176,996 results match your criteria glucocorticoid treatment

Differential DNA Methylation is associated with Hippocampal Abnormalities in Pediatric Posttraumatic Stress Disorder.

Biol Psychiatry Cogn Neurosci Neuroimaging 2021 May 5. Epub 2021 May 5.

Department of Child and Adolescent Psychiatry, The Netherlands; De Bascule, Academic Centre for Child and Adolescent Psychiatry, Amsterdam, The Netherlands.

Background: Recent findings in neuroimaging and epigenetics offer important insights into brain structures and biological pathways of altered gene expression associated with posttraumatic stress disorder (PTSD). However, it is unknown to what extent epigenetic mechanisms are associated with PTSD and its neurobiology in youth.

Methods: In this study we combined a methylome-wide association study and structural neuroimaging measures in a Dutch cohort of youth with PTSD (ages 8-18 years). Read More

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COVID-19 and endocrine and metabolic diseases. An updated statement from the European Society of Endocrinology.

Endocrine 2021 May 8. Epub 2021 May 8.

Institute of Endocrine and Metabolic Sciences, Vita-Salute San Raffaele University, IRCCS San Raffaele Hospital, Milano, Italy.

Background: COVID-19 has completely changed our daily clinical practice as well as our social relations. Many organs and biological systems are involved in SARS-Cov-2 infection, either due to direct virus-induced damage or to indirect effects that can have systemic consequences. Endocrine system is not only an exception but its involvement in COVID-19 is so relevant that an "endocrine phenotype" of COVID-19 has progressively acquired clinical relevance. Read More

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Ciprofloxacin and dexamethasone in combination attenuate S. aureus induced brain abscess via neuroendocrine-immune interaction of TLR-2 and glucocorticoid receptor leading to behavioral improvement.

Int Immunopharmacol 2021 May 4;97:107695. Epub 2021 May 4.

Department of Physiology, Immunology Laboratory, University of Calcutta, University Colleges of Science and Technology, Calcutta, West Bengal, India. Electronic address:

Staphylococcus aureus induced brain abscess is a critical health concern throughout the developing world. The conventional surgical intervention could not regulate the abscess-induced brain inflammation. Thus further study over the alternative therapeutic strategy for treating a brain abscess is of high priority. Read More

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Energy and corticosteroid mobilization following an induced stress response in an elasmobranch fish, the North Pacific spiny dogfish (Squalus acanthias suckleyi).

Gen Comp Endocrinol 2021 May 4:113799. Epub 2021 May 4.

Department of Biological Sciences, 50 Sifton Road, University of Manitoba, Winnipeg R3T 2N2, Manitoba, Canada; Bamfield Marine Sciences Centre, 100 Pachena Road, Bamfield R3T 0A8, British Columbia, Canada.

The dominant corticosteroid in elasmobranchs, 1α-hydroxycorticosterone (1α-OHB), has a described role in mineral regulation but a presumptive role in energy balance. Energy demand in vertebrates following exposure to a stressor typically involves an immediate but transient release of glucocorticoids as a means of mobilizing available energy stores, usually in the form of glucose. Although a glucocorticoid role for 1α-OHB would be expected, direct glucocorticoid function of this steroid has yet to be reported in any elasmobranch. Read More

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The Association Between Glucocorticoid Administration and the Risk of Impaired Efficacy of Axicabtagene Ciloleucel Treatment: A Systematic Review.

Front Immunol 2021 20;12:646450. Epub 2021 Apr 20.

Department of Neurosurgery, The First Affiliated Hospital, University of South China, Hengyang, China.

Background: Glucocorticoid is one of the common and important strategies for the treatment of chimeric antigen receptor T (CAR-T) cell therapy-related toxicity. However, there has been a theoretical concern about whether glucocorticoids use can impact the expansion of CAR-T cells and thus impair its efficacy. Hence, we reviewed studies related to the Axicabtagene ciloleucel (Axi-cel), a first-class and widely used CAR-T cell product, to elucidate the association between glucocorticoids administration and efficacy of Axi-cel. Read More

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Top Companion Anim Med 2021 May 3:100536. Epub 2021 May 3.

