603,244 results match your criteria glucose uric

Evaluation of disease staging and chemotherapeutic response in non-small cell lung cancer from patient tumor-derived metabolomic data.

Lung Cancer 2021 Apr 15;156:20-30. Epub 2021 Apr 15.

Department of Pharmacology and Toxicology, University of Louisville, United States; James Graham Brown Cancer Center, University of Louisville, United States; Department of Bioengineering, University of Louisville, United States; Center for Predictive Medicine, University of Louisville, United States. Electronic address:

Objectives: Despite extensive effort, the search for clinically-relevant metabolite biomarkers for early detection, disease monitoring, and outcome prediction in lung cancer remains unfulfilled. Although biofluid evaluation has been explored, the complexity inherent in metabolite data and the dynamic discrepancy between metabolites in biofluids vs. tumor tissue have prevented conclusive results. Read More

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Blended polar/nonpolar peptide conjugate interferes with human insulin amyloid-mediated cytotoxicity.

Bioorg Chem 2021 Apr 9;111:104899. Epub 2021 Apr 9.

Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, UP, India; Centre for Nanoscience, Indian Institute of Technology Kanpur, Kanpur 208016, UP, India; Centre for Environmental Science & Engineering, Indian Institute of Technology Kanpur, Kanpur 208016, UP, India. Electronic address:

Insulin, a peptide hormone and a key regulator of blood glucose level, is routinely administered to type-I diabetic patients to achieve the required glycemic control. Insulin aggregation and ensuing amyloidosis has been observed at repeated insulin injection sites and in injectable formulations. The latter occurs due to insulin agglomeration during shipping and storage. Read More

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Glucose-mediated proliferation of a gut commensal bacterium promotes Plasmodium infection by increasing mosquito midgut pH.

Cell Rep 2021 Apr;35(3):108992

State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, PRC; Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200438, PRC. Electronic address:

Plant-nectar-derived sugar is the major energy source for mosquitoes, but its influence on vector competence for malaria parasites remains unclear. Here, we show that Plasmodium berghei infection of Anopheles stephensi results in global metabolome changes, with the most significant impact on glucose metabolism. Feeding on glucose or trehalose (the main hemolymph sugars) renders the mosquito more susceptible to Plasmodium infection by alkalizing the mosquito midgut. Read More

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Rapid detection of twenty-nine common Chinese glucose-6-phosphate dehydrogenase variants using a matrix-assisted laser desorption/ionization-time of flight mass spectrometry assay on dried blood spots.

Clin Biochem 2021 Apr 18. Epub 2021 Apr 18.

Department of Pediatric Endocrinology and Genetics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute for Pediatric Research, Shanghai, 200092, China; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China. Electronic address:

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common inherited disease. Current neonatal screening methods for G6PD deficiency primarily rely on the use of biochemical tests. However, only 15%-20% of female carriers were estimated to have been detected using these tests. Read More

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Copeptin and stress-induced hyperglycemia in critically ill patients: A prospective study.

PLoS One 2021 21;16(4):e0250035. Epub 2021 Apr 21.

Post-Graduate Program in Medical Sciences: Endocrinology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.

Objectives: Copeptin, an equimolar indicator of serum antidiuretic hormone levels, has been associated with higher mortality in critically ill patients and with the development of diabetes in the general population. The aim of the present study was to investigate the association of copeptin levels with glycemic parameters in critically ill patients and to compare the time-course of copeptin in survivors and non-survivors.

Design: Prospective cohort study. Read More

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Use of hemoglobin A1c to identify dysglycemia in cystic fibrosis.

PLoS One 2021 21;16(4):e0250036. Epub 2021 Apr 21.

University of Massachusetts Medical School, Worcester, MA, United States of America.

Background: Cystic fibrosis (CF) leads to pancreatic endocrine dysfunction with progressive glycemic disturbance. Approximately 30%-50% of people with CF eventually develop CF-related diabetes (CFRD). Pre-CFRD states progress from indeterminant glycemia (INDET) to impaired fasting glucose (IFG) or impaired glucose tolerance (IGT). Read More

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Obesity, insulin resistance and their interaction on liver enzymes.

PLoS One 2021 21;16(4):e0249299. Epub 2021 Apr 21.

Department of Health Management, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Introduction: To investigate weight status, insulin resistance assessed by HOMA-IR, and their interaction on liver function in non-diabetic Chinese adults.

Methods And Results: A total of 7066 subjects were included, and divided into normal weight (n = 3447), overweight (n = 2801), and obese (n = 818) groups. Data including weight, height, waist circumference, fasting blood glucose, fasting insulin, total cholesterol, triglycerides, y-glutamyl transferase (GGT), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were acquired. Read More

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A New Stochastic Approach for Modeling Glycemic Disturbances in Type 2 Diabetes.

