161,461 results match your criteria glutathione levelsmaterials

SlGSTE9 participates in the stability of chlorpyrifos resistance in Spodoptera litura.

Pest Manag Sci 2021 Aug 1. Epub 2021 Aug 1.

College of Resources and Environment, Henan Institute of Science and Technology, Xinxiang, 453003, Henan Province, China.

Background: Spodoptera litura is an important agricultural pest and has developed serious resistance to multiple insecticides. The resistance level to several insecticides is reported to be unstable, but the mechanism is less reported.

Results: Chlorpyrifos and phoxim resistance level in a field-collected population of S. Read More

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High risk of drug toxicity in social isolation stress due to liver dysfunction: Role of oxidative stress and inflammation.

Brain Behav 2021 Aug 1. Epub 2021 Aug 1.

Department of Neurosurgery, University Medical Center Tuebingen, Tuebingen, Germany.

Background: Previous studies have shown that social isolation stress (SIS) could associate with several systemic diseases; however, the role of SIS on liver dysfunction has yet to be established. This study aimed to investigate the effect of SIS on liver function and possible drug toxicity through liver inflammation and oxidative stress.

Methods: Male Naval Medical Research Institute mice in two groups of SIS and control were treated with typical anti-depressant and anxiolytic agents including fluoxetine, norfluoxetine, desipramine, and imipramine in both groups. Read More

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Glutathione produced by γ-glutamyl cysteine synthetase acts downstream of hydrogen to positively influence lateral root branching.

Plant Physiol Biochem 2021 Jul 28;167:68-76. Epub 2021 Jul 28.

College of Life Sciences, Laboratory Center of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, China; Center of Hydrogen Science, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address:

Hydrogen gas (H) mediation of lateral root (LR) branching was previously described. However, related signaling pathway is largely unexplored. In this study, we discovered that application with H using hydrogen-rich water, mimicking the responses of exogenous glutathione (GSH), not only enhanced GSH synthesis, but also induced tomato LR development. Read More

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Tetrahydroxy stilbene glycoside ameliorates Alzheimer's disease in APP/PS1 mice via glutathione peroxidase related ferroptosis.

Int Immunopharmacol 2021 Jul 29;99:108002. Epub 2021 Jul 29.

Department of Pharmacy, Xuanwu Hospital of Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing Engineering Research Center for Nervous System Drugs, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China. Electronic address:

Amyloid beta peptide (Aβ) has been confirmed to be an essential reason of Alzheimer's disease (AD) for a long time. Ferroptosis is a newly recognized oxidative cell death mechanism, which is highly related to AD. Recently, tetrahydroxy stilbene glycoside (TSG) has been beneficial in alleviating learning and memory of AD and aged mouse model. Read More

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Dopamine-loaded lipid based nanocarriers for intranasal administration of the neurotransmitter: a comparative study.

Eur J Pharm Biopharm 2021 Jul 29. Epub 2021 Jul 29.

Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.

Both dopamine (DA) loaded Solid Lipid Nanoparticles (SLN) and liposomes (Lip), designed for intranasal administration of the neurotransmitter as an innovative Parkinson disease treatment, were already characterized in vitro in some extent by us (Trapani et al., 2018a and Cometa et al., 2020, respectively). Read More

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Microencapsulated phytogenic in dog feed modulates immune responses, oxidative status and reduces bacterial (Salmonella and Escherichia coli) counts in feces.

Microb Pathog 2021 Jul 29:105113. Epub 2021 Jul 29.

Departamento de Zootecnia, UDESC, Chapecó, SC, Brazil. Electronic address:

Improving the health and immunity of pets is a concern of the guardians, while maintaining the health of the animals directly impacts the owners' health and public health. The objective of this study was to produce a dog feed containing a microencapsulated phytogenic blend, as well as determine the impact of the additive on animal health and its intestinal microbiota. The composition included microencapsulated thymol, carvacrol, and cinnamaldehyde, at 300 mg/kg of feed. Read More

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Host metabolic reprogramming in response to SARS-CoV-2 infection: A systems biology approach.

Microb Pathog 2021 Jul 29:105114. Epub 2021 Jul 29.

Centre for Computational Natural Sciences and Bioinformatics, International Institute of Information Technology, Hyderabad, 500032, India. Electronic address:

Understanding the pathogenesis of SARS-CoV-2 is essential for developing effective treatment strategies. Viruses hijack the host metabolism to redirect the resources for their replication and survival. The influence of SARS-CoV-2 on host metabolism is yet to be fully understood. Read More

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Neuronal death, glial reactivity, microglia activation, oxidative stress and bioenergetics impairment caused by intracerebroventricular administration of D-2-hydroxyglutaric acid to neonatal rats.

