68,691 results match your criteria glucose tolerance


Metabolic effects of one-week binge drinking and fast food intake during Roskilde Festival in young healthy male adults.

Eur J Endocrinol 2021 Apr 1. Epub 2021 Apr 1.

F Knop, Department of Clinical Medicine, University of Copenhagen, Kobenhavn, 1017, Denmark.

Aims/hypothesis: Metabolic effects of intermittent unhealthy lifestyle in young adults are poorly studied. We investigated the gluco-metabolic and hepatic effects of participation in Roskilde Festival (one week of binge drinking and junk food consumption) in young, healthy males.

Methods: Fourteen festival participants (FP) were studied before, during and after one week's participation in Roskilde Festival. Read More

View Article and Full-Text PDF

Interaction of supplementary L-carnitine and dietary energy levels on feed utilization and blood constituents in New Zealand White rabbits reared under summer conditions.

Trop Anim Health Prod 2021 Apr 22;53(2):279. Epub 2021 Apr 22.

Department of Animal Production, Faculty of Agriculture, Zagazig University, Zagazig, 44511, Egypt.

In the summer season, the harmful effects of high ambient temperatures on rabbit productivity have attained global interest. Therefore, the use of new nutritional strategies to improve heat tolerance in rabbits has become highly needed. In the current experiment, the effect of the addition of L-carnitine (LC) to normal (NE) or high-energy (HE) diets of growing rabbits reared under summer conditions on their productive performance, physiological indicators, and carcass characteristics was assessed. Read More

View Article and Full-Text PDF

β-cell function in black South African women: exploratory associations with insulin clearance, visceral and ectopic fat.

Endocr Connect 2021 Apr 1. Epub 2021 Apr 1.

J Goedecke, Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa.

The role of ectopic fat, insulin secretion and clearance in the preservation of β-cell function in black African women with obesity who typically present with hyperinsulinemia is not clear. We aim to examine the associations between disposition index (DI, an estimate of β-cell function), insulin secretion and clearance and ectopic fat deposition. This is a cross-sectional study of 43 black South African women (age 20-35 years) with obesity (BMI 30-40 kg/m2) and without type 2 diabetes that measured the following: DI, insulin sensitivity (SI), acute insulin response (AIRg), insulin secretion rate (ISR), hepatic insulin extraction and peripheral insulin clearance (frequently-sampled intravenous glucose tolerance test); pancreatic and hepatic fat, visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (aSAT) volume (magnetic resonance imaging), intramyocellular (IMCL) and extramyocellular fat content (EMCL) (magnetic resonance spectroscopy). Read More

View Article and Full-Text PDF

Resistance exercise training improves glucose homeostasis by enhancing insulin secretion in C57BL/6 mice.

Sci Rep 2021 Apr 21;11(1):8574. Epub 2021 Apr 21.

Obesity and Comorbidities Research Center, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.

Resistance exercise exerts beneficial effects on glycemic control, which could be mediated by exercise-induced humoral factors released in the bloodstream. Here, we used C57Bl/6 healthy mice, submitted to resistance exercise training for 10 weeks. Trained mice presented higher muscle weight and maximum voluntary carrying capacity, combined with reduced body weight gain and fat deposition. Read More

View Article and Full-Text PDF

Risk-based diabetes screening in a Hungarian general practice: comparison of laboratory methods and diagnostic criteria.

Prim Health Care Res Dev 2021 Apr 22;22:e17. Epub 2021 Apr 22.

Department of Nursing, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary.

Aim: Aim of cross-sectional study was to survey the risk of diabetes mellitus in a severely disadvantaged Hungarian community and then to use laboratory tests to screen for potential carbohydrate metabolism disorders among those in the moderate- and high-risk groups.

Background: The prevalence of diabetes mellitus shows a worrisome trend worldwide. Low socio-economic status significantly affects the development of diabetes, healthy life years and life expectancy. Read More

View Article and Full-Text PDF

Use of hemoglobin A1c to identify dysglycemia in cystic fibrosis.

PLoS One 2021 21;16(4):e0250036. Epub 2021 Apr 21.

University of Massachusetts Medical School, Worcester, MA, United States of America.

Background: Cystic fibrosis (CF) leads to pancreatic endocrine dysfunction with progressive glycemic disturbance. Approximately 30%-50% of people with CF eventually develop CF-related diabetes (CFRD). Pre-CFRD states progress from indeterminant glycemia (INDET) to impaired fasting glucose (IFG) or impaired glucose tolerance (IGT). Read More

View Article and Full-Text PDF

Physiological performance of Kazachstania unispora in sourdough environments.

