17,123 results match your criteria gondii


Efficiency of a Single well IgG, IgM and IgA Anti T. gondii Fluorimetric Assay for Pre-natal Screening for Congenital Toxoplasmosis.

J Fluoresc 2022 Jan 15. Epub 2022 Jan 15.

Lab. Protozoology, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil.

Toxoplasmosis, worldwide protozoan disease, is usually benign, except when acute disease occurs in pregnant women, resulting in fetal infection with deaths or high morbidity after birth. Treatment blocks fetal infection or damage after infection, imposing a quick and effective diagnosis. Maternal infection is mostly asymptomatic thus regular serology are the main tool for detect seroconversion and acute infection in prenatal care. Read More

View Article and Full-Text PDF
January 2022

SAG3 Toxoplasma gondii cloning reveals unexpected fivefold infection in the blood of feral cats in the Mexican Caribbean.

BMC Vet Res 2022 Jan 14;18(1):33. Epub 2022 Jan 14.

Laboratorio de Inmunología Experimental, Instituto Nacional de Pediatría, Insurgentes Sur 3700-C, Colonia Insurgentes-Cuicuilco, Delegación Coyoacán, Insurgentes Sur 3700C, Col. Insurgentes Cuicuilco, C.P. 04530, Ciudad de México, México.

Background: Currently, more than 300 genotypes of Toxoplasma gondii (T. gondii) have been described throughout the world, demonstrating its wide genetic diversity. The SAG3 locus is one of the genes included in the genotyping panel of this parasite. Read More

View Article and Full-Text PDF
January 2022

Rapid detection of Toxoplasma gondii DNA in cat feces using colorimetric loop-mediated isothermal amplification (LAMP) assays targeting RE and B1 genes.

Comp Immunol Microbiol Infect Dis 2022 Jan 6;81:101745. Epub 2022 Jan 6.

Ege University, Vaccine Development Application and Research Center, Bornova, İzmir, Turkey; Ege University, Faculty of Medicine, Department of Parasitology, Bornova, İzmir, Turkey. Electronic address:

Toxoplasma gondii is an obligate protozoan parasite that can infect mammals and birds. Cats are the definitive host of T. gondii and have a very important role in transmission of toxoplasmosis due to the shedding of millions of unsporulated oocysts, that become infective in the environment. Read More

View Article and Full-Text PDF
January 2022

Immune response and pathogen invasion at the choroid plexus in the onset of cerebral toxoplasmosis.

J Neuroinflammation 2022 Jan 13;19(1):17. Epub 2022 Jan 13.

Institute of Inflammation and Neurodegeneration, Medical Faculty, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany.

Background: Toxoplasma gondii (T. gondii) is a highly successful parasite being able to cross all biological barriers of the body, finally reaching the central nervous system (CNS). Previous studies have highlighted the critical involvement of the blood-brain barrier (BBB) during T. Read More

View Article and Full-Text PDF
January 2022

Comparative analysis of ketone body metabolism in BALB/c mice infected with Trypanosoma evansi and Toxoplasma gondii.

Res Vet Sci 2021 Dec 20;143:134-141. Epub 2021 Dec 20.

Key Laboratory of Livestock Infectious Diseases, Ministry of Education, China; College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China. Electronic address:

KBs (ketone bodies), i.e., acetoacetate, acetone, and (R)-3-Hydroxybutanoate, constitute the intermediate products of the incomplete oxidative degradation of fatty acids. Read More

View Article and Full-Text PDF
December 2021

Toxoplasmosis impact on prematurity and low birth weight.

PLoS One 2022 13;17(1):e0262593. Epub 2022 Jan 13.

OBGYN dpt. Amedeana, Prague, Czech Republic.

Background: Toxoplasma gondii, one of the most common parasites, causes toxoplasmosis, one of the most frequent zoonotic diseases worldwide. T. gondii infects about one-third of the world's population. Read More

View Article and Full-Text PDF
January 2022

Diagnostic Value of Circulating Antigens in the Serum of Piglets with Experimental Acute Toxoplasmosis.

