35,862 results match your criteria glucose consumption


Biomimetic synthesis of a novel O2-regeneration nanosystem for enhanced starvation/chemo-therapy.

Nanotechnology 2021 Sep 20. Epub 2021 Sep 20.

Qufu Normal University, qufu, Qufu, Shandong, 273165, CHINA.

Glucose oxidase (GOX)-mediated starvation therapy that effectively cuts off energy supply holds great promise in cancer treatment. However, high glutathione (GSH) contents and anoxic conditions severely reduce therapy efficiency and cannot fully kill cancer cells. Herein, to resolve the above problem, this study constructed a biomimetic nanosystem based on nanreproo-MnO2 with porous craspedia globose-like structure and high specific surface area, and it was further modified with dopamine and folic acid to guarantee good biocompatibility and selectivity toward cancer cells. Read More

View Article and Full-Text PDF
September 2021

Circadian rhythm in hypothalamic leptin receptor (Ob-Rb) mRNA expressions and cerebrospinal fluid and circulating glucose and leptin levels in lactating rats.

Biochem Biophys Rep 2021 Dec 8;28:101129. Epub 2021 Sep 8.

Department of Animal Science, School of Veterinary Medicine, Kitasato University, Towada, Japan.

In lactating animals, the food consumption increases several-fold for milk supply to the pups. The present study was conducted to clarify the relationship between the hyperphagia during lactation and hypothalamic leptin receptor (Ob-Rb) mRNA expression, cerebrospinal fluid (CSF) and circulating leptin and glucose levels. Food intakes significantly higher in lactation than in non-lactation at all time points (3 points: light phase, 4 points: dark phase) of the day. Read More

View Article and Full-Text PDF
December 2021

Activated Pancreatic Stellate Cells Enhance the Warburg Effect to Cause the Malignant Development in Chronic Pancreatitis.

Front Oncol 2021 3;11:714598. Epub 2021 Sep 3.

Department of General Surgery, The First Affiliated Hospital of University of Science & Technology of China, Anhui Provincial Hospital, Hefei, China.

Chronic pancreatitis (CP) is a precancerous condition associated with pancreatic ductal adenocarcinoma (PDAC), but its evolutionary mechanism is unclear. Pancreatic stellate cells (PSCs) are closely related to the occurrence and development of CP and PDAC, but it is not clear whether PSCs play a key role in this "inflammation-cancer transition". Our research found that co-culture with activated PSCs promoted the proliferation, migration and invasion of normal pancreatic duct epithelial cells and pancreatic cancer cells. Read More

View Article and Full-Text PDF
September 2021

Therapeutic Effect of Sunflower Seeds and Flax Seeds on Diabetes.

Cureus 2021 Aug 17;13(8):e17256. Epub 2021 Aug 17.

Surgery, Services Hospital Lahore, Lahore, PAK.

Diabetes mellitus (DM) is a metabolic syndrome that is spreading like an epidemic throughout the world without any differentiation of races and ethnic groups and has become the cause of death worldwide. It is characterized by high levels of glucose in the blood and has different types classified on the basis of varying pathophysiology. Type 1 diabetes or insulin-dependent diabetes is characterized by insulin insufficiency due to autoimmune dysfunction. Read More

View Article and Full-Text PDF

Characterisation of the Myocardial Mitochondria Structural and Functional Phenotype in a Murine Model of Diabetic Cardiomyopathy.

Front Physiol 2021 1;12:672252. Epub 2021 Sep 1.

Heart Failure Pharmacology, Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.

People affected by diabetes are at an increased risk of developing heart failure than their non-diabetic counterparts, attributed in part to a distinct cardiac pathology termed diabetic cardiomyopathy. Mitochondrial dysfunction and excess reactive oxygen species (ROS) have been implicated in a range of diabetic complications and are a common feature of the diabetic heart. In this study, we sought to characterise impairments in mitochondrial structure and function in a recently described experimental mouse model of diabetic cardiomyopathy. Read More

View Article and Full-Text PDF
September 2021

How the COVID-19 outbreak affected patients with diabetes mellitus?

Int J Diabetes Dev Ctries 2021 Sep 10:1-9. Epub 2021 Sep 10.

Medical School Department of Endocrinology and Metabolism, Uludag University, Bursa, Turkey.