World J Microbiol Biotechnol 2021 Apr 21;37(5):88. Epub 2021 Apr 21.

Dipartimento di Scienze per gli Alimenti, la Nutrizione e l'Ambiente, Università degli Studi di Milano, Milan, Italy.

In this work we explored the potential of several strains of Kazachstania unispora to be used as non-conventional yeasts in sourdough fermentation. Properties such as carbohydrate source utilization, tolerance to different environmental factors and the performance in fermentation were evaluated. The K. Read More

View Article and Full-Text PDF

Arterial Platelet Adhesion in Atherosclerosis-Prone Arteries of Obese, Insulin-Resistant Nonhuman Primates.

J Am Heart Assoc 2021 Apr 21:e019413. Epub 2021 Apr 21.

Knight Cardiovascular Institute Portland OR.

Background Platelet-endothelial interactions are thought to contribute to early atherogenesis. These interactions are potentiated by oxidative stress. We used in vivo molecular imaging to test the hypothesis that platelet-endothelial interactions occur at early stages of plaque development in obese, insulin-resistant nonhuman primates, and are suppressed by NADPH-oxidase-2 inhibition. Read More

View Article and Full-Text PDF

Risk of Dysglycemia in Pregnancy amongst Kenyan Women with HIV Infection: A Nested Case-Control Analysis from the STRiDE Study.

J Diabetes Res 2021 5;2021:8830048. Epub 2021 Apr 5.

Division of Health Sciences, Warwick Medical School, University of Warwick, UK.

Introduction: Gestational diabetes is a common complication, whose incidence is growing globally. There is a pressing need to obtain more data on GDM in low- and middle-income countries, especially amongst high-risk populations, as most of the data on GDM comes from high-income countries. With the growing awareness of the role HIV plays in the progression of noncommunicable diseases and the disproportionate HIV burden African countries like Kenya face, investigating the potential role HIV plays in increasing dysglycemia amongst pregnant women with HIV is an important area of study. Read More

View Article and Full-Text PDF

Prevalence and Risk Factors of Gestational Diabetes Mellitus among Women Attending Antenatal Care in Hadiya Zone Public Hospitals, Southern Nation Nationality People Region.

Biomed Res Int 2021 5;2021:5564668. Epub 2021 Apr 5.

Department of Health Service Management, College of Medicine and Health Sciences, Wachemo University, Hossana, Ethiopia.

Introduction: In low- and middle-income countries, gestational diabetes mellitus is increasing globally; it is also a double burden of illness for both mothers and children. While gestational diabetes mellitus is recognized in Ethiopia, according to recent diagnostic criteria, information regarding it remains scarce.

Objective: To assess the prevalence of gestational diabetes mellitus and associated factors among women attending antenatal care in Hadiya Zone public Hospitals, Southern Ethiopia. Read More

View Article and Full-Text PDF

Glucagon-like peptide 1 and its association with dipeptidyl peptidase IV in subjects with various degrees of glucose tolerance.

Pak J Pharm Sci 2020 Nov;33(6(Supplementary)):2773-2778

Baqai Institute of Diabetology and Endocrinology, Karachi, Pakistan.

Dipeptidyl peptidase IV (DPP-4) and Glucagon like peptide 1 (GLP-1) has profound effect on insulin and glucagon secretion; ultimately decreasing glucose levels. We find out the association of GLP-1 levels and DPP-4 in normal, impaired and newly diagnose type 2 diabetic glucose tolerance. Prospective case control study was conducted at Department of Physiology, Baqai Medical University by the collaboration of Baqai Institute of Diabetology and Endocrinology; Karachi-Pakistan. Read More

View Article and Full-Text PDF
November 2020

Physicochemical characterization and the hypoglycemia effects of polysaccharide isolated from Sims peel.

Food Funct 2021 Apr 20. Epub 2021 Apr 20.

College of Chemistry and Bioengineering, Guilin University of Technology, Guilin, Guangxi 541006, China.

One polysaccharide, designated as WPEP-A, was isolated from Passiflora edulis Sims peel and its hypoglycemic effects on diabetic db/db mice were evaluated. Physicochemical characterization showed that WPEP-A was composed of galactose, glucose, xylose, rhamnose, galacturonic acid and glucuronic acid with a molecular weight of 9.51 × 104 Da. Read More

View Article and Full-Text PDF

Carbohydrates and water status in wheat plants under water stress.

