Search Our Scientific Publications & Authors

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York.

Objective:  Poor attendance at the 6-week postpartum (PP) visit has been well reported. Attendance at this visit is crucial to identify women who have persistent diabetes mellitus (DM) following pregnancies affected by gestational DM (GDM). The medical home model has eliminated barriers to care in various other settings. Read More

Exp Clin Endocrinol Diabetes 2021 Apr 20. Epub 2021 Apr 20.

FIDAM - Research Institute Diabetes Academy, Mergentheim, Gemany.

Objective: This randomized cross-over study aimed to compare different algorithms for calculating prandial insulin considering the fat and protein content of a standardized meal in type 1 diabetes patients using insulin pump therapy (CSII).

Methods: Twenty-six patients received a standardized evening meal for three consecutive days using different algorithms for insulin dose adjustment: A) exclusive consideration of carbohydrate content without considering fat-protein content, B) high-dose algorithm considering additional insulin for fat protein units (FPUs) with the same factor as for carbohydrates, and C) low-dose algorithm considering additional insulin for FPUs with half the factor as for carbohydrates. The primary outcome was the proportion of interstitial glucose values in the target range (≥ 70 to ≤ 180 mg/dl) during the post-prandial 12-hour follow-up period. Read More

Nutrition 2021 Mar 6;89:111234. Epub 2021 Mar 6.

Diabetes Centre, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece. Electronic address:

Lifestyle modification, including a healthy diet, is of paramount importance in the management of diabetes mellitus. To this end, diets have been proposed with low glycemic index (an index of carbohydrate food expressing how quickly this nutrient can increase blood glucose) and glycemic load (an index obtained by multiplying the glycemic index by the grams of carbohydrate, then dividing by 100). The aim of this review was to discuss the potential contribution of diets with low glycemic index and glycemic load in diabetic microvascular complications. Read More

Bioresour Technol 2021 Apr 6;333:125122. Epub 2021 Apr 6.

Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address:

Deep eutectic solvents (DESs) have received considerable interests as pretreatment solvents for biorefinery. In the present work, five kinds of dicarboxylic acids based DESs were introduced to pretreatments on moso bamboo (MB) with microwave irradiation assistance. Factors influencing the enzymatic conversion of MB cellulose to glucose were determined. Read More

J Biotechnol 2021 Apr 17. Epub 2021 Apr 17.

Department of biotechnology, Pukyong National University, Busan, 48513, Republic of Korea. Electronic address:

Glucose and galactose are monosaccharides obtained from Gloiopeltis furcata (Red algae). A total monosaccharide yield of 62.3 g/L was obtained from G. Read More

Kidney Int 2021 Apr 17. Epub 2021 Apr 17.

Department Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Immunoglobulin A (IgA) nephropathy is a common form of glomerulonephritis, which despite use of renin-angiotensin-aldosterone-system blockers and immunosuppressants, often progresses to kidney failure. In the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease trial, dapagliflozin reduced risk of kidney failure and prolonged survival in participants with chronic kidney disease with and without type 2 diabetes, including those with IgA nephropathy. Here we randomized participants with estimated glomerular filtration rate (eGFR) 25-75 mL/min/1. Read More

PLoS One 2021 20;16(4):e0250352. Epub 2021 Apr 20.

Cancer Research and Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.

1,25-dihydroxyvitamin-D3 and its derivatives have shown anti-arthritic and chondroprotective effects in experimental animal models with prophylactic dosing. The purpose of this preliminary study was to test the efficacy and safety of calcipotriol, vitamin D analog, as a treatment for a fully-developed knee arthritis in Zymosan-induced arthritis (ZIA) model. Forty 5-month-old male Sprague-Dawley rats were randomized into three arthritis groups and a non-arthritic control group with no injections (10 rats/group). Read More

J Clin Invest 2021 Apr 20. Epub 2021 Apr 20.

School of Biomedical Sciences, The University of Hong Kong, Hong Kong, Hong Kong.

Rapidly growing tumors often experience hypoxia and nutrient (e.g., glucose) deficiency because of poor vascularization. Read More

Acc Chem Res 2021 Apr 20. Epub 2021 Apr 20.

