80,467 results match your criteria glucose level

Relationship between the amino acid release kinetics of feed proteins and nitrogen balance in finishing pigs.

Animal 2021 Sep 15;15(10):100359. Epub 2021 Sep 15.

Key Laboratory of Animal Production, Product Quality and Security, Ministry of Education, Jilin Provincial Key Laboratory of Animal Nutrition and Feed Science, College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, PR China.

In current nutrition requirements of swine, although the protein diets are formulated based on the ileal digestibility of protein and amino acid (AA), there is a difference in nitrogen utilisation among various protein diets, which might be related to the AA release kinetics. To evaluate the relationship between AA release kinetics of feed proteins and nitrogen balance in finishing pigs, pigs were fed diets based on casein (CAS) or corn gluten meal (CGM) at normal or low-protein concentrations, and the AA release patterns were assessed. A 2 × 2 full factorial experimental design was used. Read More

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September 2021

Compound Tongluo Decoction inhibits endoplasmic reticulum stress-induced ferroptosis and promoted angiogenesis by activating the Sonic Hedgehog pathway in cerebral infarction.

J Ethnopharmacol 2021 Sep 15:114634. Epub 2021 Sep 15.

Department of Neurology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210001, Jiangsu province, PR China. Electronic address:

Ethnopharmacological Relevance: Cerebral infarction is one of the most common types of cerebrovascular diseases that threaten people's health. Compound Tongluo Decoction (CTLD), a traditional Chinese medicine formula, has various pharmacological activities, including the alleviation of cerebral infarction symptoms.

Aim Of The Study: This study aims to explore the potential mechanism by which CTLD alleviates cerebral infarction. Read More

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September 2021

Colonic inflammation induces changes in glucose levels through modulation of incretin system.

Pharmacol Rep 2021 Sep 17. Epub 2021 Sep 17.

Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6/8, 92-215, Lodz, Poland.

Background: The role of the incretin hormone, glucagon-like peptide (GLP-1), in Crohn's disease (CD), is still poorly understood. The aim of this study was to investigate whether colitis is associated with changes in blood glucose levels and the possible involvement of the incretin system as an underlaying factor.

Methods: We used a murine model of colitis induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS). Read More

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September 2021

Mothers' cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring.

Sci Rep 2021 Sep 17;11(1):18573. Epub 2021 Sep 17.

Laboratory of Neurobiology, Faculty of Veterinary Medicine and Animal Science, Poznan University of Life Sciences, Wojska Polskiego 71C, 60-625, Poznan, Poland.

"Western diet" containing high concentrations of sugar and fat consumed during pregnancy contributes to development of obesity and diabetes type 2 in offspring. To mimic effects of this diet in animals, a cafeteria (CAF) diet is used. We hypothesized that CAF diet given to rats before, and during pregnancy and lactation differently influences fat content, metabolic and inflammation profiles in offspring. Read More

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September 2021

Effects of Mobile Phone-based Telemedicine Management in Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial.

Am J Med Sci 2021 Sep 14. Epub 2021 Sep 14.

Departments of Nutriology. Electronic address:

Background: This study aims to explore the effect of mobile phone-based telemedicine management of glycemic control of type 2 diabetes mellitus (T2DM).

Methods: Patients with T2DM were followed up in Chongqing Jiulongpo District Yuzhoulu Community Health Center, and randomly divided into the telemedicine group (n=47) and the control group (n=50). The control group received regularly routine intervention. Read More

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September 2021

Association of serum proprotein convertase Subtilisin/Kexin Type 9 (PCSK9) level with thyroid function disorders.

Eur Rev Med Pharmacol Sci 2021 Sep;25(17):5511-5517

Department of Internal Medicine, University of Health Sciences, Malatya Training and Research Hospital, Malatya, Turkey.

Objective: We aimed at demonstrating the effect of thyroid function status on proprotein convertase subtilisin kexin type 9 (PCSK9) and determining the effect of thyroid hormones on lipid metabolism by comparing the PCSK9 levels of patients with subclinical hypothyroidism, overt hypothyroidism, and hyperthyroidism.

Patients And Methods: 124 patients with thyroid disorders, aged between 18 and 65 years, were included in this study. The participants were divided into 3 groups. Read More

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September 2021

Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study.

Diabetes Ther 2021 Sep 17. Epub 2021 Sep 17.

Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.

Introduction: Dulaglutide is a long-acting glucagon-like peptide 1 receptor agonist that is administered once weekly for the treatment of type 2 diabetes. However, the immediate glucose-lowering effect of dulaglutide after the first administration and the factors affecting the efficacy of the drug remain unclear.

Methods: This study was a retrospective and observational study of 80 subjects with type 2 diabetes conducted in a hospitalized setting. Read More

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September 2021

Why the diabetic heart is energy inefficient: A ketogenesis and ketolysis perspective.

Am J Physiol Heart Circ Physiol 2021 Sep 17. Epub 2021 Sep 17.

Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, United States.

Lack of glucose uptake compromises metabolic flexibility and reduces energy efficiency in the diabetes mellitus (DM) heart. Although increased utilization of fatty acid to compensate glucose substrate has been studied, less is known about ketone body metabolism in the DM heart. Ketogenic diet reduces obesity, a risk factor for T2DM. Read More

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September 2021

pH-Sensitive Polymeric Vesicles for GOx/BSO Delivery and Synergetic Starvation-Ferroptosis Therapy of Tumor.

Biomacromolecules 2021 Sep 17. Epub 2021 Sep 17.

Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, P. R. China.

Typical glucose oxidase (GOx)-based starvation therapy is a promising strategy for tumor treatment; however, it is still difficult to achieve an effective therapeutic effect via a single starvation therapy. Herein, we designed a pH-sensitive polymeric vesicle (PV) self-assembled by histamine-modified chondroitin sulfate (CS-his) for codelivery of GOx and l-buthionine sulfoximine (BSO). GOx can consume glucose to induce the starvation therapy after the PVs reach cancer cell. Read More

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September 2021

Omarigliptin protects against nonalcoholic fatty liver disease by ameliorating oxidative stress and inflammation.

J Biochem Mol Toxicol 2021 Sep 17:e22914. Epub 2021 Sep 17.

Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Nonalcoholic fatty liver disease (NAFLD) is a prevalent liver disease with high morbidity. Omarigliptin is a novel antidiabetic drug that inhibits dipeptidyl peptidase-4 and alleviates inflammation and insulin resistance. In the present study, the anti-inflammatory and antioxidative stress property of omarigliptin will be investigated to explore the potential therapeutic effects of omarigliptin on NAFLD in mice models. Read More

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September 2021

[Endoplasmic reticulum stress in hepatic stellate cells induced by tunicamycin promotes apoptosis and cell cycle arrest].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2021 Sep;37(9):794-800

Guizhou Provincial Key Laboratory of Pathogensis & Drug Research for Common Chronic Diseases, Department of Pathophysiology, College of Basic Medicine, Guizhou Medical University, Guiyang 550000, China. *Corresponding author, E-mail:

Objective To investigate the effect of endoplasmic reticulum stress (ERS) induced by tunicamycin on proliferation, activation, and apoptosis of HSC-T6 rat hepatic stellate cells and its possible mechanism. Methods With the expression level of glucose regulated protein 78 (GRP78) as an indicator to explore the optimal concentration and time, a cell model of tunicamycin-induced ERS in HSC-T6 cells was established. HSC-T6 cells were randomized into control group, treatment group with 1 mL/L of dimethyl sulfoxide (DMSO), and treatment group with 1 μg/mL of tunicamycin, and the cells were treated for 12 h. Read More

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September 2021

[Myokines and adipomyokines: inflammatory mediators or unique molecules of targeted therapy for obesity?]

Probl Endokrinol (Mosk) 2021 Aug 10;67(4):36-45. Epub 2021 Aug 10.

Endocrinology Research Center.

Skeletal muscles make up about 25% of the total mass in children and more than 40% in adults. Studies of the last twenty years have shown that along with the main functions, muscle tissue has hormonal activity. It was found that myocytes are able to release signaling molecules-myokines. Read More

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Long non-cording RNA XIST promoted cell proliferation and suppressed apoptosis by miR-423-5p/HMGA2 axis in diabetic nephropathy.

Mol Cell Biochem 2021 Sep 16. Epub 2021 Sep 16.

Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, 215006, Jiangsu, China.