J Immunol 2022 Jan 12. Epub 2022 Jan 12.

Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, China

Toxoplasmosis, caused by , an apicomplexan parasite, infects all warm-blooded animals, including a third of the human population. Laboratory diagnosis of acute toxoplasmosis is based on the detection of anti- IgM and IgG and nucleic acid; however, these assays have certain limitations. Circulating Ags (CAgs) are reliable diagnostic indicators of acute infection. Read More

View Article and Full-Text PDF
January 2022

Efficient Gene Knockout and Knockdown Systems in Neospora caninum Enable Rapid Discovery and Functional Assessment of Novel Proteins.

mSphere 2022 Jan 12:e0089621. Epub 2022 Jan 12.

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angelesgrid.19006.3e, Los Angeles, California, USA.

The development of molecular genetics has greatly enhanced the study of the biology and pathology associated with parasites of the phylum Apicomplexa. While the molecular tools are highly developed for the apicomplexan Toxoplasma gondii, the closely related parasite Neospora caninum lacks efficient tools for genetic manipulation. To enable efficient homologous recombination in N. Read More

View Article and Full-Text PDF
January 2022

Contribution of Kazal-Like Domains of the Serine Protease Inhibitor-1 from Toxoplasma gondii in Asthma Therapeutic Vaccination Effectiveness.

Int Arch Allergy Immunol 2022 Jan 11:1-8. Epub 2022 Jan 11.

Universidad Nacional de San Martín, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Laboratorio de Inmunología, Vacunas y Alergia, CESyMA, ECyT, Buenos Aires, Argentina.

Background: We have previously showed rTgPI-1 tolerogenic adjuvant properties in asthma treatment, turning it a promising candidate for allergen-specific immunotherapy. This therapy is an alternative treatment to control asthma that still presents several concerns related to its formulation. rTgPI-1 contains independent inhibitory domains able to inhibit trypsin and neutrophil elastase, both involved in asthma pathology. Read More

View Article and Full-Text PDF
January 2022

PLGA Nanoparticles as an Efficient Platform in Protein Vaccines Against Toxoplasma gondii.

Authors:
Mojgan Allahyari

Acta Parasitol 2022 Jan 11. Epub 2022 Jan 11.

Recombinant Protein Production Department, Production and Research Complex, Pasteur Institute of Iran, Karaj, Iran.

Background: Toxoplasma gondii (T. gondii) as an obligatory intracellular is widespread all over the world and causes considerable concerns in immunocompromised patients by developing toxoplasmic encephalitis and in pregnancy because of serious consequences in the fetus. Although vaccination is the only approach to overcome toxoplasmosis, there is no commercially available human vaccine against T. Read More

View Article and Full-Text PDF
January 2022

Fatal Toxoplasma gondii myocarditis in an urban pet dog.

Vet Parasitol Reg Stud Reports 2022 Jan 3;27:100659. Epub 2021 Nov 3.

Plataforma de Investigación en Salud Animal, Instituto Nacional de Investigación Agropecuaria (INIA), Estación Experimental La Estanzuela, Ruta 50 km 11, La Estanzuela 70000, Colonia, Uruguay. Electronic address:

A 70-day-old Boxer dog from a household in Montevideo, Uruguay, died after presenting neurologic, respiratory, and gastrointestinal signs for 6 days. Autopsy findings included lymphadenomegaly, ascites and hepatomegaly. Histopathology revealed severe widespread lymphohistiocytic and plasmacytic myocarditis with cardiomyocyte necrosis, mineralization and numerous intrasarcoplasmic protozoa immunoreactive with anti-Toxoplasma gondii antisera on immunohistochemistry. Read More

View Article and Full-Text PDF
January 2022

Temporal transcriptomic changes in long non-coding RNAs and messenger RNAs involved in the host immune and metabolic response during Toxoplasma gondii lytic cycle.