Neuroscience 2021 Jul 29. Epub 2021 Jul 29.

Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600, Prédio 21111, Porto Alegre, RS, 90035-003, Brazil; Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350, Porto Alegre, RS, 90035-007, Brazil. Electronic address:

D-2-hydroxyglutaric acid (D-2-HG) accumulates and is the biochemical hallmark of D-2-hydroxyglutaric acidurias (D-2-HGA) types I and II, which comprehend two inherited neurometabolic diseases with severe cerebral abnormalities. Since the pathogenesis of these diseases is poorly established, we tested whether D-2-HG could be neurotoxic to neonatal rats. D-2-HG intracerebroventricular administration caused marked vacuolation in cerebral cortex and striatum. Read More

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Antidepressant mechanism of catalpol: Involvement of the PI3K/Akt/Nrf2/HO-1 signaling pathway.

Eur J Pharmacol 2021 Jul 29:174396. Epub 2021 Jul 29.

College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China.

Catalpol is a major compound in Rehmanniae Radix with outstanding medicinal and nutritional values. Our previous studies have demonstrated catalpol's antidepressant effect, but its mechanisms remain unclear. This study aimed to explore the antidepressant mechanisms of catalpol via the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/nuclear factor E2-related factor 2(Nrf2)/heme oxygenase-1 (HO-1) pathway. Read More

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Metabolomics profiling for identification of potential biomarkers in chickens infected with avian leukosis virus subgroup J (ALV-J).

Res Vet Sci 2021 Jul 25;139:166-171. Epub 2021 Jul 25.

Guangdong Laboratory Animal Monitoring Institute, Guangdong Key Laboratory of Laboratory Animals, Guangzhou 510633, China.

There are currently no vaccines or effective drugs to prevent the disorders caused by avian leukosis virus subgroup J (ALV-J). Hence, it is critical to identify potential biomarkers in ALV-J-infected chickens to prevent ALV-J-induced disorders. We hypothesized that ALV-J infection alters metabolic profile in chickens. Read More

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Ginkgolide B protects against cognitive impairment in senescence-accelerated P8 mice by mitigating oxidative stress, inflammation and ferroptosis.

Biochem Biophys Res Commun 2021 Jul 28;572:7-14. Epub 2021 Jul 28.

Department of Neurology, Xuzhou Hospital Affiliated to Jiangsu University, Xuzhou, Jiangsu, 221005, China.

Alzheimer's disease (AD) is a destructive neurodegenerative disease that currently has no effective treatment option available. Ginkgolide B (GB) is a terpene lactone derivative of Ginkgo biloba that possesses neuroprotective effects in various diseases. The aim of the present study was to investigate whether GB protects against cognitive impairment in AD by mitigating oxidative stress, inflammation and ferroptosis using senescence-accelerated P8 (SAMP8) mice. Read More

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Discovery of 4-benzyloxy and 4-(2-phenylethoxy) chalcone fibrate hybrids as novel PPARα agonists with anti-hyperlipidemic and antioxidant activities: Design, synthesis and in vitro/in vivo biological evaluation.

Bioorg Chem 2021 Jul 16;115:105170. Epub 2021 Jul 16.

Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo 12622, Egypt. Electronic address:

In the current work, a series of novel 4-benzyloxy and 4-(2-phenylethoxy) chalcone fibrate hybrids (10a-o) and (11a-e) were synthesized and evaluated as new PPARα agonists in order to find new agents with higher activity and fewer side effects. The 2-propanoic acid derivative 10a and the 2-butanoic acid congener 10i showed the best overall PPARα agonistic activity showing E% values of 50.80 and 90. Read More

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Oxidized GAPDH transfers S-glutathionylation to a nuclear protein Sirtuin-1 leading to apoptosis.

Free Radic Biol Med 2021 Jul 28. Epub 2021 Jul 28.

Vascular Biology Section, Boston University School of Medicine, Boston, MA, USA.

Aims: S-glutathionylation is a reversible oxidative modification of protein cysteines that plays a critical role in redox signaling. Glutaredoxin-1 (Glrx), a glutathione-specific thioltransferase, removes protein S-glutathionylation. Glrx, though a cytosolic protein, can activate a nuclear protein Sirtuin-1 (SirT1) by removing its S-glutathionylation. Read More

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Copper metal-organic framework embedded carboxymethyl chitosan-g-glutathione/polyacrylamide hydrogels for killing bacteria and promoting wound healing.

