevalence in the general population and pregnant women in the west of Iran. This retrospective cross-sectional study was conducted in 2018. Read More

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October 2021

infection in children after allogeneic hematopoietic stem cell transplantation: A case report and literature review.

Pediatr Investig 2021 Sep 22;5(3):239-243. Epub 2021 Sep 22.

Department of Infectious Diseases Shanghai Children's Medical Center School of Medicine Shanghai Jiao Tong University Shanghai China.

Introduction: Toxoplasmosis is a life-threatening complication after hematopoietic stem cell transplantation (HSCT). However, for several reasons, clinicians know little about infection.

Case Presentation: We report a case of toxoplasmosis that was diagnosed by bone marrow smear and metagenomic next-generation sequencing (mNGS) after HSCT in a boy. Read More

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September 2021

Expression of immunoproteasome subunits in the brains of Toxoplasma gondii-infected mice.

Exp Mol Pathol 2021 12 20;123:104684. Epub 2021 Sep 20.

State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China. Electronic address:

The immunoproteasomes are specific proteasomes that clear oxidant-damaged proteins under inflammatory conditions in various diseases. Toxoplasma gondii (T. gondii) infects the central nervous system and causeencephalitis. Read More

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December 2021

Seroepidemiology of TORCH Infections among 1.7 Million Women of Childbearing Age in Rural China: A Population-Based Cross-Sectional Study.

Am J Trop Med Hyg 2021 Sep 20;105(5):1202-1209. Epub 2021 Sep 20.

Department of Clinical Laboratory Medicine, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, China.

We conducted a national seroepidemiological study of the TORCH (Toxoplasma gondii [TOX], Rubella [RV], Cytomegalovirus [CMV], and Herpes Simplex Virus) in rural women to provided updated baseline data on TORCH prevalence. A total of 1,541,329 women of childbearing age were gathered from 2010 to 2012 in China. Of these, 858,072 women were tested positive for anti-RV IgG antibodies, 602,251 women were tested positive for anti-CMV antibodies, and 40,055 women were tested positive for anti-TOX antibodies. Read More

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September 2021

Considering opportunistic parasitic infections in COVID-19 policies and recommendations.

Trans R Soc Trop Med Hyg 2021 11;115(11):1345-1347

Anesthesiology Institute, Cleveland Clinic, Abu Dhabi, PO Box 112412, Abu Dhabi, United Arab Emirates.

The COVID-19 pandemic has led to a significant increase in the immunosuppressed population worldwide due to the disease pathology and extensive use of corticosteroids. This has subsequently increased the risk of opportunistic parasitic infections such as Toxoplasma gondii, Strongyloides stercoralis and other parasites in these patients. The reactivation of such parasites may remain unnoticed due to overlapping symptoms, the difficulty of diagnosis and lack of guidelines for opportunistic parasitic infections in COVID-19 management. Read More

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November 2021

Yeast Shells Encapsulating Adjuvant AS04 as an Antigen Delivery System for a Novel Vaccine against .

ACS Appl Mater Interfaces 2021 Sep 17;13(34):40415-40428. Epub 2021 Aug 17.

Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Jinan University, Zhuhai 51900, China.

() infection causes severe zoonotic toxoplasmosis, which threatens the safety of almost one-third of the human population globally. However, there is no effective protective vaccine against human toxoplasmosis. This necessitates anti- vaccine development, which is a main priority of public health. Read More

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September 2021

Chronic infection enhances susceptibility to colitis.

Proc Natl Acad Sci U S A 2021 09;118(36)

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110;

Oral infection with results in dysbiosis and enteritis, both of which revert to normal during chronic infection. However, whether infection leaves a lasting impact on mucosal responses remains uncertain. Here we examined the effect of the chemical irritant dextran sodium sulfate (DSS) on intestinal damage and wound healing in chronically infected mice. Read More

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September 2021

Evaluation of the Tyrosine and Dopamine Serum Levels in Experimental Infected BALB/c Mice with Chronic Toxoplasmosis.