New Phytol 1993 Nov;125(3):609-614

Department of Animal and Plant Sciences, University of Sheffield, P. O. Box 601, Sheffield S10 2UQ, UK.

Changes in sugar content during water stress and recovery were examined in leaves of two varieties of durum wheat (Triticutn durum). The drought-resistant Mohamed Ben Bachir (MBB) from Algeria and the drought-sensitive European variety Capdur differed in the time and type of sugar increase during water stress. Glucose accumulated at a rate closely corresponding with decreasing water potential but more rapidly and to a higher concentration in MBB than in Capdur. Read More

View Article and Full-Text PDF
November 1993

Glutathione status correlates with different degrees of desiccation tolerance in three lichens.

Authors:
Ilse Kranner

New Phytol 2002 May;154(2):451-460

Institute of Plant Physiology, University of Graz Schubertstraße 51, A-8010 Graz, Austria.

•  Glutathione-related mechanisms of coping with desiccation were studied in three lichens (Pseudevernia furfuracea, Peltigera polydactyla and Lobaria pulmonaria) with different degrees of tolerance. Reduced (GSH) and oxidised glutathione (GSSG), glutathione reductase (GR) and glucose-6-phosphate dehydrogenase (G6PDH) were measured during short- and long-term desiccation, and subsequent rehydration. •  Glutathione was analysed by HPLC, and enzymes by spectrophotometry. Read More

View Article and Full-Text PDF

Unconventional β-Glucosidases: A Promising Biocatalyst for Industrial Biotechnology.

Appl Biochem Biotechnol 2021 Apr 19. Epub 2021 Apr 19.

Symbiosis School of Biological Sciences, Symbiosis International (Deemed University), Lavale, Pune, 412115, India.

β-Glucosidases primarily catalyze removal of terminal glucosyl residues from a variety of glucoconjugates and also perform transglycosylation and reverse hydrolysis. These catalytic properties can be readily exploited for degradation of lignocellulosic biomass as well as for pharmaceutical, food and flavor industries. β-Glucosidases have been either isolated in the native form from the producer organism or recombinantly expressed and gaged for their biochemical properties and substrate specificities. Read More

View Article and Full-Text PDF

Erratum to: The fungal endophyte Epichloë gansuensis increases NaCl-tolerance in Achnatherum inebrians through enhancing the activity of plasma membrane H-ATPase and glucose-6-phosphate dehydrogenase.

Sci China Life Sci 2021 Apr 17. Epub 2021 Apr 17.

State Key Laboratory of Grassland Agro-ecosystems; Center for Grassland Microbiome; Key Laboratory of Grassland Livestock Industry Innovation; Ministry of Agriculture and Rural Affairs; Engineering Research Center of Grassland Industry; Ministry of Education; College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, 730000, China.

View Article and Full-Text PDF

Sexual dimorphism in the progression of type 2 diabetic kidney disease in T2DN rats.

Physiol Genomics 2021 Apr 19. Epub 2021 Apr 19.

Physiology, Medical College of Wisconsin, United States.

Diabetic kidney disease (DKD) is a common complication of diabetes, which frequently leads to end-stage renal failure and increases cardiovascular disease risk. Hyperglycemia promotes renal pathologies such as glomerulosclerosis, tubular hypertrophy, microalbuminuria, and a decline in glomerular filtration rate. Importantly, recent clinical data have demonstrated distinct sexual dimorphism in the pathogenesis of DKD in people with diabetes, which impacts both severity- and age-related risk factors. Read More

View Article and Full-Text PDF

Increased postprandial nonesterified fatty acid efflux from adipose tissue in prediabetes is offset by enhanced dietary fatty acid adipose trapping.

Am J Physiol Endocrinol Metab 2021 Apr 19. Epub 2021 Apr 19.

Medicine, Endocrinology department, Medicine Division,CHUS Research Center, Sherbrooke University, 3001 12th Avenue North, Sherbrooke, QC, J1H 5N4, Canada.