M.G. DeGroote Institute for Infectious Disease Research, David Braley Center for Antibiotic Discovery, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S 3Z5, Canada.

ConspectusRifamycin antibiotics include the WHO essential medicines rifampin, rifabutin, and rifapentine. These are semisynthetic derivatives of the natural product rifamycins, originally isolated from the soil bacterium . These antibiotics are primarily used to treat mycobacterial infections, including tuberculosis. Read More

Nanoscale Res Lett 2021 Apr 20;16(1):63. Epub 2021 Apr 20.

Department of Neurology, Affiliated Hospital of Yangzhou University; Yangzhou University, 45 Taizhou Road, Yangzhou, 225001, Jiangsu, People's Republic of China.

Studies have greatly explored the role of microRNAs (miRNAs) in cerebral ischemia/reperfusion injury (CI/RI). But the specific mechanism of miR-326-5p in CI/RI is still elusive. Hence, this study was to unmask the mechanism of miR-326-5p/signal transducer and activator of transcription-3 (STAT3) axis in CI/RI. Read More

Arch Microbiol 2021 Apr 20. Epub 2021 Apr 20.

Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, Delhi, 110016, India.

To identify enzymes that can be effectively used for hydrolysis of lignocellulosic biomass, an attractive carbon source in biorefineries, transcriptome analysis was carried out of wheat bran grown fungus, Cyathus bulleri. A comprehensive set of transcripts, encoding carbohydrate active enzymes, were identified. These belonged to 55, 32, 12, 11 and 7 different families of the enzyme classes of Glycoside Hydrolases (GHs), Glycosyl Transferases (GTs), Auxiliary Activities (AAs), Carbohydrate Esterases (CEs) and Polysaccharide Lyases (PLs) respectively. Read More

Diabetologia 2021 Apr 20. Epub 2021 Apr 20.

Department of Internal Medicine IV, University of Tübingen, Tübingen, Germany.

The global epidemic of non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) and the high prevalence among individuals with type 2 diabetes has attracted the attention of clinicians specialising in liver disorders. Many drugs are in the pipeline for the treatment of NAFLD/NASH, and several glucose-lowering drugs are now being tested specifically for the treatment of liver disease. Among these are nuclear hormone receptor agonists (e. Read More

G3 (Bethesda) 2019 Jul;9(7):2161-2170

RIKEN Cluster for Pioneering Research, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan.

Increasing evidence indicates that parental diet affects the metabolism and health of offspring. It is reported that paternal low-protein diet (pLPD) induces glucose intolerance and the expression of genes involved in cholesterol biosynthesis in mouse offspring liver. The aim of the present study was to determine the effect of a pLPD on gene expression in offspring white adipose tissue (WAT), another important tissue for the regulation of metabolism. Read More

J Pharm Pharmacol 2021 Apr 20. Epub 2021 Apr 20.

Department of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.

Objectives: A previous in vitro study reported that the monoterpene oxide 1,8-cineole (cineole) attenuates neuronal caused by oxygen-glucose deprivation/reoxygenation in culture. However, to date, there is no in vivo evidence showing neuroprotective effects of cineole against stroke. This study aimed to investigate whether cineole attenuates cerebral ischaemic damage in rats. Read More

Clin Exp Hypertens 2021 Apr 20:1-7. Epub 2021 Apr 20.

Department of Hypertension, The First Affiliated Hospital of Xinjiang Medical University, Urumqi,Xinjiang, China.

: To investigate the correlation between transient receptor potential channel 1 () gene polymorphism and microalbuminuria in patients with primary hypertension. : A total of 468 patients with primary hypertension were admitted to the Department of Hypertension of the First Affiliated Hospital of Xinjiang Medical University from April 2015 to November 2017. According to microalbuminuria, the patients were divided into two groups: high urinary albumin group (EH+mALB group, n = 71) and normal urinary microalbuminuria group (EH group, n = 397). Read More

ACS Sens 2021 Apr 20. Epub 2021 Apr 20.

Deparment of Physics and Electronics, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.