J Parasitol Res 2021 17;2021:5511516. Epub 2021 Aug 17.

Department of Parasitology and Mycology, Medicine Faculty, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: parasite alters the transduction of neurotransmitter signals and leads to changes in the level of brain neurotransmitters including tyrosine and dopamine, so behavior changes can occur in infected hosts. Based on this concept, this study was conducted for evaluation of the tyrosine and dopamine serum levels in infected mice with chronic toxoplasmosis.

Materials And Methods: (Prugniaud strain II) was injected intraperitoneally into BALB/c mice to induce chronic toxoplasmosis. Read More

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Infection in Urban and Rural Areas in the Amazon: Where Is the Risk for Toxoplasmosis?

Int J Environ Res Public Health 2021 08 17;18(16). Epub 2021 Aug 17.

Curso de Pós-graduação em Biologia de Agentes Infecciosos e Parasitários, Instituto de Ciências Biológicas da Universidade Federal do Pará, Belém 66075-110, Brazil.

Toxoplasmosis, an infection caused by , which is found worldwide, can affect human and animal health in different ways. This study aimed to estimate the infection prevalence in humans and to determine risk factors related to urban and rural areas in a municipality in the Brazilian Amazon where an outbreak had been registered. Blood samples for serological analysis were obtained, and interviews were performed to fill out an epidemiological questionnaire. Read More

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COVID-19-associated opportunistic infections: a snapshot on the current reports.

Clin Exp Med 2021 Aug 23. Epub 2021 Aug 23.

Department of Microbiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.

Treatment of the novel Coronavirus Disease 2019 (COVID-19) remains a complicated challenge, especially among patients with severe disease. In recent studies, immunosuppressive therapy has shown promising results for control of the cytokine storm syndrome (CSS) in severe cases of COVID-19. However, it is well documented that immunosuppressive agents (e. Read More

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Effect of Harmine Alkaloid and Its -Methyl Derivatives Against .

Front Microbiol 2021 5;12:716534. Epub 2021 Aug 5.

Laboratorio de Fotoquímica y Fotobiología Molecular, Instituto Tecnológico de Chascomús (INTECH), Universidad Nacional de San Martín (UNSAM) - Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Chascomús, Argentina.

Toxoplasmosis is one of the most prevalent and neglected zoonotic global diseases caused by . The current pharmacological treatments show clinical limitations, and therefore, the search for new drugs is an urgent need in order to eradicate this infection. Due to their intrinsic biological activities, β-carboline (βC) alkaloids might represent a good alternative that deserves further investigations. Read More

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3D holotomographic monitoring of Ca dynamics during ionophore-induced Neospora caninum tachyzoite egress from primary bovine host endothelial cells.

Parasitol Res 2021 Aug 13. Epub 2021 Aug 13.

Institute of Parasitology, Biomedical Research Center Seltersberg, Justus Liebig University Giessen, Schubertstr., 81, 35392, Giessen, Germany.

Neospora caninum represents an obligate intracellular parasite that belongs to the phylum Apicomplexa and is a major abortive agent in bovines. During merogony, N. caninum tachyzoites invade and proliferate in host cells in vivo, including endothelial cells of lymphatic and blood vessels. Read More

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Acute infection with Toxoplasma gondii oocysts preferentially activates non-neuronal cells expressing serotonin in the jejunum of rats.

Life Sci 2021 Oct 2;283:119872. Epub 2021 Aug 2.

Programa de Pós-graduação em Biociências e Fisiopatologia, Universidade Estadual de Maringá, Maringá, PR, Brazil.

The interaction of Toxoplasma gondii with the gastrointestinal tract of its host is highly regulated. Once ingested, the parasite crosses the epithelium without altering the permeability of the intestinal barrier. Nevertheless, many studies report alterations ranging from structural to functional damage in cells and tissues that make up the wall of the small and large intestine. Read More

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October 2021