Parasit Vectors 2022 Jan 10;15(1):22. Epub 2022 Jan 10.

College of Veterinary Medicine, Northwest A&F University, Yangling, 712100, Shaanxi, China.

Background: Long non-coding RNAs (lncRNAs) are important regulators of various biological and pathological processes, in particular the inflammatory response by modulating the transcriptional control of inflammatory genes. However, the role of lncRNAs in regulating the immune and inflammatory responses during infection with the protozoan parasite Toxoplasma gondii remains largely unknown.

Methods: We performed a longitudinal RNA sequencing analysis of human foreskin fibroblast (HFF) cells infected by T. Read More

View Article and Full-Text PDF
January 2022

Pathological Findings in Eurasian Otters () Found Dead between 2015-2020 in Schleswig-Holstein, Germany.

Animals (Basel) 2021 Dec 28;12(1). Epub 2021 Dec 28.

Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine Hannover, Foundation, 30559 Hannover, Germany.

In times of massive biodiversity loss and ongoing environmental crises, it is extremely important to ensure long-term conservation efforts of threatened species like Eurasian otters (). To gain insights into the status of Northern Germany's otter population, 92 otters found dead in Schleswig-Holstein between 2015-2020 were collected and underwent detailed dissection with the aim to establish a monitoring program for this population. Examinations followed a protocol especially designed for otters, including various biological data assessments and extended sampling. Read More

View Article and Full-Text PDF
December 2021

Systematic Analysis of Clemastine, a Candidate Apicomplexan Parasite-Selective Tubulin-Targeting Agent.

Int J Mol Sci 2021 Dec 22;23(1). Epub 2021 Dec 22.

Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.

Apicomplexan parasites, such as , spp., spp., and spp. Read More

View Article and Full-Text PDF
December 2021

The disease burden of ocular toxoplasmosis in Denmark in 2019: Estimates based on laboratory testing of ocular samples and on publicly available register data.

Parasite Epidemiol Control 2021 Nov 12;15:e00229. Epub 2021 Oct 12.

Laboratory of Parasitology, Department of Bacteria, Parasites & Fungi, Infectious Disease Preparedness, Statens Serum Institut, Copenhagen, Denmark.

Background: is an important zoonotic protozoan parasite with worldwide distribution. Information on the contribution of ocular toxoplasmosis to the disease burden caused by this parasite is limited or lacking from many countries.

Methods: We estimated the minimum occurrence of ocular toxoplasmosis in Denmark using results from direct detection of DNA with qPCR and determination of the Goldmann-Witmer coefficient on ocular samples submitted by ophthalmological clinics and departments to the national reference laboratory in 2003-2019. Read More

View Article and Full-Text PDF
November 2021

Inhibitory Effects of Polysaccharide on Inflammatory Response in Infected RAW264.7 Macrophages.

Evid Based Complement Alternat Med 2021 29;2021:2245496. Epub 2021 Dec 29.

Agricultural College of Yanbian University, Gongyuan Street, Yanji, Jilin 133002, China.

Our previous reports have shown that polysaccharide (IOP) has protective effects against () infection . The aim of the present research is to explore the anti-inflammatory effects of IOP and its mechanism in RAW264.7 macrophages infected by . Read More

View Article and Full-Text PDF
December 2021

Protective Effect Against Toxoplasmosis in Mice Vaccinated With Recombinant MIF, CDPK3, and 14-3-3 Protein Cocktail Vaccine.

Front Immunol 2021 22;12:755792. Epub 2021 Dec 22.

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.

can infect almost all endotherm organisms including humans and cause life-threatening toxoplasmosis in immunocompromised individuals, which leads to serious public health problems. Developing an excellent vaccine against this disease is impending. In present study, we formulated a cocktail protein vaccine including the TgMIF, TgCDPK3, and Tg14-3-3 proteins, which play critical roles in infection. Read More

View Article and Full-Text PDF
December 2021

Review on diagnosis and molecular characterization of Toxoplasma gondii in humans and animals.