Background: Global COVID-19 outbreak has been such a stressful experience for most of the people. Using a web-based cross-sectional study, we aimed to evaluate the acute stress response, depression, and anxiety in patients with diabetes mellitus (DM) during the COVID-19 pandemic, and to examine the effect of these psychiatric problems on diet habits and glycemic controls of patients.

Methods: This web-based survey of COVID-19 was sent to the patients through the Whatsapp platform. Read More

View Article and Full-Text PDF
September 2021

Myrianthus arboreus P. Beauv improves insulin sensitivity in high fat diet-induced obese mice by reducing inflammatory pathways activation.

J Ethnopharmacol 2021 Sep 16:114651. Epub 2021 Sep 16.

CIBER-EHD, Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, 18071, Granada, Spain; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18012, Granada, Spain.

Ethnopharmacological Relevance: Metabolic syndrome is currently recognized as the major cause of morbidity, with dramatic complications on life expectancy and health status. Myrianthus arboreus is a medicinal plant traditionally used in local communities as a safe remedy in treating diabetes and other metabolic diseases.

Aim Of The Study: This study aimed to investigate the impact of a methanol extract of Myrianthus arboreus leaf (MAL) in a mice model of metabolic syndrome induced by a high-fat diet (HFD) intake. Read More

View Article and Full-Text PDF
September 2021

Influence of glucose on xylose metabolization by Spathaspora passalidarum.

Fungal Genet Biol 2021 Sep 15:103624. Epub 2021 Sep 15.

Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Av. PH Rolfs s/n, Campus Universitário, 36570-900 Viçosa, MG, Brazil. Electronic address:

The yeast Spathaspora passalidarum is able to produce ethanol from D-xylose and D-glucose. However, it is not clear how xylose metabolism is affected by D-glucose when both sugars are available in the culture medium. The aims of this work were to evaluate the influence of D-glucose on D-xylose consumption, ethanol production, gene expression, and the activity of key xylose-metabolism enzymes under both aerobic and oxygen-limited conditions. Read More

View Article and Full-Text PDF
September 2021

Does weight change modify the association between the consumption of sugar-sweetened beverages and 100% fruit juice and the risk of metabolic syndrome?

Clin Nutr 2021 Aug 28;40(10):5261-5268. Epub 2021 Aug 28.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background & Aims: This study aimed to determine the prospective relationship between the consumption of sugar-sweetened beverages (SSBs) and 100% fruit juice and metabolic syndrome (MetS) and to investigate whether weight change can modify this association in a representative sample of the population of Tehran, Iran.

Methods: In this 8.9-year follow-up study, the consumption of SSBs and 100% fruit juice by 1915 individuals, who participated in Tehran Lipid and Glucose Study (TLGS), was examined using a validated food frequency questionnaire. Read More

View Article and Full-Text PDF

Sustained swimming exercise training decreases the individual variation in the metabolic phenotype of gilthead sea bream (Sparus aurata).

Comp Biochem Physiol A Mol Integr Physiol 2021 Sep 14:111077. Epub 2021 Sep 14.

CIIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Portugal. Electronic address:

Cultured fish can be induced to swim, although the suitability and benefits remain to be tested. Sustained swimming exercise (SSE) training and detraining (DET) were applied in juvenile gilthead sea bream (Sparus aurata) and the metabolic rates were investigated. Fish with a total body mass of 80. Read More

View Article and Full-Text PDF
September 2021

Is the rural population of Puducherry district healthy in terms of the burden of non-communicable diseases? Findings from a cross-sectional analytical survey.

J Postgrad Med 2021 Sep 16. Epub 2021 Sep 16.

Department of Preventive and Social Medicine, JIPMER, Puducherry, India.

Introduction: Epidemiological transition remains a key contributor to the rising prevalence of non-communicable diseases (NCDs) across developing nations. Population-specific NCD risk factors estimates derived using World Health Organization (WHO) 'STEP-wise approach' are crucial for devising evidence-based public health interventions to combat NCDs.

Objective: To estimate the prevalence of behavioral and biological risk factors for NCDs among the rural adult population of Puducherry district in India. Read More

View Article and Full-Text PDF
September 2021

Different effects of lifestyle intervention in high- and low-risk prediabetes.

Diabetes 2021 Sep 16. Epub 2021 Sep 16.

