27 results match your criteria gon-1

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Genetic interactions among ADAMTS metalloproteases and basement membrane molecules in cell migration in Caenorhabditis elegans.

PLoS One 2020 2;15(12):e0240571. Epub 2020 Dec 2.

Department of Bioscience, Kwansei Gakuin University, Sanda, Japan.

During development of the Caenorhabditis elegans gonad, the gonadal leader cells, called distal tip cells (DTCs), migrate in a U-shaped pattern to form the U-shaped gonad arms. The ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) family metalloproteases MIG-17 and GON-1 are required for correct DTC migration. Mutations in mig-17 result in misshapen gonads due to the misdirected DTC migration, and mutations in gon-1 result in shortened and swollen gonads due to the premature termination of DTC migration. Read More

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January 2021

The Role of Tissue Inhibitors of Metalloproteinases in Organ Development and Regulation of ADAMTS Family Metalloproteinases in .

Genetics 2019 06 16;212(2):523-535. Epub 2019 Apr 16.

Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai 980-8577, Japan.

Remodeling of the extracellular matrix supports tissue and organ development, by regulating cellular morphology and tissue integrity. However, proper extracellular matrix remodeling requires spatiotemporal regulation of extracellular metalloproteinase activity. Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family, including MIG-17 and GON-1, are evolutionarily conserved, secreted, zinc-requiring metalloproteinases. Read More

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The performance of immobilized Candida rugosa lipase on various surface modified graphene oxide nanosheets.

Int J Biol Macromol 2018 May 19;111:1166-1174. Epub 2018 Feb 19.

Department of Chemistry, University of Isfahan, Isfahan 81746-73441, Iran.

In this study, we have reported the synthesis of graphene oxide nanosheets (GON) and its functionalization with 2, 4, 6-trichloro-1, 3, 5-triazine (TCT) through two routes, (a) directly reaction of GON with TCT (GON-1), and (b) reaction of GON with pre-functionalized TCT with 3-aminopropyltriethoxysilane (APTS) (GON-2). Subsequently, GON, GON-1 and GON-2 have been used as supports for immobilization of Candida rugosa lipase (CRL). Several techniques such as XRD, SEM, EDS, UV-Vis, CHNS, FTIR and AFM were applied to characterize the nano-structures and success of synthesis, functionalization and CRL immobilization processes. Read More

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Loss of C. elegans GON-1, an ADAMTS9 Homolog, Decreases Secretion Resulting in Altered Lifespan and Dauer Formation.

PLoS One 2015 28;10(7):e0133966. Epub 2015 Jul 28.

Department of Physiology, Tokyo Women's Medical University School of Medicine, Tokyo, 162-8666, Japan; Tokyo Women's Medical University Institute for Integrated Medical Sciences (TIIMS), Tokyo Women's Medical University, Tokyo, 162-8666, Japan.

ADAMTS9 is a metalloprotease that cleaves components of the extracellular matrix and is also implicated in transport from the endoplasmic reticulum (ER) to the Golgi. It has been reported that an ADAMTS9 gene variant is associated with type 2 diabetes. The underlying pathology of type 2 diabetes is insulin resistance and beta-cell dysfunction. Read More

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Control of the basement membrane and cell migration by ADAMTS proteinases: Lessons from C. elegans genetics.

Matrix Biol 2015 May-Jul;44-46:64-9. Epub 2015 Jan 14.

Department of Bioscience, Kwansei Gakuin University, 2-1 Gakuen, Sanda 669-1337, Japan. Electronic address:

The members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of secreted proteins, MIG-17 and GON-1, play essential roles in Caenorhabditis elegans gonadogenesis. The genetic and molecular analyses of these proteinases uncovered novel molecular interactions regulating the basement membrane (BM) during the migration of the gonadal leader cells. MIG-17, which is localized to the gonadal BM recruits or activates fibulin-1 and type IV collagen, which then recruits nidogen, thereby inducing the remodeling of the BM that is required for directional control of leader cell migration. Read More

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Regulation of synaptic extracellular matrix composition is critical for proper synapse morphology.