IEEE Trans Biomed Eng 2021 Apr 21;PP. Epub 2021 Apr 21.

Objective: To improve insulin treatment in type 2 diabetes (T2D) using model-based control techniques, the underlying model needs to be individualized to each patient. Due to the impact of unknown meals, exercise and other factors on the blood glucose, it is difficult to utilize available data from continuous glucose monitors (CGMs) for model fitting and parameter estimation purposes.

Methods: To overcome this problem, we propose a novel method for modeling the glycemic disturbances as a stochastic process. Read More

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Retinoprotective Effects of Crocin and Crocetin via Anti-angiogenic Mechanism in High Glucose-Induced Human Retinal Pigment Epithelium Cells.

Curr Mol Pharmacol 2021 Apr 19. Epub 2021 Apr 19.

Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Diabetic retinopathy (DR) is one of the most common side effects of diabetes. We aimed to investigate the effects of crocin and crocetin (as a deglycosylated form of crocin in blood stream) in gene expression or protein levels of vascular endothelial growth factor (VEGF), vascular endothelial growth factor-receptor1 (VEGFR-1), matrix metalloproteinases2 (MMP-2), matrix metalloproteinases9 (MMP-9) and thrombospondin-2 (TSP-2) in high glucose cell culture media.

Methods: The retinal pigment epithelium (RPE) cells were exposed to high glucose (HG, 30 mM glucose concentration) and normal glucose (NG, 24. Read More

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d-Glucose Isomerization with PAMAM Dendrimers as Environmentally Friendly Catalysts.

J Agric Food Chem 2021 Apr 21. Epub 2021 Apr 21.

Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China.

The isomerization of d-glucose to d-fructose plays a key role in the biochemical and chemical conversion of biomass, and it is therefore desirable to develop and improve catalysts for this reaction. In this study, the environmentally friendly polymer poly(amidoamine) (PAMAM) dendrimer's properties as catalysts for this isomerization are investigated. The experimental results showed that the PAMAM dendrimers, which have basic terminal groups, can effectively promote the d-glucose isomerization reaction. Read More

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Naturally Occurring Exopolysaccharide Nanoparticles: Formation Process and Their Application in Glutathione Detection.

ACS Appl Mater Interfaces 2021 Apr 21. Epub 2021 Apr 21.

Department of Chemical Engineering, University of New Brunswick, Fredericton, New Brunswick E3B 5A3, Canada.

Naturally occurring nanoscale exopolysaccharide (EPS) has attracted much attention in recent years. In this research, we obtained a new kind of naturally occurring spherical EPS nanoparticles (EPS-R503) from R503. The secretion, self-assembly process, morphological structure, and surface characteristics of the as-prepared nanoparticles were comprehensively revealed with transmission electron microscopy (TEM) and atomic force microscope (AFM) for the first time. Read More

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Diabetes Obes Metab 2021 Apr 21. Epub 2021 Apr 21.

Center for Drug Safety and Effectiveness, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Importance: Tens of millions of individuals in the United States have Type 2 diabetes, and most require treatment with glucose-lowering medications to manage the disease.

Objective: To examine trends in non-insulin drug treatment of Type 2 diabetes, including first-line and second-line therapies on top of metformin, from 2015 to 2019.

Design, Setting And Participants: We conducted a descriptive analysis of cross-sectional data using the IQVIA National Disease and Therapeutic Index (NDTI), a nationally representative audit of ambulatory physician practices in the United States. Read More

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Mechanism of miR-365 in regulating BDNF-TrkB signal axis of HFD/STZ induced diabetic nephropathy fibrosis and renal function.

Int Urol Nephrol 2021 Apr 21. Epub 2021 Apr 21.

Department of Endocrinology, Hengdian Wenrong Hospital, 99 Yingbin Road, Dongyang, 322118, Zhejiang, China.

Purpose: Diabetic nephropathy (DN) is one of the most serious complications of diabetes that leads to decline of renal function. Although numerous studies have revealed that microRNAs (miRNAs) play essential roles in the progression of DN, whether miR-365 is involved remains elusive.

Methods: The successful construction of DN model was confirmed by ELSIA, hematoxylin-eosin (HE) and Masson staining assay. Read More

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Adipose-Derived Mesenchymal Stem Cells-Derived Exosomes Carry MicroRNA-671 to Alleviate Myocardial Infarction Through Inactivating the TGFBR2/Smad2 Axis.

Inflammation 2021 Apr 21. Epub 2021 Apr 21.

Department of Cardiology, Tianjin Medical University General Hospital, NO. 154, Anshan Street, Heping District, Tianjin, 300052, People's Republic of China.