Int J Biol Macromol 2021 Jul 28. Epub 2021 Jul 28.

Institute of Polymer Materials, School of Materials Science and Engineering, South China University of Technology, Guangzhou, Guangdong 510275, PR China. Electronic address:

Bacterial infection and its induced oxidative stress as major clinical challenge during wound healing call for an urgent response for the development of medical dressings with multi-functions, such as antioxidant and antibacterial. To meet this demand, copper metal organic framework nanoparticles (HKUST NPs) and carboxymethyl chitosan-g-glutathione (CMCs-GSH) were synthesized and characterized. By embedding HKUST NPs into PAM/CMCs-GSH hydrogel (AOH), we developed a novel hydrogel dressing (HKUST-Hs) with dual effects of antibacterial and antioxidant. Read More

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Impact of Cell Culture and Copper Dose on Gene Expression in Bovine Liver.

Biol Trace Elem Res 2021 Jul 31. Epub 2021 Jul 31.

Department of Animal Sciences, Colorado State University, Fort Collins, CO, USA.

The objectives of these experiments were to investigate (1) the relative abundance of transcripts for Cu-responsive genes in whole bovine liver vs. cultured hepatocytes and (2) the influence of Cu dose on the relative abundance of transcripts for Cu-responsive genes in cultured bovine hepatocytes. Experiment 1: Liver samples were obtained immediately post-mortem from one healthy Angus steer. Read More

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Ameliorative mechanisms of turmeric-extracted curcumin on arsenic (As)-induced biochemical alterations, oxidative damage, and impaired organ functions in rats.

Environ Sci Pollut Res Int 2021 Jul 31. Epub 2021 Jul 31.

Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresource, College of Tropical Crops, Hainan University, Haikou, Hainan, 570228, People's Republic of China.

Arsenic (As) is known for its carcinogenic and hepatorenal toxic effects causing serious health problems in human beings. Turmeric (Curcuma longa L.) extracted curcumin (Cur) is a polyphenolic antioxidant which has ability to combat hazardous environmental toxicants. Read More

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Telfairia occidentalis mitigates dextran sodium sulfate-induced ulcerative colitis in rats via suppression of oxidative stress, lipid peroxidation, and inflammation.

J Food Biochem 2021 Jul 31:e13873. Epub 2021 Jul 31.

Department of Biochemistry, University of Ilorin, Ilorin, Nigeria.

Ulcerative colitis (UC), a subcategory of inflammatory bowel diseases, affects more than 2 million people globally. This study sought to investigate the curative ability of aqueous leaf extract of Telfairia occidentalis (ATO) on dextran sodium sulfate (DSS)-mediated colitis in rats. UC was induced by 5% of DSS in drinking water, and the curative ability of ATO was assessed at 200 mg/kg by oral administration for 10 days. Read More

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Targeting redox metabolism of the maize-Azospirillum brasilense interaction exposed to arsenic-affected groundwater.

Physiol Plant 2021 Jul 30. Epub 2021 Jul 30.

Instituto de Investigaciones Agrobiotecnológicas - Consejo Nacional de Investigaciones Científicas y Técnicas (INIAB-CONICET), Departamento de Ciencias Naturales, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto (UNRC), Córdoba, Argentina.

Arsenic in groundwater constitutes an agronomic problem due to its potential accumulation in the food chain. Among the agro-sustainable tools to reduce metal(oid)s toxicity, the use of Plant Growth-Promoting Bacteria (PGPB) becomes important. For that, and based on previous results in which significant differences of As translocation were observed when inoculating maize plants with Az39 or CD Azospirillum strains, we decided to decipher the redox metabolism changes and the antioxidant system response of maize plants inoculated when exposed to a realistic arsenate (As ) dose. Read More

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Perfluorooctanoic acid exposure in early pregnancy induces oxidative stress in mice uterus and liver.

Environ Sci Pollut Res Int 2021 Jul 31. Epub 2021 Jul 31.

College of Traditional Chinese Veterinary Medicine, Hebei Agricultural University, Baoding, 071001, China.