J Neurosci 2014 Sep;34(38):12678-89

Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305 and

Synapses are surrounded by a layer of extracellular matrix (ECM), which is instrumental for their development and maintenance. ECM composition is dynamically controlled by proteases, but how the precise composition of the ECM affects synaptic morphology is largely unknown. Through an unbiased forward genetic screen, we found that Caenorhabditis elegans gon-1, a conserved extracellular ADAMTS protease, is required for maintaining proper synaptic morphology at the neuromuscular junction. Read More

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September 2014

Perlecan antagonizes collagen IV and ADAMTS9/GON-1 in restricting the growth of presynaptic boutons.

J Neurosci 2014 Jul;34(31):10311-24

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China, and

In the mature nervous system, a significant fraction of synapses are structurally stable over a long time scale. However, the mechanisms that restrict synaptic growth within a confined region are poorly understood. Here, we identified that in the C. Read More

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The secreted AdamTS-A metalloprotease is required for collective cell migration.

Development 2013 May 27;140(9):1981-93. Epub 2013 Mar 27.

Department of Cell Biology, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205-2196, USA.

Members of the ADAMTS family of secreted metalloproteases play crucial roles in modulating the extracellular matrix (ECM) in development and disease. Here, we show that ADAMTS-A, the Drosophila ortholog of human ADAMTS 9 and ADAMTS 20, and of C. elegans GON-1, is required for cell migration during embryogenesis. Read More

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Identification of a novel ADAMTS9/GON-1 function for protein transport from the ER to the Golgi.

Mol Biol Cell 2012 May 14;23(9):1728-41. Epub 2012 Mar 14.

Department of Physiology, Tokyo Women's Medical University School of Medicine, Tokyo 162-8666, Japan.

A disintegrin-like and metalloprotease with thrombospondin type I motif (ADAMTS9) is a member of the secreted metalloprotease family that is believed to digest extracellular matrix (ECM) proteins outside of cells. Its Caenorhabditis elegans orthologue, GON-1, is involved in ECM degradation and is required for gonad morphogenesis. ADAMTS9 and GON-1 have similar domain structures, and both have a unique C-terminal domain called the "GON domain," whose function remains unknown. Read More

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Tissue architecture in the Caenorhabditis elegans gonad depends on interactions among fibulin-1, type IV collagen and the ADAMTS extracellular protease.

Genetics 2012 Apr 31;190(4):1379-88. Epub 2012 Jan 31.

Department of Bioscience, Kwansei Gakuin University, Sanda, Hyogo 669-1337, Japan.

Molecules in the extracellular matrix (ECM) regulate cellular behavior in both development and pathology. Fibulin-1 is a conserved ECM protein. The Caenorhabditis elegans ortholog, FBL-1, regulates gonad-arm elongation and expansion by acting antagonistically to GON-1, an ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) family protease. Read More

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bHLH transcription factors regulate organ morphogenesis via activation of an ADAMTS protease in C. elegans.

Dev Biol 2007 Aug 25;308(2):562-71. Epub 2007 May 25.

RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan.

The ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) family of secreted metalloproteases plays important roles in animal development and pathogenesis. However, transcriptional regulation of ADAMTS proteins during development remains largely unexplored. Here we show that basic helix-loop-helix (bHLH) transcription factors regulate the expression of an ADAMTS protease that is required for gonad development in Caenorhabditis elegans. Read More

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Adamts9 is widely expressed during mouse embryo development.

Gene Expr Patterns 2005 Jun 20;5(5):609-17. Epub 2005 Apr 20.

Department of Biomedical Engineering and Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic Foundation (ND20), OH 44195, USA.

ADAMTS metalloproteases constitute a family of 19 secreted protein or proteoglycan processing enzymes. ADAMTS9 and its closest mammalian relative, ADAMTS20, are related to gon-1, a metalloprotease required for gonadal morphogenesis in Caenorhabditis elegans. Although expressed at generally low levels in embryonic subectodermal mesenchyme, ADAMTS20 is required for melanoblast colonization of skin. Read More

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Effect of plasminogen activator inhibitor-1 deficiency on nutritionally-induced obesity in mice.

Authors:
H Roger Lijnen

Thromb Haemost 2005 May;93(5):816-9

Center for Molecular and Vascular Biology, KU Leuven, Belgium.

Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activator. Recent studies in murine models have yielded apparently conflicting data on a potential role of PAI-1 in adipose tissue development and obesity. To reinvestigate this issue, we have rederived PAI-1 deficient (PAI-1(-/-)) and wild-type (WT) mice and generated true littermates in a 81. Read More

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Effect of matrix metalloproteinase inhibition on adipose tissue development.

Biochem Biophys Res Commun 2005 Apr;329(1):105-10

Center for Molecular and Vascular Biology, University of Leuven, Belgium.

The effect of Ro 28-2653, a synthetic matrix metalloproteinase (MMP) inhibitor, on adipose tissue development was studied in mice kept on a high fat diet (HFD). Five-week-old male wild-type (C57Bl/6J) mice were fed the HFD (42% kcal as fat, 20.1 kJ/g) and received daily p. Read More

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GON-1 and fibulin have antagonistic roles in control of organ shape.

Curr Biol 2004 Nov;14(22):2005-10

Department of Genetics, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

Most developing organs are surrounded by an extracellular matrix (ECM), which must be remodeled to accommodate growth and morphogenesis. In C. elegans, the GON-1 ADAMTS metalloprotease regulates both elongation and shape of the developing gonad . Read More

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November 2004

Organogenesis: cutting to the chase.

Curr Biol 2004 Nov;14(22):R948-50

Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.

Gonad morphogenesis in Caenorhabditis elegans requires two secreted proteases. Recent studies show that alterations of the extracellular matrix component fibulin-1 rescue gonadogenesis in the absence of these proteases. This finding is a critical step toward understanding the role of extracellular matrix in organogenesis. Read More

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November 2004

Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans.

PLoS Biol 2004 Oct 7;2(10):e289. Epub 2004 Sep 7.

The Henry Wellcome Building of Genomic Medicine, University of Oxford, Oxford, United Kingdom.

The von Hippel-Lindau (VHL) tumor suppressor functions as a ubiquitin ligase that mediates proteolytic inactivation of hydroxylated alpha subunits of hypoxia-inducible factor (HIF). Although studies of VHL-defective renal carcinoma cells suggest the existence of other VHL tumor suppressor pathways, dysregulation of the HIF transcriptional cascade has extensive effects that make it difficult to distinguish whether, and to what extent, observed abnormalities in these cells represent effects on pathways that are distinct from HIF. Here, we report on a genetic analysis of HIF-dependent and -independent effects of VHL inactivation by studying gene expression patterns in Caenorhabditis elegans. Read More

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October 2004

Genomic Object Net: I. A platform for modelling and simulating biopathways.

Appl Bioinformatics 2003 ;2(3):181-4

Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Genomic Object Net (GON) 1.0 is a software package for creating models and simulations of biopathways. Its core architecture employs the notion of a hybrid functional Petri net with extension (HFPNe). Read More

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A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutation.

Development 2003 Oct;130(19):4665-72

Genetics Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02476, USA.

Several features of the pigment defect in belted (bt) mutant mice suggest that it occurs as a result of a defect in melanocyte development that is unique from those described for other classical white-spotting mutations. We report here that bt mice carry mutations in Adamts20, a novel member of the ADAMTS family of secreted metalloproteases. Adamts20 shows a highly dynamic pattern of expression in the developing embryo that generally precedes the appearance of melanoblasts in the same region, and is not expressed in the migrating cells themselves. Read More

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October 2003

Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain.

J Biol Chem 2003 Apr 31;278(15):13382-9. Epub 2003 Jan 31.

Departamento de Bioquíimica y Biologíia Molecular, Facultad de Medicina, Instituto Universitario de Oncologíia, Universidad de Oviedo, 33006-Oviedo, Spain.

We have cloned a mouse brain cDNA encoding a new protein of the ADAMTS family (a disintegrin and metalloproteinase domain, with thrombospondin type-1 repeats), which has been called ADAMTS-20. This protein shows a domain organization similar to that described for other ADAMTSs including signal sequence, propeptide, metalloproteinase domain, disintegrin domain, central TS-1 motif, cysteine-rich region, and C-terminal TS module. However, this last module is more complex than that of other ADAMTSs, being composed of a total of 14 repeats. Read More

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Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1.