Clinica Veterinaria Malpensa/Anicura, Via G. Marconi 27, 21017 Samarate, Varese (Italy), Tommaso. Electronic address:

Anaphylactoid reactions to anaesthetic drugs are rarely reported in veterinary medicine. The aim of this report is to describe a suspected anaphylactic reaction to propofol in a 14 years old Shih-Tzu undergoing general anaesthesia for ovariohysterectomy due to a pyometra. The anesthetic protocol included intramuscular methadone for premedication and fentanyl, midazolam and propofol intravenously for co-induction. Read More

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Fasting hormones synergistically induce amino acid catabolism genes to promote gluconeogenesis.

Cell Mol Gastroenterol Hepatol 2021 May 3. Epub 2021 May 3.

Institute of Biochemistry, Food Science and Nutrition. The Robert H. Smith Faculty of Agriculture, Food and Environment. The Hebrew University of Jerusalem. POB 12, Rehovot 7610001, Israel. Electronic address:

Background & Aims: Gluconeogenesis from amino acids (AAs) maintains glucose homeostasis during fasting. While glucagon is known to regulate AA catabolism, the contribution of other hormones to it and the scope of transcriptional regulation dictating AA catabolism are unknown. We explored the role of the fasting hormones glucagon and glucocorticoids in transcriptional regulation of AA catabolism genes and AA-dependent gluconeogenesis. Read More

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Pharmacologic activities of phytosteroids in inflammatory diseases: Mechanism of action and therapeutic potentials.

Phytother Res 2021 May 6. Epub 2021 May 6.

Biological Chemistry Lab, Central Department of Chemistry, Tribhuvan University, Kirtipur, Nepal.

Natural products and their derivatives are known to be useful for treating numerous diseases since ancient times. Because of their high therapeutic potentials, the use of different medicinal plants is possible to treat varied inflammation-mediated chronic diseases. Among natural products, phytosteroids have emerged as promising compounds mostly because they have diverse pharmacological activities. Read More

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Comparison of Survival of Preterm Newborn Rabbits at 25-28 Days of Gestation with Perinatal Therapies at Birth Transition.

J Appl Physiol (1985) 2021 May 6. Epub 2021 May 6.

Department of Pediatrics and Neonatology, Children's Hospital of Fudan University, China.

Background Eligibility of ventilated preterm rabbit model to investigate extreme pulmonary immaturity at birth transition is unknown. By extending this model to early saccular stage of fetal lung development, we evaluated efficacy in survival, lung maturation and underlying mechanisms of contemporary perinatal therapies.

Methods: Pregnant New Zealand White rabbit does were given dexamethasone (DEX), or sham injection as control (NDEX), 48 and 24 h before delivery at gestational age (GA) of 25-28 days. Read More

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Glucocorticoid-Induced Myopathy in People with Asthma: A Systematic Review.

J Asthma 2021 May 5:1-24. Epub 2021 May 5.

Rehabilitation Sciences Institute, University of Toronto Faculty of Medicine, Toronto, Ontario, CAN.

To review the current literature on the evidence and the underlying characteristics of glucocorticoids (type, dosage, and duration) associated with myopathy in asthma. Four electronic databases were searched to October 19, 2020. Inclusion criteria: adults or adolescents with asthma, taking systemic glucocorticoids, and measures of muscle impairments. Read More

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Collapsing focal segmental glomerulosclerosis in a patient with oral cavity cancer: A case report.

Medicine (Baltimore) 2021 May;100(18):e25857

Department of Internal Medicine, Research Institute of Clinical Medicine, Jeonbuk National University Medical School.

Rationale: Focal segmental glomerulosclerosis (FSGS) is one of the most common glomerular diseases, leading to end-stage renal disease. Among the 5 variants of FSGS, the collapsing variant is rare and has the worst prognosis. Solid and hematologic malignancies are associated with glomerular diseases, such as membranous nephropathy, minimal change disease, and FSGS. Read More

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Perfusion image guided mechanical thrombectomy combined with tirofiban successfully revascularize systemic lupus erythematosus related acute large vessel occlusion: A case report.

