J Biol Chem 2005 May 4;280(20):19689-94. Epub 2005 Apr 4.
Cellular Physiology Laboratory, Discovery Research Institute, RIKEN, Wako, Saitama, Japan.
Cdt1 is an essential component for the assembly of a pre-replicative complex. Cdt1 activity is inhibited by geminin, which also participates in neural development and embryonic differentiation in many eukaryotes. Although Cdt1 homologues have been identified in organisms ranging from yeast to human, geminin homologues had not been described for Caenorhabditis elegans and fungi. Read More