Continuous multiple data health monitoring has high potential to detect abnormal conditions or early stages of diseases in the future. To monitor a continuous small vital signal, one of the promising architectures is an attachable flexible multimodal sensor system, which can detect multiple health conditions from the skin surface. Recent breakthroughs have realized continuous sweat chemicals or physical conditions using flexible sensors. Read More

Phytother Res 2021 Apr 20. Epub 2021 Apr 20.

Nutrition Research Center, Department of Biochemistry and Diet Therapy, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

This study investigated the impact of L-citrulline on glucose homeostasis, lipid profile, and inflammatory factors in overweight and obese patients with type 2 diabetes (T2D). In total, 54 participants with T2D were assigned to L-citrulline (3 g/day L-citrulline) or placebo groups and tested for 8 weeks. Serum levels of insulin, fasting glucose, hemoglobin A1c (HbA1c), lipid profile, tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP), and L-citrulline were measured pre- and post-intervention. Read More

Food Funct 2021 Apr 20. Epub 2021 Apr 20.

College of Chemistry and Bioengineering, Guilin University of Technology, Guilin, Guangxi 541006, China.

One polysaccharide, designated as WPEP-A, was isolated from Passiflora edulis Sims peel and its hypoglycemic effects on diabetic db/db mice were evaluated. Physicochemical characterization showed that WPEP-A was composed of galactose, glucose, xylose, rhamnose, galacturonic acid and glucuronic acid with a molecular weight of 9.51 × 104 Da. Read More

Nanotoxicology 2021 Apr 20:1-25. Epub 2021 Apr 20.

Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, Lucknow, India.

Silver nanoparticles (AgNPs) are extensively utilized in food, cosmetics, and healthcare products. Though the effects of AgNPs exposure on adults are well documented, the long-term effects of gestational/perinatal exposure upon the health of offspring have not been addressed. Herein, we show that only perinatal exposure to AgNPs through the mother could lead to chronic inflammation in offspring which persists till adulthood. Read More

Environ Microbiol 2021 Apr 19. Epub 2021 Apr 19.

LIPM, Université de Toulouse, INRAE, CNRS, Castanet-Tolosan, France.

The plant pathogen Ralstonia solanacearum uses plant resources to intensely proliferate in xylem vessels and provoke plant wilting. We combined automatic phenotyping and tissue/xylem quantitative metabolomics of infected tomato plants to decipher the dynamics of bacterial wilt. Daily acquisition of physiological parameters such as transpiration and growth were performed. Read More

J Food Biochem 2021 Apr 20:e13737. Epub 2021 Apr 20.

College of Food Science and Technology, Hunan Agricultural University, Changsha, China.

Areca nut and Fuzhuan brick tea, a type of natural plant products, have obvious effects of fat reduction and weight loss; however, there is no report on their synergistic effect. This study investigated the effects of Fuzhuan brick tea supplemented with different concentrations of areca nut (5% (LAF), 10% (MAF), and 20% (HAF)) on serum and gut microbiota in Kunming (KM) mice. The results showed that Fuzhuan brick tea supplemented with areca nuts (AFTs) could reduce weight, prevent the accumulation of fat, inhibit the increase in the levels of serum triglyceride, total cholesterol, low-density lipoprotein cholesterol, blood glucose, free fatty acid, insulin, and total bile acid, alleviate the decrease in high-density lipoprotein cholesterol level, and regulate the composition of gut microbiota by high-fat diet intervention. Read More

Hormones (Athens) 2021 Apr 20. Epub 2021 Apr 20.

Division of Pediatrics, S. Chiara General Hospital, Largo Medaglie d'oro, 9, 38122, Trento, Italy.

Introduction: The PI3K/AKT/mTOR signaling pathway is important for the regulation of multiple biological processes, including cellular growth and glucose metabolism. Defects of the PI3K/AKT/mTOR signaling pathway are not usually considered among the genetic causes of recurrent hypoglycemia in childhood. However, accumulating evidence links hypoglycemia with defects of this pathway. Read More

Matern Child Health J 2021 Apr 19. Epub 2021 Apr 19.

College of Health, Medicine and Wellbeing, School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW, Australia.