Mesenchymal stem cells (MSCs) and their derived extracellular vesicles have been reported as promising tools for the management of heart disease. The aim of this study was to explore the function of adipose-derived MSCs (adMSCs)-derived exosomes (Exo) in the progression of myocardial infarction (MI) and the molecules involved. Mouse cardiomyocytes were treated with oxygen-glucose deprivation (OGD) to mimic an MI condition in vitro. Read More

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An endophytic Schizophyllum commune Fr. exhibits in-vitro and in-vivo antidiabetic activity in streptozotocin induced diabetic rats.

AMB Express 2021 Apr 21;11(1):58. Epub 2021 Apr 21.

Department of Microbiology, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.

The present study aimed at isolation of endophytic basidiomycetous fungi and evaluation of their in-vitro and in-vivo antidiabetic potential. Preliminary screening for in-vitro activity was carried out using α-glucosidase inhibition assay. An endophytic isolate Sch1 (isolated from Aloe vera), identified to be Schizophyllum commune Fr. Read More

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Streptomyces brasiliscabiei, a new species causing potato scab in south Brazil.

Antonie Van Leeuwenhoek 2021 Apr 21. Epub 2021 Apr 21.

Laboratório de Bacteriologia Vegetal, Instituto Biológico, Centro Avançado em Proteção de Plantas e Sanidade Animal-CAPSA, Alameda Dos Vidoeiros, 1097, Gramado, Campinas, SP, CEP:13101-680, Brazil.

This study aimed to characterize six Streptomyces strains associated with potato scab in south Brazil through polyphasic taxonomy involving morphology, pathogenicity and genetic features. These strains were compared with other potato-scab Streptomyces species mainly S. europaeiscabiei, S. Read More

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Physiological performance of Kazachstania unispora in sourdough environments.

World J Microbiol Biotechnol 2021 Apr 21;37(5):88. Epub 2021 Apr 21.

Dipartimento di Scienze per gli Alimenti, la Nutrizione e l'Ambiente, Università degli Studi di Milano, Milan, Italy.

In this work we explored the potential of several strains of Kazachstania unispora to be used as non-conventional yeasts in sourdough fermentation. Properties such as carbohydrate source utilization, tolerance to different environmental factors and the performance in fermentation were evaluated. The K. Read More

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Liver circadian clock disruption alters perivascular adipose tissue gene expression and aortic function in mice.

Am J Physiol Regul Integr Comp Physiol 2021 Apr 21. Epub 2021 Apr 21.

Medicine, University of Alabama at Birmingham, United States.

The liver plays a central role that influences cardiovascular disease outcomes through regulation of glucose and lipid metabolism. It is recognized that the local liver molecular clock regulates some liver-derived metabolites. However, it is unknown whether the liver clock may impact cardiovascular function. Read More

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Dietary fat and low fiber in purified diets differently impact the gut-liver axis to promote obesity-linked metabolic impairments.

Am J Physiol Gastrointest Liver Physiol 2021 Apr 21. Epub 2021 Apr 21.

Université Laval.

Purified high-fat diets are commonly used to promote obesity and metabolic disturbances in animal models. However, most studies also use unpurified chow (low in fat, high in fiber content) as a "healthy" diet which can impact gut health. Here, we investigated the impact of feeding chow or purified diets varying in fat content on metabolic and intestinal functions in relation with temporal changes in gut microbiota composition. Read More

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A yeast FRET biosensor enlightens cAMP signalling.

Mol Biol Cell 2021 Apr 21:mbcE20050319. Epub 2021 Apr 21.

Systems Biology Lab/AIMMS, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands.

The cAMP-PKA signalling cascade in budding yeast regulates adaptation to changing environments. We developed yEPAC, a FRET-based biosensor for cAMP measurements in yeast. We used this sensor with flow cytometry for high-throughput single cell-level quantification during dynamic changes in response to sudden nutrient transitions. Read More

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A Weight-of-the-Evidence Approach for Evaluating, in Lieu of Animal Studies, the Potential of a Novel Polysaccharide Polymer to Produce Lung Overload.

Chem Res Toxicol 2021 Apr 21. Epub 2021 Apr 21.

IFF, 200 Powder Mill Road, Bldg. 353, Wilmington, Delaware 19803, United States.

The United States Environmental Protection Agency (EPA) is concerned about the respiratory effects caused by respirable particles of water-insoluble high molecular weight polymers. The EPA has proposed a tiered approach to evaluate polymer lung overload, a kinetic event. Kinetic polymer lung overload in itself is not necessarily adverse, however, inhalation of respirable particulate matter can have adverse effects (i. Read More

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Pharmacoepidemiol Drug Saf 2021 Apr 21. Epub 2021 Apr 21.

Clinical Pharmacology, Pharmacy and Environmental Medicine, University of Southern Denmark.