German Center for Diabetes Research (DZD), Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.

Lifestyle intervention (LI) can prevent type 2 diabetes, but response to LI varies depending on risk subphenotypes. We tested if prediabetic individuals with low risk benefit from conventional LI and individuals with high risk benefit from an intensification of LI in a multi-center randomized controlled intervention over 12 months with 2 years follow up. 1105 prediabetic individuals based on ADA glucose criteria were stratified into a high- and low-risk phenotype, based on previously described thresholds of insulin secretion, insulin sensitivity and liver fat content. Read More

View Article and Full-Text PDF
September 2021

[Relationship between the ideal cardiovascular health behaviors and factors and newonset heart failure].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 Sep;49(9):905-911

Department of Cardiology, Kailuan General Hospital, Tangshan 063000, China.

To explore the relationship between the ideal cardiovascular health behaviors and factors and newonset heart failure. It was a prospective cohort study. People who attended the 2006-2007 physical examination of Kailuan Group Company and with complete data of cardiovascular behaviors and related factors were eligible for this study. Read More

View Article and Full-Text PDF
September 2021

Placental Passage of Humulone and Protopine in an Ex Vivo Human Perfusion System.

Planta Med 2021 Sep 16. Epub 2021 Sep 16.

Department of Obstetrics, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

The placental passage of humulone and protopine was investigated with a human placental perfusion model. The model was first validated with diazepam and citalopram, 2 compounds known to cross the placental barrier, and antipyrine as a positive control. All compounds were quantified by partially validated U(H)PLC-MS/MS bioanalytical methods. Read More

View Article and Full-Text PDF
September 2021

Ubiquitin pathways regulate the pathogenesis of chronic liver disease.

Biochem Pharmacol 2021 Sep 13:114764. Epub 2021 Sep 13.

College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, South Korea. Electronic address:

Chronic liver disease (CLD) is considered the leading cause of global mortality. In westernized countries, increased consumption of alcohol and overeating foods with high fat/ high glucose promote progression of CLD such as alcoholic liver disease (ALD) and non-alcoholic liver disease (NAFLD). Accumulating evidence and research suggest that ubiquitin, a 75 amino acid protein, plays crucial role in the pathogenesis of CLD through dynamic post-translational modifications (PTMs) exerting diverse cellular outcomes such as protein degradation through ubiquitin-proteasome system (UPS) and autophagy, and regulation of signal transduction. Read More

View Article and Full-Text PDF
September 2021

Hydrogen Sulfide Prevents Mesenteric Adipose Tissue Damage, Endothelial Dysfunction, and Redox Imbalance From High Fructose Diet-Induced Injury in Aged Rats.

Front Pharmacol 2021 30;12:693100. Epub 2021 Aug 30.

Department of Physiology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.

A high fructose diet (HFD) and advanced age are key factors for the gradual loss of physiological integrity of adipose tissue. Endogenous hydrogen sulfide (HS) has beneficial effects on cytoprotection and redox balance. But its interactive effects on age-related damage of mesenteric vessels and connective and adipose tissues (MA) during HFD which could be the base of the development of effective physiological-based therapeutic strategy are unknown. Read More

View Article and Full-Text PDF

Contrasting effects of the alkaloid ricinine on the capacity of Anopheles gambiae and Anopheles coluzzii to transmit Plasmodium falciparum.

Parasit Vectors 2021 Sep 15;14(1):479. Epub 2021 Sep 15.

Laboratoire Mixte International Sur Les Vecteurs (LAMIVECT), Bobo Dioulasso, Burkina Faso.

Background: Besides feeding on blood, females of the malaria vector Anopheles gambiae sensu lato readily feed on natural sources of plant sugars. The impact of toxic secondary phytochemicals contained in plant-derived sugars on mosquito physiology and the development of Plasmodium parasites remains elusive. The focus of this study was to explore the influence of the alkaloid ricinine, found in the nectar of the castor bean Ricinus communis, on the ability of mosquitoes to transmit Plasmodium falciparum. Read More

View Article and Full-Text PDF
September 2021

First Report of Xanthomonas campestris pv. campestris Causing Marginal Leaf Necrosis of Arugula (Eruca vesicaria subsp. sativa) in Serbia.

Plant Dis 2021 Sep 15. Epub 2021 Sep 15.