Medicine (Baltimore) 2021 May;100(18):e25779

Department of Neurological Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

Rationale: Systemic lupus erythematosus (SLE) is an important cause of stroke, more than a half the cases present as acute ischemic stroke. Thrombolysis is an effective choice in most cases, but for large vessel occlusion, mechanical thrombectomy is more effective. Here we reported a case of SLE-related stroke with left middle cerebral artery (MCA) occlusion, who was successfully treated by MT and tirofiban. Read More

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Fatal hemoperitoneum due to rupture of mesenteric artery in remission state of microscopic polyangiitis, concomitant with severe hypertension and posterior reversible encephalopathy syndrome: an autopsy case report.

CEN Case Rep 2021 May 4. Epub 2021 May 4.

Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan.

Microscopic polyangiitis (MPA) is a type of necrotizing vasculitis associated with high levels of myeloperoxidase-specific antineutrophil cytoplasmic antibody (MPO-ANCA). While generally associated with renal dysfunction, MPA can also cause intraabdominal hemorrhage in rare cases. A 66-year-old man was admitted to our hospital for renal dysfunction, numbness, and weight loss for 3 months. Read More

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Ocrelizumab-induced inflammatory bowel disease-like illness characterized by esophagitis and colitis.

Ann Gastroenterol 2021 27;34(3):447-448. Epub 2021 Jan 27.

Department of Gastroenterology (Alex Barnes, Dirk Hofmann, Réme Mountifield).

Ocrelizumab is an intravenous anti-CD20 monoclonal antibody, approved for use in primary progressive multiple sclerosis due to its selective depletion of B-lymphocytes. Herein we describe the case of a 56-year-old female who developed odynophagia and bloody diarrhea following treatment with ocrelizumab. This was characterized endoscopically by ulcerations in the esophagus and colon. Read More

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January 2021

A Novel -Butyl Derivatives of Pseudothiohydantoin as Potential Target in Anti-Cancer Therapy.

Molecules 2021 Apr 29;26(9). Epub 2021 Apr 29.

Department of Medical Biology and Biochemistry, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Karłowicza 24, 85-092 Bydgoszcz, Poland.

Tumors are currently more and more common all over the world; hence, attempts are being made to explain the biochemical processes underlying their development. The search for new therapeutic pathways, with particular emphasis on enzymatic activity and its modulation regulating the level of glucocorticosteroids, may contribute to the development and implementation of new therapeutic options in the treatment process. Our research focuses on understanding the role of 11β-HSD1 and 11β-HSD2 as factors involved in the differentiation and proliferation of neoplastic cells. Read More

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Dysbiosis and Alzheimer's Disease: A Role for Chronic Stress?

Biomolecules 2021 Apr 30;11(5). Epub 2021 Apr 30.

Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.

Alzheimer's disease (AD) is an incurable, neuropsychiatric, pathological condition that deteriorates the worth of geriatric lives. AD is characterized by aggregated senile amyloid plaques, neurofibrillary tangles, neuronal loss, gliosis, oxidative stress, neurotransmitter dysfunction, and bioenergetic deficits. The changes in GIT composition and harmony have been recognized as a decisive and interesting player in neuronal pathologies including AD. Read More

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Clinical-radiological characteristics and intestinal microbiota in patients with pancreatic immune-related adverse events.

Thorac Cancer 2021 May 4. Epub 2021 May 4.

Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.

Background: The pancreatic immune-related adverse event (irAE) is a rare but increasingly occurrence disease with limited knowledge, which was associated with the use of immune checkpoint inhibitors (ICIs).

Methods: In this case series study of pancreatic irAE patients, clinical and radiological manifestations are summarized. Baseline and post-treatment fecal microbiota of immune-related acute pancreatitis (irAP) patients were analyzed by the 16 s rDNA amplicon sequencing method. Read More

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The characteristics and its contributing factors of refractory rheumatoid arthritis, view of the rheumatologists of China: results of a nationwide cross-sectional survey.

Clin Rheumatol 2021 May 3. Epub 2021 May 3.

Department of Rheumatology and Immunology, Peking University People's Hospital, 11 Xizhimen South Street, Beijing, 100044, China.

Objective: To explore the characteristics of refractory RA and its contributory factors based on the understanding of the rheumatologists of China.