This study aimed to explore the mechanism of perfluorooctanoic acid (PFOA) toxicity on the uterus and liver of mice during early pregnancy. Pregnant mice were given 0, 1, 5, 10, 20, and 40 mg/kg PFOA daily by gavage from gestational day (GD) 1-7 and sacrificed on GD 9. Subsequently, several toxicity parameters were evaluated, including the uterus and liver weights, liver and uterine indexes, histopathological changes of the liver and uterus, and levels of malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) in the liver. Read More

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Potential antioxidant effects of Narcissus tazetta phenolic compounds against cadmium chloride-induced hepatotoxicity in Swiss albino mice.

Environ Sci Pollut Res Int 2021 Jul 30. Epub 2021 Jul 30.

Laboratory of Plant Productivity and Environmental Constraints, LR18ES04, Department of Biology, Faculty of Sciences of Tunisia, University Tunis El Manar, 2092, Tunis, Tunisia.

Narcissus tazetta (Amaryllidaceae) is a medicinal plant widely used for cut flowers and potted ornamental plant in Tunisia flora. The current study evaluated the phenolic composition and antioxidant properties of its flower extracts and investigated its potential protective activity against cadmium chloride (CdCl)-induced hepatotoxicity in mice. Mice were divided into six groups of six each: group 1, serving as negative controls, received by intraperitoneal way only distilled water; group 2 received by intraperitoneal way CdCl (0. Read More

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Antioxidant Activities and Selenogene Transcription in the European Sea Bass (Dicentrarchus labrax) Liver Depend, in a Non-linear Manner, on the Se/Hg Molar Ratio of the Feeds.

Biol Trace Elem Res 2021 Jul 31. Epub 2021 Jul 31.

Research Center for Experimental Marine Biology and Biotechnology - Plentziako Itsas Estazioa (PiE), University of the Basque Country (UPV/EHU), Areatza 47, 48620, Plentzia, Bizkaia, Spain.

Feeding 3.9 and 6.7 mg Hg/kg (Se/Hg molar ratios of 0. Read More

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Evaluation of Nephrotoxicity in Oreochromis niloticus After Exposure to Aluminum Oxide Nanoparticles: Exposure and Recovery Study.

Bull Environ Contam Toxicol 2021 Jul 30. Epub 2021 Jul 30.

Department of Zoology, College of Science, King Saud University, P.O Box 145111, Riyadh, Saudi Arabia.

Nephrotoxic impacts of AlO nanoparticles (NPs) were studied in Oreochromis niloticus after seven days of exposure and fifteen days of recovery periods. Fish were classified as group I (dechlorinated water); group II (2 mg/L AlONPs); group III (4 mg/L AlONPs); group IV (8 mg/L AlONPs). Blood creatinine and uric acid levels showed marked increases in groups III and IV. Read More

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Antioxidant and anti-inflammatory response to curcumin supplementation in hemodialysis patients: A randomized, double-blind, placebo-controlled clinical trial.

Clin Nutr ESPEN 2021 Aug 24;44:136-142. Epub 2021 Jun 24.

Faculty of Nutrition, Federal University of Goias, Goiânia, GO, Brazil.

Background And Objectives: Hemodialysis (HD) patients are vulnerable to malnutrition and cardiovascular complications due to many factors, including oxidative stress and inflammation. Curcumin supplementation is associated with attenuation of proinflammatory cytokines and increased activity of antioxidant enzymes, but its effects in HD patients are unknown. This study aimed to evaluate the effect of curcumin supplementation on oxidative stress and inflammation in HD patients. Read More

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A nanoselenium-coating biomimetic cytomembrane nanoplatform for mitochondrial targeted chemotherapy- and chemodynamic therapy through manganese and doxorubicin codelivery.

J Nanobiotechnology 2021 Jul 30;19(1):227. Epub 2021 Jul 30.

Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, People's Republic of China.

The cell membrane is widely considered as a promising delivery nanocarrier due to its excellent properties. In this study, self-assembled Pseudomonas geniculate cell membranes were prepared with high yield as drug nanocarriers, and named BMMPs. BMMPs showed excellent biosafety, and could be more efficiently internalized by cancer cells than traditional red cell membrane nanocarriers, indicating that BMMPs could deliver more drug into cancer cells. Read More

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iTRAQ-based proteomic analysis of sperm reveals candidate proteins that affect the quality of spermatozoa from boars on plateaus.

Proteome Sci 2021 Jul 30;19(1). Epub 2021 Jul 30.

College of Animal Science, Tibet Agricultural and Animal Husbandry University, Linzhi, Tibet, 860000, P.R. China.