University of Belgrade, Faculty of Agriculture, Institute of Phytomedicine, Plant Pathology, Nemanjina 6, Belgrade, Serbia, 11080;

Arugula (Eruca vesicaria subsp. sativa (Miller) Thell., syn. Read More

View Article and Full-Text PDF
September 2021

Real-world Performance of the MiniMed™ 780G System: First Report of Outcomes from 4'120 Users.

Diabetes Technol Ther 2021 Sep 15. Epub 2021 Sep 15.

Medtronic International Trading Sàrl, Toluchenaz, Tolochenaz, Switzerland, 46733;

Background: The MiniMed™ 780G system includes an Advanced Hybrid Closed Loop (AHCL) algorithm which provides for both automated basal and correction bolus insulin delivery. The preliminary performance of the system in real-world settings was evaluated.

Methods: Data uploaded from August 2020 to March 2021 by individuals living in Belgium, Finland, Italy, the Netherlands, Qatar, South Africa, Sweden, Switzerland and the United Kingdom were aggregated and retrospectively analyzed to determine the mean Glucose Management Indicator (GMI), percentage of time spent within (TIR), below (TBR) and above (TAR) glycemic ranges, system use and insulin consumption in users having ≥10 days of sensor glucose (SG) data after initiating AHCL. Read More

View Article and Full-Text PDF
September 2021

Ablation of USP21 in skeletal muscle promotes oxidative fibre phenotype, inhibiting obesity and type 2 diabetes.

J Cachexia Sarcopenia Muscle 2021 Sep 15. Epub 2021 Sep 15.

College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Goyang-si, Gyeonggi-Do, South Korea.

Background: Skeletal muscle as a metabolic consumer determines systemic energy homeostasis by regulating myofibre type conversion and muscle mass control. Perturbation of the skeletal muscle metabolism elevates the risk of a variety of diseases including metabolic disorders. However, the regulatory pathways and molecules are not completely understood. Read More

View Article and Full-Text PDF
September 2021

Could consumption of yam () or its extract be beneficial in controlling glycaemia - A Systematic Review.

Br J Nutr 2021 Sep 15:1-32. Epub 2021 Sep 15.

Division of Food, Nutrition and Dietetics, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD.

Yam (Dioscorea spp.) and its associated extracts have been shown to possess a variety of biological activities and identified as beneficial in the control of glycaemia in patients with Type II Diabetes Mellitus (T2DM). The objective was to conduct a systematic search of the literature to investigate whether yam and its extract can improve glycaemia and whether consumption of yam could be beneficial for managing T2DM. Read More

View Article and Full-Text PDF
September 2021

Beneficial effects of inorganic nitrate in non-alcoholic fatty liver disease.

Arch Biochem Biophys 2021 Oct 11;711:109032. Epub 2021 Sep 11.

Medical School, University of Western Australia, Perth, WA, Australia; Dobney Hypertension Centre, Medical School, University of Western Australia, Perth, WA, Australia. Electronic address:

Non-alcoholic fatty liver disease (NAFLD) is considered the hepatic representation of the metabolic disorders. Inorganic nitrate/nitrite can be converted to nitric oxide, regulate glucose metabolism, lower lipid levels, and reduce inflammation, thus raising the hypothesis that inorganic nitrate/nitrite could be beneficial for improving NAFLD. This study assessed the therapeutic effects of chronic dietary nitrate on NAFLD in a mouse model. Read More

View Article and Full-Text PDF
October 2021

Plasmonic enhanced enzyme activity by catalytic cascade induced mutual benefit tumor starvation/immune/photothermal therapy.

Biomater Sci 2021 Sep 14;9(18):6116-6125. Epub 2021 Sep 14.

State Key Laboratory of Metastable Materials Science and Technology, Key Laboratory of Nanobiotechnology of Hebei Province, Applying Chemistry Key Lab of Hebei Province, Yanshan University, Qinhuangdao 066004, China.

Single tumor starvation therapy can activate other signaling pathways in tumor cells and easily induce tumor cell metastasis. This research proposes an intelligent nanoparticle, which is effectively combined with plasmonic and immunotherapy to realize a new strategy of "upstream consumption and downstream blocking" of nutrients in tumor sites. The intelligent nanoparticle (Ag-G/[email protected]) was composed of Ag NCs loaded with glucose oxidase (GOx), catalase (CAT) and coated with the tumor cytomembrane (M). Read More

View Article and Full-Text PDF
September 2021

A portable and quantitative detection of microRNA-21 based on cascade enzymatic reactions with dual signal outputs.