Methods: A national cross-sectional survey was performed in 32 provinces across China, and 1381 rheumatologists were recruited. Information about the sociodemographic background, refractory RA characteristics, and contributory factors was collected using a pre-made questionnaire including fourteen single-choice and four multiple-choice questions, respectively. Read More

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Baicalein alleviates osteoarthritis by protecting subchondral bone, inhibiting angiogenesis and synovial proliferation.

J Cell Mol Med 2021 May 3. Epub 2021 May 3.

Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Osteoarthritis (OA) is one of the most frequent chronic joint diseases with the increasing life expectancy. The main characteristics of the disease are loss of articular cartilage, subchondral bone sclerosis and synovium inflammation. Physical measures, drug therapy and surgery are the mainstay of treatments for OA, whereas drug therapies are mainly limited to analgesics, glucocorticoids, hyaluronic acids and some alternative therapies because of single therapeutic target of OA joints. Read More

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A French cohort of patients with giant cell arteritis: glucocorticoid treatment and its associated side effects.

Clin Exp Rheumatol 2021 Apr 30. Epub 2021 Apr 30.

Department of Internal Medicine, Hôpital Cochin, Université de Paris, Sorbonne Paris Cité, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, Paris, and Institut Cochin, INSERM U1016, CNRS UMR 8104, Paris, France.

Objectives: Giant cell arteritis (GCA) is the most common primary large-vessel vasculitis. Glucocorticoids (GC) therapy remains the standard of care for GCA despite frequent side effects (SEs). However, treatment modality changes, prophylactic treatment of osteoporosis, or vaccinations might have decreased the frequency of GC-related SEs. Read More

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An Initiative to Improve Timely Glucocorticoid Tapering in Vasculitis.

J Clin Rheumatol 2021 Apr 27. Epub 2021 Apr 27.

From the Lupus and Vasculitis Clinic, Division of Rheumatology, McGill University Health Centre, Montreal, Quebec Division of Rheumatology, Vancouver General Hospital, Vancouver, British Columbia Division of Rheumatology, Sunnybrook Health Sciences Centre Vasculitis Clinic, Division of Rheumatology, Mount Sinai Hospital, Toronto, Ontario, Canada.

Background/objective: High-dose glucocorticoids (GCs) are required in the initial treatment of systemic vasculitis. However, slow or delayed tapering can lead to unnecessary GC exposure and toxicity. In this quality improvement initiative, we aimed to increase appropriate GC tapering among newly referred patients awaiting specialty consultation at a tertiary vasculitis clinic. Read More

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Clinical relevance of serum immunoglobulin G4 in glucocorticoid therapy of Graves' ophthalmopathy.

Clin Endocrinol (Oxf) 2021 May 3. Epub 2021 May 3.

Department of Endocrinology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, P.R. China.

Objective: Previous studies suggested IgG4 levels were associated with the development of Graves' ophthalmopathy (GO). The present study investigated the role of IgG4 levels in glucocorticoid (GC) treatment in GO patients.

Methods: Sixty-nine GO patients were enrolled. Read More

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A Novel Case of Cytomegalovirus Pneumonia in an Acquired Thrombotic Thrombocytopenic Purpura Patient Treated With Rituximab.

Cureus 2021 Mar 30;13(3):e14182. Epub 2021 Mar 30.

Internal Medicine and Nephrology, McLaren Health Care, Flint/MSU, Flint, USA.

Thrombotic thrombocytopenic purpura (TTP) is thrombotic microangiopathy that is universally fatal if not promptly recognized and treated. Standard treatment includes plasma exchange (PLEX) therapy and immunosuppression. We present a case of an 80 years old African American male with a past medical history significant for essential hypertension, chronic obstructive pulmonary disease, and a recent TTP diagnosis for which he was treated with PLEX, glucocorticoids, and rituximab. Read More

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Peripheral TIGIT+ T Follicular Helper Cells That Produce High Levels of Interleukin-21 OX40 Represent Disease Activity in IgG4-Related Disease.

Front Immunol 2021 14;12:651357. Epub 2021 Apr 14.

Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

Objectives: Multiple studies suggest that interleukin (IL)-21 plays a pivotal role in the differentiation of B cells and activation of cytotoxic T cells and is involved in the pathogenesis of IgG4-related disease (IgG4-RD). T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT) is a new marker of T follicular helper (Tfh) cells, yet its significance remains unknown. The objective of this study was to investigate whether TIGIT expression could detect high IL-21-producing peripheral Tfh populations and their association with disease activity in IgG4-RD. Read More

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Treatment Strategies for GLILD in Common Variable Immunodeficiency: A Systematic Review.