Background: Tibetan pigs (TP) exhibit heritable adaptations to their hypoxic environments as a result of natural selection. However, candidate proteins that affect the sperm quality of boars on plateaus have not yet been clearly investigated.

Methods: In this study, to reveal the candidate proteins that affect the quality of spermatozoa of boars on plateaus, we analyzed the sperm quality using computer-assisted semen analysis (CASA) system and reactive oxygen species (ROS) levels. Read More

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Ratiometric fluorescence and smartphone dual-mode detection of glutathione using carbon dots coupled with Ag+-triggered oxidation of o-phenylenediamine.

Nanotechnology 2021 Jul 30. Epub 2021 Jul 30.

College of Chemistry and Materials Science, Anhui Normal University, Huajin campus of Anhui Normal University, 189 Jiuhua South Road, Yijiang District, Wuhu City, Anhui Province, Wuhu, 241002, CHINA.

Developing ratiometric fluorescence and smartphone dual-mode bioanalysis methods is important but challenging. A ratiometric fluorescence method for determining glutathione (GSH) using carbon dots (CDs) and Ag+-triggered o‑phenylenediamine (OPD) oxidation is described here. Ag+ oxidizes OPD to give 2,3-diaminophenazine (oxOPD), which effectively quenches CD fluorescence at 436 nm through the inner filter effect and causes a new emission peak at 561 nm. Read More

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Molsidomine alleviates acetic acid-induced colitis in rats by reducing oxidative stress, inflammation and apoptosis.

Int Immunopharmacol 2021 Jul 27;99:108005. Epub 2021 Jul 27.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. Electronic address:

Ulcerative colitis (UC) is a subcategory of intestinal inflammatory bowel disease characterized by up-regulation of proinflammatory cytokines and oxidative stress. The current study was designed to assess the probable protective effect of the nitric oxide (NO) donor, molsidomine, in experimental colitis model in rats. Rats were haphazardly classified into four groups: control, acetic acid, acetic acid + molsidomine (1 mg/kg) and acetic acid + molsidomine (2 mg/kg). Read More

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Nitric oxide protects against ferroptosis by aborting the lipid peroxidation chain reaction.

Nitric Oxide 2021 Jul 27;115:34-43. Epub 2021 Jul 27.

Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, 2-2-2 Iidanishi, Yamagata, 990-9585, Japan.

Ferroptosis is a type of iron-dependent necrotic cell death, which is typically triggered by the depletion of intracellular glutathione (GSH), which is associated with increased lipid peroxidation. Nitric oxide (NO) is a highly reactive gaseous radical mediator with anti-oxidation properties that terminates lipid peroxidation reactions. In the current study, we report the anti-ferroptotic action of NOC18, an NO donor that spontaneously releases NO, in cells under various ferroptotic conditions in vitro. Read More

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Targeting the TLR4/NF-κB pathway in β-amyloid-stimulated microglial cells: A possible mechanism that oxysophoridine exerts anti-oxidative and anti-inflammatory effects in an in vitro model of Alzheimer's disease.

Brain Res Bull 2021 Jul 27;175:150-157. Epub 2021 Jul 27.

Department of Neurology, Lianshui People's Hospital Affiliated to Kangda College of Nanjing Medical University, Lianshui, Jiangsu Province, China. Electronic address:

β-amyloid (Aβ) accumulation is a major neuropathological characteristic of Alzheimer's disease (AD) and serves as an inflammatory stimulus for microglial cells. Oxysophoridine has multiple pharmacological effects, including anti-inflammatory and anti-oxidative activities. In view of this, the current study aimed to investigate the effects of oxysophoridine on Aβ-induced activation of microglial BV-2 cells. Read More

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Combined exposure to microplastics and zinc produces sex-specific responses in the water flea Daphnia magna.

J Hazard Mater 2021 Jul 16;420:126652. Epub 2021 Jul 16.

Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon 16419, South Korea. Electronic address:

Microplastics are ubiquitous environmental pollutants and a great threat to the aquatic environment. Due to their small size (ranging from 1 µm to 5 mm), microplastics be easily ingested by a wide range of organisms and can serve as a vector for various contaminants. In this study, additive or possible synergistic effects of microplastics and zinc were demonstrated through sex-specific alterations in behavior, redox status, and modulation of detoxification-related genes in Daphnia magna, with males being more sensitive than females with stronger modulations of antioxidant responses, particularly on glutathione S-transferases expressions. Read More

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