Purpose: Sodium-glucose cotransporter-2 inhibitors (SGLT2-I) are frequently used in type 2 diabetes and have recently been associated with lower rates of gout compared to glucagon-like peptide-1 receptor agonists (GLP1-RA). Our objective was to assess the association of SGLT2-I and gout using a cohort study design and a symmetry analysis.

Methods: Using the Danish nationwide health registries, we conducted an active comparator, new user cohort study comparing the 3-year risk of gout among SGLT2-I users with propensity score matched GLP1-RA users. Read More

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Tissue metabolic profiling reveals major metabolic alteration in colorectal cancer.

Mol Omics 2021 Apr 20. Epub 2021 Apr 20.

The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, 710032, China.

Metabolic reprogramming is a hallmark of cancer, which is still far from being fully understood in colorectal cancer. In order to characterize the metabolic changes in colorectal cancer, we performed metabolomics analysis of paired colon tissues from colorectal cancer patients by using a liquid chromatography-mass spectrometry (LC-MS)-based method. Bioinformation analysis was used to define important metabolites and metabolic pathways, as well as the prognosis significance and expression levels of the key molecules. Read More

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The effects of rice bran oil on left ventricular systolic function, cardiometabolic risk factors and inflammatory mediators in men with coronary artery disease: a randomized clinical trial.

Food Funct 2021 Apr 21. Epub 2021 Apr 21.

Department of Food Science and Technology, Faculty of Agricultural Sciences, University of Guilan, Rasht, Iran.

Background/objective: In the current study, we aimed to explore the effects of rice bran oil (RBO) in adjunct to conventional medical therapy on left ventricular ejection fraction (LVEF), cardiometabolic risk factors, and inflammatory mediators in male patients with coronary artery disease (CAD).

Subjects/methods: The present randomized controlled trial included 40 men diagnosed with CAD (mean age = 55.76 years) who were randomly allocated into two groups to receive either 30 grams per day of RBO (intervention group) or sunflower oil (control group) plus a standard diet for eight weeks. Read More

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A dual-catalytic nanoreactor for synergistic chemodynamic-starvation therapy toward tumor metastasis suppression.

Biomater Sci 2021 Apr 21. Epub 2021 Apr 21.

College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China.

Tumor metastasis is extremely deadly for cancer patients and developing effective treatments for deep metastatic tumors remains a major challenge. In this study, we demonstrated a dual-catalytic nanoreactor for tumor metastasis suppression by synergistic Fenton reaction activated chemodynamic therapy (CDT) and glucose oxidase (GOx) initiated starvation therapy. GOx on the surface of hollow mesoporous silica nanoparticles can catalyze the decomposition of intratumoral glucose to generate gluconic acid and H2O2, while Fe3O4 nanoparticles as a Fenton reaction catalyst can in situ catalyze H2O2 to produce highly toxic hydroxyl radicals (˙OH). Read More

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Faecal microbial metabolites of proteolytic and saccharolytic fermentation in relation to degree of insulin resistance in adult individuals.

Benef Microbes 2021 Apr 21:1-8. Epub 2021 Apr 21.

Human Biology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Universiteitssingel 40, 6229 ET Maastricht, the Netherlands.

The gut microbiota may affect host metabolic health through microbial metabolites. The balance between the production of microbial metabolites by saccharolytic and proteolytic fermentation may be an important determinant of metabolic health. Amongst the best-studied saccharolytic microbial metabolites are the short-chain fatty acids acetate, propionate and butyrate. Read More

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In Response to the Letter to the Editor on Minimizing Adverse Skin Reactions to Wearable Continuous Glucose Monitoring Sensors.

J Diabetes Sci Technol 2021 Apr 21:19322968211008241. Epub 2021 Apr 21.

Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.

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Arterial Platelet Adhesion in Atherosclerosis-Prone Arteries of Obese, Insulin-Resistant Nonhuman Primates.

J Am Heart Assoc 2021 Apr 21:e019413. Epub 2021 Apr 21.

Knight Cardiovascular Institute Portland OR.

Background Platelet-endothelial interactions are thought to contribute to early atherogenesis. These interactions are potentiated by oxidative stress. We used in vivo molecular imaging to test the hypothesis that platelet-endothelial interactions occur at early stages of plaque development in obese, insulin-resistant nonhuman primates, and are suppressed by NADPH-oxidase-2 inhibition. Read More

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Nanomechanics of Lignin-Cellulase Interactions in Aqueous Solutions.

Biomacromolecules 2021 Apr 21. Epub 2021 Apr 21.

Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 2V4, Canada.

Efficient enzymatic hydrolysis of cellulose in lignocellulose to glucose is one of the most critical steps for the production of biofuels. The nonproductive adsorption of lignin to expensive cellulase highly impedes the development of biorefinery. Understanding the lignin-cellulase interaction mechanism serves as a vital basis for reducing such nonproductive adsorption in their practical applications. Read More

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