J Biol Chem 2003 Mar 3;278(11):9503-13. Epub 2003 Jan 3.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

We demonstrate that in humans, two metalloproteases, ADAMTS-9 (1935 amino acids) and ADAMTS-20 (1911 amino acids) are orthologs of GON-1, an ADAMTS protease required for gonadal morphogenesis in Caenorhabditis elegans. ADAMTS-9 and ADAMTS-20 have an identical modular structure, are distinct in possessing 15 TSRs and a unique C-terminal domain, and have a similar gene structure, suggesting that they comprise a new subfamily of human ADAMTS proteases. ADAMTS20 is very sparingly expressed, although it is detectable in epithelial cells of the breast and lung. Read More

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Development. A degrading way to make an organ.

Authors:
J Hardin

Science 2000 Jun;288(5474):2142-3

Department of Zoology and Program in Cellular and Molecular Biology, University of Wisconsin, 1117 West Johnson Street, Madison, WI 53706, USA.

Working out how organs form during embryonic development is a fascinating area of research. In a witty Perspective, Jeff Hardin describes new findings (Nishiwaki et al.) that reveal the many intricate steps needed for gonads to form in the worm C. Read More

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A metalloprotease disintegrin that controls cell migration in Caenorhabditis elegans.

Science 2000 Jun;288(5474):2205-8

PRESTO, Japan Science and Technology Corporation and Fundamental Research Laboratories, NEC Corporation, Miyukigaoka, Tsukuba 305-8501,

In Caenorhabditis elegans, the gonad acquires two U-shaped arms by the directed migration of its distal tip cells (DTCs) along the body wall basement membranes. Correct migration of DTCs requires the mig-17 gene, which encodes a member of the metalloprotease-disintegrin protein family. The MIG-17 protein is secreted from muscle cells of the body wall and localizes in the basement membranes of gonad. Read More

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The gon-1 gene is required for gonadal morphogenesis in Caenorhabditis elegans.

Dev Biol 1999 Dec;216(1):382-93

Program in Cell and Molecular Biology, University of Wisconsin-Madison, Madison, Wisconsin, 53706, USA.

In wild-type Caenorhabditis elegans, the gonad is a complex epithelial tube that consists of long arms composed predominantly of germline tissue as well as somatic structures specialized for particular reproductive functions. In gon-1 mutants, the adult gonad is severely disorganized with essentially no arm extension and no recognizable somatic structure. The developmental defects in gon-1 mutants are limited to the gonad; other cells, tissues, and organs appear to develop normally. Read More

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December 1999

A metalloprotease prepares the way.

Authors:
D G Moerman

Curr Biol 1999 Sep;9(18):R701-3

Department of Zoology 6270 University Boulevard University of British Columbia Vancouver, British Columbia, Canada V6T 1Z4,.

In the nematode Caenorhabditis elegans gonad shape and size is determined by the migration of a leader cell, which is at the tip of the growing gonad arm. A metalloprotease secreted by the leader cell has recently been found to play an essential role in this process, preparing the way ahead for the cell's migration. Read More

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September 1999

Control of cell migration during Caenorhabditis elegans development.

Curr Opin Cell Biol 1999 Oct;11(5):608-13

Program in Cell and Molecular Biology 433 Babcock Drive University of Wisconsin-Madison Madison, WI 53706, USA.

In Caenorhabditis elegans, cell migration is guided by localized cues, including molecules such as EGL-17/FGF and UNC-6/netrin. These external cues are linked to an intracellular response to migrate, at least in part, by CED-5, a homolog of DOCK180/MBC, and MIG-2, a Rac-like GTPase. In addition, metalloproteases are required for a cell migration that controls organ shape. Read More

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October 1999

Control of organ shape by a secreted metalloprotease in the nematode Caenorhabditis elegans.

Authors:
R Blelloch J Kimble

Nature 1999 Jun;399(6736):586-90

Program in Cell and Molecular Biology, University of Wisconsin-Madison, 53706, USA.

The molecular controls governing organ shape are poorly understood. In the nematode Caenorhabditis elegans, the gonad acquires a U-shape by the directed migration of a specialized 'leader' cell, which is located at the tip of the growing gonadal 'arm'. The gon-1 gene is essential for gonadal morphogenesis: in gon-1 mutants, no arm elongation occurs and somatic gonadal structures are severely malformed. Read More

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