The mechanism of increased postprandial nonesterified fatty acid (NEFA) appearance in the circulation in impaired glucose tolerance (IGT) is due to increased adipose tissue lipolysis but could also be contributed to by reduced adipose tissue (AT) dietary fatty acid (DFA) trapping and increased 'spillover' into the circulation. Thirty-one subjects with IGT (14 women, 17 men) and 29 with normal glucose tolerance (NGT, 15 women, 14 men) underwent a meal test with oral and intravenous palmitate tracers and the oral [F]-fluoro-thia-heptadecanoic acid positron emission tomography method. Postprandial palmitate appearance (Ra) was higher in IGT vs. Read More

View Article and Full-Text PDF

Nicotinamide Protects Against Diet-Induced Body Weight Gain, Increases Energy Expenditure and Induces White Adipose Tissue Beiging.

Mol Nutr Food Res 2021 Apr 18:e2100111. Epub 2021 Apr 18.

Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau i Institut d'Investigació Biomèdica de l'Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain.

Scope: Interventions that boost NAD+ availability are of potential therapeutic interest for obesity treatment. The potential of nicotinamide (NAM), the amide form of vitamin B3 and a physiological precursor of NAD+, in preventing weight gain has not previously been studied in vivo. Other NAD+ precursors have been shown to decrease weight gain; however, their impact on adipose tissue was not addressed. Read More

View Article and Full-Text PDF

Foregut Exclusion Enhances Incretin and Insulin Secretion After Roux-en-Y Gastric Bypass in Adults with Type 2 Diabetes.

J Clin Endocrinol Metab 2021 Apr 19. Epub 2021 Apr 19.

Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Introduction: Patients with type 2 diabetes experience resolution of hyperglycemia within days after Roux-en-Y gastric bypass (RYGB) surgery. This is attributed, in part, to enhanced secretion of hindgut factors following exclusion of the gastric remnant and proximal intestine during surgery. However, evidence of the mechanisms of remission remain limited due to the challenges of metabolic evaluation during the early post-operative period. Read More

View Article and Full-Text PDF

Metabolic Control of Autoimmunity and Tissue Inflammation in Rheumatoid Arthritis.

Front Immunol 2021 2;12:652771. Epub 2021 Apr 2.

Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States.

Like other autoimmune diseases, rheumatoid arthritis (RA) develops in distinct stages, with each phase of disease linked to immune cell dysfunction. HLA class II genes confer the strongest genetic risk to develop RA. They encode for molecules essential in the activation and differentiation of T cells, placing T cells upstream in the immunopathology. Read More

View Article and Full-Text PDF

High Serum-Induced AhRL Is Associated with Prevalent Metabolic Syndrome and Future Impairment of Glucose Tolerance in the Elderly.

Endocrinol Metab (Seoul) 2021 Apr 19. Epub 2021 Apr 19.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Background: High circulating levels of dioxins and dioxin-like chemicals, acting via the aryl hydrocarbon receptor (AhR), have previously been linked to diabetes. We now investigated whether the serum AhR ligands (AhRL) were higher in subjects with metabolic syndrome (MetS) and in subjects who had developed a worsened glucose tolerance over time.

Methods: Serum AhRL at baseline was measured by a cell-based AhRL activity assay in 70-year-old subjects (n=911) in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Read More

View Article and Full-Text PDF

Broccoli microgreens juice reduces body weight by enhancing insulin sensitivity and modulating gut microbiota in high-fat diet-induced C57BL/6J obese mice.

Eur J Nutr 2021 Apr 17. Epub 2021 Apr 17.

College of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing, 210023, People's Republic of China.

Purpose: This study aimed to explore the protective effect of broccoli microgreens juice (BMJ) during C57BL/6J mice obesity development.

Methods: The obese model mice, induced by feeding high-fat diet (HFD), were treated with BMJ by gavage for 10 weeks. Melbine was gavaged at 300 mg/(kg bw)/d, as a positive control group. Read More

View Article and Full-Text PDF

Pyometra-associated insulin resistance assessment by insulin binding assay and tyrosine kinase activity evaluation in canine muscle tissue.

Domest Anim Endocrinol 2021 Mar 23;76:106626. Epub 2021 Mar 23.

Laboratório de Metabolismo e Endocrinologia Comparada, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Sarmento Leite 500, Porto Alegre - RS, Brazil. CEP: 90050-170.

Diestrus is associated with insulin resistance in bitches and pyometra can further impair insulin sensitivity. This study aimed to compare insulin sensitivity, insulin binding, and tyrosine kinase activity in bitches in anestrus, diestrus, or with pyometra. Patients submitted to elective ovariohysterectomy were divided into anestrus (n = 11) or diestrus (n = 13) according to reproductive history, vaginal cytology, and uterine histology. Read More

View Article and Full-Text PDF

Generalized anxiety disorder symptoms and type 2 diabetes onset: Findings from the Prospective Cooperative Health Research in the Region of Augsburg F4 and FF4 studies.