Trop Biomed 2021 Dec;38(4):511-539

Department of Medicine, Faculty of Veterinary Medicine and Animal Science, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur 1706, Bangladesh.

Toxoplasma gondii is an obligate intracellular protozoon which causes toxoplasmosis, an important zoonotic disease that is endemic worldwide. Common sources of T. gondii infection in humans are food or water contaminated with oocysts and raw or undercooked meat with cysts. Read More

View Article and Full-Text PDF
December 2021

First report on molecular epidemiology, seasonality and phylogeny of Toxoplasma gondii infecting goats from Khanewal district in Punjab, Pakistan.

Acta Trop 2022 Jan 6;228:106304. Epub 2022 Jan 6.

Zoology Division, Institute of Pure and Applied Biology, Bahauddin Zakariya University Multan, 60800, Pakistan. Electronic address:

Raising small ruminants is the main source of income for farmers in Pakistan. Economic losses caused by Toxoplasma gondii to small ruminants have been reported worldwide, however reports on molecular detection of T. gondii are lacking in Pakistan despite a large goat population. Read More

View Article and Full-Text PDF
January 2022

Retrospective study of toxoplasmosis prevalence in pregnant women in Benin and its relation with malaria.

PLoS One 2022 7;17(1):e0262018. Epub 2022 Jan 7.

Université de Paris, MERIT, IRD, Paris, France.

Background: Globally distributed with variable prevalence depending on geography, toxoplasmosis is a zoonosis caused by an obligate intracellular protozoan parasite, Toxoplasma gondii. This disease is usually benign but poses a risk for immunocompromised people and for newborns of mothers with a primary infection during pregnancy because of the risk of congenital toxoplasmosis (CT). CT can cause severe damage to fetuses-newborns. Read More

View Article and Full-Text PDF
January 2022

Seroprevalence of Toxoplasma gondii infection from water buffaloes (Bubalus bubalis) in northeastern and southern Thailand.

Folia Parasitol (Praha) 2021 Dec 30;68. Epub 2021 Dec 30.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido, Japan.

Toxoplasmosis is a parasitic disease resulting from infection with the apicomplexan Toxoplasma gondii (Nicolle et Manceaux, 1908), one of the world's most common parasites in warm-blooded animals, including humans. Sources of infection can be exposed to infected cat faeces, mother-to-child transmission during pregnancy, and notably, the consumption of undercooked contaminated meat of intermediate hosts. In Thailand, water buffaloes are highly valued for rice cultivation, traditional culture and meat production. Read More

View Article and Full-Text PDF
December 2021

Prevalence of Toxoplasma gondii infection in chickens in China during 1993-2021: a systematic review and meta-analysis.

Parasitol Res 2022 Jan 6;121(1):287-301. Epub 2022 Jan 6.

College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.

Toxoplasma gondii is an important intracellular parasitic protozoan with a variety of hosts, including chickens, which poses a potential threat to public health. However, little is known regarding overall T. gondii infection in chickens in China. Read More

View Article and Full-Text PDF
January 2022

Primary Toxoplasma gondii infection-associated with hemophagocytic syndrome in a man with HIV infection: a case report.

BMC Infect Dis 2022 Jan 6;22(1):35. Epub 2022 Jan 6.

Department of Infectious Diseases, The First Affiliated Hospital of China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, China.

Background: Reactivation of latent Toxoplasma gondii (T. gondii) infection is more common than primary infection in patients with human immunodeficiency virus (HIV). We report a rare case of primary T. Read More

View Article and Full-Text PDF
January 2022

Prevalence of toxoplasmosis in patients infected with tuberculosis; a sero-molecular case-control study in northwest Iran.

Comp Immunol Microbiol Infect Dis 2021 Nov 18;81:101720. Epub 2021 Nov 18.

Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address:

In this study, we investigated the possible association between TB and Toxoplasma gondii infection. One hundred confirmed TB individuals living in northwest Iran were classified into three subgroups; newly diagnosed patients (NTB), old diagnosed patients (OTB) and multidrug resistance patients (MDR-TB). One hundred healthy subjects in the same age and sex distribution were ethnically matched. Read More

View Article and Full-Text PDF
November 2021

Geospatial epidemiology of Toxoplasma gondii infection in livestock, pets, and humans in China, 1984-2020.

Parasitol Res 2022 Jan 6. Epub 2022 Jan 6.

Ningxia Key Laboratory of Clinical and Pathogenic Microbiology, General Hospital of Ningxia Medical University, Yinchuan, 750004, China.

Undercooked or raw meat containing cyst-stage bradyzoites and oocyst-contaminated pets are presumed to constitute a major source of human toxoplasmosis. As the geospatial epidemiology of Toxoplasma gondii (T. gondii) infection in livestock, pets, and humans is rarely studied in China, we undertook a geospatial analysis using GIS visualization techniques. Read More

View Article and Full-Text PDF
January 2022

Anti-infection roles of miR-155-5p packaged in exosomes secreted by dendritic cells infected with Toxoplasma gondii.

Parasit Vectors 2022 Jan 6;15(1). Epub 2022 Jan 6.

Department of Pathogen Biology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, Guangdong Province, China.

Background: Toxoplasma gondii is a zoonotic intracellular protozoon that is estimated to infect about 30% of the world's population, resulting in toxoplasmosis in immunocompromised patients and adverse outcomes in cases of primary infection during pregnancy. Exosomes are tubular vesicles secreted by cells, and function in intercellular communication. It has been reported that the exosomes secreted by T. Read More

View Article and Full-Text PDF
January 2022

Dynamics of natural infection by Toxoplasma gondii in goat herds in the semiarid region of northeastern Brazil: transitional antibody observation.

Vet Res Commun 2022 Jan 5. Epub 2022 Jan 5.

Postgraduate Program in Animal Science, Federal University of Campina Grande (UFCG), Patos, Paraíba, Brazil.

This study aimed to describe the transmission of T. gondii in naturally infected goats in the semiarid region of northeastern Brazil, through evaluating the serological status of these animals from one to 12 months of age. Seven goat farms were selected. Read More

View Article and Full-Text PDF
January 2022

Associations between infection and steroid hormone levels in spotted hyenas.

Int J Parasitol Parasites Wildl 2022 Apr 29;17:53-59. Epub 2021 Nov 29.

Michigan State University, Department of Integrative Biology and Program in Ecology, Evolution and Behavior, MI, USA.

is a common parasite that infects warm-blooded animals and influences host physiology. is known to target the host's central nervous system, affecting circulating levels of steroid hormones, fear-related behaviors, and health, although these effects appear to vary among host taxa. Here, we investigated the relationship between infection and levels of plasma testosterone and cortisol within a wild population of spotted hyenas ( , n = 109). Read More

View Article and Full-Text PDF

[Update on toxoplasmosis in poultry farming].

Schweiz Arch Tierheilkd 2022 Jan;164(1):25-34

Institut für Parasitologie, Veterinärmedizinische Fakultät der Universität Leipzig.

Introduction: Toxoplasmosis is a worldwide occurring zoonosis caused by the obligate intracellular parasite Toxoplasma gondii (T. gondii). All warm-blooded species, including humans, serve as intermediate hosts. Read More

View Article and Full-Text PDF
January 2022

Sero-molecular survey on Toxoplasma gondii infection among drug addicted and non-addicted individuals: a case-control study.

BMC Infect Dis 2022 Jan 4;22(1):19. Epub 2022 Jan 4.

Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran.

Background: Up to now, epidemiological studies on the prevalence of Toxoplasma gondii infection among drug addicted individuals have been rarely performed. By designing an age and sex matched case-control study, we sought to determine the prevalence and associated factors with T. gondii infection in these population using serological and molecular techniques. Read More

View Article and Full-Text PDF
January 2022