This research studied the effect of long non-coding RNA X-inactive-specific transcript (XIST) on DN. The effect of high glucose (HG) on the expression of XIST and miR-423-5p was detected by quantitative real-time PCR (qRT-PCR) in human kidney (HK) cells (human glomerular mesangial cells (HMCs) and human kidney-2 (HK-2) cells). The effect of XIST depletion and miR-423-5p inhibition or overexpression on high mobility group protein A2 (HMGA2) protein level was examined by western blot in HG-induced HK cells. Read More

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September 2021

Evaluation of the Obesity Prevention, Blood Glucose, and Blood Lipid Control of Vietnamese Rice Varieties in High-Fat Diet-Induced Obese Mice.

Int J Food Sci 2021 7;2021:4880603. Epub 2021 Sep 7.

Ho Chi Minh City University of Technology and Education, Ho Chi Minh City, Vietnam.

Five Vietnamese rice varieties, which differ in their basic chemical composition (starch content, amylose content, fiber content) including polished rices and whole grain rices, were chosen for this study. High-fat diet-induced obesity, using these rice, was subjected to in vivo experiments to evaluate the effects of body weight gain, caloric intake, postprandial blood glucose level (PBGL), and glycemic index (GI) in tested mice groups. PBGL peaks appeared at 30 minute after eating, and GI of each experimental group was ranked in order as GN > TL > HR > GM > LĐ and GN > LT > HR > LĐ > GM, respectively, in which, brown rice (LĐ) and germinated brown rice (GM) had low GI. Read More

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September 2021

Factors Associated With Gestational Diabetes Mellitus: A Cross-Sectional Study.

Cureus 2021 Aug 11;13(8):e17113. Epub 2021 Aug 11.

Obstetrics and Gynaecology, Isra University, Hyderabad, PAK.

Introduction The absence of tolerance in the levels of carbohydrates at the onset or at the time of pregnancy amongst females is known as gestational diabetes mellitus (GDM). This study is designed to determine the frequency of GDM and factors responsible for GDM to assess the actual magnitude of the outcome. Furthermore, it allows for developing strategies to minimize morbidities and improve the pregnancy outcome by early diagnosis and timely management, which can help reduce the frequency of GDM. Read More

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Antidiabetic effects of the ethanolic extract of R.M. Fritsch on streptozotocin-induced diabetes in a mice model.

Food Sci Nutr 2021 Sep 18;9(9):4815-4826. Epub 2021 Jun 18.

Department of Basic Sciences and Pathobiology Faculty of Veterinary Medicine Razi University Kermanshah Iran.

Medicinal plants can protect different organs against diabetes-induced oxidative stress due to their antioxidant compounds. The present study was designed to investigate the potential of R.M. Read More

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September 2021

LncRNA SOX2OT is Upregulated in Gestational Diabetes Mellitus (GDM) and Correlated with Multiple Adverse Events.

Diabetes Metab Syndr Obes 2021 10;14:3989-3995. Epub 2021 Sep 10.

Department of Obstetrics and Gynecology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, 401147, People's Republic of China.

Purpose: LncRNA SOX2OT plays protective roles in high glucose-induced injuries, suggesting its potential involvement in diabetes. Therefore, we analyzed the role of SOX2OT in gestational diabetes mellitus (GDM).

Methods: A total of 216 pregnant women with a gestational age of about 2 months were enrolled in this study. Read More

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September 2021

Body mass index in relation to prostate-specific antigen-related parameters.

BMC Urol 2021 Sep 16;21(1):130. Epub 2021 Sep 16.

Health Management Centre, The First Affiliated Hospital of Army Medical University, Chongqing, China.

Background: Only a few previous studies conducted to assess the association between body mass index (BMI) and prostate-specific antigen (PSA) related parameters have taken prostate volume (PV) and blood volume (BV) into consideration. The objective of this study was to assess the relationship between BMI and parameters of PSA concentrations in Chinese adult men.

Methods: A total of 86,912 men who have received annual physical examination at the First Affiliated Hospital of Army Medical University from 1 January 2011 to 31 December 2018 were included in this study. Read More

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September 2021

Circuit imaging biomarkers in preclinical and prodromal Parkinson's disease.

Mol Med 2021 Sep 16;27(1):111. Epub 2021 Sep 16.

Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Parkinson's disease (PD) commences several years before the onset of motor features. Pathophysiological understanding of the pre-clinical or early prodromal stages of PD are essential for the development of new therapeutic strategies. Two categories of patients are ideal to study the early disease stages. Read More

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September 2021

First trimester metabolomics 1H-NMR study of the urinary profile predicts gestational diabetes mellitus development in obese women.

J Matern Fetal Neonatal Med 2021 Sep 16:1-9. Epub 2021 Sep 16.

Department of Medical and Surgical Sciences for Mother, Child and Adult, Azienda Ospedaliero Universitaria Policlinico, University of Modena and Reggio Emilia, Modena, Italy.

Objective: Obesity is one of the main risk factors for the development gestational diabetes mellitus (GDM). Thus, we aim to identify changes in the urinary metabolomics profile of obese women at first trimester of pregnancy in order to predict later GDM diagnosis.

Research Design And Methods: In this nested case-control study, urine samples collected in the first trimester of pregnancy obtained from obese women who developed GDM ( = 29) and obese women who did not develop diabetes ( = 25 NO GDM) were analyzed with Nuclear Magnetic Resonance spectroscopy combined with Multivariate Statistical Analysis. Read More

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September 2021

Glucose Tolerance after Pancreatectomy: A Prospective Observational Follow-Up Study of Pancreaticoduodenectomy and Distal Pancreatectomy.

J Am Coll Surg 2021 Sep 9. Epub 2021 Sep 9.

Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

Background: Effects of pancreatectomy on glucose tolerance have not been clarified, and evidence regarding the difference in postoperative glucose tolerance between pancreaticoduodenectomy (PD) and distal pancreatectomy (DP) is lacking.

Study Design: This prospective single-center observational study analyzed 40 patients undergoing PD and 29 patients undergoing DP (Clinical trial registry number UMIN000008122). Glucose tolerance, including insulin secretion (Δ C-peptide immunoreactivity, ΔCPR) and insulin resistance (homeostasis model assessment of insulin resistance, HOMA-IR) were assessed before and 1 month after pancreatectomy using the oral glucose tolerance test (OGTT) and glucagon stimulation test. Read More

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September 2021

The pharmacokinetic profiles of mogrosides in T2DM rats.

J Ethnopharmacol 2021 Sep 13:114639. Epub 2021 Sep 13.

School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Minhang District, Shanghai, 200240, China. Electronic address:

Ethnopharmacological Relevance: Luohanguo (LHG) extract major contenting mogrosides, as a nonnutritive sweetener, has been reported to exert a hypoglycemic effect on diabetic patients and animals. As the pharmacokinetics and pharmacodynamics of drugs were changed with diabetes, it may lead to the different pharmacological of mogrosides between diabetic and normal subjects.

Aims Of The Study: To characterise the pharmacokinetic profiles of mogrosides in T2DM rats. Read More

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September 2021

Resveratrol Protects against Myocardial Ischemia-Reperfusion Injury via Attenuating Ferroptosis.

Gene 2021 Sep 13:145968. Epub 2021 Sep 13.

Departments of Cardiovascular Medicine, The First Affiliated Hospital,University of South China, Hengyang, Hunan, 421001, P.R. China.

Resveratrol (Res) is a polyphenol with a variety of biological activities. However, whether Res can prevent myocardial ischemia-reperfusion (I/R) injury is not yet known. This study aimed to investigate the protective effect of Res on myocardial I/R injury and to explore its potential mechanism. Read More

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September 2021

Upregulated circRAD18 promotes tumor progression by reprogramming glucose metabolism in papillary thyroid cancer.

Gland Surg 2021 Aug;10(8):2500-2510

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China.

Background: By regulating complex functional processes, circRNAs are crucial in the development of different cancers. Nevertheless, most circRNAs in papillary thyroid cancer metabolic reprogramming remain unknown.

Methods: The expression of circRNA was assessed by qRT-PCR in papillary thyroid cancer tissues and cell lines. Read More

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Glucose Metabolism and Insulin Response to Oral Glucose Tolerance Test (OGTT) in Prepubertal Patients with Transfusion-Dependent β-thalassemia (TDT): A Long-Term Retrospective Analysis.

Mediterr J Hematol Infect Dis 2021 1;13(1):e2021051. Epub 2021 Sep 1.

First Department of Paediatrics, National Kapodistrian University of Athens 11527, Greece.