J Psychosom Res 2021 Mar 30:110480. Epub 2021 Mar 30.

Department of Psychosomatic Medicine and Psychotherapy, University of Gießen and Marburg, Germany; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD), Partner Helmholtz Zentrum München, Germany. Electronic address:

Objective: To investigate the association of generalized anxiety disorder (GAD) symptomology on the incidence of type 2 diabetes.

Research Design & Methods: Participants from the prospective KORA F4/FF4 German cohort were followed for a mean of 6.5 years. Read More

View Article and Full-Text PDF

Who should return for an oral glucose tolerance test? A proposed clinical pathway based on retrospective analysis of 332 children.

J Pediatr Endocrinol Metab 2021 Apr 15. Epub 2021 Apr 15.

Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong.

Objectives: Fasting plasma glucose or oral glucose tolerance test (OGTT) is the traditional diagnostic tool for type 2 diabetes (T2DM). However, fasting is required and implementation in all overweight/obese subjects is not practical. This study aimed to formulate a clinical pathway to stratify subjects according to their risk of abnormal OGTT. Read More

View Article and Full-Text PDF

Dietary-challenged mice with Alzheimer-like pathology show increased energy expenditure and reduced adipocyte hypertrophy and steatosis.

Aging (Albany NY) 2021 Apr 16;13. Epub 2021 Apr 16.

Department of Endocrinology and Metabolism, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 10117, Germany.

Alzheimer's disease (AD) is frequently accompanied by progressing weight loss, correlating with mortality. Counter-intuitively, weight loss in old age might predict AD onset but obesity in midlife increases AD risk. Furthermore, AD is associated with diabetes-like alterations in glucose metabolism. Read More

View Article and Full-Text PDF

Efficacy of Citrus maxima fruit segment supplemented paranthas in STZ induced diabetic rats.

J Food Sci 2021 Apr 16. Epub 2021 Apr 16.

Department of Fruit and Vegetable Technology, CSIR-Central Food Technological Research Institute, Mysuru, Karnataka, India.

The study was conducted to investigate the efficacy of Citrus maxima (Pomelo) fruit segments fortified paranthas compared to pomelo juice and naringin in streptozotocin-induced diabetic rats. The animals were divided into nine groups, Groups 1 to 3: negative control; Group 4: diabetic control; Groups 5 through 8: treatments with pomelo juice, naringin, plain paranthas, and pomelo supplemented paranthas; and Group 9 was positive control metformin. The groups were monitored for weight, oral glucose tolerance, insulin tolerance, bioavailability, biochemical parameters, and histopathological studies. Read More

View Article and Full-Text PDF

L-Theanine Activates the Browning of White Adipose Tissue through the AMPK/α-Ketoglutarate/Prdm16 Axis and Ameliorates Diet-induced Obesity in Mice.

Diabetes 2021 Apr 16. Epub 2021 Apr 16.

Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Biochemistry and Molecular Biology of School of Basic Medical, Sciences and Department of Endocrinology and Metabolism of Zhongshan Hospital, Fudan University, Shanghai 200032, China.

L-Theanine is a nonprotein amino acid with much beneficial efficacy. We found that intraperitoneal treatment of the mice with L-Theanine(100mg/kg/day) enhanced adaptive thermogenesis and induced the browning of inguinal white adipose tissue (iWAT) with elevated expression of Prdm16, Ucp1 and other thermogenic genes. Meanwhile, administration of the mice with L-Theanine increased energy expenditure. Read More

View Article and Full-Text PDF

Determinants of hepatic insulin clearance - results from a Mendelian Randomization study.

Metabolism 2021 Apr 13:154776. Epub 2021 Apr 13.

Department of Internal Medicine IV, Division of Endocrinology, Diabetology and Nephrology, University Hospital of Tübingen, Tübingen, Germany; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen (IDM), Tübingen, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany. Electronic address:

Aims/hypothesis: Besides insulin resistance, type 2 diabetes associates with decreased hepatic insulin clearance (HIC). We now tested for causal relationship of HIC to liver fat accumulation or features of the metabolic syndrome.

Methods: HIC was derived from oral glucose tolerance tests with the "Oral C-peptide and Insulin Minimal Models" (n = 3311). Read More

View Article and Full-Text PDF