Talanta 2021 Dec 13;235:122802. Epub 2021 Aug 13.

The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China. Electronic address:

MicroRNAs (miRNAs) are physiological status-related molecules which can be used as biomarkers for diseases, such as cancers. The point-of-care testing (POCT) of miRNAs has great application potential in early diagnosis and process monitoring of diseases. In this paper, a fast and dual signal outputs detection for microRNA-21 (miRNA-21) was established by using both personal glucose meter (PGM) and fluorescence spectrometer. Read More

View Article and Full-Text PDF
December 2021

CircTUBGCP3 Contributes to the Malignant Progression of Rectal Cancer.

Dig Dis Sci 2021 Sep 13. Epub 2021 Sep 13.

Academy of Medical Engineering and Translational Medicine, Tianjin University, Nankai District, No. 92, Weijin Road, Tianjin, 300072, China.

Background: Circular RNA (circRNA) tubulin gamma complex associated protein 3 (circTUBGCP3) has been reported to play an oncogenic role in colorectal cancer and osteosarcoma.

Aims: We further assessed the role and working mechanism of circTUBGCP3 in rectal cancer progression.

Methods: Colony formation assay and transwell assays were performed to analyze cell colony formation ability and motility. Read More

View Article and Full-Text PDF
September 2021

Erectile dysfunction and diabetes: a melting pot of circumstances and treatments.

Diabetes Metab Res Rev 2021 Sep 13:e3494. Epub 2021 Sep 13.

Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.

Diabetes mellitus (DM), a chronic metabolic disease characterised by elevated levels of blood glucose, is among the most common chronic diseases. The incidence and prevalence of DM have been increasing over the years. The complications of DM represent a serious health problem. Read More

View Article and Full-Text PDF
September 2021

Pomegranate fruit pulp polyphenols reduce diet-induced obesity with modulation of gut microbiota in mice.

J Sci Food Agric 2021 Sep 13. Epub 2021 Sep 13.

College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China.

Background: Pomegranate is a rich source of polyphenols and has been used as dietary supplements and pharmaceutical ingredients. This study aimed to investigate the pomegranate fruit pulp polyphenols (PFP) regarding their anti-obesity activity and gut microbiota-modulating effect in mice. Thirty-six four-week-old specific pathogen free C57BL/6J mice (weight: 17. Read More

View Article and Full-Text PDF
September 2021

Panax Ginseng C.A.Mey. as Medicine: The Potential Use of Panax Ginseng C.A.Mey. as a Remedy for Kidney Protection from a Pharmacological Perspective.

Front Pharmacol 2021 26;12:734151. Epub 2021 Aug 26.

Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Panax ginseng C.A.Mey. Read More

View Article and Full-Text PDF

Association between diet quality index, food and nutrient intake, and metabolic parameters in adolescents from Recife, northeastern Brazil.

Br J Nutr 2021 Sep 13:1-28. Epub 2021 Sep 13.

Postgraduate Program in Child and Adolescent Health, Federal University of Pernambuco, Recife, Pernambuco, Brazil.

Nutritional studies shifted the focus of attention to the analysis of food quality, addressing general diet considering the foods, food groups, and nutrients included. This study evaluates the association between diet quality index, food and nutrient intake, and metabolic parameters of adolescents from Recife, northeastern Brazil. It is a cross-sectional study involving adolescents aged 12 to 19 years. Read More

View Article and Full-Text PDF
September 2021

Fructose-Rich Diet Attenuates Stress-Induced Metabolic Disturbances in the Liver of Adult Female Rats.

J Nutr 2021 Sep 11. Epub 2021 Sep 11.

Department of Biochemistry, Institute for Biological Research "Siniša Stanković", National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia.

Background: Both fructose consumption and chronic stress contribute to the development of metabolic disorders. The consequences of such combination are not fully understood.

Objective: We investigated whether fructose supplementation and chronic stress synergistically disturb hepatic lipid and glucose metabolism. Read More

View Article and Full-Text PDF
September 2021