Background: Glucose dysregulation (GD), including prediabetes and diabetes mellitus (DM), is a common complication of transfusion-dependent β-thalassemia (TDT) patients. The prevalence increases with age and magnitude of iron overload, affecting a significant proportion of patients. According to the international guidelines, the development of GD is frequently asymptomatic. Read More

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September 2021

Medicinal Plant Extracts Evaluated and for Antidiabetic Activities in Ethiopia: Bases for Future Clinical Trials and Related Investigations.

Evid Based Complement Alternat Med 2021 4;2021:9108499. Epub 2021 Sep 4.

Pharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia.

Background: Diabetes mellitus (DM) is a metabolic disorder characterized by a persistent rise in the blood glucose level resulting from defects in cellular insulin function, secretion, or both, which affects millions of people every year. Several drawbacks have been stated with the use of marketed antidiabetic medicines such as drug resistance, adverse effects, toxicities, and even costs. Due to these several limitations, searching for novel antidiabetic medicines from medicinal plants (MPs) is becoming an active area of research. Read More

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September 2021

Hydrogen Sulfide Prevents Mesenteric Adipose Tissue Damage, Endothelial Dysfunction, and Redox Imbalance From High Fructose Diet-Induced Injury in Aged Rats.

Front Pharmacol 2021 30;12:693100. Epub 2021 Aug 30.

Department of Physiology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.

A high fructose diet (HFD) and advanced age are key factors for the gradual loss of physiological integrity of adipose tissue. Endogenous hydrogen sulfide (HS) has beneficial effects on cytoprotection and redox balance. But its interactive effects on age-related damage of mesenteric vessels and connective and adipose tissues (MA) during HFD which could be the base of the development of effective physiological-based therapeutic strategy are unknown. Read More

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Sex Hormone-Binding Globulins and Testosterone Levels as a Risk Marker for Type 2 Diabetes Mellitus among Postmenopausal Women.

J Midlife Health 2021 Apr-Jun;12(2):155-160. Epub 2021 Jul 27.

Department of Endocrinology, Medical College, Thiruvananthapuram, Kerala, India.

Background: Endogenous sex hormones and sex hormone-binding globulins (SHBG) determine the risk of occurrence of Type 2 diabetes mellitus (T2DM) in postmenopausal (PM) women.

Aims: To investigate the association between sex hormones (estradiol and testosterone) and SHBG with plasma glucose, fasting insulin levels, HbA1c, and homeostasis model assessment insulin resistance (HOMA-IR) and also to investigate independent role of sex hormones in the occurrence of T2DM among PM.

Settings And Design: Cross-sectional case-control study. Read More

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Evaluation of the Efficacy and Safety of Root Extract (ERr 731) for Menopausal Symptoms in Perimenopausal Indian Women: An Interim Analysis.

J Midlife Health 2021 Apr-Jun;12(2):108-115. Epub 2021 Jul 27.

Department of Obstetrics and Gynecology, Life Care Hospital, Indore, Madhya Pradesh, India.

Background: Hormonal therapy for menopause has been found to be the most efficacious treatment, but it may be associated with adverse effects in some of the women. Rheum rhaponticum root extract ("ERr 731"), which is available worldwide, is a natural, reliable, effective, and well-tolerated remedy for women in perimenopausal women with menopausal symptoms (MSs), but there is no Indian study demonstrating its efficacy, safety, and tolerability till date.

Objective: This study aimed to evaluate the efficacy and safety of ERr 731 in alleviating MSs in perimenopausal Indian women. Read More

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Contrasting effects of the alkaloid ricinine on the capacity of Anopheles gambiae and Anopheles coluzzii to transmit Plasmodium falciparum.

Parasit Vectors 2021 Sep 15;14(1):479. Epub 2021 Sep 15.

Laboratoire Mixte International Sur Les Vecteurs (LAMIVECT), Bobo Dioulasso, Burkina Faso.

Background: Besides feeding on blood, females of the malaria vector Anopheles gambiae sensu lato readily feed on natural sources of plant sugars. The impact of toxic secondary phytochemicals contained in plant-derived sugars on mosquito physiology and the development of Plasmodium parasites remains elusive. The focus of this study was to explore the influence of the alkaloid ricinine, found in the nectar of the castor bean Ricinus communis, on the ability of mosquitoes to transmit Plasmodium falciparum. Read More

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September 2021