Objectives: In order to manage blood glucose levels in pregnancy, women need to know what and how much to eat, particularly for foods containing carbohydrate. The aim was to assess pregnant women's carbohydrate and standard serve size knowledge and examine whether health professionals provided nutrition education.

Methods: Between July 2017 and April 2018 Australian pregnant women were recruited to complete an online survey, including a modified PedCarbQuiz carbohydrate knowledge questionnaire and an online buffet, where they selected images equivalent to one Australian Guide to Healthy Eating (AGHE) standard serve size. Read More

Int J Community Based Nurs Midwifery 2021 Apr;9(2):152-158

Department of Medical Surgical Nursing, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Diabetes is the most common endocrine disorder. Non-pharmacological methods can be used for treatment of these patients. The present study aimed to investigate the effect of acupressure point on fasting blood glucose and glycosylated levels of diabetic patients. Read More

Lab Invest 2021 Apr 19. Epub 2021 Apr 19.

Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, PR China.

Accumulating evidences have suggested that extracellular vesicles (EVs) are crucial players in the pathogenesis of ischemic brain injury. This study was designed to explore the specific functions of M2 phenotype microglia-derived EVs in ischemic brain injury progression. The expression of microRNA-135a-5p (miR-135a-5p) in M2 microglia-derived EVs was determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR), followed by the identification of expression relationship among miR-135a-5p, thioredoxin-interacting protein (TXNIP), and nod-like receptor protein 3 (NLRP3) by dual luciferase reporter gene assay. Read More

Commun Biol 2021 Apr 19;4(1):482. Epub 2021 Apr 19.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Cancer cells are a major source of enzymes that modify collagen to create a stiff, fibrotic tumor stroma. High collagen lysyl hydroxylase 2 (LH2) expression promotes metastasis and is correlated with shorter survival in lung adenocarcinoma (LUAD) and other tumor types. LH2 hydroxylates lysine (Lys) residues on fibrillar collagen's amino- and carboxy-terminal telopeptides to create stable collagen cross-links. Read More

Sci Rep 2021 Apr 19;11(1):8416. Epub 2021 Apr 19.

Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, 6139001, Tel Aviv, Israel.

This study examined differences in glycated hemoglobin (HbA1c), fasting plasma glucose and cholesterol levels between H. pylori infected and uninfected persons with diabetes. Anonymized data of Maccabi Healthcare Services in Israel were analyzed, of 12,207 individuals (50. Read More

Sci Rep 2021 Apr 19;11(1):8440. Epub 2021 Apr 19.

Institute of Materials, China Academy of Engineering Physics, P.O. Box 9071-7, Mianyang, 621907, China.

In this work, we reported for the first time a novel magnetic composite graphene oxide/FeO/glucose-COOH (GO/FeO/GC) that was facilely prepared from glucose through the hydrothermal carbonization and further combination with graphene oxide (GO). The chemical and structural properties of the samples were investigated. By the batch uranium adsorption experiments, the magnetic composite GO/FeO/GC exhibits an excellent adsorption performance and fast solid-liquid separation for uranium from aqueous solution. Read More

Aging (Albany NY) 2021 Apr 19;13. Epub 2021 Apr 19.

Department of Neurology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 133000, Zhejiang, China.

Cerebral ischemia-reperfusion (CI/R) injury is a serious complication when treating patients experiencing ischemic stroke. Although the microRNA miR-27a-3p reportedly participates in ischemia/reperfusion (I/R) injury, its actions in CI/R remain unclear. To mimic CI/R , HT22 cells were subjected to oxygen glucose deprivation/reoxygenation (OGD/R). Read More

Diabetes Care 2021 Apr 19. Epub 2021 Apr 19.

Dallas Diabetes Research Center, Dallas, TX.

Objective: Insulin icodec (icodec) is a novel once-weekly basal insulin analog. This trial investigated two approaches for switching to icodec versus once-daily insulin glargine U100 (IGlar U100) in people with type 2 diabetes receiving daily basal insulin and one or more oral glucose-lowering medications.

Research Design And Methods: This multicenter, open-label, treat-to-target phase 2 trial randomized (1:1:1) eligible basal insulin-treated (total daily dose 10-50 units) people with type 2 diabetes (HbA 7. Read More