Front Immunol 2021 15;12:606099. Epub 2021 Apr 15.

Department of Pediatric Immunology and Rheumatology, Wilhelmina Children's Hospital, Utrecht, Netherlands.

Introduction: Besides recurrent infections, a proportion of patients with Common Variable Immunodeficiency Disorders (CVID) may suffer from immune dysregulation such as granulomatous-lymphocytic interstitial lung disease (GLILD). The optimal treatment of this complication is currently unknown. Experienced-based expert opinions have been produced, but a systematic review of published treatment studies is lacking. Read More

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Dexamethasone can be safely and effectively used for treatment of masticatory muscle myositis in dogs.

Top Companion Anim Med 2021 Apr 29:100538. Epub 2021 Apr 29.

Department of Neurology and Neurosurgery, Dick White Referrals, Six Mile Bottom, UK.

Dexamethasone is the glucocorticoid of choice in many human inflammatory and immune-mediated conditions, given its reported effectiveness and limited side effect profile. In veterinary medicine, the glucocorticoid of choice is prednisone, however the safety of longer-term use of dexamethasone has not previously been studied. The aim of this study was to evaluate the safety, effectiveness and side effects of dexamethasone use as the glucocorticoid treatment for masticatory muscle myositis in dogs - an immune-mediated inflammatory condition. Read More

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Elevated glucocorticoids during gestation suggest sex-specific effects on offspring telomere lengths in a wild lizard.

Comp Biochem Physiol A Mol Integr Physiol 2021 Apr 29:110971. Epub 2021 Apr 29.

Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, PA 16802, United States of America; Intercollege Graduate Degree Program in Ecology, The Pennsylvania State University, University Park, PA 16802, United States of America.

The effects of maternal glucocorticoids (e.g. corticosterone, CORT) on offspring interest biologists due to increasing environmental perturbations. Read More

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Involvement of BMP-15 in glucocorticoid actions on ovarian steroidogenesis by rat granulosa cells.

Biochem Biophys Res Commun 2021 Apr 28;559:56-61. Epub 2021 Apr 28.

Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. Electronic address:

To elucidate the impact of glucocorticoids on ovarian steroidogenesis and its molecular mechanism by focusing on bone morphogenetic proteins (BMPs), we examined the effect of dexamethasone (Dex) on estradiol and progesterone synthesis by using primary culture of rat granulosa cells. It was revealed that Dex treatment dose-dependently decreased estradiol production but increased progesterone production induced by follicle-stimulating hormone (FSH) by granulosa cells. In accordance with the effects of Dex on estradiol synthesis, Dex suppressed P450arom mRNA expression and cAMP synthesis induced by FSH. Read More

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Proteomic analysis of hemocyte reveals the immune regulatory mechanisms after the injection of corticosteroid-releasing hormone in mud crab Scylla Paramamosain.

J Proteomics 2021 Apr 27;242:104238. Epub 2021 Apr 27.

Key Laboratory of Tropical Hydrobiology and Biotechnology of Hainan Province, Hainan Aquaculture Breeding Engineering Research Center, College of Marine Sciences, Hainan University, Haikou, Hainan 570228, China. Electronic address:

Corticosteroid-releasing hormone (CRH) is a crucial neuroendocrine-immune factor regulating the immune response of Scylla paramamosain. To understand the regulatory mechanisms of CRH in S. paramamosain, the hemolymph of S. Read More

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What if COVID-19 affects the child: which weapons and how to use them.

Eur Rev Med Pharmacol Sci 2021 Apr;25(8):3325-3337

School of Pediatrics, University of Cagliari, Cagliari, Italy.

Since the reports in Wuhan (China), in December 2019, of the first cluster of cases of pneumonia caused by the new Coronavirus called 2019-nCoV or SARS-CoV-2, there has been a pandemic spread of the infection. By now, we have no specific therapy to counteract this emergency. The latest epidemiological data suggest that children are just as likely as adults to get infected by the virus. Read More

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